Low-Dose Aspirin and Miscarriage

 

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A low-dose aspirin pill contains 81 milligrams (mg) of medication. It’s also why daily low-dose aspirin, plus another blood thinner called heparin, often are prescribed for pregnant women with a history of recurrent miscarriages who have a condition called antiphospholipid syndrome. THURSDAY, Feb.

9, 2017 (HealthDay News) Miscarriage is an often unexpected and traumatic event for a woman and her partner. But new research. Many health care providers prescribe low dose aspirin therapy for women who have had a pregnancy loss (miscarriage or stillbirth), and who would like to get pregnant again.

However, the effectiveness of this treatment has not been proven, the researchers wrote. used low-dose aspirin and the impact of this on miscarriage. Surely the authors were not unaware of the widespread use of low-dose aspirin by women and by clinics.

I might also be described as one of the women who self-prescribes low-dose aspirin, because I have. Mini Doses for Specific Cases Doctors often prescribe “baby aspirin” in combination with heparin or enoxaparin to prevent miscarriage in women with these conditions, and some doctors recommend aspirin to some women who have had unexplained recurrent miscarriages. The associated between miscarriage and Aspirin use was weaker than that between miscarriage and other NSAIDs, however. [ 7 ] While other studies have actually concluded that low-dose Aspirin in pregnancy may prevent miscarriage in women who have already suffered recurrent miscarriages [ 8 ] a more recent study found that this is not an effective way to reduce the risk of miscarriage. MISCARRIAGE RATES Compared with low-dose aspirin plus corticosteroids: Low-dose aspirin alone may be as effective as prednisolone plus low-dose aspirin at reducing miscarriage rates ( very low-quality evidence ). Several studies looked at the possibility that low-dose Aspirin — 75 mg daily — could prevent further miscarriages in women who tested positive for antiphospholipid antibodies, lupus anticoagulant or anticardiolipin antibodies.

Taking low doses of aspirin is not thought to increase the chance of miscarriage. Some studies have shown that low dose aspirin can lower the chance of miscarriage in some women. The rate of live births with low dose aspirin and heparin was 71% (32/45 pregnancies) and 42% (19/45 pregnancies) with low dose aspirin alone (odds ratio 3.37 (95% confidence interval 1.40 to 8.10)).

More than 90% of miscarriages occurred in the first trimester.

List of related literature:

These treatments are still the subject of controversy and research, e.g., studies of women with recurrent miscarriage have found little benefit for the use of aspirin or anticoagulants, even in women with known clotting tendencies.25 However, this medication is widely prescribed to women diagnosed with such factors.

“Treatment of Infertility with Chinese Medicine E-Book” by Jane Lyttleton
from Treatment of Infertility with Chinese Medicine E-Book
by Jane Lyttleton
Elsevier Health Sciences, 2013

Regular-dose aspirin or other NSAIDs are not advisable during a pregnancy because they may induce bleeding, which leads to miscarriage, prolongs labor, and causes early closure of the opening between the pulmonary artery and descending aorta near the fetal heart.

“The Lupus Book: A Guide for Patients and Their Families” by Daniel J Wallace
from The Lupus Book: A Guide for Patients and Their Families
by Daniel J Wallace
Oxford University Press, USA, 2008

During pregnancy, women with APLA syndrome are usually advised to take low doses of aspirin or aspirin and heparin to prevent miscarriage, although researchers still haven’t determined whether taking aspirin or aspirin plus heparin is any more effective than taking nothing at all.

“The New Harvard Guide to Women's Health” by Karen J. Carlson, Stephanie A. Eisenstat, Stephanie A. Eisenstat, M.D., Terra Diane Ziporyn, Alvin & Nancy Baird Library Fund, Harvard University. Press
from The New Harvard Guide to Women’s Health
by Karen J. Carlson, Stephanie A. Eisenstat, et. al.
Harvard University Press, 2004

Aspirin use and miscarriage risk.

“Meyler's Side Effects of Analgesics and Anti-inflammatory Drugs” by Jeffrey K. Aronson
from Meyler’s Side Effects of Analgesics and Anti-inflammatory Drugs
by Jeffrey K. Aronson
Elsevier Science, 2009

Information on the use of low-dosage aspirin for prevention of stillbirth is limited.

“Creasy and Resnik's Maternal-Fetal Medicine: Principles and Practice” by Robert Resnik, MD, Robert K. Creasy, MD, Jay D. Iams, MD, Charles J. Lockwood, MD, MHCM, Thomas Moore, MD, Michael F Greene, MD
from Creasy and Resnik’s Maternal-Fetal Medicine: Principles and Practice
by Robert Resnik, MD, Robert K. Creasy, MD, et. al.
Elsevier Health Sciences, 2013

At the base of this practice is an assumption that aspirin interferes with the ability of antiphospholipid antibodies to compromise implantation and placental angiogenesis.223,224 Aspirin is also frequently prescribed to reduce the risk of maternal thrombosis.

