The Way Your Genes Modify the Number in your Scale

 

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How Your Genes Affect the Number on Your Scale. Sept. 12, 2019. Sept.

12, 2019, at 9:00 a.m. More. How Your Genes Affect the Number on Your Scale. More. By Len Canter HealthDay Reporter.

How Your Genes Affect the Number on Your Scale THURSDAY, Sept. 12, 2019 Could your genes be keeping you from losing weight? While you shouldn’t use a family tendency toward wide hips or an apple shape as an excuse to stray from a healthy diet, acceptance can help you reassess your personal ideal and make you happier with your body.

By Len Canter HealthDay Reporter. THURSDAY, Sept. 12, 2019 (HealthDay News) Could your genes be keeping you from losing weight? While you shouldn’t use a family tendency toward wide hips or an apple shape as an excuse to stray from a healthy diet, acceptance can help you reassess your personal ideal and make you happier with your body.. Hundreds of genes.

Hundreds of genes have been linked to weight. Some affect where fat is distributed on your body while others impact metabolism, cravings and even whether you reach for food to cope with stress. Their influence on overweight can be as little as 25% or as much as 80%. Citation: How your genes affect the number on your scale (2019, September 12).

How Your Genes Affect the Number on Your Scale. By ariannawmd on September 12, 2019 Tweet; Pin It; Could your genes be keeping you from losing weight? While you shouldn’t use a family tendency toward wide hips or an apple shape as an excuse to stray from a healthy diet, acceptance can help you reassess your personal ideal and make you happier.

How Your Genes Affect the Number on Your Scale. By Weekly Sauce | September 12, 2019. Could your genes be keeping you from losing weight? While you shouldn’t use a family tendency toward wide hips or an apple shape as an excuse to stray from a healthy diet, acceptance can help you reassess your personal ideal and make you happier with your body. Hundreds of genes have been linked to weight.

Some affect where fat is distributed on your body while others impact metabolism, cravings and even whether you reach for food to cope with stress. Their influence on overweight can be as little as 25% or as much as 80%. Posted September 12, 2019; How Your Genes Affect the Number on Your Scale. Could your genes be keeping you from losing weight?

While you shouldn’t use a family tendency toward wide hips or an apple shape as an excuse to stray from a healthy diet, acceptance can help you reassess your personal ideal and make you happier with your body. Posted September 12, 2019; How Your Genes Affect the Number on Your Scale. Could your genes be keeping you from losing weight?

While you shouldn’t use a family tendency toward wide hips or an apple shape as an excuse to stray from a healthy diet, acceptance can help you reassess your personal ideal and make you happier with your body.

List of related literature:

For example, some genes that affect weight are turned on in fat cells and control how much fat you store away in reserve.

“Blueprint: How DNA Makes Us Who We Are” by Robert Plomin
from Blueprint: How DNA Makes Us Who We Are
by Robert Plomin
MIT Press, 2019

As presented later in this chapter and others, some typical epigenetic factors involve changes in DNA methylation or modifications to chromatin that change genome structure and hence influence gene expression even in the absence of changes in the DNA sequence.

“Genomic and Personalized Medicine: V1-2” by Geoffrey S. Ginsburg, Huntington F Willard
from Genomic and Personalized Medicine: V1-2
by Geoffrey S. Ginsburg, Huntington F Willard
Elsevier Science, 2008

This division can result in alterations of the genetic code by anything that can damage DNA (e.g., physical, chemical, or biologic factors; spontaneous mutations of genes; exposure to radiation).

“Pathology for the Physical Therapist Assistant E-Book” by Catherine C. Goodman, Kenda S. Fuller
from Pathology for the Physical Therapist Assistant E-Book
by Catherine C. Goodman, Kenda S. Fuller
Elsevier Health Sciences, 2016

Changes in individual genes can result in the transmission of altered genetic messages while changes at the chromosomal level can result in the transmission of abnormalities in chromosomal number or structure.

