The Hyperlink Between Factor V Leiden and Recurrent Miscarriages

 

Factor V Leiden Blood Disorder

Video taken from the channel: Medical-Question


 

Factor V leiden causes, symptoms, diagnosis, treatment, pathology

Video taken from the channel: Osmosis


 

Presentation #4: Case 4 Homozygous Factor V Leiden with No Thrombosis

Video taken from the channel: Foundation for Women & Girls With Blood Disorders


 

Factor V Leiden and Pregnancy Success Story

Video taken from the channel: mycoachbrianna Brianna Rangel


 

Nova Journal Club ESHRE guidelines recurrent pregnancy loss

Video taken from the channel: Nova IVF Fertility


 

THE RESULTS ARE IN | Bloodwork After Recurrent Miscarriage

Video taken from the channel: ItsKelsiesLife


 

TTC TIPS |WHAT I AM DOING DIFFERENTLY PREGNANCY AFTER MISCARRIAGES| MTHFR, LOVENOX, FACTOR 5 LEIDEN

Video taken from the channel: EmsEssentials


Heritable thrombophilia is a category of genetic disorders of the coagulation cascade with the increasing risk of thrombus formation and recurrent pregnancy loss (RPL). Factor V Leiden (FVL) (R506Q) mutation is the most common genetic cause of deep venous thrombosis, but its association with RPL has been inconsistent in studies arising from non. Factor V Leiden is a common thrombophilic mutation. METHODS: The prospective outcome of untreated pregnancies amongst 25 women heterozygous for the Factor V Leiden allele who had a history of either recurrent early miscarriages only (three or more miscarriages at <12 weeks gestation; n = 19) or of late miscarriage (>12 weeks gestation; n = 9) was studied. The live birth rate was significantly lower amongst women with a history of recurrent early miscarriage who carried the Factor V Leiden allele (6/16; 37.5%) compared with.

Purpose: Heritable thrombophilia is a category of genetic disorders of the coagulation cascade with the increasing risk of thrombus formation and recurrent pregnancy loss (RPL). Factor V Leiden (FVL) (R506Q) mutation is the most common genetic cause of deep venous thrombosis, but its association with RPL has been inconsistent in studies arising from non-Western countries. Our results show that factor V Leiden is associated with a nonsignificant trend towards risk of miscarriage in a subsequent pregnancy among women with recurrent miscarriage. The risk was 52% compared with that of 43% in women with unexplained recurrent.

Background Although numerous replication case-control studies have attempted to determine the association between Factor V Leiden (FVL) 1691G > A mutation and susceptibility to Recurrent pregnancy loss (RPL), there have been confliction among the results of. In summary, if you have experienced recurrent miscarriages or later-term pregnancy loss, talk to your healthcare provider about the potential for factor V Leiden being a culprit. It is important to do so prior to trying for another baby.

The most common cause of hereditary thrombophilia is factor V Leiden (FVL) and prothrombin gene mutation.5 Studies have reported prevalence of FVL mutation among women with recurrent miscarriage ranging from 3% to 42%.6 FVL. between Factor V Leiden (FVL) 1691G>A mutation and susceptibility to Recurrent pregnancy loss (RPL), there have been confliction among the results of various ethnic groups. To address this limitation, here we implemented first meta-analysis to provide with consistent conclusion of the association between FVL 1691G>A mutation and RPL risk. Protein C, Factor V Leiden, Protein S deficiency, Prothrombin gene mutation and Antithrombin III deficiency These are the hereditary thrombophilias that seem to be linked to miscarriages after 10 weeks.

Some doctors test for these and others do not.

List of related literature:

Factor V. Leiden in pregnancies complicated by placental abruption.

