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Do low folic acid levels cause miscarriage? A few studies have suggested that being deficient in folic acid is associated with a higher risk of early miscarriage. One 2002 study by Swedish researchers found that women with low folate levels had a significantly increased risk of having a miscarriage affected by chromosomal abnormalities. Not all studies, however, show.
Folate deficiency also has been associated with placental separation during pregnancy, pregnancy-induced hypertension, and low blood supply to the placenta. These effects may in part be responsible. Pregnant women who have low blood levels of the vitamin folate are more likely to have early miscarriages than are pregnant women who have adequate folate levels, according to a study of Swedish women by researchers at the Karolinska Institute in Sweden and at the National Institute of Child Health and Human Development (NICHD). Two recent cohort studies reported that the use of folic acid or multiple vitamins during pregnancy was associated with a 50–60% reduced risk of miscarriage (28, 29).Our study allowed us to improve on previous studies by contrasting the relationship between prepregnancy folate from food and supplements and spontaneous abortion and to examine a dose-response relationship.
After all the risk factors had been taken into account, women with low folate concentrations had a higher risk of miscarriage, compared with women whose plasma folate concentration was between 5.0 and 8.9 nmol/l (odds ratio 1.47 (95% confidence interval 1.01. Low folate status associated with 47% higher risk of miscarriage, may cause abnormal karyotype. Compared with women with plasma folate levels between 2.20 and 3.95 ng/mL, women with low (< or =2.19. MTHFR handles the breakdown of the vitamin folic acid. This breakdown leads to elevated levels of homocysteine.
Homocysteine is a chemical produced from an amino acid in our bodies when folic acid. Folate levels in your body can become low in just a few weeks if you don’t eat enough folate-rich foods. Disease. Diseases that affect absorption in the gastrointestinal tract can cause folate. The biggest sign of folate deficiency is megaloblastic anemia, a condition in which the body has a low number of abnormally large red blood cells, according to the National Institutes of Health.
Low blood folate levels are associated with an increased risk of cervical, breast, colon, brain and lung cancer. Epidemiologic evidence generally indicates that a high intake of folate-rich foods offers protection against the development of some common cancers, but the relationship between folic acid and cancer is complicated, as you’ve learned.
List of related literature:
|from It Starts with the Egg: How the Science of Egg Quality Can Help You Get Pregnant Naturally, Prevent Miscarriage, and Improve Your Odds in IVF (Second Edition)|
|from Drugs During Pregnancy and Lactation: Treatment Options and Risk Assessment|
|from Herbs and Natural Supplements Inkling: An Evidence-Based Guide|
|from Anatomy and Physiology for Midwives E-Book|
|from The Active Female: Health Issues Throughout the Lifespan|
|from Nathan and Oski’s Hematology of Infancy and Childhood E-Book|
|from Krause and Mahan’s Food and the Nutrition Care Process E-Book|
|from Essential Herbs and Natural Supplements|
|from Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk|
|from Encyclopedia of Human Nutrition|