Dr. Matt Goetz reviews hormonal therapy options for both preand post-menopausal women with estrogen receptor positive, early stage breast cancer. Risks and benefits of Tamoxifen and the Aromatase Inhibitors (anastrozole, letrozole, exemestane) are also discussed. To learn more about breast cancer care at Mayo Clinic, visit: https://mayocl.in/2v60NoX
One of the themes covered during Thursday’s San Antonio Breast Cancer Symposium was hormonal therapies, a very important aspect of breast cancer care.. Debu Tripathy, MD, editor-in-chief of CURE magazine, describes the latest advances in hormonal therapies, which was discussed at the 2013 annual meeting of SABCS.
Post-surgical treatment depends on the type and stage of breast cancer. Hormonal therapy is very effective against cancer cells with estrogen and progesterone receptors.
This week on Toward a Cancer-Free World, Medical Oncologist Dr. Rachel Layman clears up misconceptions about hormone therapy and breast cancer. The confusion, she says, lies in the term “hormone therapy,” which many women assume means they will be receiving hormones during breast cancer treatment. Dr. Layman says a more accurate term would be “hormone suppression therapy” or “anti-estrogen therapy,” which means that the experts are actually removing the effects of estrogen in a patient’s body as part of breast cancer treatment – helping treat and, in many cases, prevent the disease.
This webcast provides expert insight on management strategies for patients with HR-positive breast cancer. Over a review of several cases, the faculty will provide their assessments, as well as additional details on current abemaclib, ribociclib, palbociclib, and faslodex studies, everolimus and NSABP B 42, breast cancer index and other biomarkers. The webcast is moderated by Dr. Jame Abraham of the Cleveland Clinic.. Visit http://www.ccfcme.org/tumorboard to claim CME credit or learn more about the Biologic Therapies VII series.. Interested in related CME education? Visit http://www.ccfcme.org
We teach you about hormonal therapy for breast cancer. Drugs such as tamoxifen and aromatase inhibitors are key treatment options for most breast cancers.. VISIT THE BREAST CANCER SCHOOL FOR PATIENTS:. http://www.breastcancercourse.org. LIST OF QUESTIONS FOR YOUR DOCTORS: http://www.breastcancercourse.org/breast-health-updates-latest-videos/. FOLLOW US: Facebook: https://www.facebook.com/Breast-Cancer-School-for-Patients-958519147618444/. _ Questions for your Medical Oncologist: 1. What type of hormonal therapy do you recommend? 2. Will I also benefit from chemotherapy? 3. What are the side effects of hormonal therapy? 4. Will I need 5 or 10 years of these medications? 5. Would the genomic assay Oncotype DX be helpful? 6. What is Hormonal Therapy? Anti-estrogen (estrogen-blocking) medications, prescribed as pills, are incredibly effective at treating certain types of breast cancer. Hormonal therapy is given to about 70 to 80% of women with breast cancer. Chemotherapy, on the other hand, is a more intense cancer treatment that is generally administered intravenously. Most patients will not need chemotherapy. Many women that do need chemotherapy will also benefit from hormonal therapy. These treatment decisions are complex ones with your medical oncologist. You will make better choices when you are well informed before meeting with your medical oncologist.. Do my “Receptors” suggest Hormonal Therapy? When the estrogen circulating in your blood stream interacts with a breast cancer that has “Estrogen Receptors” (ER) present on its surface, it tends to flip the ER switch to the “on” or “grow” position for ER Positive tumors. The same can be said to a lesser extent for the “Progesterone Receptor,” if your cancer is found to also be PR positive. Patients with ER+ breast cancers almost always benefit from the anti-estrogen effects of hormonal therapy. These medications can make cancer cells die, or slow down their growth. If a few cancer cells have already spread to other parts of the body, these medications are incredibly effective at preventing these cells from growing and threatening your life in the future. In other words, those who take hormonal therapy for ER+ tumors have a more successful chance at long-term survival when compared to those who do not.. About 80% of all breast cancers are ER+. Even if your medical oncologist recommends chemotherapy for you, if your tumor is ER+ you will also benefit from up to 10 years of hormonal therapy after chemotherapy. Hormonal therapy is never given during chemotherapy nor during radiation therapy.. What is “Tamoxifen?”