Three-Drug Inhaler Might Be funding for Bronchial asthma Patients

 

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Inhalers (Asthma Treatment & COPD Treatment) Explained!

Video taken from the channel: MedCram Medical Lectures Explained CLEARLY


Three-Drug Inhaler May Be an Advance for Asthma Patients. TUESDAY, Oct. 1, 2019 A new 3-in-1 asthma drug inhaler may provide better and easier control of symptoms for tough-to-treat patients, two new studies suggest. The two phase 3 trials involved more than 2,500 asthma patients across 17 countries. Patients tested out an inhaler that contained three drugs: A steroid preventer to.

TUESDAY, Oct. 1, 2019 (HealthDay News) A new 3-in-1 asthma drug inhaler may provide better and easier control of symptoms for tough-to-treat. TUESDAY, Oct.

1, 2019 (HealthDay News) A new 3-in-1 asthma drug inhaler may provide better and easier control of symptoms for tough-to-treat patients, two new studies suggest. The two phase 3 trials involved more than 2,500 asthma patients across 17 countries. Patients tested out an inhaler that contained three drugs: A steroid preventer to control inflammation; a long-acting bronchodilator to.

In both trials, lung function as measured by a standard breathing test improved for patients using the triple-drug inhaler versus those using a two-drug inhaler, the investigators found. The combo inhaler also showed some effectiveness in preventing asthma attacks. A new 3-in-1 asthma drug inhaler may provide better and easier control of symptoms for tough-to-treat patients. TUESDAY, Oct.

1, 2019 (HealthDay News) A new 3-in-1 asthma drug inhaler may provide better and easier control of symptoms for tough-to-treat patients, two new studies suggest. The two phase 3 trials involved more than 2,500 asthma patients across 17 countries. Three-Drug Inhaler May Be an Advance for Asthma Patients TUESDAY, Oct. 1, 2019 (HealthDay News) A new 3-in-1 asthma drug inhaler may provide better and easier control of symptoms for tough-to-treat patients, two new studies suggest. Three-Drug Inhaler May Be an Advance for Asthma Patients.

A new 3-in-1 asthma drug inhaler may provide better and easier control of symptoms for tough-to-treat patients, two new studies suggest. The two phase 3 trials involved more than 2,500 asthma patients across 17 countries. Three-Drug Inhaler May Be an Advance for Asthma Patients. TUESDAY, Oct. 1, 2019 (HealthDay News) A new 3-in-1 asthma drug inhaler may provide better and easier control of symptoms for tough-to-treat patients, two new studies suggest.

The two phase 3 trials involved more than 2,500 asthma patients across 17 countries. TUESDAY, Oct. 1, 2019 (HealthDay News) A new 3-in-1 asthma drug inhaler may provide better and easier control of symptoms for tough-to-treat patients, two new studies suggest.

The two phase 3 trials involved more than 2,500 asthma patients across 17 countries.

List of related literature:

It is not surprising, therefore, that this antibody successfully completed clinical trials and was subsequently approved by the FDA for use in those adults and adolescents with moderate or severe persistent atopic asthma whose symptoms are inadequately controlled with inhaled corticosteroids.

“Roitt's Essential Immunology” by Peter J. Delves, Seamus J. Martin, Dennis R. Burton, Ivan M. Roitt
from Roitt’s Essential Immunology
by Peter J. Delves, Seamus J. Martin, et. al.
Wiley, 2017

Montelukast improves asthma control in asthmatic children maintained on inhaled corticosteroids.

“Pediatric Allergy: Principles and Practice E-Book” by Donald Y. M. Leung, Hugh Sampson, Raif Geha, Stanley J. Szefler
from Pediatric Allergy: Principles and Practice E-Book
by Donald Y. M. Leung, Hugh Sampson, et. al.
Elsevier Health Sciences, 2010

It is not surprising therefore that this antibody successfully completed phase II clinical trials and was subsequently approved by the FDA for use in those adults and adolescents with moderate or severe persistent atopic asthma whose symptoms are inadequately controlled with inhaled corticosteroids.

