Learn more about VTE blood clots at http://www.YouAndBloodClots.com. In this video, Dr Sandra Adams explains how older and newer blood thinners work for the treatment of VTE blood clots, and how they are taken. The main older blood thinner used is called warfarin. The newer blood thinners fall into two groups. The first group includes low molecular weight heparin and fondaparinux. The second group includes pills that are taken by mouth, such as apixaban, dabigatran, edoxaban, and rivaroxaban.
In this video, i discuss the risk of bleeding in patients who take or may have to consider taking blood thinners for stroke prevention in Afib. I discuss an interesting study which showed that the risk of bleeding with Eliquis is no greater than with Aspirin. https://www.nejm.org/doi/full/10.1056/NEJMoa1007432
After receiving a coronary stent to repair a blocked artery to the heart, patients are given blood-thinning medications. This can help prevent clots from forming in the stent. A new study examined whether patients with a newer generation, drug-releasing stent can reduce the number of months they take blood-thinning medications without increasing complication risks. Catherine Dolf explains in this week’s JAMA Report.
Addresses concerns and answers questions you may have about taking a blood-thinning drug, like Warfarin. Introduces a strategy for incorporating your blood thinner medication into your daily life. (Running Time: 10:42).
Anticoagulants, commonly referred to as blood thinners, are drugs that prevent or reduce coagulation of blood, prolonging the clotting time. Antiplatelet drugs, also known as a platelet aggregation inhibitors, decrease platelet aggregation and inhibit clot formation. These drugs play an important role in the treatment of various disorders such as myocardial infarction, thrombotic stroke and venous thromboembolism. This pharmacology lecture covers topics such as pathophysiology of blood clot formation and platelet function; activation, aggregation, cross-linking; ADP receptors, glycoprotein IIb/IIIa receptors, cyclooxygenase-1 (COX-1) enzyme, fibrinogen, fibrin mesh, coagulation cascade; intrinsic & extrinsic pathways, clotting factors, antithrombin, heparin induced thrombocytopenia, INR, plasmin, and plasminogen; mechanism of action of platelet inhibitors, anticoagulants, thrombolytic agents, and drugs used for treatment of bleeding. Drugs mentioned include; Aspirin, Clopidogrel, Ticagrelor, Ticlopidine, Prasugrel, Abciximab, Eptifibatide, Tirofiban, Heparin, low molecular weight heparins; Enoxaparin, Dalteparin, Protamine sulfate, Apixaban, Rivaroxaban, Univalent & Bivalent direct thrombin inhibitors; Argatroban, Dabigatran, Bivalirudin, Desirudin, Warfarin, Vitamin K, Alteplase, Reteplase, Tenecteplase, Urokinase, Streptokinase, Aminocaproic acid, Tranexamic acid.. Thanks for watching and don’t forget to SUBSCRIBE, hit the LIKE button�� and click the BELL button�� for future notifications!!!. Like what we do? Learn how to support us on Patreon! ��https://www.patreon.com/speedpharmacology. Looking for more pharmacology knowledge? Follow us on Facebook!��. https://www.facebook.com/SpeedPharmacology. 0:00 Platelet plug formation. 2:04 Platelet aggregation inhibitors. 5:34 Coagulation cascade. 7:38 Anticoagulants. 12:03 Warfarin. 14:11 Thrombolytics
Millions of people in the U.S. are taking blood thinners to prevent a clot and possible stroke, but some patients wind up in the hospital due to a dangerous side effect.
However, there are some instances when a reversal treatment may be needed to reverse the effect of a blood-thinning medication. Emergency situations when extensive bleeding occurs are serious and can become life threatening if you’re taking a blood thinner. In these instances, a reversal treatment may be necessary to reduce the bleeding risk.
“If you have an accident or need emergency surgery, doctors have three ways to reverse [the older, standby blood-thinner] warfarin that work in a matter of minutes to hours. Praxbind is an injected drug that is the first reversal medication approved specifically for Pradaxa. In three clinical trials involving over 280 volunteers who. For reversal that needs to occur within 6 hours, then patients may simply receive IV vitamin K (oral vitamin K works but it’s a lot slower up to 24 hours).
Drug: Rivaroxaban (Xarelto) or apixaban (Eliquis) Reversal: Andexanet alfa (AndexXa) In 2018 the FDA approved a reversal agent for Factor Xa Inhibitors, which up until this time had none. In an emergency situation or in the case of life-threatening or uncontrolled bleeding, excessive bleeding can be serious, but this risk is reduced by using a reversal treatment. Reversal treatments work to reverse the blood-thinning effect of blood-thinning medications. Ask your health care provider about reversal treatment options.
