Sperm DNA Damage Can lead to Repeat Miscarriages

 

What can cause Recurrent Miscarriages? Dr. Suhasini Inamdar

Video taken from the channel: Doctors’ Circle World’s Largest Health Platform


 

Sperm DNA Fragmentation and miscarriage

Video taken from the channel: Fertility Courses


 

Can husband be responsible for recurrent abortions? Dr. Apoorva P Reddy

Video taken from the channel: Doctors’ Circle World’s Largest Health Platform


 

SPERM DNA FRAGMENTATION & IVF | SHOULD WE DO TESE?

Video taken from the channel: Tim and Celeste


 

REPEAT MISCARRIAGES MAY BE DUE TO DEFECTIVE SPERM

Video taken from the channel: HOWARD G. SMITH MD


 

Damaged Sperm DNA & Recurrent Pregnancy Loss

Video taken from the channel: Austin Fertility and Reproductive Medicine


 

REPEAT MISCARRIAGES MAY BE DUE TO DEFECTIVE SPERM

Video taken from the channel: HOWARD G. SMITH MD


Compared with the men in the miscarriage-free couples, men in couples with recurrent pregnancy loss had twice as much sperm DNA damage and four times the amount reactive oxygen species. Damaged sperm DNA is known to reduce fertility, the researchers noted. Sperm DNA damage may lead to repeat miscarriages A new study found that men in couples with recurrent pregnancy loss had twice as much sperm DNA damage and four times the amount reactive oxygen.

Compared with the men in the miscarriage -free couples, men in couples with recurrent pregnancy loss had twice as much sperm DNA damage and four times the amount reactive oxygen species. Damaged sperm DNA is known to reduce fertility, the researchers noted. Sperm DNA Damage May Lead to Repeat Miscarriages When couples experience recurrent pregnancy loss, it’s natural for them to want to know why. Now, a new study suggests that sperm DNA damage could be a factor. Sperm DNA damage may contribute to repeat miscarriages.

Some cases of recurrent pregnancy loss may be caused by sperm DNA damage in the male partner, rather than by a problem in affected women, according to research to be presented Sunday, March 24 at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La. Compared with the men in the miscarriage-free couples, men in couples with recurrent pregnancy loss had twice as much sperm DNA damage and four times the amount reactive oxygen species. Damaged sperm DNA is known to reduce fertility, the researchers noted. Sperm DNA Damage May Lead to Repeat Miscarriages Study SUNDAY, March 24, 2019 (HealthDay News) When couples experience recurrent pregnancy loss, it’s natural for them to want to know why. Now, a new study suggests that sperm DNA damage could be a factor.

Sperm DNA Damage May Lead to Repeated Miscarriages. Sperm quality may be linked to miscarriages. Sperm DNA Damage May Lead to Repeat Miscarriages: Study.

When couples experience recurrent pregnancy loss, it’s natural for them to want to know why. Now, a new study suggests that sperm DNA damage could be a factor. Recurrent pregnancy loss is defined as the consecutive loss of three or more pregnancies before 20 weeks’ gestation.

Some cases of recurrent pregnancy loss may be caused by sperm DNA damage in the male partner, rather than by a problem in affected women, according to research to be presented Sunday, March 24 at.

List of related literature:

Evidence is emerging that DNA damage in sperm also increases the risk of miscarriage.

“It Starts with the Egg: How the Science of Egg Quality Can Help You Get Pregnant Naturally, Prevent Miscarriage, and Improve Your Odds in IVF (Second Edition)” by Rebecca Fett
from It Starts with the Egg: How the Science of Egg Quality Can Help You Get Pregnant Naturally, Prevent Miscarriage, and Improve Your Odds in IVF (Second Edition)
by Rebecca Fett
Franklin Fox Publishing LLC, 2019

Oxidative DNA damage in human sperm influences time to pregnancy.