“Creasy and Resnik's Maternal-Fetal Medicine: Principles and Practice E-Book” by Robert Resnik, Charles J. Lockwood, Thomas Moore, Michael F Greene, Joshua Copel, Robert M Silver
from Creasy and Resnik’s Maternal-Fetal Medicine: Principles and Practice E-Book
by Robert Resnik, Charles J. Lockwood, et. al.
Elsevier Health Sciences, 2018

Lissalde-Lavigne G, Fabbro-Peray P, Quere I, et al: Factor V Leiden and prothrombin G20210A polymorphisms as risk factors for miscarriage during a first intended pregnancy: The matched case-control “NOHA First” study.

“Creasy and Resnik's Maternal-Fetal Medicine: Principles and Practice E-Book” by Robert Resnik, Robert K. Creasy, Jay D. Iams, Charles J. Lockwood, Thomas Moore, Michael F Greene, Lesley Frazier
from Creasy and Resnik’s Maternal-Fetal Medicine: Principles and Practice E-Book
by Robert Resnik, Robert K. Creasy, et. al.
Elsevier Health Sciences, 2008

Factor V Leiden and prothrombin G20210A polymorphisms as risk factors for miscarriage during a first intended pregnancy: the matched case-control “NOHA first” study.

“Comprehensive Gynecology E-Book” by Rogerio A. Lobo, David M Gershenson, Gretchen M Lentz, Fidel A Valea
from Comprehensive Gynecology E-Book
by Rogerio A. Lobo, David M Gershenson, et. al.
Elsevier Health Sciences, 2016

Factor V Leiden and prothrombin G20210A mutations, but not methylenetetrahydrofolate reductase C677T, are associated with recurrent miscarriages.

“Oxford Textbook of Obstetrics and Gynaecology” by Sabaratnam Arulkumaran, William Ledger, Stergios Doumouchtsis, Lynette Denny
from Oxford Textbook of Obstetrics and Gynaecology
by Sabaratnam Arulkumaran, William Ledger, et. al.
Oxford University Press, 2019

Procházka M, Happach C, Marsal K, et al: Factor V Leiden in pregnancies complicated by placental abruption.

“High Risk Pregnancy E-Book: Management Options Expert Consult” by David K. James, Philip J. Steer, Carl P. Weiner, Bernard Gonik
from High Risk Pregnancy E-Book: Management Options Expert Consult
by David K. James, Philip J. Steer, et. al.
Elsevier Health Sciences, 2010

Prochazka M, Happach C, Marsal K, et al: Factor V Leiden in pregnancies complicated by placental abruption.

“Obstetrics: Normal and Problem Pregnancies E-Book” by Steven G. Gabbe, Jennifer R. Niebyl, Henry L Galan, Eric R. M. Jauniaux, Mark B Landon, Joe Leigh Simpson, Deborah A Driscoll
from Obstetrics: Normal and Problem Pregnancies E-Book
by Steven G. Gabbe, Jennifer R. Niebyl, et. al.
Elsevier Health Sciences, 2016

Coppens M, Folkeringa N, Teune M, et al: Natural course of the subsequent pregnancy after a single loss in women with and without the factor V Leiden or prothrombin 20210A mutations.

“Consultative Hemostasis and Thrombosis E-Book” by Craig S. Kitchens, Barbara A Konkle, Craig M. Kessler
from Consultative Hemostasis and Thrombosis E-Book
by Craig S. Kitchens, Barbara A Konkle, Craig M. Kessler
Elsevier Health Sciences, 2013

Natural course of the subsequent pregnancy after a single loss in women with and without the factor V Leiden or prothrombin 20210A mutations.

“Consultative Hemostasis and Thrombosis E-Book” by Craig S. Kitchens, Barbara A Konkle, Craig M. Kessler
from Consultative Hemostasis and Thrombosis E-Book
by Craig S. Kitchens, Barbara A Konkle, Craig M. Kessler
Elsevier Health Sciences, 2018

Patients who are homozygous for factor V Leiden have a >80% lifetime risk of thrombosis, as well as a significantly higher risk of adverse pregnancy outcomes, including recurrent miscarriage.