“Roitt's Essential Immunology” by Peter J. Delves, Seamus J. Martin, Dennis R. Burton, Ivan M. Roitt
from Roitt’s Essential Immunology
by Peter J. Delves, Seamus J. Martin, et. al.
Wiley, 2011

Similarly, new inhaler regimens of once-daily LABA (and potentially LAMA) drugs plus an inhaled corticosteroid are being developed as successors to the single inhaler combinations noted previously.

“Clinical Respiratory Medicine E-Book: Expert Consult Online and Print” by Stephen G. Spiro, Gerard A Silvestri, Alvar Agustí
from Clinical Respiratory Medicine E-Book: Expert Consult Online and Print
by Stephen G. Spiro, Gerard A Silvestri, Alvar Agustí
Elsevier Health Sciences, 2012

Asthma occurs in 8% to 10% of the U.S. population, and 10% of this group have severe asthma defined as requiring high-dose inhaled or systemic steroids (≥880 µg of inhaled fluticasone propionate or equivalent) in combination with a second long-term inhaled therapy.

“Pharmacology and Physiology for Anesthesia E-Book: Foundations and Clinical Application” by Hugh C. Hemmings, Talmage D. Egan
from Pharmacology and Physiology for Anesthesia E-Book: Foundations and Clinical Application
by Hugh C. Hemmings, Talmage D. Egan
Elsevier Health Sciences, 2018

A controlled trial of inhaled corticosteroids in patients receiving prednisolone tablets for asthma.

“Crofton and Douglas's Respiratory Diseases” by Anthony Seaton, A. Gordon Leitch, Douglas Seaton
from Crofton and Douglas’s Respiratory Diseases
by Anthony Seaton, A. Gordon Leitch, Douglas Seaton
Wiley, 2008

Leukotriene receptor antagonists in addition to usual care for acute asthma in adults and children.

“Critical Care Medicine E-Book: Principles of Diagnosis and Management in the Adult” by Joseph E. Parrillo, R. Phillip Dellinger
from Critical Care Medicine E-Book: Principles of Diagnosis and Management in the Adult
by Joseph E. Parrillo, R. Phillip Dellinger
Elsevier Health Sciences, 2018

Long-term inhaled corticosteroids in preschool children at high risk for asthma.

“Asthma and COPD: Basic Mechanisms and Clinical Management” by Peter J. Barnes, Jeffrey M. Drazen, Stephen I. Rennard, Neil C. Thomson
from Asthma and COPD: Basic Mechanisms and Clinical Management
by Peter J. Barnes, Jeffrey M. Drazen, et. al.
Elsevier Science, 2009

Randomized trial of the addition of ipratropium bromide to albuterol and corticosteroid therapy in children hospitalized because of an acute asthma exacerbation.

“Neonatal and Pediatric Respiratory Care E-Book” by Brian K. Walsh
from Neonatal and Pediatric Respiratory Care E-Book
by Brian K. Walsh
Elsevier Health Sciences, 2018

Therefore, nearly all children with acute asthma should receive systemic corticosteroids, preferably at the start of their ED treatment.

“Pediatric Emergency Medicine Secrets E-Book” by Steven M. Selbst, Kate Cronan
from Pediatric Emergency Medicine Secrets E-Book
by Steven M. Selbst, Kate Cronan
Elsevier Health Sciences, 2008

Oktay Kutluk

Kutluk Oktay, MD, FACOG is one of the world's foremost experts in fertility preservation as well as ovarian stimulation and in vitro fertilization for infertility treatments. He developed and performed the world's first ovarian transplantation procedures as well as pioneered new ovarian stimulation protocols for embryo and oocyte freezing for breast and endometrial cancer patients.

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  • I’m Ian Venamore I was diagnosed with chronic obstructive pulmonary disease (COPD) in my mid-fifties. Today I’m an active volunteer member of Lung Foundation Australia and chair of the associated COPD Patient Advocacy Group (CPAG).I also participates in international meetings with the goal to change the future of COPD recognition, diagnosis and treatment.I am a strong advocate for pulmonary rehabilitation and attends to gym classes “religiously.” I am also a firm believer in and proponent of patient education and self management. I obtain this cure from an Africa home of herbal roots for traditional treatment and they are 100% active and effective, which make it very difficult for science to discover or believe this traditionally cure, try your luck if you are CHRONIC OBSTRUCTIVE PULMONARY DISEASE Patient, their contact is as follow. [email protected]  their Website: http://www.healthmedlabclinic.com recommended by Ian Venamore their satisfied previous COPD cured patient a living witness.

