What you ought to Learn About Acetaminophen Use While Pregnant

 

Can I Take Tylenol If I’m Pregnant?

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Safe Medication During Pregnancy

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DANGERS OF TYLENOL DURING PREGNANCY?

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Is acetaminophen safe for pregnant moms?

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Tylenol during pregnancy

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Is it safe to take acetaminophen during pregnancy?

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Study: Small amount of acetaminophen does not appear to be harmful during pregnancy

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While the study found an association between an expectant mother’s use of acetaminophen and the development of ADHD and possibly autism in her child, it can’t prove a definitive cause-and-effect link. Doctors Weigh In. Don’t panic if you’ve taken acetaminophen during pregnancy. For many years, acetaminophen and brand-name versions like Tylenol were considered almost completely safe for use during pregnancy. However, new reports have created a different perspective.

For example, there was a study released in 2016 which linked the use of acetaminophen while pregnant to future behavior problems in children. Acetaminophen Pregnancy Warnings In pregnant rats receiving oral drug at doses up to 0.85 times maximum human daily dose (MHDD) during organogenesis, fetotoxicity and dose-related increases in bone variations (reduced ossification and. The Food and Drug Administration (FDA) advises pregnant women to consult with a doctor before taking acetaminophen. Acetaminophen remains the only drug generally considered safe for treating pain relief and fever during pregnancy, and an estimated 65 percent of pregnant women in the United States take it at some point. Although generally considered safer than taking ibuprofen or aspirin, the scientific community, in recent years, has come to find that acetaminophen use during pregnancy may pose its own set of health risks to the child.

The study authors theorize that the drug could cause an increase in “oxidative stress” (the difficulty of the body to fight off toxins) during pregnancy, which is thought to raise the risk. Doctors say the concern is overblown. “When the study came out, a lot of headlines suggested that acetaminophen use in pregnancy causes kids to have ADHD, but that’s not at all what the study said,” Kasper says. Instead, the study found that women who reported taking acetaminophen during pregnancy were more likely to say they had a child who demonstrated ADHD-like behavior.

Evidence of a link between attention deficit and hyperactivity disorder (ADHD) and the use of acetaminophen during pregnancy has been steadily mounting over the past few years. In the past week, two new studies have joined the ranks, and they point to the potential effects on fertility and language development after acetaminophen use. Overall, the children whose mothers took acetaminophen during pregnancy were about 1.4 times more likely to have behavioral problems and 1.3 times more likely to be hyperactive.

Acetaminophen has been shown to cross the placenta during pregnancy. That means if an expectant mom takes acetaminophen, some of the drug gets into the baby’s system.

List of related literature:

Research has found that “the use of acetaminophen in middle to late but not early pregnancy may be related to respiratory symptoms in the first year of life.”74 This finding, although not completely validated, should be discussed with pregnant patients when an analgesic is being considered.

“Cohen's Pathways of the Pulp Expert Consult” by Louis H. Berman, DDS, FACD, Kenneth M. Hargreaves
from Cohen’s Pathways of the Pulp Expert Consult
by Louis H. Berman, DDS, FACD, Kenneth M. Hargreaves
Elsevier Health Sciences, 2015

For pain that may be mild-to-moderate and of relatively slow onset, acetaminophen, NSAIDs during early pregnancy, and opioids can be taken in moderation.

“Encyclopedia of the Neurological Sciences” by Robert B. Daroff, Michael J. Aminoff
from Encyclopedia of the Neurological Sciences
by Robert B. Daroff, Michael J. Aminoff
Elsevier Science, 2014

Acetaminophen use during pregnancy: effects on risk for congenital abnormalities.

“Chestnut's Obstetric Anesthesia E-Book” by David H. Chestnut, Cynthia A Wong, Lawrence C Tsen, Warwick D Ngan Kee, Yaakov Beilin, Jill Mhyre, Brian T. Bateman, Naveen Nathan
from Chestnut’s Obstetric Anesthesia E-Book
by David H. Chestnut, Cynthia A Wong, et. al.
Elsevier Health Sciences, 2019

It is also important to note that the risk comes from prolonged use of acetaminophen during pregnancy.

“Brain Health From Birth: Nurturing Brain Development During Pregnancy and the First Year” by Rebecca Fett
from Brain Health From Birth: Nurturing Brain Development During Pregnancy and the First Year
by Rebecca Fett
Franklin Fox Publishing LLC, 2019

Among the offspring of the 55 women who had received an acetaminophen prescription up to 30 days before conception and/or during the 1st trimester, there were 6 (10.9%) infants with congenital malformations compared with 697 (5.2%) from controls.

“Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk” by Gerald G. Briggs, Roger K. Freeman, Sumner J. Yaffe
from Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk
by Gerald G. Briggs, Roger K. Freeman, Sumner J. Yaffe
Lippincott Williams & Wilkins, 2008

At recommended dosages, acetaminophen is considered safe in pregnancy.

“Integrative Medicine E-Book” by David Rakel
from Integrative Medicine E-Book
by David Rakel
Elsevier Health Sciences, 2012

The use of single-ingredient acetaminophen during the first trimester does not appear to increase the risk of major birth defects.