“Comprehensive Gynecology” by Gretchen M. Lentz, David M. Gershenson
from Comprehensive Gynecology
by Gretchen M. Lentz, David M. Gershenson
Elsevier Mosby, 2012

The association between thrombophilias and pregnancy loss is also stronger for Factor V Leiden, the prothrombin gene mutation, and protein S deficiency than for other thrombophilic defects.”

“Clinical Gynecologic Endocrinology and Infertility” by Leon Speroff, Marc A. Fritz
from Clinical Gynecologic Endocrinology and Infertility
by Leon Speroff, Marc A. Fritz
Lippincott Williams & Wilkins, 2005

Oktay Kutluk

Kutluk Oktay, MD, FACOG is one of the world's foremost experts in fertility preservation as well as ovarian stimulation and in vitro fertilization for infertility treatments. He developed and performed the world's first ovarian transplantation procedures as well as pioneered new ovarian stimulation protocols for embryo and oocyte freezing for breast and endometrial cancer patients.

Mail: [email protected]
Telephone: +1 (877) 492-3666

Biography: https://medicine.yale.edu/profile/kutluk_oktay/
Bibliography: oktay_bibliography

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  • One of my friend told me to try herbal medicine to get rid of my hsv2. I tried this treatment and I got great results…So I am recommending this product to all of you guys.. you can as well reach him on email [email protected] gmail.com or WhatsApp +2348114047176…..

  • I have factor 5 Leiden and have suffered 2 early miscarriages as well. I am seeing a Reproductive Endocrine Specialist now about it. I asked if I should take aspirin now he said to wait:( it sucks I really think I need to be on something before I conceive again that way we have a better chance of holding on to the pregnancy �� I wish you luck thank you for sharing your story!

  • I’m so thankful you made this video ♥️ I’ve had two miscarriages & TTC my 3rd. I have MTHFR & Factor 5 Leiden. I will be put on Lovenox as soon as positive test! It gives me hope to see someone have a successful pregnancy w/ the same things ♥️

  • It’s nice to come across fellow believers! I’ve had two miscarriages in the past year and haven’t been able to conceive since. I found out a month ago I’m compound heterozygous with the MTHFR. What mutation do you have? I’ve done a lot of research and read the book called “dirty Genes” it says to avoid folic acid but my doctor didn’t think it plays a roll and prescribed me taking 2mg of folic acid on top of my 1600mcg of folate. I’m so nervous to take it!!

  • Just tested positive for Factor V. Heterozygous. I had a miscarriage in February, and no luck sense. Does the baby aspirin help you conceive with factor V? Thanks so much for the video.

  • I love your faith. I had a heartbreaking miscarriage that damaged my faith, and that didn’t help with dealing with everything. Now years later, I see how wrong I was. God bless you in your journey!

  • I just experienced my 3rd miscarriage, I go in tomorrow for my second d&c. I am just like you completely healthy except I have pcos. They have no clue why I have had 3 miscarriages but my Dr. Want to do a test called Hysteroscopy so that way he can better see what’s going on.

  • Hi My Name Is Andy Nathaniel Travis Martin. Even Back When I Was At The Age Of Twenty Three Years Old At The Time, I Actually Ended Up With A Deep Vein Thrombosis/Pulmonary Embolism Blood Clot On My Left Leg At A Younger Age, Because I Have Both Copies Of The Same Rare Blood Disease That You Have, Called (Factor V Leiden) As Well. Another Words Both Copies Merged Together. Which Puts Me At A Higher Risk For Developing Newer Ones. The 1st Copy That Runs A lot On My Mom’s Side Of The Family, It Skipped My Mom & It Passed Down To Me. Due To A Family/Relative History Of Blood Clots, The 2nd Copy Came From My Father & It Passed Down To Me Because He Also Had A Blood Clot Too. Which Is One Of The Reasons Why I Ended Up With It Severely. Plus It’s One Of The Reasons Why It’s Genetic Too. My Doctor Said To Me That I’m Way Too Young Too Even Have This Kind Of Blood Disorder That Causes Blood Clots. But I Have It All Under Control Now. I Didn’t Know I Have It Too, But Now I Do. My Mom Says To Me, It’s Probably Something That’s A Dormant Inside Me. I’m Thinking It’s In The Genes. It’s like Juvenile (Diabetes Mellitus). The Sad Thing Is, I Have It Just As Bad As My Grandfather Had Gout.