“High Risk Pregnancy E-Book: Management Options Expert Consult” by David K. James, Philip J. Steer, Carl P. Weiner, Bernard Gonik
from High Risk Pregnancy E-Book: Management Options Expert Consult
by David K. James, Philip J. Steer, et. al.
Elsevier Health Sciences, 2010

Initial small studies suggested that low-dose aspirin reduces the risk of preeclampsia, although patients who received aspirin had a higher incidence of placental abruption and bleeding.111-118 Larger, randomized trials failed to confirm the benefit of low-dose aspirin.112,113

“Hematology E-Book: Basic Principles and Practice, Expert Consult Premium Edition Enhanced Online Features” by Leslie E. Silberstein, John Anastasi, Ronald Hoffman, Edward J. Benz, Helen Heslop, Jeffrey Weitz
from Hematology E-Book: Basic Principles and Practice, Expert Consult Premium Edition Enhanced Online Features
by Leslie E. Silberstein, John Anastasi, et. al.
Elsevier Health Sciences, 2012

Low-dose aspirin in prevention of miscarriage in women with unexplained or autoimmune related recurrent miscarriage: effect on prostacyclin and thromboxane A2 production.

“Consultative Hemostasis and Thrombosis E-Book” by Craig S. Kitchens, Barbara A Konkle, Craig M. Kessler
from Consultative Hemostasis and Thrombosis E-Book
by Craig S. Kitchens, Barbara A Konkle, Craig M. Kessler
Elsevier Health Sciences, 2018

The safety of low-dose aspirin in pregnancy has been confirmed in a study of more than 20,000 women.396 Heparin does not cross the placenta.

“Yen & Jaffe's Reproductive Endocrinology E-Book” by Jerome F. Strauss, Robert L. Barbieri
from Yen & Jaffe’s Reproductive Endocrinology E-Book
by Jerome F. Strauss, Robert L. Barbieri
Elsevier Health Sciences, 2009

A number of studies have demonstrated that low-dose aspirin is safe for both mother and fetus in the second and third trimester [263– 265].

“Critical Care Obstetrics” by Michael A. Belfort, George R. Saade, Michael R. Foley, Jeffrey P. Phelan, Gary A. Dildy
from Critical Care Obstetrics
by Michael A. Belfort, George R. Saade, et. al.
Wiley, 2010

Oktay Kutluk

Kutluk Oktay, MD, FACOG is one of the world's foremost experts in fertility preservation as well as ovarian stimulation and in vitro fertilization for infertility treatments. He developed and performed the world's first ovarian transplantation procedures as well as pioneered new ovarian stimulation protocols for embryo and oocyte freezing for breast and endometrial cancer patients.

Mail: [email protected]
Telephone: +1 (877) 492-3666

Biography: https://medicine.yale.edu/profile/kutluk_oktay/
Bibliography: oktay_bibliography

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44 comments

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  • What I understand is COX-1 plays a key role for forming blood clot so blocking it out prevents new clots from forming. But what about an already formed clot staying intact? Does it play a role in that, too? If not, what I assume is blocking COX-1 with aspirin only stops new clots from forming, which is already good enough. But you’ve mentioned that if someone is having a heart attack the doctors give the patient 325mg of it, for… ‘dissolving’ the already formed clot?

  • Thank you so much for your video!!! I have my third miscarriage and this time was at 9 weeks. Early miscarriage is because low progesterone? The Drs do not believe in testing for progesterone.

  • Is the blood clot disorder your talking about antiphospholipid syndrome by chance? I was told I have that and that’s part of the reason I miscarried but my baby passed around the time that the placenta started taking over. Ugh it’s so hard to know the right thing to do or what to take.

  • I was able to fix my infertility problem at 44 years old. I was very thrilled during my menstrual cycle was delayed. I am now about to experience maternity and parenthood. You can learn about this guide more by getting to Google. I think name of this guide is Sofia Goρazna
    Best luck

  • Did you notice any negative side effects from taking the progesterone? My doctor prescribed it to me, and I’m a little scared to try it, based upon what I read.

  • Mam i had a 3times miscarriage,so now i have passed 4months from last miscarriage doctor ask me to wait atleast 6onths, sowhat can ido before and after planning a baby

  • I had my 4th miscarriage lost at 9 weeks. My progesterone was low. I was prescribed progesterone 200mg capsule. The baby’s heart stopped before I began taking the meds. Please pray for me. Going to TTC after I heal. Thanks for your videos ��♥️

  • I am surprised you didn’t mention the latest studies which showed that aspirin might not be effective or worth the risks.
    https://www.nih.gov/news-events/news-releases/daily-low-dose-aspirin-found-have-no-effect-healthy-life-span-older-people

  • If you`d like to learn more about this excellent pregnant program “Zο Fanvuko”, search it on Google. At the age of forty-four, I was able to solve my big fertility problem utilizing it. I had been glad during my period was late. After learning about my delayed menstruation, I made essential adjustments since I’m glad about this. I am ushering myself currently into parenthood.

