Obese Patients With Pancreatic Cancer Have Shorter Survival, Study Finds

 

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TUESDAY, Oct. 22 (HealthDay News) A diagnosis of pancreatic cancer usually carries with it a poor prognosis, and the news may be even worse for those who are obese: It could mean dying two to. TUESDAY, Oct.

22, 2013 (HealthDay News) A diagnosis of pancreatic cancer usually carries with it a poor prognosis, and the news may be even worse for those who are obese: It could mean dying two to three months sooner than pancreatic cancer patients of normal weight, new research shows. TUESDAY, Oct. 22 (HealthDay News) A diagnosis of pancreatic cancer usually carries with it a poor prognosis, and the news may be even worse for those who are obese: It could mean dying two to three months sooner than pancreatic cancer patients of normal weight, new research shows.

Prior studies have tied obesity to a higher chance of getting pancreatic cancer, but the new study. Colon cancer rates and pancreatic cancer deaths rose by 10% worldwide between 1990 and 2017, according to a new study of global trends in digestive diseases. In pancreatic cancer, increased BMI has been reported to be an adverse prognostic factor for survival after surgery in two surgical series of 285 and 356 patients, respectively.16, 17However, another surgical report of 306 patients undergoing resection of pancreatic adenocarcinoma reported increased postoperative complications in obese patients, but the slight decrease in survival. Further, other studies found no relationship between obesity and the long-term survival of patients with PC [ 31, 32 ]. Large prospective studies of cohorts found that BMI ≥35 kg/m 2 is associated with significantly shorter survival of patients with PC [ 33 ], which is confirmed by a multicenter cohort study [ 34] and a meta-analysis [ 35 ].

Pancreatic cancer is currently the fourth leading cause of cancer death but is projected to be the second leading cause before 2020 (Pancreatic Cancer Action Network, 2012).In 2013, 45 220 Americans will be diagnosed with pancreatic cancer and 85% (38 460) of them will die from the disease (Siegel et al, 2013).Thus, identifying factors that impact pancreatic cancer survival. In the series of 313 patients diagnosed with pancreatic cancer, 98 (31.3%) were initially misdiagnosed, with a total of 119 diagnoses other than pancreatic cancer, he said. The most common misdiagnosis was gallbladder disease, which led to a cholecystectomy in 38 cases, followed by gastroesophageal reflux disease in 15 cases, and peptic ulcer. We have also conducted a meta-analysis of 29 studies on diabetes and overall survival of patients with pancreatic cancer and found a reduced survival of patients with diabetes in 25 clinic-based studies (pooled HR, 1.13; 95% CI, 1.02 to 1.25), but not in four cohort studies 4–7 (pooled HR, 1.12; 95% CI, 0.95 to 1.32).

The prevalence of. “Before our work, the largest study looking at long-term survivors of pancreatic cancer had only eight patients,” Dr. Balachandran says. “We had 82.” To further define what makes a good neoantigen, the MSK team joined up with computational biologists Benjamin Greenbaum and Marta Luksza from the Icahn School of Medicine at Mount Sinai.

List of related literature:

Patients with pancreatic, gastric, or esophagus cancer appear to have highest prevalence of weight loss, whereas those with breast or prostate cancer have the lowest ones.

“Handbook of Anthropometry: Physical Measures of Human Form in Health and Disease” by Victor R. Preedy
from Handbook of Anthropometry: Physical Measures of Human Form in Health and Disease
by Victor R. Preedy
Springer New York, 2012

In this study, the apparent effect of weight loss at the time of diagnosis in this study on median survival for certain cancers was greater than the impact of chemotherapy.

“Nutritional Oncology” by David Heber, George L. Blackburn, Vay Liang W. Go, John Milner
from Nutritional Oncology
by David Heber, George L. Blackburn, et. al.
Elsevier Science, 2011

Only 15% to 20% of patients diagnosed with pancreatic cancer are candidates for resection, which has a 10% to 30% 5-year survival rate.