Longstanding blood thinner warfarin has a reversal agent. During an emergency bleeding episode, doctors simply give the patient vitamin K. Vitamin K reverses warfarin’s blood-thinning effects in order to help clots form. A patient can thus avoid bleeding out, saving the person’s life.
Xarelto had no antidote available until May 2018. Anticoagulant reversal agents are required when anticoagulant therapy needs to be reversed or neutralized in situations when there are bleeding complications, an overdose of anticoagulant therapy or unplanned surgery is required. And, while warfarin’s effects can be reversed quickly in the event of excessive bleeding, dabigatran is the only DOAC with an FDA-approved antidote: idarucizumab (Praxbind). However, a reversal agent for the other DOACs, andexanet, is expected to gain regulatory approval this spring.
Warfarin is an anticoagulant medication.This means it helps prevent clots from forming in the blood. Blood thinners treat some types of heart disease.. Your doctor may. Anticoagulants are drugs that treat blood clots, and help prevent blood clot formation in the veins and arteries.
Common side effects of these drugs are bruises, diarrhea, fever, intestinal gas, and headache. These drugs are prescribed to patients to treat and prevent a variety of diseases and conditions (DVT, pulmonary embolism, blood clot during atrial fibrillation).
List of related literature:
In some situations such as hemorrhage or acute thrombosis, following surgery, or concomitant heparin therapy, the half-life of ATIII may be decreased, so plasma levels should be monitored more frequently, and dosage or frequency of drug administration adjusted as necessary.
D ✦ ● If signs and symptoms of a cerebrovascular accident or hypertensive encephalopathy occur: • Administer antihypertensive agents if ordered: • Vasodilators • Maintain client on bed rest.
Halogenated agents cause dosedependent depression of uterine contractility,243,245,246 which may lead to greater blood loss after delivery.247 Therefore, the concentration of the volatile agent is reduced to 0.5 to 0.75 MAC after delivery.
Reversal Agents Acute reversal of anticoagulation may be required for drug overdose with clinically significant bleeding or emergent procedures.
from Conn’s Current Therapy 2020, E-Book by Rick D. Kellerman, KUSM-W Medical Practice Association, David Rakel Elsevier Health Sciences, 2019
There are no known reversal agents for the platelet inhibitors aspirin and clopidogrel [Plavix] or factor Xa inhibitors rivaroxaban [Xarelto] or apixaban [Eliquis].
All three cause prolongation of the PTT, such that this can be used to monitor their anticoagulant effect, and all have a short half-life (1 hour or less).168 No specific reversal agent is available.
e. Heparin therapy for patients receiving streptokinase: Heparin is used only for those at high risk of thromboembolism, such as those with large infarctions, atrial fibrillation, or congestive heart failure.
A nonheparin anticoagulant (e.g., argatroban, bivalirudin, fondaparinux) should be begun immediately unless there is a strong contraindication to anticoagulation, such as active bleeding or high bleeding risk.
Kutluk Oktay, MD, FACOG is one of the world's foremost experts in fertility preservation as well as ovarian stimulation and in vitro fertilization for infertility treatments. He developed and performed the world's first ovarian transplantation procedures as well as pioneered new ovarian stimulation protocols for embryo and oocyte freezing for breast and endometrial cancer patients.
