Metformin and Pregnancy Is That This Drug Safe


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Video taken from the channel: Dr. Sam Bailey


Metformin in pregnancy – is it safe?

Video taken from the channel: Maternity and Me

Pregnant women with gestational diabetes or type 2 diabetes are commonly given metformin during their pregnancy. If they have an adverse reaction to the drug, changes to their gastrointestinal. Metformin Pregnancy Warnings Animal studies do not indicate harmful effects with respect to pregnancy, embryo or fetal development, birth or postnatal development. Poorly-controlled diabetes in pregnancy increases the maternal risk for diabetic ketoacidosis, pre-eclampsia, spontaneous abortions, preterm delivery, stillbirth and delivery complications. Insulin has long been the first drug of choice (and still is) but Metformin is now increasingly being used with success in the treatment of diabetes in pregnancy.

Insulin has been around a very long time and there have been extensive trials both during pregnancy and beyond in following up babies until adults to ensure we know it is safe to use. There are no adequate and well controlled studies in pregnant women with metformin-sitagliptin. AU TGA pregnancy category C: Drugs which, owing to their pharmacological effects, have caused or may be suspected of causing, harmful effects on the human fetus or neonate without causing malformations. These effects may be reversible. Limited data with Metformin hydrochloride tablets in pregnant women are not sufficient to determine a drug-associated risk for major birth defects or miscarriage.

Published studies with Metformin use during pregnancy have not reported a clear association with Metformin and major birth defect or miscarriage risk [see Data ]. Update [8/21/2020] FDA is alerting patients and health care professionals to Bayshore Pharmaceuticals’ voluntary recall of two lots of extended release (ER) metformin (one lot. The following FDA safety notices may be specifically about metformin or relate to a group or class of drugs which include metformin. These notices may include a list of possible medication recalls, market withdrawals, alerts and warnings. While metformin can be used for the treatment of infertility, it is not a fertility drug.

When taken to treat infertility, it is considered an off-label use (which means that pregnancy achievement is not the original intended purpose of the drug). Here’s an overview of what metformin is and how it might help you conceive. Metformin and Pregnancy: Is This Drug Safe?

Medically reviewed by Lindsay Slowiczek, Pharm.D. Metformin is a prescription drug used to. The Food and Drug Administration (FDA) has announced that several lots of metformin — a popular type 2 diabetes drug — contain high levels of a cancer-causing contaminant called N.

List of related literature:

These patients have higher conception and lower miscarriage rates with metformin treatment.181 Although two small series documenting the apparent safety of continuing metformin during pregnancy have been published,182,183 discontinuing metformin after pregnancy is established is recommended.

“Creasy and Resnik's Maternal-Fetal Medicine: Principles and Practice E-Book” by Robert Resnik, Robert K. Creasy, Jay D. Iams, Charles J. Lockwood, Thomas Moore, Michael F Greene, Lesley Frazier
from Creasy and Resnik’s Maternal-Fetal Medicine: Principles and Practice E-Book
by Robert Resnik, Robert K. Creasy, et. al.
Elsevier Health Sciences, 2008

Nonetheless, metformin appears to be a safe drug for use during pregnancy.

“Lehne’s Pharmacotherapeutics for Advanced Practice Nurses and Physician Assistants E-Book” by Laura Rosenthal, Jacqueline Burchum
from Lehne’s Pharmacotherapeutics for Advanced Practice Nurses and Physician Assistants E-Book
by Laura Rosenthal, Jacqueline Burchum
Elsevier Health Sciences, 2017

However, a woman taking a sulfonylurea or metformin who is discovered to be pregnant should not stop these agents until she can be effectively switched to insulin, because the risk of teratogenicity from hyperglycemia is much higher than any risk from these agents.

“Endocrine Secrets E-book” by Michael T. McDermott
from Endocrine Secrets E-book
by Michael T. McDermott
Elsevier Health Sciences, 2013

Some providers advocate discontinuing metformin on discovery of the pregnancy, whereas others will continue metformin until the end of the first trimester, and still others would continue the metformin throughout pregnancy.

“Perinatal Nursing” by Kathleen Rice Simpson, Patricia A. Creehan, Association of Women's Health, Obstetric, and Neonatal Nurses
from Perinatal Nursing
by Kathleen Rice Simpson, Patricia A. Creehan, Association of Women’s Health, Obstetric, and Neonatal Nurses
Wolters Kluwer Health/Lippincott Williams & Wilkins, 2008

With the exception of metformin and glibenclamide, there are few available data regarding the safety of most of these drugs in pregnancy, or whether they cross the placenta.

