Progesterone Treatment during pregnancy to avoid Miscarriage

 

IVF When is it ok to stop progesterone?

Video taken from the channel: Infertility TV


 

I’m pregnant and want to take progesterone due to my previous miscarriages. What kind should I take?

Video taken from the channel: IntermountainMoms


 

Does progesterone prevent miscarriages? Fetal Medicine Foundation Webinar

Video taken from the channel: Prof Arri Coomarasamy MBChB MD FRCOG FMedSci


 

Preventing Miscarriage

Video taken from the channel: All Health TV


 

Progesterone for the Prevention of Miscarriage. The PRISM Trial: evidence and recommendations.

Video taken from the channel: Prof Arri Coomarasamy MBChB MD FRCOG FMedSci


Studies show that progesterone supplements do not really help prevent miscarriage in the average pregnancy, even when there is a threatened miscarriage. 2  There is evidence that progesterone supplementation is imperative in pregnancies. Researchers in the United Kingdom say progesterone treatments given to pregnant women with a history of miscarriage can make a difference. Studies in previous years had concluded there was no.

New research says that vaginal suppositories of progesterone given to pregnant women experiencing bleeding in the first trimester did not result in a significantly higher incidence of live births. A new method to protect the most vunerable pregnancies Women who have had miscarriages and bleeding in the first trimester may find help preventing subsequent miscarriages in new research on the use of the hormone progesterone to prevent pregnancy loss during the first twelve weeks (the most common time for a miscarriage. “In pregnancy, progesterone will maintain the uterine lining, provide endometrial nutrition for the fetus, and will prevent premature uterine contractions,” Allison Jung, a physician’s assistant. Progesterone helps your uterus (womb) grow during pregnancy and keeps it from having contractions.

If you have contractions in early pregnancy, it may lead to miscarriage. This is the death of a baby in the womb before 20 weeks of pregnancy. In later pregnancy, progesterone. Progesterone is essential for the maintenance of pregnancy.

Several small trials have suggested that progesterone supplementation may reduce the risk of miscarriage in women with recurrent or threatened miscarriage. Cochrane Reviews summarized the evidence and found that the trials. Progesterone supplements (also known as micronized progesterone) have been recommended for more than 50 years for women struggling with infertility, but there’s been less. Inadequate secretion of progesterone in early pregnancy has been linked to the aetiology of miscarriage and progesterone supplementation has been used as a treatment for threatened. Progesterone in early pregnancy is necessary to prevent miscarriage.

However, if the level of progesterone drops, the uterine lining might not be able to carry forward the pregnancy and will.

List of related literature:

Treatment of early pregnancy with progesterone has not been shown to improve pregnancy outcome in women with recurrent miscarriage, though the treatment is widely prescribed and thought to be of minimal-to-no risk to the embryo-fetus or mother.

“Reproductive Endocrinology and Infertility: Integrating Modern Clinical and Laboratory Practice” by Douglas T. Carrell, C. Matthew Peterson
from Reproductive Endocrinology and Infertility: Integrating Modern Clinical and Laboratory Practice
by Douglas T. Carrell, C. Matthew Peterson
Springer New York, 2010

When patients inquire about the use of progesterone as a rescue measure, they can be assured that if progesterone deficiency is the cause of a pregnancy loss, the pregnancy is expelled early in gestation, usually before the sixth week.

“Comprehensive Gynecology E-Book” by Rogerio A. Lobo, David M Gershenson, Gretchen M Lentz, Fidel A Valea
from Comprehensive Gynecology E-Book
by Rogerio A. Lobo, David M Gershenson, et. al.
Elsevier Health Sciences, 2016

Progesterone then increases throughout pregnancy, and is necessary for the safe maintenance of pregnancy.

“Mama Glow” by Latham Thomas
from Mama Glow
by Latham Thomas
Hay House, 2012

Progesterone is essential for the maintenance of a pregnancy, and early failure of the corpus luteum may lead to miscarriage.

“Essential Obstetrics and Gynaecology E-Book” by Ian M. Symonds, Sabaratnam Arulkumaran
from Essential Obstetrics and Gynaecology E-Book
by Ian M. Symonds, Sabaratnam Arulkumaran
Elsevier Health Sciences, 2019

2—To prevent miscarriage:John Lee M.D. recommends transdermal progesterone 40mg a day to help prevent miscarriage caused by luteal phase failure.