“Conn's Current Therapy 2019” by Rick D. Kellerman, David Rakel
from Conn’s Current Therapy 2019
by Rick D. Kellerman, David Rakel
Elsevier Health Sciences, 2018

This is primarily because the majority of pancreatic cancers are diagnosed at an advanced stage, with a 5year survival rate of only 3%.

“Conn's Current Therapy 2020, E-Book” by Rick D. Kellerman, KUSM-W Medical Practice Association, David Rakel
from Conn’s Current Therapy 2020, E-Book
by Rick D. Kellerman, KUSM-W Medical Practice Association, David Rakel
Elsevier Health Sciences, 2019

[Contrast their prognosis with that of a recently diagnosed pancreatic exocrine adenocarcinoma patient (see Figure 11.12B), whose overall five-year survival is only 5%.]

“The Biology of Cancer” by Robert A. Weinberg
from The Biology of Cancer
by Robert A. Weinberg
W.W. Norton, 2013

Fewer than 24% of affected individuals survive 1 year after diagnosis, and the overall 5-year survival rate is only 5%.1 The majority of pancreatic cancers are metastatic at the time of diagnosis.

“Cancer Nursing: Principles and Practice” by Connie Henke Yarbro, Yarbro, Debra Wujcik, Barbara Holmes Gobel
from Cancer Nursing: Principles and Practice
by Connie Henke Yarbro, Yarbro, et. al.
Jones & Bartlett Learning, 2010

However, this is mostly due to declining incidence; survival in patients with diagnosed gastric cancer remains poor.

“Holland-Frei Cancer Medicine 8” by Waun Ki Hong, Robert C. Bast Jr, American Association for Cancer Research, William Hait, Donald W. Kufe, James F. Holland, Emil Frei Iii
from Holland-Frei Cancer Medicine 8
by Waun Ki Hong, Robert C. Bast Jr, et. al.
People’s Medical Publishing House, 2010

Long-term cancer survivors should now focus on healthy weight management, healthy diets, and physical activity geared toward secondary cancer and chronic disease prevention.

“Krause's Food & the Nutrition Care Process E-Book” by L. Kathleen Mahan, Janice L Raymond
from Krause’s Food & the Nutrition Care Process E-Book
by L. Kathleen Mahan, Janice L Raymond
Elsevier Health Sciences, 2016

Weight gain and being overweight during cancer treatment and survivorship may increase risk of recurrence and lower odds for survival

“Holland-Frei Cancer Medicine Cloth” by Robert C. Bast, Jr., Carlo M. Croce, William N. Hait, Waun Ki Hong, Donald W. Kufe, Martine Piccart-Gebart, Raphael E. Pollock, Ralph R. Weichselbaum, Hongyang Wang, James F. Holland
from Holland-Frei Cancer Medicine Cloth
by Robert C. Bast, Jr., Carlo M. Croce, et. al.
Wiley, 2017

People who are overweight and physically inactive also have a higher rate of contracting pancreatic cancer.

“Diseases and Disorders” by Marshall Cavendish Corporation
from Diseases and Disorders
by Marshall Cavendish Corporation
Marshall Cavendish, 2007

Oktay Kutluk

Kutluk Oktay, MD, FACOG is one of the world's foremost experts in fertility preservation as well as ovarian stimulation and in vitro fertilization for infertility treatments. He developed and performed the world's first ovarian transplantation procedures as well as pioneered new ovarian stimulation protocols for embryo and oocyte freezing for breast and endometrial cancer patients.

Mail: [email protected]
Telephone: +1 (877) 492-3666

Biography: https://medicine.yale.edu/profile/kutluk_oktay/
Bibliography: oktay_bibliography

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22 comments

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  • I have less than 6 months to live
    Because of this illness
    Actually looking forward to my death.. so the pain will stop
    I want to commit suicide so i can get this pain over.

  • Praying for Mr.Ken and his family.My mother was diagnosed with Pancreatic Cancer.Praying for Healing,Peace and a lot of Prayers and Love.God Bless

  • Such a positive story my prayers definitely go out to the Hall family during this time���� I’m just glad though he had an abundance of positivity all around him professionally from the doctors and also from his family just so much love and support!!