  • I’m in the same boat as you! I’m currently pregnant with baby number three! I also made a video about my story… I actually found out because I had a pulmonary embolism while I was pregnant with my first. I only get blood clots when I’m pregnant because of the hormones. I get the knots too….

  • Wow thank you, many of the patients I see have this and I never really understood it. I always thought it was super interesting that a majority of them weren’t on chronic OAC therapy (unless they had other relevant diagnoses)

  • Have you watched BunInTheOven’s channel? She’s suffered recurrent miscarriage and found out her husband had a rare genetic transmutation. Check it out when you get a chance. Very informative!

  • Love this video!!! So real. Capturing how some women feel when they make a decision to have more kids. I am heterozygous factor V Leiden and I had preeclampsia with my first. I was unaware that the gene could effect pregnancy but now I’m more aware and we are trying for number 2.

  • I was 15 and almost died because of factor 5 I had a blood clot in my lung one pressing against my heart and my whole right leg and left arm was completely compacted.

  • Hi Kelsei, I am glad that you are doing well. I can totally relate to how you feel.
    I am just now experiencing my second miscarriage and it’s such a rough patch.
    Since it happened for the second time, I want to speak to my doctor about why this keep happening.
    Would you kindly advise of the tests I should ask my doctor to run?

    Thank you!

  • I have factor 5 Leiden. I just had my 4th miscarriage on May 6th 2015. It was a lil boy I named him David after his father. He once again I thought would be my miracle baby but unfortunately it didn’t happen for me that way. I refused to give up and definitely would like to try again. I’m trying to work with a whole new team of doctors so this way we can figure out what’s going on I’ve taken lovenox and I’ve also been on coumadin when I wasn’t pregnant. I am prone to clotting. I share my story just to say if you have a story similar or know someone going through a similar situation please share their story or if you you’ve been able to conceive please pass on some information that may help someone else thank you.

  • I completely understand. Feel exactly the same way. It’s like all I want is for someone to promise me it won’t happen again but without a reason for why it happened i will always worry that it will happen again. Also it’s great that you can get pregnant but I hate when people say “that’s the hardest part” because when you’ve experienced the pain of a miscarriage there’s no escaping the anxiety that comes along with every pregnancy thereafter which in my experience is definitely harder… knowing how much you stand to lose is… crippling:( you seem to be handling everything so beautifully with a lot of grace and positivity. Thanks for sharing your story!

  • Thank you for sharing this. I am glad to hear you are healthy, and I understand the frustration though that you wish it would have been your body so that you could fix it. I am in the same exact place after my recent miscarriage. I will be praying for you and your journey, and I hope for the best for both of us as my husband and I will be trying again soon. I have shared my story on my channel so feel free to check it out. Thank you for speaking out and for being an encouragement, and for encouraging women that it’s OK to talk about this. You are brave. Thank you:-)

  • They tested me for my thyroid but kept missing my TPO antibodies being high. I also found out I have MTHFR which can cause miscarriages as well.

  • I’m so glad you’re healthy but I understand your frustration. You just want answers, you just want to be able to see into your own body with Xray vision and see what the heck is going on. I didn’t have any genetic testing done after my February miscarriage, just hormonal testing thyroid, etc and everything came back normal. The doctor just said it was “bad luck” this time around but “at least I could get pregnant because that’s the hardest part.” So we didn’t get any answers either! Try to keep yourself busy, busy, busy so you stay positive and we are all rooting for you.