  • So I have a question. I’m in nursing school and we have been told that LABAs should be given first to increase the surface area of the lumen so that the subsequent medications have more surface area on which to react. In fact, they’ve been saying it’s crucial they come first. What are your thoughts on that? And this is specifically in context to Asthma.

  • Your video sir just saved my grade and me from reading 20 plus pages. I’ve aways struggled understanding these meds and u have made everything so clear and simple… thank you!!!

  • I have really bad acute COPD, diagnosed since 2 years back many attacks led me to take ambulances to the A&E, 5/6/7 times, 4/5 days in there on drip amoxyciline, levofloxycina, later Prednisona uuurrrg at home, that was the only thing that would relieve the extreme exacerbations after an hour of almost dying,,. I tried everything medicinal, believe me. BUT, the ONE thing that has changed my life, really, is inhaling dry himalayan salt. It is a Godsend. 3 bucks a kilo, which will last me a years, please, if you have COPD, just do it. My mucus cleared up in a matter of days, now after a couple of months, along with heavy dosage daily of Vitamin D3 2000 i/u /day, plus Zinc daily, and a small Vit. B supplement to help absorb the D3 into the blood and not over create calcium in the blood, still use a Ventolin(Salbutemol) spray, but much much less, i used to use one a day!!! now one a week…I feel like I am being cured, it’s AMAAAAAAZING!!!Trust me,it’s natural, it’s real!!!

  • …So what do you do re: treatment if you have BOTH asthma and COPD. I’ve had asthma for 30+years, well-controlled most of the time; was diagnosed with COPD two months ago. Am currently finding I’m using my rescue inhaler A LOT, and the additional inhaler isn’t working. Lots of shortness of breath. I have other immune issues that would do better if I got off any steroids. Can’t do that? Anybody else have asthma and COPD together?

  • I have talked to Physicians, Resp techs, nurses and I get all kinds of conflicting answers for inhalers for my condition. What is the right inhaler for Pulmonary Fibrosis??

  • 0:12 Zinc Deficiency? (smooth muscle) B1, B12 deficiency? low/underproduction of HCI stomach acid = Leads to Asthma/GERD trigger.

  • love to find a great doc in Ohio by Dayton. One who knows the difference asthma/COPD as i am not breathing right, the time spent for years on COPD you would think by now, there would be a HELP for this an a combination med and NOT prednisone. That stuff makes me nuts. It is a zone between the zone and on an on. It should never be stopped abruptly, I did and was in coma. not good…but need asthma and copd combo and i am already on on albuterol 3 times day. and pro air which i use at least once a day. This is crazy. Have read where the CDB oils help.Lord knows smoking it would not be good. lol.I am great example of why you SHOULD NOT SMOKE CIGS.so just saying..quit please. This is hell and you do not want this. I have had pneumonia 4 times since this virus and yep, it isn’t pretty either as i do not think they tested in Feb March and had it once in Sep so put off pacemaker but no help for pneumonia just kicked out the hosp. So go home and get help and back in hosp for 3 more trips till now. It is a nightmare. Please wear the masks and be safe…thank you for this..it is information i am taking to doc and not sure if the Trelegy which is new is good or not. He took me off Incruse /bero combo. thanks again.

  • Thank you for your lectures Doctor! As a Paramedic and Lead EMT /Paramedic Instructor, we directly deal with everything in your lectures and our Paramedics, as a whole, but specifically even more so where I teach, are held to a higher standard in regards to depth of knowledge/understanding of physiology. Some of your lectures are repeat information, but I greatly appreciate that! I always teach my student’s there is a take-away from every lecture or demonstration, even if you know the subject matter! I have also learned quite a bit from your presentations, which in turn makes me a more effective Provider and Instructor, thank you for this opportunity! Its hard for Paramedics to learn at this type of level with “advanced topics”, without going to med school. Unfortunately Paramedicine is still the red-headed step child of Medicine…but hopefully that will be different one day! All of us providers are integral to the system! Looking forward to more of your videos! Thanks again for all of your hard work!

