Diclegis for Vomiting and nausea during pregnancy

 

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Diclegis ® is a prescription medicine used to treat nausea and vomiting of pregnancy in women who have not improved with change in diet or other non-medicine treatments. LIMITATIONS OF USE It is not known if Diclegis ® is safe and effective in women with severe nausea and vomiting of pregnancy, a condition called hyperemesis gravidarum. Diclegis is currently the first-line pharmacological treatment recommended by the American College of Obstetricians and Gynecologists (ACOG) for nausea and vomiting in pregnancy. The FDA has approved Diclegis (Duchesnay), a fixed-dose, delayed-release combination of the H1-antihistamine doxylamine and the vitamin B6 analog pyridoxine, for treatment of nausea and vomiting of pregnancy in women who do not respond to conservative management. It.

User Reviews for Diclegis to treat Nausea/Vomiting of Pregnancy. The following information is NOT intended to endorse any particular medication. While these reviews might be helpful, they are not a substitute for the expertise, knowledge and judgement of healthcare practitioners.

Overview; Side Effects; Dosage; Professional; Interactions; More. Diclegis (doxylamine succinate and pyridoxine hydrochloride) is an antiemetic (anti-nausea and vomiting) agent used to treat nausea and vomiting in pregnant women. Available only by prescription, Diclegis is used to control nausea and vomiting of pregnancy (NVP).

It has two main ingredients: vitamin B6 and the antihistamine doxylamine. Diclegis is a delayed-release tablet containing a combination of doxylamine and pyridoxine. Doxylamine is an antihistamine that reduces the effects of natural chemical histamine in the body. Pyridoxine is a form of vitamin B (B6).

Diclegis is used to treat nausea and vomiting during pregnancy, sometimes called morning sickness. You should also speak to your doctor or midwife if you’re experiencing any of the following: nausea and vomiting so severe you can’t keep food or water down pain and fever along with vomiting nausea and vomiting that continue past the first trimester. According to a 2014 overview, the Food and Drug Administration (FDA) approved Diclegis in 2013 for the treatment of nausea and vomiting in pregnancy.

Diclegis ® is a combination of an antihistamine (doxylamine succinate) and vitamin B6 (pyridoxine hydrochloride) to help control nausea and vomiting of pregnancy when diet and lifestyle changes are.

List of related literature:

A combination product of doxylamine 10 mg and pyridoxine 10 mg (Diclegis) has recently been approved by the FDA for the treatment of nausea and vomiting of pregnancy in women who do not respond to conservative management.

“Conn's Current Therapy 2016” by Edward T. Bope, Rick D. Kellerman
from Conn’s Current Therapy 2016
by Edward T. Bope, Rick D. Kellerman
Elsevier, 2015

Delayed release doxylamine 10 mg plus pyridoxine 10 mg (Diclegis) is effective and well tolerated.48 Doxylamine (Unisom Sleeptabs) is an effective antihistamine for nausea in pregnancy and can be combined with vitamin B 6 to produce a therapy similar to Diclegis.

“Obstetrics: Normal and Problem Pregnancies E-Book” by Mark B Landon, Henry L Galan, Eric R. M. Jauniaux, Deborah A Driscoll, Vincenzo Berghella, William A Grobman, Sarah J Kilpatrick, Alison G Cahill
from Obstetrics: Normal and Problem Pregnancies E-Book
by Mark B Landon, Henry L Galan, et. al.
Elsevier Health Sciences, 2020

In Canada and the USA, a combination of pyridoxine (vitamin B6 ) and an antihistamine (doxylamine) is approved for the treatment of nausea in pregnancy but this combination treatment appears to be less effective for controlling vomiting.

“Clinical Pharmacy and Therapeutics E-Book” by Roger Walker, Cate Whittlesea
from Clinical Pharmacy and Therapeutics E-Book
by Roger Walker, Cate Whittlesea
Elsevier Health Sciences, 2011

Currently doxylaminepyridoxine (Diclegis) is the only medication listed with FDA approval to treat vomiting in pregnancy.

“Foundations and Adult Health Nursing E-Book” by Kim Cooper, Kelly Gosnell
from Foundations and Adult Health Nursing E-Book
by Kim Cooper, Kelly Gosnell
Elsevier Health Sciences, 2018

The current ACOG guidelines for treatment of nausea and vomiting in pregnancy recommend the use of pyridoxine (vitamin B6), either alone or in combination with doxylamine (Unisom) as initial medical management.

