Low-Dose Aspirin and Miscarriage

 

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A low-dose aspirin pill contains 81 milligrams (mg) of medication. It’s also why daily low-dose aspirin, plus another blood thinner called heparin, often are prescribed for pregnant women with a history of recurrent miscarriages who have a condition called antiphospholipid syndrome. THURSDAY, Feb.

9, 2017 (HealthDay News) Miscarriage is an often unexpected and traumatic event for a woman and her partner. But new research. Many health care providers prescribe low dose aspirin therapy for women who have had a pregnancy loss (miscarriage or stillbirth), and who would like to get pregnant again.

However, the effectiveness of this treatment has not been proven, the researchers wrote. used low-dose aspirin and the impact of this on miscarriage. Surely the authors were not unaware of the widespread use of low-dose aspirin by women and by clinics.

I might also be described as one of the women who self-prescribes low-dose aspirin, because I have. Mini Doses for Specific Cases Doctors often prescribe “baby aspirin” in combination with heparin or enoxaparin to prevent miscarriage in women with these conditions, and some doctors recommend aspirin to some women who have had unexplained recurrent miscarriages. The associated between miscarriage and Aspirin use was weaker than that between miscarriage and other NSAIDs, however. [ 7 ] While other studies have actually concluded that low-dose Aspirin in pregnancy may prevent miscarriage in women who have already suffered recurrent miscarriages [ 8 ] a more recent study found that this is not an effective way to reduce the risk of miscarriage. MISCARRIAGE RATES Compared with low-dose aspirin plus corticosteroids: Low-dose aspirin alone may be as effective as prednisolone plus low-dose aspirin at reducing miscarriage rates ( very low-quality evidence ). Several studies looked at the possibility that low-dose Aspirin — 75 mg daily — could prevent further miscarriages in women who tested positive for antiphospholipid antibodies, lupus anticoagulant or anticardiolipin antibodies.

Taking low doses of aspirin is not thought to increase the chance of miscarriage. Some studies have shown that low dose aspirin can lower the chance of miscarriage in some women. The rate of live births with low dose aspirin and heparin was 71% (32/45 pregnancies) and 42% (19/45 pregnancies) with low dose aspirin alone (odds ratio 3.37 (95% confidence interval 1.40 to 8.10)).

More than 90% of miscarriages occurred in the first trimester.

List of related literature:

These treatments are still the subject of controversy and research, e.g., studies of women with recurrent miscarriage have found little benefit for the use of aspirin or anticoagulants, even in women with known clotting tendencies.25 However, this medication is widely prescribed to women diagnosed with such factors.

“Treatment of Infertility with Chinese Medicine E-Book” by Jane Lyttleton
from Treatment of Infertility with Chinese Medicine E-Book
by Jane Lyttleton
Elsevier Health Sciences, 2013

Regular-dose aspirin or other NSAIDs are not advisable during a pregnancy because they may induce bleeding, which leads to miscarriage, prolongs labor, and causes early closure of the opening between the pulmonary artery and descending aorta near the fetal heart.

“The Lupus Book: A Guide for Patients and Their Families” by Daniel J Wallace
from The Lupus Book: A Guide for Patients and Their Families
by Daniel J Wallace
Oxford University Press, USA, 2008

During pregnancy, women with APLA syndrome are usually advised to take low doses of aspirin or aspirin and heparin to prevent miscarriage, although researchers still haven’t determined whether taking aspirin or aspirin plus heparin is any more effective than taking nothing at all.

“The New Harvard Guide to Women's Health” by Karen J. Carlson, Stephanie A. Eisenstat, Stephanie A. Eisenstat, M.D., Terra Diane Ziporyn, Alvin & Nancy Baird Library Fund, Harvard University. Press
from The New Harvard Guide to Women’s Health
by Karen J. Carlson, Stephanie A. Eisenstat, et. al.
Harvard University Press, 2004

Aspirin use and miscarriage risk.

“Meyler's Side Effects of Analgesics and Anti-inflammatory Drugs” by Jeffrey K. Aronson
from Meyler’s Side Effects of Analgesics and Anti-inflammatory Drugs
by Jeffrey K. Aronson
Elsevier Science, 2009

Information on the use of low-dosage aspirin for prevention of stillbirth is limited.

