So What Can an AFP Test Let You Know About Your Child

 

Alpha Fetoprotein test(AFP) Test results mean & normal range (Clear explanation)

Video taken from the channel: MEDI LAB ZONE


 

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Video taken from the channel: Washington State Department of Health


 

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Video taken from the channel: Humain Health


 

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Video taken from the channel: Northwell Health


One of the screening tests that is typically done during pregnancy is the alpha-fetoprotein (AFP) test, also called the maternal serum alpha-fetoprotein (MSAFP) test. It’s generally done as part of the triple screen test, which also contains an hCG test and estriol test, and helps to. Unborn babies normally make alpha-fetoprotein (AFP), and it shows up in their mother’s blood.

Checking the level of AFP in a mom-to-be can show if her baby may have problems with their neural tub. What this means is that it can give you an idea of the *risk* that your baby has a given condition, but it cannot tell you *whether* your baby has that condition. ”False positive” results (where the AFP showed an elevated risk, but the baby is entirely normal and healthy) are very common. AFP is a test used to check for birth defects in your baby. AFP is a protein made by your baby during pregnancy.

This passes into your blood and can be used to spot problems with your baby while in the womb. To test AFP levels, a blood sample is taken from you. Alpha-fetoprotein (AFP) is a protein produced in the liver of a developing fetus. During a baby’s development, some AFP passes through the placenta and into the mother’s blood. An AFP test measures the level of AFP in pregnant women during the second trimester of pregnancy.

Too much or too little AFP in a mother’s blood may be sign of a birth defect or other condition. Since the test is noninvasive, if you’re worried about your baby’s health only because of your age, this test is a good option. Your family has a history of developmental irregularities at birth.

AFP tests can also check for birth defects in an unborn baby. Doctors may test spinal fluid for AFP, too, depending on what they’re looking for. AFP is a protein normally made by the immature liver cells in the fetus. Healthy, nonpregnant adults have very low levels of AFP in the bloodstream (undetectable to about 10 ng/ml). At birth, infants have relatively high levels of AFP in the blood, which fall to normal low adult levels by the first year of life.

Can the AFP blood test determine what sex your baby is?? I just read about someone getting a call back about their AFP results and also being told the sex of the baby at the same time Update: Nevermind, I just called the doctors office, they can tell with an amnio but not the AFP. Answer Save.

2 Answers. Relevance. NIcole V. 1 decade ago. Alpha-fetoprotein (al-fa-FETO-pro-teen) can be found with a blood test and is also called AFP.

AFP is an important fetal (FEE-tal) serum protein that disappears soon after birth. It returns in pregnant women. It can also appear as a tumor marker in other adults.

List of related literature:

A high level of AFP after week 16 usually indicates that the fetus has a neural tube defect, such as spina bifida or anencephaly.

“Principles of Anatomy and Physiology” by Gerard J. Tortora, Bryan H. Derrickson
from Principles of Anatomy and Physiology
by Gerard J. Tortora, Bryan H. Derrickson
Wiley, 2018

AFP measurements in maternal serum are used for early diagnosis of fetal neural tube defects such as spina bifida and anencephaly.

“Mosby's Comprehensive Review of Practical Nursing for the NCLEX-PN® Exam E-Book” by Mary O. Eyles
from Mosby’s Comprehensive Review of Practical Nursing for the NCLEX-PN® Exam E-Book
by Mary O. Eyles
Elsevier Health Sciences, 2010

Serum AFP measurement is believed to increase accuracy of antenatal detection of Down syndrome from 35% to 67%, but its accuracy can be affected by maternal weight, smoking history, and diabetes mellitus and by whether the gestational age of the fetus is correctly estimated.

“Laboratory Tests and Diagnostic Procedures E-Book” by Cynthia C. Chernecky, Barbara J. Berger
from Laboratory Tests and Diagnostic Procedures E-Book
by Cynthia C. Chernecky, Barbara J. Berger
Elsevier Health Sciences, 2012

AFP is measured to detect neural tube defects in a fetus.

“Clinical Chemistry E-Book: Fundamentals and Laboratory Techniques” by Donna Larson
from Clinical Chemistry E-Book: Fundamentals and Laboratory Techniques
by Donna Larson
Elsevier Health Sciences, 2015

Maternal serum AFP test at about 16–18 weeks b.

“Smart Study Series:Obstetrics & Gynecology E-Book” by PUNIT S BHOJANI
from Smart Study Series:Obstetrics & Gynecology E-Book
by PUNIT S BHOJANI
Elsevier Health Sciences, 2014

AFP is elevated when the fetus has a major central nervous system

“An Introduction to Human Disease: Pathology and Pathophysiology Correlations” by Leonard V. Crowley
from An Introduction to Human Disease: Pathology and Pathophysiology Correlations
by Leonard V. Crowley
Jones and Bartlett, 2007

In young patients, blood tests should include serum hCG and AFP levels, a complete blood count, and liver function tests.