“Maternal Child Nursing Care E-Book” by Shannon E. Perry, Marilyn J. Hockenberry, Kathryn Rhodes Alden, Deitra Leonard Lowdermilk, Mary Catherine Cashion, David Wilson
from Maternal Child Nursing Care E-Book
by Shannon E. Perry, Marilyn J. Hockenberry, et. al.
Elsevier Health Sciences, 2017

A classic example is a once-popular antiemetic medication, Bendectin (doxylamine succinate and pyridoxine hydrochloride with or without dicyclomine hydrochloride), used by as many as 30% of American women for the treatment of nausea and vomiting of pregnancy.

“Creasy and Resnik's Maternal-Fetal Medicine: Principles and Practice E-Book” by Robert Resnik, Charles J. Lockwood, Thomas Moore, Michael F Greene, Joshua Copel, Robert M Silver
from Creasy and Resnik’s Maternal-Fetal Medicine: Principles and Practice E-Book
by Robert Resnik, Charles J. Lockwood, et. al.
Elsevier Health Sciences, 2018

Research shows that extra vitamin nausea or vomiting for some B6 may women be effective during at relieving pregnancy.51 The DRI during pregnancy is 1.9 mg/day.

“Obstetrics: Normal and Problem Pregnancies E-Book” by Steven G. Gabbe, Jennifer R. Niebyl, Henry L Galan, Eric R. M. Jauniaux, Mark B Landon, Joe Leigh Simpson, Deborah A Driscoll
from Obstetrics: Normal and Problem Pregnancies E-Book
by Steven G. Gabbe, Jennifer R. Niebyl, et. al.
Elsevier Health Sciences, 2016

This combination agent of pyridoxine and doxylamine (Diclegis) is the only US Food and Drug Administration pregnancy Category A approved therapy for N&V of pregnancy.

“Mosby's Guide to Nursing Diagnosis E-Book” by Gail B. Ladwig, Betty J. Ackley, Mary Beth Makic
from Mosby’s Guide to Nursing Diagnosis E-Book
by Gail B. Ladwig, Betty J. Ackley, Mary Beth Makic
Elsevier Health Sciences, 2019

Vitamin B6 is effective therapy for nausea and vomiting of pregnancy: a randomized, double-blind placebo-controlled study.

“Clinical Naturopathic Medicine E-Book” by Leah Hechtman
from Clinical Naturopathic Medicine E-Book
by Leah Hechtman
Elsevier Health Sciences, 2012

Bendectin, a combination of doxylamine and pyridoxine (vitamin B6), was approved by the FDA in the 1950s to treat nausea and vomiting of early pregnancy.

“Pharmacology for Women's Health” by King, Tekoa L. King, Mary C. Brucker
from Pharmacology for Women’s Health
by King, Tekoa L. King, Mary C. Brucker
Jones & Bartlett Learning, 2010

Oktay Kutluk

Kutluk Oktay, MD, FACOG is one of the world's foremost experts in fertility preservation as well as ovarian stimulation and in vitro fertilization for infertility treatments. He developed and performed the world's first ovarian transplantation procedures as well as pioneered new ovarian stimulation protocols for embryo and oocyte freezing for breast and endometrial cancer patients.

Mail: [email protected]
Telephone: +1 (877) 492-3666

Biography: https://medicine.yale.edu/profile/kutluk_oktay/
Bibliography: oktay_bibliography

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7 comments

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  • I was relying on herbals for nausea during first trimester, been drinking an herbal supplement “no to morning sickness tea” to soothe my morning sickness and that was great.

  • I was going thru debilitating morning sickness and fatigue also. I had all day and night morning sickness and hadn’t started prenatal yet. Anyways, I was taking “No to morning sickness tea”. It’s definitely worth a shot.

  • Omg you have through so much with this pregnancy mama! I did not know throwing up could be part of it. I hope you feel better soon!

  • Also i took it for the first time lastnight and woke up so drowsy. I see all these pregnant women that could not get off it because they were so sick when they would stop but i only took it one time and i honestly rather stick it out untill my nauseou naturally goes away.

  • Asked my doctor for dicliges but sadly my insurance didn’t cover it and it was going to be 122$ for 30$ pills so she told me to get unisom tablet take half with a 100mg vitamin b6.. took it around 10pm fell asleep within 30 min woke up in the morning and have not felt nausea definitely worked for me!

  • Kefir helped me with heartburn. I would drink a small glass specially before bed and that would do it. Plus it’s probiotics so that’s amazing for your gut health.

  • “no to morning sickness tea” works. I have found it the most impressive source of relief while suffering with nausea. secretsoftea develops this organic formula.