“Obstetrics & Gynaecology: An Evidence-based Text for MRCOG, Third Edition” by David M. Luesley, Mark Kilby
from Obstetrics & Gynaecology: An Evidence-based Text for MRCOG, Third Edition
by David M. Luesley, Mark Kilby
CRC Press, 2016

Metformin is a Category B medication in the first trimester of pregnancy and appears to be safe.

“Clinical Reproductive Medicine and Surgery” by Tommaso Falcone, William W. Hurd
from Clinical Reproductive Medicine and Surgery
by Tommaso Falcone, William W. Hurd
Mosby/Elsevier, 2007

There is greater concern about the effects on the fetus of these drugs compared with metformin, and they should not be used by women actively trying to become pregnant.

“Treatment of Infertility with Chinese Medicine E-Book” by Jane Lyttleton
from Treatment of Infertility with Chinese Medicine E-Book
by Jane Lyttleton
Elsevier Health Sciences, 2013

The use of metformin in pregnancy is likely safe [56], and its use in early pregnancy for women with glucose intolerance would seem reasonable.

“Reproductive Endocrinology and Infertility: Integrating Modern Clinical and Laboratory Practice” by Douglas T. Carrell, C. Matthew Peterson
from Reproductive Endocrinology and Infertility: Integrating Modern Clinical and Laboratory Practice
by Douglas T. Carrell, C. Matthew Peterson
Springer New York, 2010

Metformin is a category B drug; no serious adverse effects have been reported with use during pregnancy.

“Sex Hormones” by Raghvendra Dubey
from Sex Hormones
by Raghvendra Dubey
IntechOpen, 2012

More studies on the safety of these medications on a developing fetus are needed, and women trying to get pregnant should discuss taking metformin with a fertility specialist.

“It's My Ovaries, Stupid!” by Elizabeth Lee Vliet
from It’s My Ovaries, Stupid!
by Elizabeth Lee Vliet
Scribner, 2003

Oktay Kutluk

Kutluk Oktay, MD, FACOG is one of the world's foremost experts in fertility preservation as well as ovarian stimulation and in vitro fertilization for infertility treatments. He developed and performed the world's first ovarian transplantation procedures as well as pioneered new ovarian stimulation protocols for embryo and oocyte freezing for breast and endometrial cancer patients.

Mail: [email protected]
Telephone: +1 (877) 492-3666

Bibliography: oktay_bibliography

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  • 1. I love the smiles.
    2. You make it sounds so beautiful it almost seams that disbetes is not a bad thing hehe��.
    3. I keep picturing you as an angel without wings.
    4. Your doing a fantasic job here on Earth and one day you will carry on in heaven and we mortals just hope we will be there to see you for eternity with the Lord.
    5. There will not be any need for medications so I guess you may be playing the harps then and singing.
    Bu the way sing? I wonder what it would be like.����

  • Was curious to hear about the side effects, specifically the one(s) that I experienced. Will say that I had been on metformin successfully for 13 years. The last two years though I had to go to urgent care or emergency about 7 times because my bowels had stopped working causing me to continuously throw up, fever of 105 etc. Each time I was kept under supervision until the symptoms passed. The last time I was admitted into the hospital under the premise that I might need surgery…until the day before surgery scheduled and my system cleared (I was taken off metformin while in hospital). All the emergency doctors said I didn’t do anything wrong…”just happens”. My endocrinologist decided to take me off of metformin and the next day my stomach issues resolved. It’s been over a year without metformin and never again with IBS. Curious why no one talks about this side effect.

  • I stop taking metformin for three months. I was taking 1000 mil per day. When I start up again because my blood sugar was up. I experience diarrhea. It was awful.
    Now the doc told be to take half a day for two weeks then increase dosage gradually. I have done that and now I am too 1000 mil again. I have to lose weight or else.

  • Hey actually my doctor recommended this since I have PCOS along with birth control pill so I took the birth control pill but didn’t take thos since someone told me that it will affect my kidney now after 3months I am taking this without askin any doctor will there be a problem? Please reply soon

  • What do I like about your videos? ell, first and foremost you’re not some 30-something guy wearing a white doctors jacket. I like that you dress informally yet professionally. I started watching your vids about 2 months ago. I only watch those that pertain to me or someone I know. They are vary informative. And here is where I say you have an uncanny resemblance to actress Jeri Ryan (and that’s not a bad thing).

