Women Selecting Less Aggressive Strategy to Early Cancer Of The Breast


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Video taken from the channel: HealthDialog


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Video taken from the channel: European Society for Medical Oncology


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Video taken from the channel: MedStar Health


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Video taken from the channel: PBS NewsHour


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Treatment of early stage breast cancer

Video taken from the channel: ecancer

:FRIDAY, Oct. 9, 2015 (HealthDay News)—American women with an early, noninvasive stage of breast cancer are increasingly opting for less extensive surgery, a new study says. Women Choosing Less Aggressive Treatment for Early Breast Cancer | HealthyWomen. In general, less aggressive treatment became more common during the study period.

Rates of single breast removal (mastectomy) fell from about 45 percent to 19 percent, while rates of lumpectomyand. In the past, most women who’d been diagnosed with breast cancer had been advised to have aggressive chemotherapy in addition to surgery, radiation and hormonal therapies, but. Adjuvant chemotherapy clearly improves survival for women with early-stage breast cancer. 1 Women age 50 to 69 years with breast cancer will achieve a 20% proportional reduction in the risk of recurrence and an 11% proportional reduction in the risk of death if they receive adjuvant polychemotherapy.

1 However, there are limited data on the benefit of chemotherapy in women age 70 years or older. Survival for these women isn’t higher than it is for women choosing less aggressive options like lumpectomy. Also called breast-conserving surgery, only a portion of the affected breast.

Women with advanced breast cancer may be a step closer to an NHS blood test that tells them which personalised treatment they need.. There are around 35,000 women in the UK with advanced breast. That means women usually require less aggressive treatment and, as a group, have a better prognosis and lower risk of recurrence. “Most postmenopausal women are likely to derive the effects they need from antiestrogen therapy,” says Weiss. These drugs, usually taken once a day, prevent cancer cells from being stimulated by estrogen. As the point of first contact for breast cancer patients, surgeons have a tremendous influence on how patients choose treatment options.

Which is why Shumway thinks they could play a crucial role in counseling older women about options for less aggressive therapy. Unfortunately, women over 65 who are diagnosed with early onset breast cancer are more likely to pass away due to the disease. Women in that same age group are more likely to have the cancer recur, as well. More than 40,000 women die from breast cancer every year.

Most breast cancers in older women are low-grade, less aggressive “early” cancers; and in most cases, breast conservation surgery (lumpectomy) is.

List of related literature:

Hormone replacement therapy and risk of breast cancer with a favorable histology: results of the Iowa Women’s Health Study.

“Meyler's Side Effects of Drugs 15E: The International Encyclopedia of Adverse Drug Reactions and Interactions” by Jeffrey K. Aronson
from Meyler’s Side Effects of Drugs 15E: The International Encyclopedia of Adverse Drug Reactions and Interactions
by Jeffrey K. Aronson
Elsevier Science, 2014

Much research is being done in an effort to identify those 30% of women destined to relapse and ultimately die of met— astatic breast cancer, so that aggressive chemothera— peutic “adjuvant” therapies can be directed toward that high risk subset, and thus sparing the cured 70% the toxic side effects of chemotherapy.

“Encyclopedia of Cancer” by Manfred Schwab
from Encyclopedia of Cancer
by Manfred Schwab
Springer Berlin Heidelberg, 2011

Some early data suggest that BRCA-positive women might wish to pursue more aggressive treatment if diagnosed with breast cancer.”

“The Breast Cancer Wars: Hope, Fear, and the Pursuit of a Cure in Twentieth-Century America” by Barron H. Lerner
from The Breast Cancer Wars: Hope, Fear, and the Pursuit of a Cure in Twentieth-Century America
by Barron H. Lerner
Oxford University Press, 2001

The majority of older woman diagnosed with breast cancer will likely be estrogen receptor positive and demonstrate less aggressive forms of disease.

“Maternity and Women's Health Care E-Book” by Deitra Leonard Lowdermilk, Shannon E. Perry, Mary Catherine Cashion, Kathryn Rhodes Alden
from Maternity and Women’s Health Care E-Book
by Deitra Leonard Lowdermilk, Shannon E. Perry, et. al.
Elsevier Health Sciences, 2014

(A matched case—control study, finding a significantly increased risk of breast cancer associated with radiation therapy.)

“Primary Care Medicine: Office Evaluation and Management of the Adult Patient” by Allan H. Goroll, Albert G. Mulley
from Primary Care Medicine: Office Evaluation and Management of the Adult Patient
by Allan H. Goroll, Albert G. Mulley
Wolters Kluwer Health/Lippincott Williams & Wilkins, 2009

This information helps personalize breast cancer treatment and determine which women need aggressive systemic treatment for high-risk cancers and close surveillance for dormant tumors.