  • I have this as well. I had my daughter with no problems at all. Then 3 years lasted I had my son and found out after almost dying that I had factor 5! I’m on blood thinners daily now for the foreseeable future. I would love a 3rd baby but now I’m sooo scared!

  • I too have homozygous factor 5 leiden but I am currently in my third pregnancy! Fortunately I was diagnosed before my frist pregnancy and had to take daily heparin shots and wear compressions stockings.
    But everything went well: during my frist delivery I was even allowed to get a PDA (because I always get my shots in the evening and hadn’t had one in over 24 hours).
    Now in my third pregnancy (in addition to the heparin shots) I take acetylsalicy acid pills to support the placenta (because it was so not well supplied during the first two pregnancies. By the way: I always fpund shots in the stomach too painfull, that’s why I get them n my upper thigh ;)
    To all women out there who have FVL and are afraid: you don’t have to be. Just find a doctor whom you trust and who is prepared for your situation. You can definetly cope with this! (and sorry for my bad English, I’m not a native speaker ;-))

  • I felt the same way you do. I had a ton of testing, including genetic testing, hoping I would have answers. But nothing… it would just be nice to have answers.

  • I can completely relate to this, nothing came back on my tests either and I was really hoping something would and it would be something that would be easily treatable! Has your doctor mentioned doing any genetic tests on you and Anthony? The results of genetic blood testing took months to come back and luckily the results of those were fine for me and Andrew, as I think it’s extremely rare but if there’s something wrong with genetic compatibility it’s a much bigger issue, but could definitely be worth looking into if you want to try and rule everything out! If not, I cannot recommend speaking to your doctor about HCG boosters enough. My hormones just stopped doubling for some unbeknown reason with my last miscarriage, everything had looked fine until then, and I truly believe I wouldn’t have got this far without them! Sorry for the long and rambley comment, just wanted to say you are not alone in wanting them to find something, I was exactly the same, that’s a completely normal way to feel! It’s so weird feeling torn between being disappointed nothing came up but thankful at the same time that they can’t find a medical reason to say it would happen again! Xx

  • I am homozygous for Factor 5 Leiden. I did not find out until my children where teenagers. For women who are scared of the risks. Know that you can have both alleles for this and have pregnancy and child birth with no complications or medications. I am not saying if you know don’t take thinners. Just know that it is possible to be fine. I did it twice and no one had a clue.

  • I’m a new subscriber I have watched a bunch of your videos today. I had an 11 mc a year ago. We are still ttc currently in my two week wait after a round of clomid. I love how honest you are it’s nice to see someone be so honest about something so hard! ❤❤❤

  • I notice a lot of people keep on speaking about Erectodom Secrets. But I’m uncertain if it is good. Have you ever tried using this popular erectile dysfunction treatment?

  • Hey idk if your still active on here but I have factor v and have had several miscarriages I just found out not to long ago but it seems like I miscarry before 7 weeks is this normal?

  • My husband had Leiden V mutation with one copy of the allele and I had two miscarriage so depressed, the heartbeat stopped in week 7 both times and because we live in Iraq there is no that much knowledge about the reason. If you could help me contacting a doctor in the state to be in the safe in the third try.
    I really one have kid and it’s heartbreaking to have more than one miscarriage.

  • Thank you for posting this, I have factor 5 Leiden and have had 2 miscarriages, waiting to see the fertility specialist. I am scared but I won’t give up, thank you for reminding me there is hope and there are women out there with successful pregnancies

  • I can understand how your feeling. I recently had a miscarriage and found out it is due to my thyroid levels being low. I have actually had som relief knowing something is wrong and fixable. If the test all came back normal I would probably be driving myself insane trying to find something wrong.

    Thank you for sharing!