“Encyclopaedia of Occupational Health and Safety: The body, health care, management and policy, tools and approaches” by Jeanne Mager Stellman, International Labour Organisation, International Labour Office
from Encyclopaedia of Occupational Health and Safety: The body, health care, management and policy, tools and approaches
by Jeanne Mager Stellman, International Labour Organisation, International Labour Office
International Labour Office, 1998

this is because the information that determines body size and shape is contained in the genes people inherit from their parents.

“Nutrition: Science and Applications” by Lori A. Smolin, Mary B. Grosvenor
from Nutrition: Science and Applications
by Lori A. Smolin, Mary B. Grosvenor
Wiley, 2019

The variations that you inherit from your parents, mixed and matched, specify variations in cellular and developmental processes that ultimately result in variations in physiological states.

“The Gene: An Intimate History” by Siddhartha Mukherjee
from The Gene: An Intimate History
by Siddhartha Mukherjee
Scribner, 2016

Although individual genetic factors could be small differences in DNA sequences—single nucleotide polymorphisms or small insertions/deletions— in both the nuclear and mitochondrial genomes, the overall genetic contribution to aging processes is polygenic and complex.

“Brocklehurst's Textbook of Geriatric Medicine and Gerontology E-Book” by Howard M. Fillit, Kenneth Rockwood, Kenneth Woodhouse
from Brocklehurst’s Textbook of Geriatric Medicine and Gerontology E-Book
by Howard M. Fillit, Kenneth Rockwood, Kenneth Woodhouse
Elsevier Health Sciences, 2010

For a particular person, the genome is almost identical in all of their cells, however, there are some mutations due to random events such as copying errors and the influence of external stresses such as exposure to toxins or radiation.

“Future Foods: How Modern Science Is Transforming the Way We Eat” by David Julian McClements
from Future Foods: How Modern Science Is Transforming the Way We Eat
by David Julian McClements
Springer International Publishing, 2019

that is determined by one’s genes or a change in the number or structure of the chromosomes.

“Building a Medical Vocabulary E-Book: with Spanish Translations” by Peggy C. Leonard
from Building a Medical Vocabulary E-Book: with Spanish Translations
by Peggy C. Leonard
Elsevier Health Sciences, 2017

An individual’s genetic makeup probably plays a part in determining the sizes and basic shapes of the patterns and ridges, but it is not the only factor.

“Forensic Science: An Introduction to Scientific and Investigative Techniques, Second Edition” by Stuart H. James, Jon J. Nordby, Suzanne Bell, Jon J. Nordby, Ph.D.
from Forensic Science: An Introduction to Scientific and Investigative Techniques, Second Edition
by Stuart H. James, Jon J. Nordby, et. al.
Taylor & Francis, 2005

Oktay Kutluk

Kutluk Oktay, MD, FACOG is one of the world's foremost experts in fertility preservation as well as ovarian stimulation and in vitro fertilization for infertility treatments. He developed and performed the world's first ovarian transplantation procedures as well as pioneered new ovarian stimulation protocols for embryo and oocyte freezing for breast and endometrial cancer patients.

Mail: [email protected]
Telephone: +1 (877) 492-3666

Biography: https://medicine.yale.edu/profile/kutluk_oktay/
Bibliography: oktay_bibliography

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52 comments

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  • I’m competing in a Oahu regional science competition in February, with my main solo category being genetics and proteins. I saw at around 1:45 how there were heterozygous and homozygous combinations of alleles, I got super excited because now that I’ve spent so much time into researching, exercise science and anatomy isn’t my only strong subject. I just want to say that you’re a HUGE inspiration for me and I love your scientific work!❤️❤️ also I remember you mentioning in your PhD video you held multiple leadership positions for sports, what sports did you compete/do?