My name is William,i am here to testify of how i got cured from Cancer by a Doctor called DR Eddymon, i was browsing through the Internet searching for cure on CANCER and i saw comment of people talking about how Dr Eddymon cured them. I was scared because i never believed in the Internet but i decided to give him a try because i was having no hope of been cured. so i decided to contact him with his email that was listed on the comment when i contacted him he gave me hope and sent a Herbal medicine to me that i took and it help me a lot, now i’m a free person now without sickness, my CANCER test repot came out negative, even when I went back after three months again there was still no trace of any cancer in my body. I pray for you DR Eddymon, God will give you everlasting life, you shall not die before your time for being a sincere and great man. I’m so happy. You can also contact him if you have any problem via Email:[email protected] gmail.com, you can also WhatsApp him on +2348128107710. HE ALSO CURES OTHER DISEASES LIKE (1).HERPES CURE(2).ALS (3).HEPATITIS B(4).HIV/AIDS CURE(5).HPV CURE(6).SPIRITUAL HEALINGS (7).ASTHMA(8).DIABETES and many more
Few months ago I was Comfirm that I have HIV And AIDS virus and ever since then I have been on research on how I will get rid of my HIV And AIDS but on one faithful day i saw someone testifying about Dr ODIN and she. Was saying that she was cured from HIV And AIDS virus and also I quickly copy his email address and I emailed Dr odin and he told me that I need to get some herbs which i purchased and he told me that he will ship the herbal medicine to me through UPS courier service and he also told that his herbal medicine is going to take five days to cure me from HIV And AIDS and behold his herbal medicine work accord to him and i am free from HIV And AIDS now and Dr ODIN is a wonderful man and he is the best doctor I ever met in my life and he is the best doctor in Africa you can also email him via his via his whatsap +2348139424847
Dr. Sanjay my wife is been on Eliquis Almost 4 years she’s very scared of the side effects she was on Xarelto and I had to stop because it was hurting her kidneys then they started Eliquis can she just stop This medication abruptly or does she need to wean off any information would be much appreciated thank you sir
So is there any reason to take baby aspirin over Eliquis then-besides the lower cost? (I am taking 50 mg. Flecainide for my PACs/ occsional AFibs but my Dr. also wants me to take Eliquis OR aspirin twice a day, just in case I have AFibs.) Which should I take? Thank you so much for taking the time to make these videos! So much more informative than my own Dr!
নতুন এক গবেষণা বলছে করোনা তে মৃত্যুর কারণ শুধু নিউমোনিয়ায় নয়। করোনা ভাইরাস ফুসফুসে জমাট বেঁধে দিচ্ছে রক্ত কে। যাকে পালমোনারি এম্বলিসম বলে। যা সাধারণত বিভিন্ন হৃদরোগের কারণে হোয়ে থাকে। আর ফুসফুসে এই রক্ত জমাট বেঁধে ঘটছে মানুষের মৃত্যু। তাই আসুন জেনে নেই প্রাকৃতিক কোন কোন জিনিসের মধ্যে লুকিয়ে আছে এর থেকে মুক্তির উপায়। জানতে ক্লিক করুন নিচের লিঙ্কে: https://youtu.be/tLpBtK1j1gU
Plzzz…change the person delivering the lecture….coz there are too many words which we are unable to understand….His way of words expression is deplorable…����
Please keep making those videos, it was organized, simple, and really straightforward. You just save my 5-hour listening to recording lectures. Thank you so much
Blood thinners do thin the blood but do nothing to dissolve or remove the blockage. AMA and drug CO….less than 20% of doctors belong to the AMA…studies by doctors see how many are on the boards or get money from BIG FARMA… know what drugs u r taking and other illnesses that may occur. It’s your body,it’s your life…. FDA / AMA do u really want to just take their word????
It’s nice to have a diagram of the cascade and then interject each drug class where it acts. Thank you! This is how all topics should be taught by all teachers!
Hello Dr. Thank you so much for this very informative video. My husband had 4 heart valve stents put in about 10 years ago. He was prescribed Clopidogrel for a year then put on Aspirin. In your opinion, should he still be taking asprin or is there another, perhaps more appropriate anti coagulant he could enquire about with his dr. He also take Amlodipin 10mgs, Atorvastatin 40 mgs, Candesartan Cilexetil 2mgs and as mentioned Asprin 75mgs. Many thanks, Caroline
Aap boht mast kaam karta hai speed pharmacology bhai……. par koi apko thank u nahi bolta aj apun tuje thanks bolta hai….. tu itni complicated kitabe parhta hai….. hamare liye itne asan lecture videos banata hai………thank u speed bhai……