  • I just started watching your Lesson on Disease.I have COPD and I have yet to get a Emergency Inhaler and its been a Year since I found out I have it.

  • Well now I realized my doctor is not exactly following protocol, hell he hasn’t tested me for asthma yet he says I probably have it and I’m already on 2 inhalers and he started with albuterol, super randomly, then when I complained of using it more than 3 times a week suddenly, he gave me a ICS inhaler… which I haven’t taken yet because all these things terrify me (that’s why I decided to educate myself first to lose the fear) but I will use it soon before this gets any worse and then I’ll ask my doctor for actual breathing tests. Apparently my allergies got out of control and suddenly I had hives and sinus issues for months and then out of nowhere I have Adult asthma it seems so… sigh, I’ll demand tests from now on. Thank you for your very easy to understand videos. I wish doctors would take the time to explain to their patients how it all works, it’s my body and I think I have a right to understand what’s really going on.

  • confused about the ICS, when I used SABA multiple times per week, I had went from using just the SABA along with SABA + symbicort (which ends with ide??) I dont know what ICS is atm. Just ventolin and symbicort. Once my allergies were under control, I was able to just have SABA and I use it rarely.
    EDIT: I guess ventolin is a SBA+ICS, Also the symbicort, that is: Inhaled glucocorticoid and Long acting beta-2-agonist

  • Medical treatment of asthma has for decades meant more asthma (asthma paradox) and yoga is more relevant.

    I suffered through taking asthma medication for some time and am now decidedly more healthy after curing my asthma. So search for “breathe through the nose weitzberg” to find instructions and a more scientific account of asthma than that of doctors leaving the cause of asthma unexplained. A crucial point about curing asthma is developing normal belly breathing.

  • Wow. So wonderfully explained! Thanks you so much for putting this video together….

    Regarding the Lukotriene receptor antagonist you mentioned in the very end, do you have another video which explains the use of that drug in more detail? Re. Motelukast Sodium

  • Wow, nice job. So easy to understand. Thank you. I had severe asthma 40 years ago, beginning in my early thirties. I used Albuterol 20-30 times per week, just to stay alive. Doc kept trying to add Advair (now I can see he should have added ICS alone first), and that would start to help after a week, but after a couple weeks I seemed to get dependent on Advair, and if I didn’t take it, I got more chronic. Also, I started to get throat irritation from the Advair. So, I continued to survive on the SABA, but tried to limit it when possible. After 10-20 years of trying things like breathing and diets, I gradually improved, and now have not used drugs for years, and have no sense of asthma, unless I get in mold or cat dander, and then it will start to come on. Doc told me at time that ICS had long term side effects, and now I know that it may have harmed me on the long term, and I was lucky to stay away. But the drug companies probably would say I would have gotten better quicker if I used ICS. I point this out because this looks easy from the doc’s point of view, but it can be a nightmare from the patient’s point of view, and knowing what I know now, I would put a lot more effort into studying alternative treatments. Keto diet might help I seemed to get complete relief one time when I accidentally got into ketosis. Also, breathing out and delaying breathing back in seemed to help over a couple months. Seems that pasta (maybe glucose) made it worse.

  • This sleeping method has not just prevented me from getting various prescription drugs but also helped me obtain an excellent night rest after 3-4 months of nightly insomnia episode. Prior to all of these, I could simply have 3 to 4 hours of good sleep. Yet after using this system, I been able to attain Seven straight great sleeping hours. Soon after 1 year of using it, my sleep became a lot better and longer than what I have achieved in a few years.. Good luck, you will get the results, get it on Google. It calls Zoey Sυnodoz
    take care

  • Wow! After years of treatment for COPD and much reading and attempt at understanding YOU have made it so simple. I now much more clearly appreciate what medications I am taking and why. Since this is 2017 and you refer to newer medications coming combining all three I am hopeful that I am going to the website and see such inhalers as breo ellipta combinations addressed. No matter either way your video was extremely enlightening to me as a patient.

  • Note, the FDA STRONGLY discourages use of LABA alone for asthma treatment because it found that scenario led to an increase risk of death.