  • I am not sure what my Fitzpatrick level is, I assume it is between level I and II but I believe I am combination with a touch of sensitivity. I am a red head who was diagnosed with a treatable melanoma and I have noticed some skin damage starting to become more evident now I am in my early thirties. I also have thickening (hardening skin in one area on my forehead) that my derm says is not ulceration, scleroderma or any cancer from biopsies although solar keratosis, but that my skin concern is an enigma that is likely to be treatable with steroid injections.
    For me seeing a derm or a trained professional who can diagnose skin cancers is going to be added to my routine half yearly plan as well as being better with my sunscreen under my make up.

  • You can see in children the difference. My side of the family is pudgy but my husband’s side is thin. My children do not normally turn down food, ever. His (my step children) will happily go most of the day without eating or mentioning food. There’s definitely something in the brain that helps thin people to not desire food as much, or to be satisfied with much less. I’m not a scientists but it’s pretty obvious.

  • True my dad was skinny and my mom fat and both worked hard in tire factories. We all ate the same meals every day. My mom was big boned and fat all her life. I took after my mom with large bones and large calves that I could never wear boots even when I was young and thinner. My pants had to be tailored because my legs were too big even though I only weighed 225 lbs and was 6′ 8 inches tall..

  • Confused, can someone help me �� I have dark hair and eyes but extremely fair skin which usually burns, one parent is mixed the other is very white, do I sound like a 2? Lol

  • I think I’m lvl 3: light skin that can tan, rarely burns. Light brown hair and light Hazel-green eyes.
    However I have freckles, and I try not to get tan.

  • When you said you had a YouTube channel you weren’t kidding! Wowza! You’re videos are super interesting (even though I’m not a fitness person) and well done!! keep up the good work! And it was nice meeting you the other night ��

  • Can you do a work out for beginners into weightlifting for overall body video, and (I’m so demanding lol) an abdominal one as well… thanks love youuu����

  • Your ancestors ate deer, goat, cow, fish once or twice a day and they fasted many times a year.

    But we eat sugar and starch and canola oil and chemicals 5 times a day and NEVER fast.

  • Me, as a dark eyed/haired brazilian who burns by just thinking on going under the sun, dating a finn from the article circle who tans and has naturally darker skin than me: EXCUSE MR FITZPATRICK, DO YOU HAVE A MOMENT

  • I used to work at a medical spa and the head laser person joked that IF there was a zero, that would be me. See that profile pic? That’s SPF 50, UPF 50 hat and an umbrella at the beach. The head laser person would often ask me to be a volunteer for a treatment with new employee orientation. An hour not working and getting paid? Sure!

  • Speaking of DNA, have you considered taking an ethnicity DNA test? You’ve mentioned before that you’re half Thai, and I always wondered what your other half was. I hope this does not come across as offensive. Support, sister <3

  • I have combo skin with oily skin and acne/whiteheads/fungal acne/mila around my t zone and dry to normal skin around my c zone but I have some unevenness (teenie tiny bumps but skin coloured) at the sides of my face. My skin gets really red especially around my forehead and my cheeks are sensitive to most products so it’s really difficult to find a product for me. What’s worse is that I could be using a product for a few weeks and it’s fine but then it suddenly starts reacting with my skin even though I haven’t really changed anything. What I’ve found to help my skin is Avene’s thermal water, it helps with the sensitivity on my cheeks and I used to get flaky around my cheeks and mouth but not anymore, I spray it on about 2-3 times a day (after whenever I shower or wash my face) and just leave it on to absorb into my face or apply a moisturiser on top. Hope this helps anyone with similar skin!

  • I don’t know exactly which one I’m but I’m probably a type 3 or 4. I’ve dark hair, brown eyes and I tan easily, but I’ve had sunburns before.
    I have very dry skin, not sensitive and never had problem with acne, one or two pimples appear when I’m on my period but that’s it.

  • I really enjoyed this video a lot and I appreciate how you clearly display where your drawing your conclusions from. Sometimes other videos like these make assumptions without referencing their sources, but yours highlights the particular studies and research so it feels a lot more trustworthy and reliable.

  • I’ve always wondered about this. I wonder if genetic information companies like 23 and Me have an ability to see if an individual has the FTO gene in their DNA. Gonna check that out now. Thank you for your videos! I am learning lots about health and nutrition, thanks to you!

