Skin psoriasis Might Be Genetically Associated with Weight problems and Diabetes Type 2

 

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HealthDay Reporter WEDNESDAY, April 27, 2016 (HealthDay News) The chronic skin disease psoriasis may be linked to excess weight and type 2 diabetes, results of a new study suggest. Danish. WEDNESDAY, April 27, 2016 (HealthDay News) The chronic skin disease psoriasis may be linked to excess weight and type 2 diabetes, results of a new study suggest. Danish researchers found that people with type 2 diabetes had more than 50 percent greater odds of having psoriasis compared to people without diabetes.

WEDNESDAY, April 27, 2016 The chronic skin disease psoriasis may be linked to excess weight and type 2 diabetes, results of a new study suggest. Danish researchers found that people with type 2. “Psoriasis, type 2 diabetes mellitus and obesity are strongly associated in adults after taking key confounding factors such as sex, age and smoking into account,” the researchers wrote. “Results indicate a common genetic etiology of psoriasis and obesity.”. Psoriasis is connected to obesity and type 2 diabetes, according to a new study.

A genetic link between psoriasis and obesity has also been suggested from an examination of twins from Denmark. HealthDay Reporter WEDNESDAY, April 27, 2016 (HealthDay News) The chronic skin disease psoriasis may be linked to excess weight and type 2 diabetes, results of a new study suggest. Danish researchers found that people with type 2 diabetes had more than 50 percent greater odds of having psoriasis compared to people without diabetes.

Researchers noted that these results indicate that psoriasis, type 2 diabetes mellitus, and obesity are all strongly linked, and the relationship between psoriasis and obesity could be partly due. A link has been found between the skin condition psoriasis, type 2 diabetes and obesity, researchers have said. The study has also shown that people with psoriasis are more likely to develop obesity and type 2 diabetes. The research involved looking at medical data including height, weight, diagnoses of psoriasis and diabetes, lifestyle and environmental [ ].

The main findings were that psoriasis is associated with diabetes independent of sex, age, smoking, and body mass index (BMI) (OR 1.53, 1.03–2.27) and that increases in BMI are associated with increasing odds of twins reporting a diagnosis of psoriasis. Similar findings were reported for patients receiving a hospital diagnosis of psoriasis. Psoriasis could also lead to obesity in some people.

For instance, you could gain weight if being active were painful (which is especially likely if you have psoriatic arthritis) or if you avoided.

List of related literature:

Psoriatic arthritis, which occurs in 10% of patients with psoriasis, represents the primary systemic complication, though recent evidence suggests psoriasis may be linked to the metabolic syndrome (diabetes, hypertension, obesity, etc.).

“Comprehensive Dermatologic Drug Therapy E-Book” by Jashin J. Wu
from Comprehensive Dermatologic Drug Therapy E-Book
by Jashin J. Wu
Elsevier Health Sciences, 2012

More recently, moderate to severe plaque type psoriasis in adults has been clearly linked to an increased risk of metabolic syndrome and cardiovascular disease.34,35 Studies in pediatric patients suggest that the risk of obesity and, most likely, cardiovascular complications, begins in childhood and adolescence.

“Hurwitz Clinical Pediatric Dermatology E-Book: A Textbook of Skin Disorders of Childhood and Adolescence” by Amy S. Paller, Anthony J. Mancini
from Hurwitz Clinical Pediatric Dermatology E-Book: A Textbook of Skin Disorders of Childhood and Adolescence
by Amy S. Paller, Anthony J. Mancini
Elsevier Health Sciences, 2011

In addition to skin and joint manifestations, severe psoriasis is associated with inflammatory bowel disease and metabolic syndrome, which includes hypertension, insulin resistance, dyslipidemias, abdominal obesity, and nonalcoholic fatty liver disease.

“Understanding Pathophysiology E-Book” by Sue E. Huether, Kathryn L. McCance
from Understanding Pathophysiology E-Book
by Sue E. Huether, Kathryn L. McCance
Elsevier Health Sciences, 2019

Patients with psoriasis are more likely to have coronary artery disease, elevated blood pressure, obesity, and insulin resistance.

“Conn's Current Therapy 2015 E-Book” by Edward T. Bope, Rick D. Kellerman
from Conn’s Current Therapy 2015 E-Book
by Edward T. Bope, Rick D. Kellerman
Elsevier Health Sciences, 2014

Obesity is also associated with increased inflammation and the presence of psoriasis, an inflammatory dermatoses.

“Acute and Chronic Wounds E-Book” by Ruth Bryant, Denise Nix
from Acute and Chronic Wounds E-Book
by Ruth Bryant, Denise Nix
Elsevier Health Sciences, 2015

There is now clear evidence that obesity produces a chronic systemic inflammatory state, which in turn promotes the development of a wide variety of diseases, ranging from CVD to cancer to diabetes to skin conditions such as eczema and psoriasis.

“Women and Health” by Marlene B. Goldman, Rebecca Troisi, Kathryn M. Rexrode
from Women and Health
by Marlene B. Goldman, Rebecca Troisi, Kathryn M. Rexrode
Elsevier Science, 2012

An obesity induced proinflammatory state may exacerbate psoriasis symptoms, and psoriasis itself may contribute to weight gain, partially because of social isolation, unhealthy dietary habits, and reduced physical activity.

“Dermatology in Public Health Environments: A Comprehensive Textbook” by Renan Rangel Bonamigo, Sergio Ivan Torres Dornelles
from Dermatology in Public Health Environments: A Comprehensive Textbook
by Renan Rangel Bonamigo, Sergio Ivan Torres Dornelles
Springer International Publishing, 2018

In addition, some genes associated with psoriasis may predispose to cardiovascular disease and diabetes.