  • as a COPD person, and far, far away from being a doctor, to the point to where i will have to write all these meds down, THANK YOU. you just explained the hell out of what to look for in a rescue inhaler.

  • albuterOL, metaproterenOL, levslbuterOL, pirbuterOL ACTUALLY ALL END IN “OL” but contrary to what you say, are NOT LABA but in fact are SABA…?????

  • What kinda test or differences are between Asthma and COPD? The symptoms are both very similar… if a patient comes in my practice and is symptomatic of COPD and or asthma, how do I know patience has COPD and not asthma?

  • The sound of your voice is SO incredibly nice to my ears.. as well as every single lecture, simple /on point/makes sense! I’m in nursing school and I love listening to you… Gracias Roger!

  • I have cured so many people around the world with my herbal medicine, my herbal medicine which takes 2 weeks to cure any deadly diseases. If you are ready to be cured you have to purchase the herbal medicine.

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  • Is asthma treatment usually a lie? Pressing lips together as in nose breathing relaxes lung airways, but asthma treatment is based on medication which does not heal.

  • Had Asthma all my life never understood the difference between Ventolin and Seretide and how they work together.Or rather not,and that’s why the doctor keeps asking me how many times I’m using my Ventolin or SABA.
    And I must take my Seretide regularly.

  • Nice video content! Forgive me for the intrusion, I would appreciate your thoughts. Have you thought about Patlarny Calm Lungs Principle (google it)? It is a great exclusive guide for curing asthma without the normal expense. Ive heard some interesting things about it and my cousin at very last got great success with it.

  • I never had asthma until I hit my 20s, then it came in full swing and have had to use a “rescue inhaler” ever since. It was scary because when I had my first asthma attack I had no idea what was going on and I could barely breathe, I thought I was going to die! My mom rushed me to the ER, I then was breathing what I think is albuterol but it was in a machine of some sort and it created like a humid vapor that tastes like albuterol I guess. I breathed on that thing for 30 minutes and then was sent home with a prescription for Albuterol and given a diagnosis of Asthma. I’ve always had allergies since I was a little kid (pets, pollen) but it wasn’t until my 20s that pets and pollen started triggering Asthma. I pretty much can’t have any pets at all, and have to be well medicated during spring to avoid needing a long term super-expensive inhaler. I can manage my asthma by avoiding triggers and that allows me to only need a rescue inhaler maybe once a month or so.

    It was really sad not having pets. I love both cats and dogs but they make me very sick. Even if I am taking claritin or something similar, prolonged exposure to animal dander triggers my asthma to the point of needing a rescue inhaler 3x a day. From there I end up needing something like Symbicort + claritin + SABA 1-3x a week. No way in hell I can be around animals:(

  • In Asthma; we have to give broncho dilator first to relax and open the airway and then administrate ICS.
    How come ICS is the first line of treatment for asthma? I think you need to change ICS and LABG in the chart.

  • Excellent. Your flowchart at 6:00 is so helpful, I will never forget this in my life. I was COPD new Nice guideline and all those long pages of information confused me. But your video cleared it all.

  • Asthma eradication: Nose breathing and no inhalers.

    According David P. Strachan it is unlikely that trends in either outdoor or indoor air pollution have contributed substantially to the rise in prevalence of asthma and allergic disease in recent decades,

    Then we have the asthma-paradox that for many decades more asthma drugs have led to more asthma. Although acupressure treatment for asthma is widely recommended the points are mostly not on the face.

    However a distinct positive effect on breathing opening up lung airways to counter asthma with wheezing may be felt on pressing the lips together.

    This means we have a simple back to nature approach.

    Accordingly an important cause of asthma is asthma drug addiction.

    So we are left with asthma paradox that more drug treatment has long been associated with more asthma for decades on end.

  • Hello and thanx for your informative and simple online lectures. I would like to ask are these steps still applicable for asthmatic patient if beta agonists are contraindicated?

  • really helpful vedio. Thanks for posting. I have a doubt though..how do we decide the use of short acting beta agonist ( how many times a week) in the first place?

  • I was born with asthma, when I was born I also had meningitis. I’m lucky to be alive. I take Dulera and Ventolin which is Albuteral. I haven’t watched the video, but I know it’ll be interesting and helpful