My name is William,i am here to testify of how i got cured from Cancer by a Doctor called DR Eddymon, i was browsing through the Internet searching for cure on CANCER and i saw comment of people talking about how Dr Eddymon cured them. I was scared because i never believed in the Internet but i decided to give him a try because i was having no hope of been cured. so i decided to contact him with his email that was listed on the comment when i contacted him he gave me hope and sent a Herbal medicine to me that i took and it help me a lot, now i’m a free person now without sickness, my CANCER test repot came out negative, even when I went back after three months again there was still no trace of any cancer in my body. I pray for you DR Eddymon, God will give you everlasting life, you shall not die before your time for being a sincere and great man. I’m so happy. You can also contact him if you have any problem via Email:[email protected] gmail.com, you can also WhatsApp him on +2348128107710. HE ALSO CURES OTHER DISEASES LIKE (1).HERPES CURE(2).ALS (3).HEPATITIS B(4).HIV/AIDS CURE(5).HPV CURE(6).SPIRITUAL HEALINGS (7).ASTHMA(8).DIABETES and many more
Few months ago I was Comfirm that I have HIV And AIDS virus and ever since then I have been on research on how I will get rid of my HIV And AIDS but on one faithful day i saw someone testifying about Dr ODIN and she. Was saying that she was cured from HIV And AIDS virus and also I quickly copy his email address and I emailed Dr odin and he told me that I need to get some herbs which i purchased and he told me that he will ship the herbal medicine to me through UPS courier service and he also told that his herbal medicine is going to take five days to cure me from HIV And AIDS and behold his herbal medicine work accord to him and i am free from HIV And AIDS now and Dr ODIN is a wonderful man and he is the best doctor I ever met in my life and he is the best doctor in Africa you can also email him via his via his whatsap +2348139424847
Dr. Sanjay my wife is been on Eliquis Almost 4 years she’s very scared of the side effects she was on Xarelto and I had to stop because it was hurting her kidneys then they started Eliquis can she just stop This medication abruptly or does she need to wean off any information would be much appreciated thank you sir
So is there any reason to take baby aspirin over Eliquis then-besides the lower cost? (I am taking 50 mg. Flecainide for my PACs/ occsional AFibs but my Dr. also wants me to take Eliquis OR aspirin twice a day, just in case I have AFibs.) Which should I take?
Thank you so much for taking the time to make these videos! So much more informative than my own Dr!
ANTIPLATELET DRUGS
https://youtu.be/JGy9-CSoQY4
#antiplatelet #antiplateletdrugs #antiplateletpharmacology #pharmacologymadeeasy #bloodclot #bloodclotting #hematology #aspirin #coxinhibitor #myocardialinfarction
নতুন এক গবেষণা বলছে করোনা তে মৃত্যুর কারণ শুধু নিউমোনিয়ায় নয়। করোনা ভাইরাস ফুসফুসে জমাট বেঁধে দিচ্ছে রক্ত কে। যাকে পালমোনারি এম্বলিসম বলে। যা সাধারণত বিভিন্ন হৃদরোগের কারণে হোয়ে থাকে। আর ফুসফুসে এই রক্ত জমাট বেঁধে ঘটছে মানুষের মৃত্যু। তাই আসুন জেনে নেই প্রাকৃতিক কোন কোন জিনিসের মধ্যে লুকিয়ে আছে এর থেকে মুক্তির উপায়। জানতে ক্লিক করুন নিচের লিঙ্কে:
https://youtu.be/tLpBtK1j1gU
Plzzz…change the person delivering the lecture….coz there are too many words which we are unable to understand….His way of words expression is deplorable…����
THanks for the video!
Could someone please explain why the new-generation anticoagulants (like Dabigatran and Rivaroxaban) do not prolong INR?
Please keep making those videos, it was organized, simple, and really straightforward. You just save my 5-hour listening to recording lectures. Thank you so much
Blood thinners do thin the blood but do nothing to dissolve or remove the blockage. AMA and drug CO….less than 20% of doctors belong to the AMA…studies by doctors see how many are on the boards or get money from BIG FARMA…
know what drugs u r taking and other illnesses that may occur. It’s your body,it’s your life….
FDA / AMA do u really want to just take their word????
It’s nice to have a diagram of the cascade and then interject each drug class where it acts. Thank you! This is how all topics should be taught by all teachers!
Hello Dr. Thank you so much for this very informative video. My husband had 4 heart valve stents put in about 10 years ago. He was prescribed Clopidogrel for a year then put on Aspirin. In your opinion, should he still be taking asprin or is there another, perhaps more appropriate anti coagulant he could enquire about with his dr. He also take Amlodipin 10mgs, Atorvastatin 40 mgs, Candesartan Cilexetil 2mgs and as mentioned Asprin 75mgs. Many thanks, Caroline
Aap boht mast kaam karta hai speed pharmacology bhai……. par koi apko thank u nahi bolta aj apun tuje thanks bolta hai….. tu itni complicated kitabe parhta hai….. hamare liye itne asan lecture videos banata hai………thank u speed bhai……