“Linda Page's Healthy Healing: A Guide To Self-Healing For Everyone” by Linda Page
from Linda Page’s Healthy Healing: A Guide To Self-Healing For Everyone
by Linda Page
Healthy Healing Publications, 2004

In addition, continuing progesterone supplementation through the early stages of pregnancy may help sustain the pregnancy and avoid miscarriage.

“What to Expect: Before You're Expecting” by Sharon Mazel, Heidi Murkoff
from What to Expect: Before You’re Expecting
by Sharon Mazel, Heidi Murkoff
Simon & Schuster UK, 2010

2–To prevent miscarriage:John Lee M.D., says transdermal progesterone 40mg a day can help prevent miscarriage caused by luteal phase failure.

“Linda Page's Healthy Healing: A Guide to Self-healing for Everyone” by Linda G. Rector-Page
from Linda Page’s Healthy Healing: A Guide to Self-healing for Everyone
by Linda G. Rector-Page
Traditional Wisdom, 2000

The primary function of hCG in early pregnancy is to prevent deterioration of the corpus luteum so it can continue producing estrogen and progesterone until the placenta is sufficiently developed.

“Foundations of Maternal-Newborn and Women's Health Nursing E-Book” by Sharon Smith Murray, Emily Slone McKinney
from Foundations of Maternal-Newborn and Women’s Health Nursing E-Book
by Sharon Smith Murray, Emily Slone McKinney
Elsevier Health Sciences, 2017

Daya S. Efficacy of progesterone support for pregnancy in women with recurrent miscarriage.

“Oxford Textbook of Obstetrics and Gynaecology” by Sabaratnam Arulkumaran, William Ledger, Stergios Doumouchtsis, Lynette Denny
from Oxford Textbook of Obstetrics and Gynaecology
by Sabaratnam Arulkumaran, William Ledger, et. al.
Oxford University Press, 2019

In cases of a threatened abortion, progesterone supplementation does appear to reduce the risk of miscarriage.

“Creasy and Resnik's Maternal-Fetal Medicine: Principles and Practice E-Book” by Robert Resnik, Charles J. Lockwood, Thomas Moore, Michael F Greene, Joshua Copel, Robert M Silver
from Creasy and Resnik’s Maternal-Fetal Medicine: Principles and Practice E-Book
by Robert Resnik, Charles J. Lockwood, et. al.
Elsevier Health Sciences, 2018

Oktay Kutluk

Kutluk Oktay, MD, FACOG is one of the world's foremost experts in fertility preservation as well as ovarian stimulation and in vitro fertilization for infertility treatments. He developed and performed the world's first ovarian transplantation procedures as well as pioneered new ovarian stimulation protocols for embryo and oocyte freezing for breast and endometrial cancer patients.

Mail: [email protected]
Telephone: +1 (877) 492-3666

Biography: https://medicine.yale.edu/profile/kutluk_oktay/
Bibliography: oktay_bibliography

View all posts

3 comments

Your email address will not be published. Required fields are marked *

  • After 3 miscarriages I had to go to india to get help as the uk wouldn’t help and didnt seem to be bothered about miscarriages they prescribe me progestrone a gynecologist in India it worked the first time I took it I am now currently 6 months pregnant my miscarriages previous did not last longer than 5 weeks

  • Hi, Dr. How about Estradiol pills-Estrofem? I had frozen embryo transfer. It’s successful. I have been taking Estradiol pills, 2 tablets each intake twice a day. It was prescribed by IVF dept. and they told me to take these pills up to 12 weeks of pregnancy.

    My concern is, one of the reasons I had ivf was because my uterus was infantile and my uterine lining was almost nothing. My question is, is it really safe now to stop taking estradiol pills at 12 weeks of pregnancy? Will my uterus and the uterine lining continue to grow if I stop taking Estradiol pills at 12 weeks of pregnancy?

    I am worried for the growth of my uterus and my baby. I am no longer seen by IVF dept. I was already endorsed to Early Pregnancy department and this department said that I would not take Estradiol pills anymore at 12 weeks. They said that I only need to take Progesterone vaginal suppository for one more month from 12 weeks. Will my baby be safe with Progesterone suppository only? Should I not worry anymore that they are stopping my Estradiol pills at 12 weeks of pregnancy? Please enlighten me, Dr. Thanks you.

  • Can I stop taking Progesterone(2 tablet-100 mg each and 6 tablets in a day) after 14 weeks of pregnancy post blastocyst transfer?