  • I have been taking Metformin for around two years. I am taking the slow release tablets. I have been trying to increase up to 4 tablets a day. The regular Metformin tablets caused violent diarhea, not acceptable. I have had somewhat the same experience with the delayed release if I take the two tablets twice a day as they would like. I take one tablet with breakfast and one tablet with dinner and take one tablet should I have something in-between or after dinner. One huge problem that I don’t want to attribute to the use of Metformin is extreme weakness, the worst being my legs. As I’ve taken more notice of it, the weakness is actually body wide. In the last 3 months I was taking another diabetic med that was causing sudden sugar lows. I was in the middle of the store where I was having extreme fatigue in my legs and I had brought my diabetic meter with me and my sugar had dropped from 109 to 64 all within 20 minutes. All I want to know at this time is when the Metformin causes weakness would only being able to physically walk for only 150 feet before needing to sit down, be within the realm of the kind of weakness metformin can cause? Every single thing has been checked out to see if there is anything else that could be causing it, and nothing has shown up. Metformin remains the only possible culprit. Prior to treating my Type 2 diabetes, I was someone who could and did walk indefinitely. I could walk as long as I wanted without fatigue.

  • Hi Dr Sam Bailey. I’m a medical professional from uk can I please have your contact details as I tried to find your social media but couldn’t succeed. Please give me your contact details I need your help. I will be waiting. Thank you

  • I get side effects from the first tablet, I have stomach ache, feels like bubbles bursting in my tummy and I get diarrhoea. I have Pcos, is the slow release any better, and is there a diet you should it in combination with this to reduce the side effects. It also made my face feel taut, like all the sugar had gone from my face. ����‍♀️ made me go light headed aswell.

  • Thank you for this video, Dr. Sam. I recently took myself off of Metformin after taking it for over 10 years. I did a lot of research and decided I wanted to try reversing my type 2 diabetes. Now I avoid all sugars and I completely changed my diet. I never eat breakfast anymore. I eat twice a day now. My diet consists of mostly raw vegetables in olive oil and Balsamic Vinegar for lunch, and whatever my wife cooks for dinner. I don’t eat anything after 7:00 p.m. I’m also intermittent fasting, so I gave myself a window for eating between 12:00 p.m. and 7:00 p.m. My A1c went from 7.8 to 5.1without Metformin over the last 4 months. Needless to say, my doctor would rather I stay on medication. Where’s the sense in that? Can you please do a video on Atorvastatin. I hear so many things about the side effects such as memory loss, dementia, and joint pain. Don’t know if it’s true or not. I decided to stop taking Atorvastatin last nigh for now. I have a doctor’s appointment in two months and can’t wait to see how that goes. Are you accepting new patients, just in case he throws me out?�� Thank you in advance, Dr. Sam.

  • Thank you Dr. Baily, for this very informative and comprehensive video. You have answered questions that I hadn’t thought to ask my own doctor. I do enjoy your sunny disposition very much, also.

  • I hate taking this crap.The VA sent me a letter there is a recall on the SA metformin.It has the same poison as the zantac.I am suppose to get a replacement and mail back the bad Metformin.It has been 2 months and I am still taking this crap.Is there any thing I can take to lower my blood sugar fast?

  • I went to a herbalogist (sp) only paid 100.00
    Or under got a few drops of? And do not take novolog or lantus
    Been a year now.
    Cut all sugar soda fruits.
    Eat pork. beef grass feed. fish..chicken
    No breads noodles much weed bug killers gmo in milk
    That they eat.

  • This video is really helpful.. I suffer PCOS and this video help me to know about the side effects, etc. of metformin that I did not asked to the doctor. Thank you so much. Godbless!

  • I’ve been on metformin for about 5 weeks now. We are doing IVF if I donf fall pregnant naturally this month. I take 2 x 500ml tablets at 6:30 every night.
    It can make you feel sick but if you eat something even if its something small before taking the tablets then you’ll be fine and not feel sick at all.

  • You mention that there is a time release version of Metformin, if someone had to stop Metformin (due to diarrhea)while using the tablet form, is it possible that switching to a time release Metformin it would be tolerable?

  • early squad. wonderful video. I had many patients asking me about more information about metformin and i will use this video in my patient counselling sessions.

  • Dr. Sam thank you for sharing your knowledge. This is very informative, though I am not a diabetic. I know many people who are. These videos are super helpful and your smile brightens our day! ☺️☀️��

  • I love your videos Dr Sam. I wish you’d do a video on benzodiazepines, because most doctors kinda just sweep them under the rug. Because they concentrate more on the opiate epidemic. But alot of ppl suffer from benzo dependence and not addiction. Anyways ill keep watching while you keep making these great videos.