“Holland-Frei Cancer Medicine 8” by Waun Ki Hong, Robert C. Bast Jr, American Association for Cancer Research, William Hait, Donald W. Kufe, James F. Holland, Emil Frei Iii
from Holland-Frei Cancer Medicine 8
by Waun Ki Hong, Robert C. Bast Jr, et. al.
People’s Medical Publishing House, 2010

Maternal serum AFP testing thus provides a screening method to identify pregnancies at high risk or to estimate the numerical risk of having a fetus with an open NTD.

“Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics E-Book” by Nader Rifai
from Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics E-Book
by Nader Rifai
Elsevier Health Sciences, 2018

Explain that the AFP level is determined by a maternal blood sample that is drawn at 15 to 18 weeks’ gestation.

“Saunders Comprehensive Review for the NCLEX-PN® Examination E-Book” by Linda Anne Silvestri
from Saunders Comprehensive Review for the NCLEX-PN® Examination E-Book
by Linda Anne Silvestri
Elsevier Health Sciences, 2012

A small amount of blood is taken from the mother’s arm and sent to a laboratory, where the levels of AFP are measured.

“The New Harvard Guide to Women's Health” by Karen J. Carlson, Stephanie A. Eisenstat, Stephanie A. Eisenstat, M.D., Terra Diane Ziporyn, Alvin & Nancy Baird Library Fund, Harvard University. Press
from The New Harvard Guide to Women’s Health
by Karen J. Carlson, Stephanie A. Eisenstat, et. al.
Harvard University Press, 2004

Oktay Kutluk

Kutluk Oktay, MD, FACOG is one of the world's foremost experts in fertility preservation as well as ovarian stimulation and in vitro fertilization for infertility treatments. He developed and performed the world's first ovarian transplantation procedures as well as pioneered new ovarian stimulation protocols for embryo and oocyte freezing for breast and endometrial cancer patients.

Mail: [email protected]
Telephone: +1 (877) 492-3666

Biography: https://medicine.yale.edu/profile/kutluk_oktay/
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11 comments

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  • This video came to me at the perfect moment. I got the call with my results today and am meeting with a genetic specialist tomorrow. Over the phone I was told my baby is high risk for Down syndrome, they told me it was a 1 in 50 chance, instead of the normal 1 in 100. I am 25 and this is my first pregnancy, and I am so terrified. But just like you, I would never ever terminate my pregnancy just because of that. I am hopeful that I got a false positive, and am trying to think of every and any question I can ask the specialist tomorrow.

  • Thanks for this video. My wife and I are going through this now. Her NIPT results came back inconclusive (she went in today for a retest) however they said it looks to be due to low fetal fraction. Now she also had an NT scan ultrasound which she was told the measurement was within normal range. Trying not to jump to conclusions until we get new blood results, but hoping does not come back inconclusive again. Hoping no result does not mean higher chance of positive result. We know she is high risk due to her age and higher than average BMI, but hoping for the best…

  • Madam mera abhi 14 week chal raha hai or first baby main hearing loss hai abhi mujhe ek infection ya viral hua jise mujhe fever tha or boby pe red spot ho gaye to kya abhi bhi risk hai baby ko yya koi ese test jo pata Lagene ki baby ke sare organ thik hai. Ap bataye kya karna chaiye

  • I’m also going through this type of situation….my screening test result is positive and we are (me & my husband) are waiting for further test.. your video helped me a lot to stay positive. ♥️From India.

  • Came across this video because I just got my test results back & it came back abnormal & I’m worried now too �� all we can do is pray to our heavenly father & ask him to protect out baby while in the womb not that down syndrome is the most awful thing but its just scary & sad not knowing

  • My blood test just came back a week ago positive for down syndrome but in my heart I feel she doesn’t have down syndrome. My first blood work was normal this one’s positive. I’m doing the amotesis test. But my baby did get diagnosed with vsd a hole in her heart. I’m 27 weeks. I’m praying the blood work is wrong for down syndrome. But eaither way I will love her I feel at pieace when I got the call I was a wreck that day but I couldn’t be sad after that. I’m worried and stressed but when I do worry I get this sensation of pieace.�� I pray ur blood work is wrong to..

  • Thank you for making this video I just got my results from my blood test and tested for trisomy13 and I felt so hopeless when I got that call.

  • Your video helped me out so much thank you for making this! I’ve been so emotional all day today…I’m so confused, I got the call today that my blood work was abnormal so I went to my doctors office right away. I thought maybe I had something because my first test was negative and the second came back positive?? Did not expect that…any thoughts??

  • My test came as 1:125 which is high risk of Down Syndrome. But my gut feelings say its false. On friday I am doing diagnostic test to get accurate result.

  • Hi I just have a question to ask. I had my prenatal screening test last May 6 and result came out positive high risk for down syndrome then I had an NIPT on May 12 then I got a call from my OB-GYN that everything was fine that everythint came out as low risk.. does low risk means negative result?

  • I’m going threw this now my heart is ripping apart slowly my trisomy was positive and my baby has just a little extra fluid behind neck first ultrasound said baby had nose bone yesterday I went for my amniocentesis and the didn’t find a nose bone I just don’t know what to think. Me estoy muriendo por dentro. But everything else in the ultrasound is fine but those 2 markers are important in my eyes