  • Heyyoooo! Hope you enjoy this video! I wanted to make this video as entertaining and easy to understand as possible, but if you want the nitty gritty science behind all of this, I’ve listed the papers I discuss on the FTO gene in the the description box! I’m actually heading to Hong Kong TOMORROW!! SO the next video will include my travel n’ such! If you are from Hong Kong or have been there, PLEASE leave me suggestions in the comments!! I’d REALLY appreciate it! Love you all so much! xoxo ��

  • Many studies concluded that many factors weighed (no pun intended) in the current obesity crisis we are witnessing.

    Those studies determined there are 7 causes whom lead to obesity (eating habits, exercising, genetics, sleep, etc.). But, genes isn’t the sole problem here.

    Which explains why the obesity rate went from less than 3% to 42% in the USA in less than 75 years.

    I was a former obese (I’ve lost 100 pounds since) and you have to work on what lead to your weight gain.

    Sorry for my English mistakes.

  • Thank you! GREAT info!! As you may know by now, COVID-19 severity correlates to skin type; the darker the complexion the higher the probability one has Vitamin D deficiency. Those with Fitzgerald Skin Type VI may have a 90% chance of D deficiency, and Skin Type I may have a 30% chance. This is not a surprise, melanin is a potent sunscreen that blocks UVB rays, thereby reducing conversion of 7-dehydrocholesterol to Vitamin D3. Since we stay indoors and since we are generally covered in fashion, most of our skin does not get sufficient sunlight. Thus, we need a daily dose (maybe 1000 IU) vitamin D3 (preferably vegan with no magnesium stearate nor silica). Allow 1 week for serum D levels to build up to optimal levels. NOTE 1: Vitamin D does not wash off skin when we shower; D is formed deep within the skin. NOTE 2: A healthy plant-based diet helps all skin types!

  • I honestly like you better now after you’ve found your set weight. I don’t believe everyone has a specific way they have to look like, I myself went through a thin phase to then regaining weight. But I just see you much more healthier now with a full face, a full curvy body and maybe you can find new ways of being fit that don’t necessarily aline with the “bikini competition” kind of fit. <3
    Much love <3 And props for taking care of your health!

  • Stephanie, I feel very discouraged. I’m what’s called skinny fat. I really feel defeated, I don’t know how to approach or fix this. Can you please make a video on this. I’ve looked up other videos, but they make me feel discouraged. I know that your content is something that I can really trust.

  • Your english is so clear! I’m a brazilian learning english and i just love to see your videos over and over again cause i love how i can understand everything you’re talking about. Besides you, your boyfriend and your videos are just amazing! Love u ��

  • Green (blue/grey) eyes, medium brown hair, type 3 probably, hardly ever burn, more tan. Normal-oily, a little sensitive, and starting to get lines on my forehead(I’m 31��). Routine as follows:
    Gentle cleanser, morning and night, followed by pure rose waterboth day and night, then niacinimide/tretinoin/tranexamic acidat night only. Lastly, a medium-rich moisturizer and spray zinc spf in the day. I’ll use a super rich moisturizer at night to combat my fine lines and the dryness of my medication.

  • I think we are genetically predisposed to a certain level of propensity for food. I have 4 cats, all are happy to “come to eat”, but the black cat always “stops” eating after half a can of cat food.
    The fatter cat cannot have enough and she eats other cats’ food. Children who are not “picky” about food tend to become fat latter in life. So, in some ways, one can say that if you were in
    an environment where food is limited.(eg three plain food meals in jail), you would tend to be skinny.

  • Thank you so much for taking the time to make this video! Very interesting info! You are incredible. One of my fav youtube stars fo sho!

