NK cell activity and recurrent pregnancy loss Reproductive Immunology
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In contrast to their presumptive role in the maintenance of a healthy pregnancy, uNK cells and peripheral NK cells are dysregulated in unexplained recurrent pregnancy loss. Herein, we review NK cell populations, their changes in number and function in altered endocrine environments during the menstrual cycle and pregnancy, the current data on their potential role in unexplained recurrent pregnancy loss, and. Not only by making a firmer case for the role of natural killer (NK) immune cells in some cases of recurrent miscarriage, but also in bridging the gap. Natural Killer cells can be a factor in unexplained infertility, and might be more prevalent in those with autoimmune disease or other inflammatory conditions such as endometriosis, tubal disease and PCOS (polycystic ovarian syndrome). In my clinic, I screen my fertility patients for NK cells, especially those who have had recurrent miscarriage.
Natural Killer Cells and Recurrent Miscarriage How can natural killer cells (NK cells) cause RPL? There are several different types of cells used by the immune system to attack a foreign “invader” these are part of two systems, the innate (first responders) and the acquired (second responders). They suggested that NK cells can be used as an indicator of steroid deficiency in the body, the womb especially.
So, often, doctors give steroids which are thought to work by reducing the percentage of NK cells in the womb, as a common treatment for recurrent miscarriage, and it appears to help some women go on to have a normal pregnancy. Blood tests for Natural Killer Cells are not helpful. Based on the assumed similarities between NK cells in blood and uterine NK cells, it has become increasingly common for fertility doctors to recommend blood tests for Natural Killer cells in women with infertility and recurrent miscarriage. These recommendations are based on the unproven assumption that women with recurrent miscarriage and infertility have.
Background: Peripheral natural killer (pNK) and uterine NK (uNK) cells have been associated with reproductive failure. We systematically reviewed the literature to assess whether numbers or activity of pNK or uNK cells predicted subsequent pregnancy and outcome. Ntrivalas EI, Kwak-Kim JY, Gilman-Sachs A, et al.
Status of peripheral blood natural killer cells in women with recurrent spontaneous abortions and infertility of unknown aetiology. Hum Reprod 2001; 16:855. Laird SM, Tuckerman EM, Cork BA, et al.
A review of immune cells and molecules in women with recurrent miscarriage. Practice Committee. Recurrent pregnancy loss.
Fertil Steril 2012. FIGURE 1 Kaplan-Meier plot showing percentage of women in the recurrent miscarriage cohort who have had at least one live birth after ﬁrst consultation by number of miscarriages before ﬁrst consultation. (Lund et al. Recurrent miscarriage and prognosis for live birth.
[Decidual natural killer cells in recurrent spontaneous abortions]. [Article in Serbian] A repeated or habitual miscarriage (PSP) is defined as three or more consecutive losses of pregnancy. In the first three months of pregnancy, habitual miscarriages occur in about 1% of pregnant women, out of which 50% are of an unknown etiology.
List of related literature:
|from Maternal, Fetal, & Neonatal Physiology4: Maternal, Fetal, & Neonatal Physiology|
|from High Risk Pregnancy E-Book: Management Options Expert Consult|
|from Dewhurst’s Textbook of Obstetrics and Gynaecology|
|from Creasy and Resnik’s Maternal-Fetal Medicine: Principles and Practice E-Book|
|from Sex Hormones and Immunity to Infection|
|from Churchill Livingstone Medical Dictionary E-Book|
|from It Starts with the Egg: How the Science of Egg Quality Can Help You Get Pregnant Naturally, Prevent Miscarriage, and Improve Your Odds in IVF (Second Edition)|
|from Hormones and Reproduction of Vertebrates|
|from Gynaecology E-Book: Expert Consult: Online and Print|
|from Obstetrics: Normal and Problem Pregnancies E-Book|