“Creasy and Resnik's Maternal-Fetal Medicine: Principles and Practice” by Robert Resnik, MD, Robert K. Creasy, MD, Jay D. Iams, MD, Charles J. Lockwood, MD, MHCM, Thomas Moore, MD, Michael F Greene, MD
from Creasy and Resnik’s Maternal-Fetal Medicine: Principles and Practice
by Robert Resnik, MD, Robert K. Creasy, MD, et. al.
Elsevier Health Sciences, 2013

At the base of this practice is an assumption that aspirin interferes with the ability of antiphospholipid antibodies to compromise implantation and placental angiogenesis.223,224 Aspirin is also frequently prescribed to reduce the risk of maternal thrombosis.

“High Risk Pregnancy E-Book: Management Options Expert Consult” by David K. James, Philip J. Steer, Carl P. Weiner, Bernard Gonik
from High Risk Pregnancy E-Book: Management Options Expert Consult
by David K. James, Philip J. Steer, et. al.
Elsevier Health Sciences, 2010

Initial small studies suggested that low-dose aspirin reduces the risk of preeclampsia, although patients who received aspirin had a higher incidence of placental abruption and bleeding.111-118 Larger, randomized trials failed to confirm the benefit of low-dose aspirin.112,113

“Hematology E-Book: Basic Principles and Practice, Expert Consult Premium Edition Enhanced Online Features” by Leslie E. Silberstein, John Anastasi, Ronald Hoffman, Edward J. Benz, Helen Heslop, Jeffrey Weitz
from Hematology E-Book: Basic Principles and Practice, Expert Consult Premium Edition Enhanced Online Features
by Leslie E. Silberstein, John Anastasi, et. al.
Elsevier Health Sciences, 2012

Low-dose aspirin in prevention of miscarriage in women with unexplained or autoimmune related recurrent miscarriage: effect on prostacyclin and thromboxane A2 production.

“Consultative Hemostasis and Thrombosis E-Book” by Craig S. Kitchens, Barbara A Konkle, Craig M. Kessler
from Consultative Hemostasis and Thrombosis E-Book
by Craig S. Kitchens, Barbara A Konkle, Craig M. Kessler
Elsevier Health Sciences, 2018

The safety of low-dose aspirin in pregnancy has been confirmed in a study of more than 20,000 women.396 Heparin does not cross the placenta.

“Yen & Jaffe's Reproductive Endocrinology E-Book” by Jerome F. Strauss, Robert L. Barbieri
from Yen & Jaffe’s Reproductive Endocrinology E-Book
by Jerome F. Strauss, Robert L. Barbieri
Elsevier Health Sciences, 2009

A number of studies have demonstrated that low-dose aspirin is safe for both mother and fetus in the second and third trimester [263– 265].

“Critical Care Obstetrics” by Michael A. Belfort, George R. Saade, Michael R. Foley, Jeffrey P. Phelan, Gary A. Dildy
from Critical Care Obstetrics
by Michael A. Belfort, George R. Saade, et. al.
Wiley, 2010

Oktay Kutluk

Kutluk Oktay, MD, FACOG is one of the world's foremost experts in fertility preservation as well as ovarian stimulation and in vitro fertilization for infertility treatments. He developed and performed the world's first ovarian transplantation procedures as well as pioneered new ovarian stimulation protocols for embryo and oocyte freezing for breast and endometrial cancer patients.

Mail: [email protected]
Telephone: +1 (877) 492-3666

Biography: https://medicine.yale.edu/profile/kutluk_oktay/
Bibliography: oktay_bibliography

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5 comments

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  • What I understand is COX-1 plays a key role for forming blood clot so blocking it out prevents new clots from forming. But what about an already formed clot staying intact? Does it play a role in that, too? If not, what I assume is blocking COX-1 with aspirin only stops new clots from forming, which is already good enough. But you’ve mentioned that if someone is having a heart attack the doctors give the patient 325mg of it, for… ‘dissolving’ the already formed clot?

  • Thank you so much for your video!!! I have my third miscarriage and this time was at 9 weeks. Early miscarriage is because low progesterone? The Drs do not believe in testing for progesterone.

  • Is the blood clot disorder your talking about antiphospholipid syndrome by chance? I was told I have that and that’s part of the reason I miscarried but my baby passed around the time that the placenta started taking over. Ugh it’s so hard to know the right thing to do or what to take.

  • I was able to fix my infertility problem at 44 years old. I was very thrilled during my menstrual cycle was delayed. I am now about to experience maternity and parenthood. You can learn about this guide more by getting to Google. I think name of this guide is Sofia Goρazna
    Best luck

  • Did you notice any negative side effects from taking the progesterone? My doctor prescribed it to me, and I’m a little scared to try it, based upon what I read.