  • What happens if one stops taking medicine strictly after taking it regularly. What might be problems associated.
    (In favour of PCOS)

  • Someone may have mentioned this already and I just haven’t seen it. I recently discovered that Metformin uses the same carrier system in your body as Thiamine. So in essence it blocks Thiamine which you need. What I have been unable to learn is that if taking additional Thiamine (quantities?) will overcome the blocking properties of Metformin (dosage?) There is also a form of Thiamine named TTFD (the scientific name is too long). It uses a different carrier system. Still learning about it. I am not a doctor and I don’t mean to cause anyone to stumble, health wise. I urge individual research. I am just seeking knowledge and boy do I have a long way to go.

  • Thank you so much Dr. Bailey for this information/education. I have been taking metformin for almost 5 years and I learned more about it today from you. You are amazing beautiful doctor. Greetings and big hugs from the state of Oklahoma. ��������

  • My question is. I was recently told by a breast doctor for an ultrasound on one of my breasts for abnormal discharge. My Question is: When I see my OBGYN in July of 2020. Can I actually ask for metformin? Will the obgyn doctor give me the medication so I can conceive? (Of course, after he tests me for pcos) I have irregular periods (I didn’t get my period last month, of November)
    My symptoms of PCOS are: irregular periods, skin discoloration, hair thinning/loss, unwanted facial hairs on my chin, cheek bones and neck, & I became overweight… I changed my diet full of fruits & veggies. Less meat. I do my best to avoid any sugar/Caffeine. No dairy products. I have been eating grilled chicken & no beef because it gives me heartburn.

  • Have you heard of Dr Jason Fung. Cures diabetes with closely monitored diet and eating regimes. Super human being. Another option for people with diabetes.

  • The NP I used to have put me on a high dose and I couldn’t eat or even stand the smell of food. Left me on it for almost 5 month. It took the flu to get to see a Dr there who wasn’t a Quack. He took me off Metformin and put me on something else. During that time the 3 A-C tests were Perfect. I fired the first NP for being a fool and violating the Hippocratic Oath. She was a fool. New Dr, and then the Covid. Now I have pre-diabetes again.

    What pills should I take if and when this lockdown stops??

  • Interesting, has anyone here had the opportunity to read Dobbie Nerkstrol’s Infertility Cure? Well.. there’s this one certain plan she recommends for conceiving within 8 weeks, and start sensing your body react within the first weeks, not for everyone! But, to each their own.

  • Thank you for the clear explanation on metformin. Much clearer now. ( p.s. do you place your appearance on the babarella book on the self behid you.) Ha ha.

  • Fist off I would like to apologize for the long winded post and thank

    you for making these videos, they have been very helpful, since I got
    diagnosed as a type 2 diabetic in November 2016.

    Being 53 years of
    age at the time, I had all of the classic systems, dry mouth,
    uncontrollable thrust, urinating constantly, finally after 3 months
    having a really bad dream that was something terribly wrong that I
    needed something removed from by bum. I checked myself to the
    hospital and low and behold a sausage growth had manifested itself
    and it had to be removed. By the time I checked into the hospital my
    sugar levels were over 600+ and I instantly became the next
    attraction once the surgery was done and after being there for over 3
    weeks…to this date I don’t really know what it really was.

    Once I got released
    I got the tools to help me manage my diabetes, the insulin and the
    monitor. Things were great for the first since I was watching my
    diet and what I ate. After a two year period I have declined and my
    last doctors visit was not all that great. My AC1 is 7.4 as of
    1/23/02, I got prescribed Metformin (500mg) twice a day, then on top
    of that I got prescribed Atorvastain (20mg), I took your advice and
    stared doing it only on Monday, Wednesday and Friday and doing a
    Pro-biotic in the morning with peanut butter to cut down on the time
    I spend in the crapper.


    Due to my insurance
    coverage I go to go on a program called Onduo, so far it gave me a
    BioTel Monitor with unlimited test strip and lancets. It has been a
    month or two later and I have switched heath insurance and now I
    qualify for a 14 day CGM FreeStyle Libre Sensor, the only thing that
    I have concerns is that I’m a smoker (trying to quit, even got a
    box of free box of Chantix (I need to commit) and on top of that I do
    drink more then two-four sometimes six beers a day after work to help
    me relax and help me sleep. I have tried sleeping pill but they do
    not work, all I do is toss and turn all night long and wake up in a
    cold sweat after two maybe three hours of sleep.

    What are your thoughts or have any insights on how to go about this?

