What Causes Recurrent Miscarriage

 

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Anatomical factors that may cause recurrent miscarriages include: 1  Uterine septum (or other congenital problems) Cervical insufficiency Fibroids (controversial) Uterine scarring. In the other half, causes can be found and these include: Abnormalities of the pregnant woman’s womb (uterus). For example, long-standing infection or inflammation of the womb A weak (incompetent) neck of the womb (cervix), also known as cervical. Another possible cause of recurrent miscarriage is a congenital anomaly of the uterus. Examples include a septate uterus, adhesions and scarring of the uterus, an incompetent cervix, fibroids, and polyps.

Women with certain medical conditions may. Recurrent miscarriage may be attributed to an underlying health condition. For example, an autoimmune disorder called antiphospholipid syndrome (APS) is associated with miscarriage and fetal death. In this condition, the immune system creates antibodies to certain substances involved in normal blood clotting. Recurrent miscarriage is two or more consecutive pregnancy losses.

In contrast, infertility is the inability to conceive. In many cases the cause of RPL is unknown. After three or more losses, a thorough evaluation is recommended by American Society of Reproductive Medicine. About 1% of couples trying to have children are affected by recurrent miscarriage.

Recurrent early miscarriages (within the first trimester) are most commonly due to genetic or chromosomal problems of the embryo, with 50-80% of spontaneous losses having abnormal chromosomal number. Structural problems of the uterus can also play a role in early miscarriage. The miscarriage may be due to poor blood supply to the pregnancy or inflammation. Some women may be born with an irregularly shaped uterus, and some women may develop abnormalities with their uterus over time.

A woman’s immune system may also play a role in recurrent pregnancy loss. Usually, the cause was a random genetic problem in the developing baby, and there was nothing that could have prevented it. 1  And as you probably know, the majority of women who have one miscarriage go on to have an uneventful next pregnancy.

Miscarriage Causes and Risk Factors Most miscarriages happen when the unborn baby has fatal genetic problems. Usually, these problems are not related to the mother. However, the likelihood of having recurrent miscarriages (at least 2 or 3) is low, only occurring in about 1 percent of women.

Studies have shown an increased risk for miscarriage in.

List of related literature:

The most common cause of late miscarriage is a maternal factor involving premature dilation of the cervix, but fibroid tumors and uterine abnormalities are other maternal causes of late miscarriage.

“Having Your Baby Through Egg Donation: Second Edition” by Evelina Weidman Sterling, Ellen Sarasohn Glazer
from Having Your Baby Through Egg Donation: Second Edition
by Evelina Weidman Sterling, Ellen Sarasohn Glazer
Jessica Kingsley Publishers, 2013

The most common known causes of stillbirth are maternal diabetes, bacterial infection, high blood pressure, placental problems, growth restriction, and umbilical cord accidents.

“Our Bodies, Ourselves: Pregnancy and Birth” by Boston Women's Health Book Collective, Judy Norsigian
from Our Bodies, Ourselves: Pregnancy and Birth
by Boston Women’s Health Book Collective, Judy Norsigian
Atria Books, 2008

Other possible causes of early miscarriage include endocrine imbalance (as in women who have luteal phase defects, hypothyroidism, or insulin-dependent diabetes mellitus with high blood glucose levels in the first trimester), immunologic factors (e.g.,

“Maternal Child Nursing Care E-Book” by Shannon E. Perry, Marilyn J. Hockenberry, Kathryn Rhodes Alden, Deitra Leonard Lowdermilk, Mary Catherine Cashion, David Wilson
from Maternal Child Nursing Care E-Book
by Shannon E. Perry, Marilyn J. Hockenberry, et. al.
Elsevier Health Sciences, 2017

Although the actual cause of the miscarriage is frequently unclear, the most common reasons include the following: • Genetic factors: Chromosomal abnormalities are probably the most common underlying cause for first and early second trimester miscarriages.

“Textbook for MRCOG-1: Basic Sciences in Obstetrics & Gynaecology” by Richa Saxena
from Textbook for MRCOG-1: Basic Sciences in Obstetrics & Gynaecology
by Richa Saxena
Jaypee Brothers,Medical Publishers Pvt. Limited, 2019

Other causes of miscarriage include endocrine abnormalities, maternal infection, uterine abnormalities (e.g., uterine fibroids, endometriosis), immunologic factors, and environmental factors.