  • My ex died from this at 33 years old. He was a truley beautiful soul. Unfortunately he passed 6 months from diagnosis and it was a horrible ride. I sometimes wish he had seen another doctor who had seen him as an individual

  • My grandfather suffer from it I’m so depressed I dont know what to do I love him so much I hope he is going to get better everyone your health is the most important thing there are people that love you from the bottom of their heart so be thankful.Anyways thanks for reading wish you all the best.��

  • And if you were just a regular Joe like 99% of us.. forget that you will get this kind of surgery if you can’t pay for it. So yeah.. Im dead if this happens to me.

  • Hello ken, my brother in law is having stage 3 pancreatic cancer and I am out of my mind. no idea what to do.. can you help me out? any suggestion?

  • My teacher who was my EA teacher helper that helped me in school when i was alot younger has passed away from this cancer and i never new she had cancer. I found out she had this cancer after she died I miss her �� so much and still hurting. She died a feel years ago. I would of been there for her and support her and hug if she was still alive. But i wish i was there for her if i knew early before she died. I feel like its my fault for not knowing �� just gonna blame it on me cuz I never knew �� at least she’s not in pain anymore and that she’s in a better and not suffering from this awful horrible disease. �������� i wish to tell Eric that I lost my childhood teacher to this cancer ��������

  • Hi how are you i love your story it’s so reassuring, I’ve been in stomach pain since last Friday and have lost 11 pounds the pain goes from the abdomen to the back I have no appetite I’m itching I’ve been to the ER 4 times in 7 seven days different ERs they said it’s normal it’s probably heartburn I know it’s not but they refuse to listen to my symptoms.
    I am in severe pain Norco helps for 2 hours then it comes back. What do you suggest.

  • I have less than 6 months to live
    Because of this illness
    Actually looking forward to my death.. so the pain will stop
    I want to commit suicide so i can get this pain over.

  • Is Eric still alive though? I sincerely hope he is. Updates would be helpful having gone through the effort of sharing this story.

  • It will come back. This video does not show us the whole story. The cancerous cells cannot be destroyed. My father has this type of cancer. I witness it
    This video is more like a TV commercial

  • Lost my mother to this deadly disease 12 days ago! She was diagnosed at stage 4b and lived one and a half years with chemo theraphy and immuno theraphy! I’d say its probably the most deadliest cancer of them all, Someone’s gotta find a cure to this!

  • Where is this simple test for pancreatic cancer created over seven years ago. Want to bet big pharma bought the rights and got rid of it. Cancer is big business. https://www.smithsonianmag.com/science-nature/jack-andraka-the-teen-prodigy-of-pancreatic-cancer-135925809/

  • Right now my father is struggling with this cancer. I don’t know how many days he will survive.He doesn’t now. May God bless him. Please pray for his recovery.

  • earlier diagnosis the better for survival! but most doctors dont check for it if u are ill and wait til your old than the cancer its at its last stage!

  • He is so profoundly lucky as most people diagnosed with Pancreatic Cancer die within a year. Five years after diagnosis and he is healthy with a good life This is really inspiring.

  • I was diagnosed with pancreatic cancer a month ago. It is operable but I can’t get the health system to give me any answers. Tick tock. I am ready to die but I don’t have to. It’s just an inept system that keeps me from moving forward.

  • https://www.youtube.com/watch?v=40umFI1kNmM Amazing Testimony of God completely Curing Pancreatic Cancer!!!

  • In italy, in pisa, there is a good hospital who treat this disease with good chances of survival after the surgery. My brother in low was operated here, and now is full recoverd after he had whipple surgery. He is working, eating everything. He did after the surgery 1 month of gentabicine taken oraly. But is full recovered.

  • It’s rare to see a pancreatic cancer survivor like this man. I hope he recovers well and that they will find a better early diagnosis and cure for all cancers.

  • And since our body is made of stemcells. The only hope to get cured is also stemcells but stemcells injection is bloody expensive. Thanks God there is now oral livecells therapy. It REGENERATES NEW CELLS AND REPAIR DAMAGED CELLS Get yours today +639175110518