    Your new fan, Rafael

  • Hi Dr. Richardson,
    I truly wish there was a way to contact you privately. Remember, just because something might be negative does not mean that this is hate mail. You covered a very interesting topic and your presentation was almost perfect, however, it is INCREDIBLY IRRITATING to listen to you smack your lips or tisk between every sentence and paragraph.
    I cannot believe that as a physician you could have given so many lectures in your career and no other person has given you this phenomenal advice. It’s a chronic tisk and wet lip smack beginning every sentence and paragraph. Again, I would like to state how I thought your topic was phenomenal and your information was extremely helpful but if you could accept one
    small piece of constructive criticism, please try and fix that most irritating problem. I’m going to subscribe but I will have to unsubscribe if that just continues to be your way. Thank you for the informative piece of information.

  • I am taking metgormin in the morning by 7am and taking my breakfast by 8.30 am. Is it correct or I have to chnge. I am taking olmesortan ( for BP) along with metformin. Any problem if both together consumed in morning 7 am and night 7 pm. Pl reply

  • This is such good news. I’m trying to conceive and I will try to ask my OBGYN if I can start with metformin and other medications. I am going to buy prenatal & other healthy supplements for PCOS

  • hi everyone,I’ve been ttc about 3 years now n nothing happen,later on i found out i wasnt ovulateing, on June the 11,I start taking metformin,500,n today I ovulate. I’ll keep u update if I got pregnant.

  • The best way is not to take anything and eat the human species diet which is mostly defined by the ketogenic diet its done wonders for me 3 years now no meds and perfect A1C year round

  • I was given metformin when I was diagnosed with type 2diabetes. After 4 months I halved my medication for a month with no change on my glucose meter testing.So I stopped taking it 2 months ago with still no change on my testing results.I switched to cinnamon, bitter melon and Apple cider vinegar supplements.Ive just had my 2nd blood test since I was diagnosed 7 months ago and it’s gone from 7.7 to 5.6 and now it’s 4.7.

  • Thanks for this and all your videos! I am a 68yo white male and was diagnosed with severe insulin resistance this past January, and have been taking Metformin about 4 months now. Luckily I was able to quickly titrate to 4 x 500mg tablets daily. As you say, together with diet and exercise, it has helped me to lose 60 lbs so far! I feel fortunate, not only to lose the weight, but to have hopefully avoided a future Type 2 diabetes status. This drug has been a real boon to me….I say all this mainly to offer some degree of optimism to those who might be in a similar situation. I have read that insulin resistance is quite prevalent among “seniors” these days. Cheers!

  • British practice is different: I was put on my full dose immediately. And, oh God, bowel problems!
    Yoghurt (which I hate) or kefir (which I hate more) can both help to re-balance your gut bacteria and reduce flatulence and diarrhea. You will almost certainly need something because metformin really does obliterate your “good” gut bacteria and can make you very anti-social!
    Tingling in your nerve ends? Insufficient vitamin B12 may be the cause. It works for me but I’m not qualified to say whether this is a recommended course of action.

  • iam taking this two time a day from a month bt i stop takig coz of diarhea after that i feel badly shortness if breath please some one help me out what should i do now cn i start it again or what???

  • I started a week ago! I can’t stop running to toilet, I vomited few days ago when I woke up, I’m nauseated almost ALL DAY… & I’m only on 500mg once a day EXTENDED release

  • Thank you! Great video. I also take metformin. With exercise and diet, I keep my A1c at 5.6 or 5.7. I’ve never had the upset gut but I’ve heard for those that have experienced it that it’s quite unpleasant. Thank you for for your wisdom and knowledge.

  • Do you take metformin while menstruating? My dr gave me no instructions, told me he was giving me 500mg bid but actually gave me 1000mg bid. Which I decided to start at 500 and I’m working up to 1500 mg/day this week or next (depending on side effects) This is my 3rd week on it. I started spotting and cramping today. Plus my dr isn’t answering the phone.

  • Thank you for sharing this vital and valuable information!!! June 16th 2020!!! ❤️❤️❤️������♥️♥️♥️������������������❤️❤️❤️❤️❤️����������

  • Did you experience any ovulation pain? I’ve been on metformin for a month and a half and got my cycle the second month, also got ovulation the end of September and released a egg so fingers crossed for a October baby

  • Awwww. Congratulations girl, my question is did you continue taking metformin after finding out that you pregnant? I will be waiting for ur reply thanks.

  • I also pcos when I started metformien 5 month but not required but this one year counting period regularlly and I have no pregnancy then you have any suggestions

  • I wasnt ovulating. AAAAnd then i started metformin for PCOS and BAAMMM! pregnant that same month. They should really warn you about this! lol love my baby so it all worked out.