ttc vlog 1, recurrent miscarriage,balanced translocation
Video taken from the channel: Family of 5
Recurrent pregnancy loss from balanced translocations
Video taken from the channel: Dr. Allison K. Rodgers
My first video Pregnant with balanced translocation, after 4 miscarriages
Video taken from the channel: Kaben Fam
Translocation PGD (subtitles)
Video taken from the channel: CambridgeBlueGnome
GENETIC TEST RESULTS | IVF NEXT?
Video taken from the channel: Tim and Celeste
Miscarriage Chromosomal Analysis Results | Recurrent Pregnancy Loss
Video taken from the channel: ItsKelsiesLife
Dr. Benjamin Sandler Discusses Miscarriage & Recurrent Pregnancy Loss
Video taken from the channel: RMA of New York
Balanced chromosome translocations, in which sections of chromosomes change their geographical position on the chromosomal map without any loss or gain of important genetic material, are an important cause of recurrent miscarriages because they are common; one in 500 people carries a balanced translocation. They may have a child with a normal chromosome pattern, or the child may have a balanced translocation just like the parent. Natural conception and live birth is possible in cases of balanced translocation, but those with the condition may have more difficulty conceiving and are at a greater risk of recurrent miscarriage than those without it.
Such rearrangements are, for example, one of the commoner causes of recurrent miscarriage. For reasons which are not entirely clear, a mother with a balanced translocation seems slightly more likely to have a miscarriage than when her male partner has this chromosomal rearrangement. A couple with a balanced translocation can have a natural conception and a live birth but it is a statistics game.
For example a 50% chance that the fetus will not have the translocation. Therefore one may need to go through X miscarriages before a fertilization and implantation occurs with two gametes that do not have the chromosomal abnormality. These rearrangements are twice more common in females than males. In most cases, carriers of balanced reciprocal translocations have a normal phenotype but may experience reproductive issues such as infertility or multiple miscarriages.
Nearly, 6% of apparently balanced de novo translocations are associated with clinical abnormalities. In our study, the female partners. In recurrent miscarriage however, the situation is different and the doctor will look for a specific type of mutation called a balanced translocation.
While associated with recurrent miscarriage, it is still a very uncommon occurrence. If you have had two or more losses, you and your partner should consider a karyoptype to check for a balanced translocation. The chance of finding a balanced translocation in either parent is 4%.
In some cases of recurrent pregnancy loss, in vitro fertilization with preimplantation genetic testing may be considered. The logic being that the loss is likely due to a chromosomally. Learn how recurrent miscarriages may have a variety of causes, ranging from anatomical/uterine problems to autoimmune disorders to hormonal imbalance. Menu. one or both partners may have a balanced translocation or other silent chromosomal abnormality that gives the couple statistically increased odds of miscarriage in each pregnancy. Balanced reciprocal translocations and Robertsonian translocations (6) are observed in about 2%–5% of couples with recurrent miscarriage.
Geneticcounselingisimportantwhenastructuralgenetic factorisidentiﬁed.Thelikelihoodofasubsequenthealthylive birth depends on the chromosome(s). A balanced translocation or Robertsonian translocation in one of the partners leads to unviable fetuses that are miscarried. This explains why a karyogram is often performed in both partners if a woman has experienced repeated miscarriages.
About 3% of the time a chromosomal problem of one or both partners can lead to recurrent pregnancy loss.
List of related literature:
|from Textbook for MRCOG-1: Basic Sciences in Obstetrics & Gynaecology|
|from Chromosome Abnormalities and Genetic Counseling|
|from Creasy and Resnik’s Maternal-Fetal Medicine: Principles and Practice E-Book|
|from Bratton’s Family Medicine Board Review|
|from In Vitro Fertilization: A Textbook of Current and Emerging Methods and Devices|
|from Hematology E-Book: Basic Principles and Practice, Expert Consult Premium Edition Enhanced Online Features|
|from Textbook of Natural Medicine E-Book|
|from Sonography Exam Review: Physics, Abdomen, Obstetrics and Gynecology E-Book|
|from The New Harvard Guide to Women’s Health|
|from Mucosal Immunology|