  • Hey darling, newish kinda subscriber here. I TOTALLY UNDERSTAND YOUR FRUSTRATION. I haven’t been unfortunate to have a miscarriage, but I have been 2 years with not even a BFP. Every test I have comes back negative, 100% fine.. No problems to worry about. Not getting answers is hard! It is just so frustrating to know that there is nothing you know of you can do to improve. I do connect so much with the relief but also the overwhelming frustration. My heart is with you darling.. Following along this journey and hopefully we can get pregnant soon!! xoxo

  • I would love to hear about the vitamins and supplements you’re taking!! My husband and I have two healthy children, for which we thank God for every day, but were heartbroken to lose our 3rd child 3 months ago. We’re currently ttc again, but my mama heart still aches for that baby. ❤️ Sending prayers and love to you, Kelsie! Can’t wait to see your next video!!

  • Im a mum of 5 healthy children and pregnant with my 6th and final baby and was diagnosed with factor V heterozygous in my fourth pregnancy. I was lucky up until my third pregnancy that my babies were healthy and nothing happened. It was during my third pregnancy that I had hypertension so extra testing was conducted with my fourth pregnancy and so I was diagnosed. I have common problems with my kidney function but being closely monitored so everything is done possible for baby and my health. Yes its a miracle God graced me with all my healthy babies andand for people to have hope there is a light at the end of the tunnel for
    people living with Factor V:)

  • I’ve been watching you for a while but have no commented, I totally understand the frustration that comes with being told your blood work results come back negative for any reasons as to why it happens. I’ve been ttc for over 2 years and have had 3 miscarriages in a row and it doesn’t get any easier:( sending you all my love and best wishes to you and your husband x

  • thank you so much for the advice I have factor v Leiden. only from my dads side I really want a child but I’m terrified as I have this condition but thank you so much for the advice ��

  • I have factor 5 deficiency, not Leiden, but I’m looking at videos of others who have something similar to what I have. I’m extremely happy that you had a successful pregnancy! I don’t have risk of clots with what I have thankfully, instead I don’t really clot at all (it will of course eventually clot as I’m sure you know, but it takes forever). again I’m very happy for you.

  • I am sorry you didn’t get the answers you are looking for that can be so frustrating. At least this helps you and your doctors narrow things down in case you need to do more investigation (and hoping you don’t). I would love to see a video on the vitamins and supplements you are taking and if your hubby is taking anything as well. Hang in there.

  • Sorry for your lost. I too have had recurrent miscarriages carrying my first baby 38 weeks and losing my second and third babies at 26 and 27 weeks my fourth pregnancy in 2016 I delivered at 27 weeks and my baby weighed one pound one ounce and lived for four months passing on because of his lungs. Throughout my storm, no one took the time to really test me to explain to me why. I was told for the first three pregnancies that it was an incompetent cervix. My cousin referred me to a physician in St. Charles Mo. at Fertility Partnership Dr. Elan Simckes. Day one he told me we are going to get you closure and started with a lot of blood work. After conceiving he referred me to a high-Risk doctor Dr. Michael Paul at Missouri Baptist Hospital St. Louis, Mo. I am currently 16 weeks pregnant with number five and after multipe test he concluded that i have a genetic clotting condition prothrombin gene mutation which prevented the baby in my recent pregnancies from receiving the proper blood flow and nutrition to the placenta. Knowing that i am taking aspirin daily along with lovenox injections along with other meds daily and i will have to take these blood thinners throughout my pregnancy to keep my blood thin and from clotting. I wish you the best and pray that they are able to provide you with a reason.

  • I completely get this! We had the opposite problem and I used to get frustrated with problem after problem and my husband would always remind me that at least we know what to do now. We have something to fix. so glad you got a clean bill of health and praying that the next pregnancy makes it all the way!