  • Watching your video has given me so much hope. I had a miscarriage in July and that scared me from trying again. After watching your video I have hope. ❤️❤️

  • I really love what u r doing,it’s kind of give hope to those trying to bring a new soul to the world.
    I v had 4 losses and d last MC was 2 months ago and thy all end at 6-7 weeks.

    I will try this but am scared of Asprin,can u enlighten me on the progesterone tab.

  • Thanks for this! I also have had 3 miscarriages, and we’ve been on progesterone but never got blood drawn for it. I just had my iui yesterday so I will ask for a progesterone test as soon as we get a positive ���� love and light to you and your family!

  • Just a heads up for anyone considering taking maca root supplements…it has a rare side effect of heart palpitations. My dr. sent me for all sorts of testing before either of us realized the issue was coming from the maca. I was taking it to regulate cycles that were irregular due to pcos, so I did some research and switched to an inositol blend & conceived two months later after years of trying. Unfortunately, I’m currently recovering from a complicated miscarriage but I’ll be trying inositol again once I’m healed and we’re ready to try again. It was my first miscarriage after 3 healthy pregnancies/deliveries and was a missed miscarriage diagnosed at my 11wk checkup so it totally blindsided us. I’m so glad to see that more women are starting to talk about miscarriage because until it happened to me, I had absolutely no idea how common it was or what the physical experience was going to be like (although mine apparently wasn’t normal and was much more painful than any of my labors with my kids!) I think it’s so important to keep that conversation going women who go through this can know they’re not alone.��

  • How are you doing? There isn’t any video available from your side about your pregnancy. I hope lord keeps you healthy and happy with life….love from Pakistan

  • I’m trying to get pregnant again I’ve had like 26 loss been looking for something like this I’m hoping to try again soon after I move to my new house in NC. I have lupus and RA would this help me.

  • I’m 11+5 today and have been taking baby aspirin since 4 weeks. the doctor told me i can stop taking it at 12 weeks, but i’m sooooo scared…..

  • Just a small audio geek note: You guys need to pay a little more attention to your audio levels. The v/o levels change frequently with the change of sections or overdubs. Not drastically but enough that I found myself adjusting the volume to keep the levels consistent.

  • Hey girl. I have to take cytotec today because I’m currently going through a miscarriage which is incomplete. This is miscarriage #3 for me, and it sucks so bad. I have three healthy children as well, but it’s still so hard each time I lose a pregnancy. Currently waiting on my results for antiphospholipid (the clotting disorder) but all the rest of my results came back normal. I’m definitely trying some of your tips for my next pregnancy ♥️ So happy and excited for you!

  • Love this! Any weekly, or monthly updates on baby and the changes your body is making is always welcome! Love following your journey! ��

  • Hey girl! I just found out I’m pregnant and have had 2 losses. I was taking Maca before getting pregnant but now I’m not sure if I should. Have you continued to take it during this pregnancy? It sounded like you are still taking it in the video, just wanted to make sure:) Thanks!

  • I’ve had 1 miscarriage, so I greatly feel for the ladies that have experienced many. We are going to be trying again in about a month… But I just wanted to speak up for some OBs… My OB clinic assured me that they will do blood work as soon as I have a positive test, they do prescribe progesterone when needed, and assured me I’d be monitored more closely from the gait. And this is an OB who believes there are no indicators at this point that I won’t have a healthy pregnancy…. And, ladies, if you think there is something that will be helpful, ASK… I’m very interested in the asprin and being tested for clotting… My sister has a rare clotting antibody. We started with thyroid and all I had to do was ask and she ordered the test. Find a good OB… For me fertility clinic isn’t an option yet, I don’t believe my insurance will cover it at this point. God Bless!

  • My sister has an inflammatory disease (Chrone’s disease) and she also takes a small amount of aspirin each day… it’s important especially since she had a stroke when she was two. Thanks, Science!

  • Aspirin used to be derived from Willow tree bark. Now it’s being derived from petroleum processes. Some stores are selling aspirin 81 mg. 250 tablets for 99 cents. Is it the same? Do comment. Thank you.

  • There is a new clinical trial (4/2020) testing to see whether aspirin is effective against Covid-19, because aspirin also has an antiviral effect by inhibiting activation of NF-κB. The trial announcement is here: https://clinicaltrials.gov/ct2/show/study/NCT04365309

  • I found out a week ago that my baby had stopped growing and had a very low heart rate and now after too many blood tests, I found out today their heart has stopped. Watching your videos is helping me through this. You’re so strong ❤️

  • Low dose aspirin for cardiovascular issues is still viable but it must be managed by a doctor in the right cases. And don’t forget the important studies on aspirin and cancer prevention. These are still good studies and deserve attention. See MD anderson video. Consult a doctor.