“Male Infertility: Contemporary Clinical Approaches, Andrology, ART and Antioxidants” by Sijo J. Parekattil, Sandro C. Esteves, Ashok Agarwal
from Male Infertility: Contemporary Clinical Approaches, Andrology, ART and Antioxidants
by Sijo J. Parekattil, Sandro C. Esteves, Ashok Agarwal
Springer International Publishing, 2020

Such DNA damage is associated with male infertility; its aberrant repair in the fertilized egg may result in mutations in the embryo with the potential to either induce

“Textbook of Natural Medicine E-Book” by Joseph E. Pizzorno, Michael T. Murray
from Textbook of Natural Medicine E-Book
by Joseph E. Pizzorno, Michael T. Murray
Elsevier Health Sciences, 2020

The ultimate fate of this damage, whether it is repaired in the embryo or fixed as mutations, is not known but clearly there is a potential risk that such genetic damage could not only compromise the sperm function but also cause transmissible abnormalities in the offspring.

“Andrology: Male Reproductive Health and Dysfunction” by Eberhard Nieschlag, Hermann M. Behre, Susan Nieschlag
from Andrology: Male Reproductive Health and Dysfunction
by Eberhard Nieschlag, Hermann M. Behre, Susan Nieschlag
Springer Berlin Heidelberg, 2010

Evidence suggests that damage to human sperm DNA might adversely affect reproductive outcomes and that the spermatozoa of infertile men possess substantially more sperm DNA damage than do the spermatozoa of fertile men (Zini and Libman, 2006).

“Reproductive and Developmental Toxicology” by Ramesh C. Gupta
from Reproductive and Developmental Toxicology
by Ramesh C. Gupta
Elsevier Science, 2011

It appears that the etiology of sperm DNA damage is multifactorial and may be due to intrinsic and/or external factors.

“Biennial Review of Infertility: Volume 4” by Douglas T. Carrell, Peter N. Schlegel, Catherine Racowsky, Luca Gianaroli
from Biennial Review of Infertility: Volume 4
by Douglas T. Carrell, Peter N. Schlegel, et. al.
Springer International Publishing, 2015

However, studies attempting to correlate an abnormal semen analysis with increased rates of recurrent miscarriage have been largely unsuccessful.153 More recently, a number of small studies have correlated other sperm parameters, specifically sperm aneuploidy and DNA fragmentation, with RPL.154–156

“Creasy and Resnik's Maternal-Fetal Medicine: Principles and Practice E-Book” by Robert Resnik, Charles J. Lockwood, Thomas Moore, Michael F Greene, Joshua Copel, Robert M Silver
from Creasy and Resnik’s Maternal-Fetal Medicine: Principles and Practice E-Book
by Robert Resnik, Charles J. Lockwood, et. al.
Elsevier Health Sciences, 2018

Damage to sperm and possibly to sperm stem cells can result in male infertility, whereas damage to sperm DNA can result in genetic defects in the offspring, which result in miscarriage or postnatal defects.

“Anatomy and Physiology for Midwives E-Book” by Jane Coad, Kevin Pedley, Melvyn Dunstall
from Anatomy and Physiology for Midwives E-Book
by Jane Coad, Kevin Pedley, Melvyn Dunstall
Elsevier Health Sciences, 2019

DNA fragmentation has been shown to be associated with an increased risk of birth defects, increased miscarriage rates, and reduced fertilization and implantation during IVF.

“Oxford Textbook of Obstetrics and Gynaecology” by Sabaratnam Arulkumaran, William Ledger, Stergios Doumouchtsis, Lynette Denny
from Oxford Textbook of Obstetrics and Gynaecology
by Sabaratnam Arulkumaran, William Ledger, et. al.
Oxford University Press, 2019

Sperm DNA damage can occur and can be assessed at different levels in the reproductive tract.

“Reproductive Endocrinology and Infertility: Integrating Modern Clinical and Laboratory Practice” by Douglas T. Carrell, C. Matthew Peterson
from Reproductive Endocrinology and Infertility: Integrating Modern Clinical and Laboratory Practice
by Douglas T. Carrell, C. Matthew Peterson
Springer New York, 2010

Oktay Kutluk

Kutluk Oktay, MD, FACOG is one of the world's foremost experts in fertility preservation as well as ovarian stimulation and in vitro fertilization for infertility treatments. He developed and performed the world's first ovarian transplantation procedures as well as pioneered new ovarian stimulation protocols for embryo and oocyte freezing for breast and endometrial cancer patients.