“The Developing Human E-Book” by Keith L. Moore, T. V. N. Persaud, Mark G. Torchia
from The Developing Human E-Book
by Keith L. Moore, T. V. N. Persaud, Mark G. Torchia
Elsevier Health Sciences, 2011

Rebordosa C, et al: Acetaminophen use during pregnancy: Effects on risk for congenital abnormalities.

“Rosen's Emergency Medicine Concepts and Clinical Practice, 2-Volume Set,Expert Consult Premium Edition Enhanced Online Features and Print,7: Rosen's Emergency Medicine Concepts and Clinical Practice, 2-Volume Set” by John A. Marx, Robert S. Hockberger, Ron M. Walls, James Adams
from Rosen’s Emergency Medicine Concepts and Clinical Practice, 2-Volume Set,Expert Consult Premium Edition Enhanced Online Features and Print,7: Rosen’s Emergency Medicine Concepts and Clinical Practice, 2-Volume Set
by John A. Marx, Robert S. Hockberger, et. al.
Mosby/Elsevier, 2010

• For pain after dental work, acetaminophen with codeine is most commonly prescribed during pregnancy, and is considered safe.

“Our Bodies, Ourselves: Pregnancy and Birth” by Boston Women's Health Book Collective, Judy Norsigian
from Our Bodies, Ourselves: Pregnancy and Birth
by Boston Women’s Health Book Collective, Judy Norsigian
Atria Books, 2008

In summary, acetaminophen (Tylenol) is the safest medication for pain control during all three trimesters of pregnancy.

“Interventional Spine E-Book: An Algorithmic Approach” by Curtis W. Slipman, Richard Derby, Frederick A. Simeone, Tom G. Mayer
from Interventional Spine E-Book: An Algorithmic Approach
by Curtis W. Slipman, Richard Derby, et. al.
Elsevier Health Sciences, 2007

Oktay Kutluk

Kutluk Oktay, MD, FACOG is one of the world's foremost experts in fertility preservation as well as ovarian stimulation and in vitro fertilization for infertility treatments. He developed and performed the world's first ovarian transplantation procedures as well as pioneered new ovarian stimulation protocols for embryo and oocyte freezing for breast and endometrial cancer patients.

Mail: [email protected]
Telephone: +1 (877) 492-3666

Biography: https://medicine.yale.edu/profile/kutluk_oktay/
Bibliography: oktay_bibliography

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3 comments

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  • Depends on who your husband is if he ugly as fuck hit that shit like there’s no tomorrow cause the babys already gonna come out funny lookin

  • There is evidence of damage to the young (both male and female) per the murine model by way of this drug being administrated during pregnancy.

    Here is just one edited to be a bit to be smaller:

    Reproduction. 2017 Aug;154(2):145-152. doi: 10.1530/REP-17-0165. Epub 2017 May
    30.

    Prenatal exposure to paracetamol/acetaminophen and precursor aniline impairs
    masculinisation of male brain and behaviour.

    Hay-Schmidt A(1), Finkielman OTE(1), Jensen BAH(2), Høgsbro CF(2), Bak Holm J(2),
    Johansen KH(2), Jensen TK(3), Andrade AM(4), Swan SH(5), Bornehag CG(5)(6),
    Brunak S(7), Jegou B(8)(9), Kristiansen K(2), Kristensen DM(10)(7).

    Author information:
    (long snip)

    Paracetamol/acetaminophen (N-Acetyl-p-Aminophenol; APAP) is the preferred
    analgesic for pain relief and fever during pregnancy. It has therefore caused
    concern that several studies have reported that prenatal exposure to APAP results
    in developmental alterations in both the reproductive tract and the brain.
    Genitals and nervous system of male mammals are actively masculinised during
    foetal development and early postnatal life by the combined actions of
    prostaglandins and androgens, resulting in the male-typical reproductive
    behaviour seen in adulthood. Both androgens and prostaglandins are known to be
    inhibited by APAP. Through intrauterine exposure experiments in C57BL/6 mice, we
    found that exposure to APAP decreased neuronal number in the sexually dimorphic
    nucleus (SDN) of the preoptic area (POA) in the anterior hypothalamus of male
    adult offspring. Likewise, exposure to the environmental pollutant and precursor
    of APAP, aniline, resulted in a similar reduction. Decrease in neuronal number in
    the SDN-POA is associated with reductions in male sexual behaviour. Consistent
    with the changes, male mice exposed in uteri to APAP exhibited changes in urinary
    marking behaviour as adults and had a less aggressive territorial display towards
    intruders of the same gender. Additionally, exposed males had reduced
    intromissions and ejaculations during mating with females in oestrus. Together,
    these data suggest that prenatal exposure to APAP may impair male sexual
    behaviour in adulthood by disrupting the sexual neurobehavioral programming.
    These findings add to the growing body of evidence suggesting the need to limit
    the widespread exposure and use of APAP by pregnant women.

    ©(snip)
    PMID: 28559473

  • Acetaminophen, found in common pain relieving pills, if taken during pregnancy can cause those babies to have ADD/ADHD symptoms

    Please try to keep your diet as natural and simple as possible during your pregnancy and breast-feeding, use organically grown and raised whole foods (fruits, vegetables, nuts, seeds, whole raw milk products, grass fed meats, and clean distilled water) to prepare home-cooked meal’s.