Oestrogen Can Substantially Decrease the chance of Alzheimer’s

 

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Estrogen Can Substantially Decrease the Risk of Alzheimer’s Alzheimer’s disease is a concern for many menopausal women, and yet most do not consider taking hormone replacement therapy, even though estrogen can significantly delay Alzheimer’s. Barb DePree, MD, NCMP,MMM 27 Mar 2019 Your Health. In spite of everything you read and the drugs that are being tried —both those advertised and those requiring a prescription—nothing significantly delays or prevents Alzheimer’s disease except estrogen, which can decrease the risk of Alzheimer’s disease by up to 50 percent.

There’s new evidence that a woman’s levels of female sex hormones, including estrogen and progesterone, can influence her risk of Alzheimer’s and other forms of dementia. Estrogen and Dementia Previous studies have made it clear that women stand a higher risk of developing Alzheimer’s: Women aged 65 or older stand a one in six chance of developing the disease when compared to one in 11 men. These results were a disappointment since earlier studies had reported that women taking estrogen hormone therapy had a substantially lower risk of developing dementia. In preclinical studies, estrogen was shown to improve energy production, reduce oxidative stress, increase brain cell survival during damage, enhance the release of protective chemicals, and.

On a positive note, a large epidemiological study found that estrogen given early in menopause reduced Alzheimer’s risk, and results from a small cohort indicated that early treatment with the hormone may have slowed amyloid accumulation. However, another study found that early treatment with the hormone shrank the brain. New research has found a link between dementia and estrogen levels — the more estrogen a woman receives from pregnancy, for example, the less the risk of. Women who took estrogen in mid-life but not in late life had a 26 percent decreased risk of developing dementia in old age compared with women who had never taken estrogen at any age, whereas women who took estrogen in late life but not in mid-life had a 48 percent increased risk of dementia compared with non-estrogen-taking women.

The women who took the estrogen had an average 22% increase in cerebral blood flow compared with the placebo group. The largest increase was in the left temporal region, which is typically affected. The exclusive use of vaginal estrogen was not associated with an increased risk for Alzheimer’s.

For women who initiated HRT after the age of 60, the use of HRT (estrogen and progestogen or estrogen alone) was associated with a 15-38% increase in risk for Alzheimer’s disease compared to women who did not use HRT.

List of related literature:

Estrogen alone does not seem to increase the risk of breast cancer and may decrease coronary plaques but may increase the risk of Alzheimer’s dementia and thromboses (Heiss, Wallace, Anderson, et al., 2008).

“Brunner & Suddarth's Textbook of Medical-surgical Nursing” by Lillian Sholtis Brunner, Suzanne C. O'Connell Smeltzer, Brenda G. Bare, Janice L. Hinkle, Kerry H. Cheever
from Brunner & Suddarth’s Textbook of Medical-surgical Nursing
by Lillian Sholtis Brunner, Suzanne C. O’Connell Smeltzer, et. al.
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Loss of estrogen also appears to increase the risk for Alzheimer’s disease.

“Foundations of Maternal-Newborn and Women's Health Nursing” by Sharon Smith Murray, MSN, RN, C, Emily Slone McKinney, MSN, RN, C
from Foundations of Maternal-Newborn and Women’s Health Nursing
by Sharon Smith Murray, MSN, RN, C, Emily Slone McKinney, MSN, RN, C
Elsevier Health Sciences, 2013

Nevertheless, the potentially beneficial characteristics of estrogen in relation to Alzheimer’s disease should be shared with women who are considering estrogen replacement therapy, especially if Alzheimer’s disease is a particular concern.

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from Textbook of Family Medicine E-Book
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The risk of dementia also decreased more the longer women took estrogen: Women who took estrogen seven years or more had a 50 percent lower risk of dementia than those not taking ERT.

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from It’s My Ovaries, Stupid!
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While estrogen may delay or reduce the risk of Alzheimer’s disease, it does not seem to improve established disease.

“Principles and Practice of Geriatric Medicine” by M.S. John Pathy, Alan J. Sinclair, John E. Morley
from Principles and Practice of Geriatric Medicine
by M.S. John Pathy, Alan J. Sinclair, John E. Morley
Wiley, 2006

Observational data suggest that estrogen may reduce the risk of Alzheimer disease if initiated soon after menopause but that estrogen replacement may increase the risk of dementia when initiated in women over 65 years of age.247

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In addition, longterm deficiency in estrogen has been associated with increasing the risk and mortality of coronary artery disease, as well as the memory loss and cognitive deficits associated with Alzheimer’s disease.

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The therapy with oestrogen reduces the risk of Alzheimer’s disease by a third or even half.17 After several years of menopause, there is a decline in cognitive function of the brain due to lack of oxygen with a possibility of developing Alzheimer’s disease.

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Estrogen therapy initiated in the early postmenopausal period improves cognitive function, particularly memory, and may decrease risk of Alzheimer’s disease.

“Encyclopedia of Behavioral Neuroscience” by Elsevier Science
from Encyclopedia of Behavioral Neuroscience
by Elsevier Science
Elsevier Science, 2010

The researchers found that the estrogen users were 40 percent less likely to die of Alzheimer’s disease or dementia than women who had not taken estrogen.

“Screaming to be Heard: Hormonal Connections Women Suspect... and Doctors Still Ignore” by D. Lee D. Vliet
from Screaming to be Heard: Hormonal Connections Women Suspect… and Doctors Still Ignore
by D. Lee D. Vliet
M. Evans, 2005

Oktay Kutluk

Kutluk Oktay, MD, FACOG is one of the world's foremost experts in fertility preservation as well as ovarian stimulation and in vitro fertilization for infertility treatments. He developed and performed the world's first ovarian transplantation procedures as well as pioneered new ovarian stimulation protocols for embryo and oocyte freezing for breast and endometrial cancer patients.

Mail: [email protected]
Telephone: +1 (877) 492-3666

Biography: https://medicine.yale.edu/profile/kutluk_oktay/
Bibliography: oktay_bibliography

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