Mail: [email protected]
Telephone: +1 (877) 492-3666

Biography: https://medicine.yale.edu/profile/kutluk_oktay/
Bibliography: oktay_bibliography

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11 comments

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  • Can a blood clotting disorder such as homozygous for MTHFR and heterozygous for Factor V leiden also be in that category of DNA sperm damage? I also have the same question with regards to type 2 diabetes as well?

  • Honey. You are so beautiful in face and yr soul.my marriage unfortunately end up with devorce because of this dammed dna fragmentation of sperm. My husband didn’t tell me about his valicoce surgery before marriage. So after marriage I suffered from 4 miscarriage and nothing was found in me but SDF above 45% in my husband. I didn’t give up but depression caused by this journey caused my husband asked for divorce.

  • I know I am a little late, but if I am counting correctly, you have not had retrieval yet. My husband had a TESE done the same day as my retrieval because he had blockage in both of them. Our retreival was Saturday and he was back to work Monday. If you guys go that route, make sure to order him a jock strap, my husband said that helped a lot and a lot of icing. 13 eggs were fertilized with my husband’s sperm and 6 vials were frozen. Out of those 13, 8 made it to day 5 and were frozen and the first FET resulted in our daughter who is now 11 months and we are now 11 weeks with our 2nd FET. All the best to you and feel free to ask any questions:)

  • Hey Celeste, I’m not sure if you’ve heard of the NZ mini series called Inconceivable-it follows six couples undergoing fertility treatment. One of the couples had to undergo TESE because the husband was a carrier of the CFTR gene and his sperm count was zero. It might be worth a watch if you want an idea of the process!

  • Hi dear, i am new to your channel. I hope you hold your baby in your arm soon. I couldn’t watch all of your videos but want to ask a question. Have you tried acupuncture? It is really helpful. You should go for it cause you guys are in too much stress. I can understand even I went through so much stress since I lost my first baby. It has been 3 years and 1 in infertility treatments. I saw your another video that your going for surrogacy but I have a faith that you will definitely conceive and that time is not far. Also acupuncture can heal you from having multiple miscarriages and so many things. It worked for me and i am sure i will work fr you too. Baby dust to you.
    Just adding a bit more, i did ERA at the same time along with acupuncture. May be that helped me to conceive. It will you exact timing when to transfer embryo.

  • Hi Celeste, did you get a semen culture analysis done? Silent Semen bacterial infections (not STIs) can lead to dna frag. Treatment is a course of antibiotics for you both. What specific vitamins /antioxidants is Tim on? Interested to hear what was recommended to you. Best of luck and baby dust xx

  • Hahaha Cooper had me cracking up when he was behind you, his tail was going back and forth. Lol….Celeste & Tim, Gosh my heart goes out to you two and I have to agree about being your own advocate and not just on the IVF or defragment issue but on everything, at least here in the U.S. Not so much in Europe. Still praying for you both & positive vibes sent your way. ����

  • I hope and pray u will get that baby ��.. Nothing is more of a gift then a gift from God!! there’s so many people out this world who are not fit to be parents & or do things to their children then there are couples and or people who want & try years to have that gift but can’t ugh my heart breaks for I’ll bite one day it will happen!!����

  • TESE is very worth it Ryan only had 3 days off work it helped us get Benny, also did you ever have an multinucleated embryos day 2 or 3, after ICSI, this can be because the DNA in the sperm can break off and the egg acts like it has fertilized again. We lost a few to having this issue. Benny is TESE baby.

  • when my husband had the TESE performed he went back to work almost immediately which was a terrible mistake but we couldn’t be out of money because that procedure cost us $2000 here in Canada. He ended up getting an infection & was on medical leave for three weeks to recover. I think it depends on the physical requirements of the job, if it’s a sitting job it shouldn’t be too bad but my husband is a powerline technician so his job is entirely physical & wore him out fast. Hope this helps:)

  • We did TESE twice. He was sore for almost two weeks after. I had a successful first fresh transfer that was going great but resulted in a miscarriage from DNA sperm fragmentation. Going to release his video on that next week.