  • Fitzpatrick scale is a 6. My skin is relatively oil balanced, however I’m acne prone due to hormonal/digestinal reasons. I’m also sensitive to certain acids but not in general ��

  • Thank you i was seriously thinking this was another damn excuse people can use to demotivate people to workout since everyone wants to follow like sheeps

  • I honestly find just knowing the Fitzpatrick scale exists quite comforting. I used to get teased for how easily I burned and how pale I was. I grew up around folks that would “get a base tan” before vacation, and I would just load on sunscreen, inevitably rub it out of my burning eyes, burn, and still be pale when the peeling was done. Not that I have a longing for a tan, but there is comfort in knowing it is a normal genetic thing, and I am not a freak that cannot tan.

  • Hi Stephanie! LOVE from Singapore! I am loving how you help break down scientific studies to bite size beneficial proven information for your viewers and I am learning so much from it! Currently blending fruits and veges are in such hype and there are many dichotomous opinions about it. I would love to get a clearer idea and understanding counting its calories and the limits to blending as a meal alternative. Have a good time in HK!! <3

  • I have normal skin, it doesn’t feel particularly oily or dry by the end of the day and it’s not sensitive. I had perfect skin for years but NOW I HAVE ACNE AND IDK WHAT TO DO. I’m still not particularly oily or sensitive tho.

  • Giiirl can i please be you? You are a doctor, stunningly beautiful, fit, succesfull on youtube and have such a cool personality too. You are awesome!

  • I feel dermatologists never bother to take the time to explain anything that’s going on with our skin. They are not helpful at least the ones I’ve been to.

  • On of my friends is on the bigger side of weight but she runs so much and eats healthy but she’s still the same.

    I like ur channel ��

  • Pollution, GMO’s, everyday chemicals, all can effect our endocrine system and in turn our body’s ability to work properly. Gaining weight, getting cancer (disease), etc.

  • I love how a study comes out from the University of Michigan that basically says “yes, obesity has genetic links” and all of the people in the comment section are angrily thin/fitsplaining how the UoM and this woman is wrong, this woman who is a scientist and has an M.D. Ph.D, that is, who has studied this kind of thing for years and yet somehow she is wrong! So hilarious! Sorry but I am going to believe this scientist over these fatphobic thin/fitsplainers.

  • Soon I vil be 17
    And I can’t believe hw I became so fat….I have a lot of thigh fat and bit Belly.
    I have been doing workout but it’s not working

  • Thanks for this video, you asked a few weeks or months ago about a video idea. I asked if you could make one about cortisol levels and how they can impact fat loss/gains. Not exactly brushing that specific topic but still very informative to me since I’ve al eww says been chubby as a child. Fat loss has always been a struggle for me. Anyway thanks for the video always really great science. Keep it up!

  • Obesity is 100% genetics. Fat people almost never lose weight and if they do they regain their “normal” weight in just a few short months.

  • My parents were fat, ate food common to the era, and were obese. I ate natural foods, exercised, and did not have HAVE THIS PROBLEM!

  • What if you’re like me? I NEVER wear makeup (unless lip balm and a swipe of lip color counts not now because of the masks we wear outside) and pretty much any skin care product works for me. I’m not terribly brand loyal when it comes to skincare. I use whatever my mom gives me she gets a lot of samples. I wash, use a toner, moisturize, and use sunscreen every day. I get occasional hormonal or stress related acne that usually clears up on its own. I have freckles and am similar to Lucy Liu in skin tone. I would say I’m normal to oily. Nothing really makes my skin freak out. I’ve done TERRIBLE things to my skin like those charcoal & glue masks! �� Even then, my skin was very forgiving. I don’t have wrinkles and I’m in my mid forties, but can pass for late 20s to early 30s. I chalk it up to good genes. Can it just be that?

  • I have combination skin. T zone is oily but not super oily and the rest is dry. I didn’t use much of a skin care routine. Only cleansed my face at night and used some kind of moisturizer. Now I have completely changed my routine. I honestly still don’t do anything in the morning �� but at night i wash my face with a facial mousse that doesn’t contain harsh sulfates but I still haven’t found a good one. I use rose water as a toner ( no alcohol ) then a the ordinary hyaluronic Acid, buffet and the Natural moisturizer. Sometimes the niacinamide. I tried to keep it as simple as possible and haven’t been testing around much. I don’t have acne but I do get some hormonal pimples. I never had issues even in my teenage times I had clear skin. My skin is still clear for the most part just seeing bigger pores and I do have whiteheads on the side of my nose. I also use the B oil as an occlusive after to seal in all the moisture.