“Lewis's Medical-Surgical Nursing E-Book: Assessment and Management of Clinical Problems, Single Volume” by Mariann M. Harding, Jeffrey Kwong, Dottie Roberts, Debra Hagler, Courtney Reinisch
from Lewis’s Medical-Surgical Nursing E-Book: Assessment and Management of Clinical Problems, Single Volume
by Mariann M. Harding, Jeffrey Kwong, et. al.
Elsevier Health Sciences, 2019

Other factors are stress, uterine anomalies or cervical trauma; uterine stretch caused by multiple gestation or polyhydramnios; smoking, drug, or alcohol use; and maternal age extremes or low socioeconomic and educational status or an uncontrolled medical condition.

“Core Curriculum for Maternal-Newborn Nursing E-Book” by AWHONN, Susan Mattson, Judy E. Smith
from Core Curriculum for Maternal-Newborn Nursing E-Book
by AWHONN, Susan Mattson, Judy E. Smith
Elsevier Health Sciences, 2010

Recurrent miscarriage, three or more consecutive miscarriages, occur in 2% to 3% of women and are usually caused by chromosomal abnormalities, metabolic disorders, immune factors, problems with the woman’s reproductive anatomy, or metabolic disorders (Horn & Alexander, 2005).

“Dimensions of Human Behavior: The Changing Life Course” by Elizabeth D. Hutchison
from Dimensions of Human Behavior: The Changing Life Course
by Elizabeth D. Hutchison
SAGE Publications, 2008

• Previous repeated miscarriages may be due to genetic causes, antiphospholipid antibody syndrome, syphilis, mullerian anomalies such as an intrauterine septum or concomitant pathology such as fibroids in the uterus or immunological causes.

“Manual of Obstetrics E-book” by Daftary, SUDIP Chakravarti, Muralidhar Pai, Prahalad Kushtagi
from Manual of Obstetrics E-book
by Daftary, SUDIP Chakravarti, et. al.
Elsevier Health Sciences, 2015

Other contributing causes to recurrent miscarriage are: endocrine abnormalities; blood disorders; environmental agents; immunologic reactions; and maternal

“Infertility Counseling: A Comprehensive Handbook for Clinicians” by Sharon N. Covington, Linda Hammer Burns
from Infertility Counseling: A Comprehensive Handbook for Clinicians
by Sharon N. Covington, Linda Hammer Burns
Cambridge University Press, 2006

Other causes are trauma, sudden uterine decompression, short cord, supine hypotension syndrome, placental anomalies, sick placenta, folic acid deficiency, uterine factor, torsion of the uterus, cocaine abuse, thrombophilias, prior abruption, etc.

“Elsevier Comprehensive Guide to Combined Medical Services (UPSC)-E-Book” by Rajeev Kumar, Prakash Nayak
from Elsevier Comprehensive Guide to Combined Medical Services (UPSC)-E-Book
by Rajeev Kumar, Prakash Nayak
Elsevier Health Sciences, 2015

Oktay Kutluk

Kutluk Oktay, MD, FACOG is one of the world's foremost experts in fertility preservation as well as ovarian stimulation and in vitro fertilization for infertility treatments. He developed and performed the world's first ovarian transplantation procedures as well as pioneered new ovarian stimulation protocols for embryo and oocyte freezing for breast and endometrial cancer patients.

Mail: [email protected]
Telephone: +1 (877) 492-3666

Biography: https://medicine.yale.edu/profile/kutluk_oktay/
Bibliography: oktay_bibliography

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6 comments

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  • Watch the next video in this series, all about what we did differently to have a successful pregnancy after miscarriage: https://www.youtube.com/watch?v=t5AV1-Ow-WM

  • Thank you for this video! I wish I could find a doctor who takes my concerns about recurrent miscarriage seriously ��. I just had my fifth miscarriage and this was the latest it’s happened (I was 13.5 weeks). I’ve had two perfectly healthy pregnancies so I don’t know what’s going on. All the doctors I’ve seen have told me it’s just bad luck and keep trying.

  • After having three children with no issues I suddenly started having miscarriages.
    I’ve Just had my 5th back to back loss. We’ve tried progesterone, low dose aspirin. Lots of tests. Still waiting on our rainbow ��

  • I had recurrent miscarriage in early trimester and again twice within two month my Gyn give me injection that I should inject my belly for six months and pills to insert in my vag as soon as I start using that I had miscarriage with my second pregnancy what was the problem Dr Uthuman what must I do rectify it.

  • What a through explanation! I absolutely enjoyed your lecture. As a medical professional I found the information to be accurate, easy to understand, and mentally stimulating. Thank you for being so informative!

  • Ive just watch your videos and love the way you’ve explain it…i just want to ask hope you apprehend to reply..since 2013 i got pregnant but got miscarriage at that time my age is 39 till now hopeless to get pregnant again.Do i still have a chance to get pregnant again?and if so what medicine can i take to get pregnant? Have a heart to reply pls!