“Understanding Pathophysiology E-Book” by Sue E. Huether, Kathryn L. McCance
from Understanding Pathophysiology E-Book
by Sue E. Huether, Kathryn L. McCance
Elsevier Health Sciences, 2019

In the Iowa Women’s Health Study, only one type of breast cancer—invasive breast cancer with a favorable histology cell type—was found to have a slightly increased risk in women using hormone therapy.

“Screaming to be Heard: Hormonal Connections Women Suspect... and Doctors Still Ignore” by D. Lee D. Vliet
from Screaming to be Heard: Hormonal Connections Women Suspect… and Doctors Still Ignore
by D. Lee D. Vliet
M. Evans, 2005

This approach assumes that breast cancers identified through screening will be smaller, have a better prognosis, and require less aggressive treatment than cancers identified by palpation.

“Sabiston Textbook of Surgery E-Book” by Courtney M. Townsend, R. Daniel Beauchamp, B. Mark Evers, Kenneth L. Mattox
from Sabiston Textbook of Surgery E-Book
by Courtney M. Townsend, R. Daniel Beauchamp, et. al.
Elsevier Health Sciences, 2012

Most women older than 50 years of age with newly recognized metastatic breast cancer are treated initially with hormonal therapy, because it is usually effective and has fewer side effects than chemotherapy.

“Medicine” by Mark C. Fishman
from Medicine
by Mark C. Fishman
Lippincott Williams & Wilkins, 2004

Women with a substantially elevated risk of developing another breast cancer in the future may opt for a more aggressive risk-reducing surgical approach, such as bilateral mastectomy.

“Current Surgical Therapy E-Book” by John L. Cameron, Andrew M. Cameron
from Current Surgical Therapy E-Book
by John L. Cameron, Andrew M. Cameron
Elsevier Health Sciences, 2019

Oktay Kutluk

Kutluk Oktay, MD, FACOG is one of the world's foremost experts in fertility preservation as well as ovarian stimulation and in vitro fertilization for infertility treatments. He developed and performed the world's first ovarian transplantation procedures as well as pioneered new ovarian stimulation protocols for embryo and oocyte freezing for breast and endometrial cancer patients.

Mail: [email protected]
Telephone: +1 (877) 492-3666

Biography: https://medicine.yale.edu/profile/kutluk_oktay/
Bibliography: oktay_bibliography

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  • My breast cancer Dr. Got upset I sought out a 2nd opinion from Mayo Clinic, they recommend radiation, my primary breast cancer Dr. Has failed to refer me.

  • Daughter age 45 is in full remission from Her2pos. Her tumor was stage 4 having jumped to liver.
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  • My 86 y/o mother was just biopsied and was told she will need surgery and radiation. Her oncology consult is on 9/4/19. Is her age a factor for a good prognosis?

  • I was stage 2 with no lymph nodes jnvolment but got a dr who left me go to stage 4 in 6years because she said I was to healthy looking and never gave me a scan in 6 years,only seeing me once a year. my pcp dr. found the bone cancer. Then she said she would give me a scan to see where else I had it. my lungs were full and I blame her

  • I just found out 30 min ago a coworker that sits next to me every day has stage 3 breast cancer and is getting
    Radiation treatments at 4am in the morning. My mom died of it so this hit me like a rock dropped on my head. I wanna scream cry yell at God for allowing cancer to kill us at a young age like her. Damit this sucks so much. Damit I feel soooo sad for her now.she has young kids.

  • I just got a call from my dr saying in have a invasive breast cancer. Thank you for this video it calmed me down. I’ll see me dr at 7am in the morning

  • I have stage 4 mastetic cancer spread to my organs and bones even my skull I didn’t want chemotherapy but I’m fighting for life and I’ll do anything started chemotherapy pills recently will do a PET scan in March to see what’s going on sadly enough I started of with only breast cancer I did chemotherapy my surgeon was pregnant and going on maternity leave I wanted a double mastectomy but she was adament on a limpectom all said and done what was two spots on my breast and one only one lymph node after surgery she informed me I had 12 positive lymph nodes went on hormone therapy and she even went on to say in her words your cancer free!! I went to the oncologist every month because I have a condition where my bloods clots so I needed to go on treatment for menopausal women I had to take an injection every month for this and took pills everyday I had blood work done and CT scan MRI for various reasons the last scan was a MRI of the breast cause I felt a lump but the Dr said it’s scar tissue moving forward a few months later I started getting tired more than usual and breathing was labored I thought I had Pneumonia went to the emergency room in a different hospital only to my horror to find out I had after doing a CT scan cancer in my lung which I was explained by my new oncologist after testing further I have stage 4 cancer that has metastasized to my lung,liver,tumor in my kidney and it’s also in my bones including spine,ribs and skull I was told I had to have it for at least a year or more I very upset that my old oncologist did not pick up on it if she had I would of not been this far gone ��

  • What I don’t understand is, if the long-term survival for all three procedures is the “same”, how is it that a “local recurrence” for lumpectomy and radiation “slightly higher” than for the other two treatments?   Isn’t a local recurrence affect one’s long-term survival in a negative way?