“Dermatology E-Book: An Illustrated Colour Text” by David Gawkrodger, Michael R Ardern-Jones
from Dermatology E-Book: An Illustrated Colour Text
by David Gawkrodger, Michael R Ardern-Jones
Elsevier Health Sciences, 2016

Many of these genetic variations are also associated with immune disorders considered psoriatic comorbidities, including Crohn’s disease and diabetes.5 Although in the past psoriasis was considered a disorder of keratinocytes, it is now generally accepted that it is primarily an immune-mediated disorder.

“Textbook of Natural Medicine E-Book” by Joseph E. Pizzorno, Michael T. Murray
from Textbook of Natural Medicine E-Book
by Joseph E. Pizzorno, Michael T. Murray
Elsevier Health Sciences, 2012

In a study analyzing data from 39 patients with moderate-to-severe plaque-type psoriasis, a correlation between insulin secretion as well as resistin levels and psoriasis severity has been shown [33], supporting a link between a chronic state of inflammation in obesity and chronic systemic inflammation in psoriasis.

“Management of Psoriasis” by Nikhil Yawalkar
from Management of Psoriasis
by Nikhil Yawalkar
Karger, 2009

Oktay Kutluk

Kutluk Oktay, MD, FACOG is one of the world's foremost experts in fertility preservation as well as ovarian stimulation and in vitro fertilization for infertility treatments. He developed and performed the world's first ovarian transplantation procedures as well as pioneered new ovarian stimulation protocols for embryo and oocyte freezing for breast and endometrial cancer patients.

Mail: [email protected]
Telephone: +1 (877) 492-3666

Biography: https://medicine.yale.edu/profile/kutluk_oktay/
Bibliography: oktay_bibliography

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12 comments

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  • Breaking scientific research shows that there’s a green vegetable that INFLAMES diabetes type 2 symptoms…
    Causing deadly spikes in blood sugar, increased fat storage, hormonal imbalances, brain fog, arterial plaque and debilitating chronic fatigue…
    There’s only one way to find out how to avoid it and that’s to click below:
    https://sites.google.com/view/erratic-blood-sugar/home
    https://everyonefactified.blogspot.com/2020/08/how-to-get-rid-of-type-2-diabetes.html

  • Thank you for the information.
    The incidence of type 2 diabetes, hitherto considered a disease of middle and old age, has been steadily increasing among children and adolescents. Data from developed countries shows that this increase parallels a similar rise in the prevalence of childhood and adolescent obesity. While type 2 diabetes in children and adolescents is as yet not a major public health problem in India, recent reports revealing increasing levels of obesity among youngsters especially in our metropolitan cities, gives cause for concern.
    For more details about Childhood Obesity and Type 2 Diabetes visit: https://drmohans.com/childhood-obesity-and-type-2-diabetes/

  • I must tell you about a person who helped me with Diabetes! He is the only person, who can tell you a step by step way how to cure it. Just open DIABETES. XCOURSE. XYZ and watch his amazing story!

  • At a young age of Twenty, my partner has already been encountering scalp problem. I am happy I`ve discovered this chemical-free and risk-free skin psoriasis treatment solution. I suggest this resolution. Right after using this therapy, I have observed good improvements in my dilemma.. Google showed me this guide, the guide`s name is Kαyden Molonduz
    best wishes

  • As specialist, I believe Hybetez Remedy can be great way to cures your diabetes naturally. Why don’t you give it a chance? maybe it is going to work for you too.

  • Start drinking goat kefir. Heal the gut heal your skin. Don’t focus on the symptoms of psoriasis, this will end on failure and alot of money wasted.

  • Thank you for giving me an overview of psoriasis I have been suspected by my primary care and referred to a dermatologist about a week ago. symptoms seem to have started a few months ago my arms legs feet and spots on my back and chest broke out. The spots on my scalp have gone away, a haircut seemed to had brought that out. there is nothing that I’ve been able to do to get rid of the spots they itch and hurt immensely. The past year something had started on the backs of my hands and fingers like blisters graduating 2 lesions that took forever to heal then somewhat in between a blister and red spot with a tiny core in a callous now it seems to be a permanent rash resembling chicken pox The stressor I can identify is a battery explosion on my leg causing 2nd degree burns. the scar will not heal and the rash seems to affect It now covering a large area of my thigh. I will not wear shorts I tried to keep my hands hidden I’m devastated by it. My biggest shame is that I will not go swimming with my 10yo daughter. I just want to crawl in a hole and go away forever.
    -clint

  • Obviously out of date with todays research which says that a calorie is NOT a calorie and exercise and lower calorie diets DONT WORK. you cant exercise your way out of a crap diet full of processed grains fast food and sugar. Eat REAL FOOD and exercise, mainly strength training and NOT endless cardio.

  • Can you talk scleroderma? The doctor says I have it. It manifested about 18 years ago.. I’m 62 yo. I have bald spots and itchy patches on my scalp that require me to wear wigs in public.

  • Anyone tested out the Hybetez Remedy (just search it on google)? We have noticed several amazing things about this popular cholesterol home remedy

  • Honestly we still have to fight for good quality food. I guess you guys didn’t know (but can find this out fairly easily from talking to anthropologists) that people in foraging societies spend/spent less than half the time modern humans living in cities in western societies do in looking for and preparing food. In many ways foraging societies were healthier not necessarily in terms of acute trauma or infectious diseases, but certainly with respect to chronic diseases. Western societies in most cases have constructed a situation in which it is now challenging to be healthy in the long term, when it comes to our eating habits and activity levels. You have to basically go against the grain entirely in order to be and remain healthy.

  • Obesity a disease? LOL. Perhaps a diseased society with its priorities upside down, certainly not a disease to cure with pills. I can’t believe my tax dollars help spread this ignorance.:(