  • Hi Stephanie! I love your videos! I’m in a class right now called lifestyle genomics and it’s all about the influence of genetics on obesity. Other topics we’ve talked about is pre-natal nutrition and how the foods that the mother eats during pregnancy can affect the genes (epigenome) of the fetus (specifically methylation) and can influence the risk of obesity and obesity related disease of baby for the rest of their life. Another new research area about ECS (and CB1 receptor), which are derived from omega-6 fatty acids, and how they influence appetite is very interesting. In class we also talked about gut bacteria and how the types of food you eat affects the way you digest food and influences hormone secretion (would be really awesome if you could do a video on that).
    Love your video!!

  • Stephanie, do you think you could review this article and give me feedback on whether or not it seems accurate please? I want to make an effort to improve my body composition as soon as possible. https://www.muscleforlife.com/skinny-fat-solution/

  • Is there any chance you could make a video talking about why some people end up suffering with an eating disorder, and others never do. I always ask myself, why me?

  • I am confused. I have dark brown hair and brown eyes. My face is light and the rest of my body is different levels of light tan to medium tan. I get freckles but no sunbrns. I have been told tht my skin is really fair. Like anne hathaway. But again i get no sunburns. But i do get freckles. And if i spend enogh time in the sun i can get to a tan brown. Its like im a combination of 1 and 3 does that make me a 2? Or just 3 with freckles?

  • I love your videos! I love how articulate you are and enjoy the scientific research. I’ve always wondered why I tend to keep weight on so easily. Diet and exercise make it possible to keep a “normal” weight, but getting lean is so hard for me.

  • On the past years I’ve seen more and more studies pointing to the effects of gut bacteria on weight gain/loss. It would be interesting to see you explore this topic too:)

  • Japanese: go to Sushi Shin in Tai Hang for lunch Omakase best value for high end sushi (less than HKD500); Keyaki for skewers
    Chinese: Mott 32, Tsui Wah, Xiao Nan Guo, Maxim Palace, Tim Ho Wan, Hang Zhou Restaurant, Chiu Chow Garden; Xiao Yu Hotpot; As you like Chicken hotpot
    Fusion: Yardbird, Little Bao, Moyo, Bedu
    Western: Pici, Meats, Belon, Carbone, La Petite Maison
    Drinks: Sevva, Stockton, Bitters & Sweets, Please Don’t Tell, Lily & Bloom, Cassio

    Have fun!! PM me if you are looking for something specific and I’d love to help or show you around!

  • I have had one sunburn in my entire life so I’m prob somewhere on the fair side but also not at the extremes of the scale. I do get sun freckles on my shoulders that seem to stay forever once formed (ugh), so I recently started using sunscreen on face and shoulders.
    I have oily skin. My friends have commented on how “buttery”/soft my skin feels now that totally makes sense!!!! �� but it is prone to comedones and milia. I can’t go a day without chemical exfoliation or my pores get clogged. I haven’t figured out the forehead milia thing yet but I’m hoping Curology will help! Extracting milia by myself is kinda like creating craters on the face. �� I’m terrible at it.

  • Mannn, the ppl in these comments are extremely sensitive and petty for no good reason. Go find something better to do!

    This info is extremely valuable and important! Thank you Stephanie ����

  • Thank you so much for this!! I really love your scientific approach to fitness. You really back it up with hard evidence. This was a very interesting topic!!

  • I am around a 2-3, lol is 2.5 possible? I have dry/dry to combination skin type, combination in the summer, but dry in the winter.
    I have maturing and sensitive skin conditions.
    My sensitive skin usually leads to break outs, so would that mean acne prone as well?

    Thank you for this video I learned lot!!