  • Here’s an update for you-there’s new research out there that says there’s no benefit of taking low dose aspirin in older healthy adults. Here’s the study if you’re into it: https://www.nih.gov/news-events/news-releases/daily-low-dose-aspirin-found-have-no-effect-healthy-life-span-older-people

  • I am on aspirin 75mg, rosuvastatin10mg and exforge 5/80 for whole life by my physician on accidentally diagnosis of confirmed hypertension patient as he checked my blood pressure at an age of 35. Thanks for my physician on his preventive approach.

  • This is so scary I have a 10 y/o son I recently became pregnant in July and miscarried at 6 weeks the later got pregnant in early October and lost it in November the first time I thought it was random but now I’m afraid I can’t carry idk what to do I never thought this would be me.

  • Aspirin is good for Houseplants also!
    You might know that it’s based on an extract from White Willow bark. What does it do for that tree?
    It’s a powerful plant growth hormone. It spurs root growth, esp. in cuttings to start new plants. It also improves plant health and reactions to infections.
    A regular-dose aspirin dissolved in 2 gal. water is a good health routine for your plants.
    Many professional nurseries use this regularly.
    http://www.plantea.com/plant-aspirin.htm

  • I loved this video, I would love if you did more of this kind, i. e. explaining how medicines work. I would like to know, I didn’t quite understand how it is that platelets detect that there’s a wound. Does it have to be something with detecting a difference in the chemistry between the blood solution and what’s outside of it?

  • Hi I had two times misscarriages but now we wana plan but I am scared because doctors did not tell me any reason behind it..I am from India so I sent my reports to doctor there she said I have thicker blood thats why I hv to face two miscarriages.Would you please suggest me anything..my HCG was also low during 9 week.

  • Thank you for sharing your story to help others. I have a sister who refused to share and talk with me about what helped her get pregnant when I was struggling. Thank you for being a sister to all of us.

  • Low dose aspirin for coronary problems has been shown to be no more useful than a placebo, with a lot of potentially negative side effects.
    https://www.nih.gov/news-events/news-releases/daily-low-dose-aspirin-found-have-no-effect-healthy-life-span-older-people

  • Thank you for posting this! I have had 2 early miscarriages, and found out I have a blood clotting disorder Factor 5 Leiden. I’m currently seeing a fertility specialist and now I’m taking aspirin, also waiting to see hematologist to go over if/how/when I need the Lovenox. Your video gave me such peace of mind in a stressful time and you reminded me to trust in my fertility clinic, thank you for sharing!

  • My mother has had 3 strokes serve enough to be hospitalized and she has been taking baby aspirin for years, so I just would like to thank you for explaining the science behind taking low dose aspirin.

  • None of our aspirin or aspirin and blood thinner injection pregnancies survived with ten miscarriages. I agree fully with conclusions. Our surviving child was born with no treatment.

  • Thank you for bringing me hope. Today is the last day I take the baby aspirin and I can feel getting depressed, worried, and scared because idk what will happen with my baby after stopping. I have had 2 previous miscarriages for a blood clotting disorder. In 1 wk I’ll be 6 months with a boy ��

  • i know the one i take is only once a day not like some of them where they have to take 3 a day which can make you really sick. be careful with aspirin my doctor said its a big no no can be very harmful to you and the baby.

  • How long is aspirin given in pregnancy, kindly suggest. Lupus syndrome is normal. Normal pregnancy. Earlier 2 miscarriage and 1 IVF fail. Age 35 sir, my wife is facing GERD with aspirin, is there any alternative to aspirin?

  • I am going to take it this month. I had 2 chemicals in the last 6 months. Hoping it helps with implantation. Will aspirin help endometriosis?

  • Is 100mg okay? It’s all I could get from pharmacy right now. My gyno mentioned I would take when pregs but I’ve started taking since ovulating this week. I had a miscarriage in Feb. Recently specialist thinks I’ve Endo after past Drs thought pcos. Thank You

  • ? Cool content, You’ve got yourself a new subscriber! Have you seen SMZeus[.]com!? It would help you grow your channel and get the views you deserve!

  • Thank you! I have a question. So what about taking it early like 4-5 weeks. Taking it every other day early in pregnancy? Is this safe. I asked my obgyn could I take it and he said it was fine. After having a miscarriage last year I have been researching and now taking progesterone & baby aspirin.

    I am 34 will be 35 in sep. I have boarderline high blood pressure and over weight BMI 29.
    Just want to make sure because u mentioned starting it later than 6 weeks. I am 5 weeks now ����