  • I have Factor V Leiden and had trouble getting pregnant. I was prescribed Lovenox and finally got pregnant. I took Lovenox into the third trimester. The doctor says I can now stop taking Lovenox, what do you think? What has been your experience? Thank you.

  • Hi friend! Have you ever read Heart Made Whole by Christa Black Gifford? I can’t recommend it enough, especially for those in a season of difficulty like you are in right now. It’s all about trauma that occurs in our lives and letting Jesus in to those situations to open and heal our hearts. I think you would be a good read for you in this season. I’m praying for you Kelsie!

  • I have factor v and I had pulmonary embolism 2/05. I was told I couldn’t have children but I was blessed with my little monster last year. I took lovenox shots every day 2x a day. It can be very overwhelming but it was worth it. I got my son tested to see if he have it and he don’t. Thank you for posting this video. It’s not a lot of factor v vids out here for pregnant women.:)

  • I didn’t know I had FVL and had severe preeclampsia. I had a late miscarriage at 11 weeks. Then had preeclampsia and kidney failure and my son was born at 38 weeks and I almost died. Then I had severe PIH, liver issues and then Preeclampsia. I was hospitalised over and over again even as a high risk patient. My daughter was born 7 weeks prematurely when my blood pressure peaked at 220/140. I was on low dose aspirin but it didn’t help. I had to have 2 PICC lines, lots of cannulas in my hands and elbows (wherever else they could put them), central and arterial line… My PICC line clotted from my elbow to my shoulder after they took it out so I was on clexane for 2 weeks, 2 shots a day and then I was on warfarin and had to get my INR checked every day to every second day:( That’s when I found out I have FVL I only have the one gene but it still effected me very badly. I was bruised all over my thighs, stomach, elbows, hands, wrist and neck. It looked like I had been beaten badly and had PTSD.

    Now that I’m no longer pregnant and won’t be having children again I feel a lot better. I haven’t had any other complications however I always get scared when I get muscle pain in my legs thinking I could have another clot. I am so glad to hear that you had success with having shots! I wish I had known I had it beforehand I think if it worked for me I would be a lot better off right now (chronic high blood pressure and heart, kidney issues and elevated liver enzymes 1.5 years later). I am however thankful I never took birth control pills. I am scared thinking about what could have happened if I did.

  • Thank you for the encouragement. I’m heterozygous for Factor V. I am hoping to get pregnant through IVF with donor eggs as I also have a condition called Turner Syndrome, which you can google but ultimately means that my ovaries never developed.

     Because of undeveloped ovaries I have to have hormone replacements to go through puberty and now have to continue HRT (given in the form of ORtho-tri-cyclen-lo) to avoid menopausal symptoms (at 34) and serious bone demineralization that would result. Because of the HRT, when I found out my grandfather died of something called “Factor V” and researched it, I asked to be tested to have knowledge with whether to continue with the HRT.. My endocrinologist recommended staying on HRT as long as I’m not incapacitated or undergo surgery, as tests showed that I’m only heterozygous… but the thought is scary… In-vitro is risky enough, but to do it with Factor V is terrifying.. BOTH me and my husband really want a child (or at least to try) that is biologically his before going the adoption route. 

  • Make sure you watch the video the whole way through! I want to be sure it’s know that I am incredibly grateful that my lab results all came back negative! I’m overjoyed that I am a healthy individual and not a day goes by that I don’t thank God for that.
    I was hoping to receive some answers as to why these things have happened. Since that doesn’t appear to be an option right now, I’m learning to cope with the unknown.
    I trust God to take care of me and my future.

    Thank you all for watching and being with me on this journey! Love my #TTCSisters

  • Have you had any progesterone monitoring during pregnancy? My doctor was telling me today as he gave me a prescription that a sudden drop of levels prior to 12weeks is one of the most common causes in miscarriages.

  • Ah, and here I was, thinking that this meant my blood just coagulated better. Oh well �� Thank you for an interesting and well-made video!