. Tamoxifen is an anti-estrogen medication (pills) that has been used with great success with ER+ cancers for three decades. It is now the primary hormonal therapy for younger, pre-menopausal women. It is also the primary drug for men with breast cancer. It is used for some post-menopausal women.. What are “Aromatase Inhibitors?”. Aromatase inhibitors (AIs) are a class of anti-estrogen medications (pills) that have proven to be slightly more effective than Tamoxifen for post-menopausal women. It is not recommended for younger, pre-menopausal women, except in certain circumstances. The three most common versions are Anastrozole (Arimidex), Letrozole (Femara), and Exemestane (Aromasin).. What are the side effects of Hormonal Therapy? Side effects vary greatly from one person to the next for both types of hormonal medications. Some have no symptoms at all. Most have very tolerable side effects. Some patients will need to change hormonal therapy medications to find the best balance of cancer benefit versus side effects. Several side effects that are rather common for both tamoxifen and aromatase inhibitors are hot flashes, night sweats, joint pain, and vaginal dryness. Below, we list some of the other specific side effects for both drugs.. Tamoxifen Side Effects: Increased risk of uterine (endometrial) cancer. Increased risk of developing blood clots. Slows normal bone loss in most women (a “good” side effect). Cannot be taken during pregnancy because of risk of birth defects or fetal death. Can temporarily induce menopause in pre-menopausal women.. . Aromatase Inhibitor Side Effects: Can worsen bone loss (osteoporosis) in women. Muscle and joint aches and pains. . Would an “Oncotype DX” assay help me? Patients who have a small, estrogen receptor positive, HER2 receptor negative tumor, and no evidence of cancer in their lymph nodes may benefit from an Oncotype DX genomic assay. This cutting-edge test looks deeper into your cancer cells to better identify people who may also benefit from chemotherapy with ER+ breast cancers. The decision to undergo chemotherapy, in addition to hormonal therapy, is a complicated one. Your medical oncologist uses many factors to help decide if you will benefit from chemotherapy. An Oncotype DX analysis of a portion of your breast cancer tissue can be instrumental in this decision.
WEDNESDAY, Oct. 15, 2014 (HealthDay News) A Medicare subsidy program makes it more likely that breast cancer patients in all racial and ethnic groups will continue hormone therapy after surgery for their cancer, a new study found. “Patients are more likely to take their medications if they are able to afford them,” said lead author Dr. Alana Biggers, an assistant professor of clinical medicine at.
WEDNESDAY, Oct. 15, 2014 (HealthDay News) A Medicare subsidy program makes it more likely that breast cancer patients in all racial and ethnic groups will continue hormone therapy after surgery for their cancer, a new study found. “Patients are more likely to take their medications if they are able to afford them,” said lead author Dr. Alana Biggers, an assistant professor of clinical medicine at.
WEDNESDAY, Oct. 15, 2014 (HealthDay News) A Medicare subsidy program makes it more likely that breast cancer patients in all racial and ethnic groups will continue hormone therapy after surgery for their cancer, a new study found. “Patients are more likely to take their medications if they are able to afford them,” said lead author Dr. Alana Biggers, an assistant professor of clinical medicine at the University. Alone to treat advanced breast cancer after other hormone drugs (like tamoxifen and often an aromatase inhibitor) have stopped working. In combination with a CDK 4/6 inhibitor or PI3K inhibitor to treat metastatic breast cancer as initial hormone therapy or after other hormone treatments have been tried.
It is given by injections into the buttocks. Symptoms of breast cancer may include a lump in the breast, a change in size or shape of the breast or discharge from a nipple. Breast self-exam and mammography can help find breast cancer early when it is most treatable. Treatment may consist of radiation, lumpectomy, mastectomy, chemotherapy and hormone therapy.” Breast Cancer Resources.
Palbociclib is also approved to be used in combination with fulvestrant for the treatment of women with hormone receptor–positive, HER2-negative advanced or metastatic breast cancer whose cancer has gotten worse after treatment with another hormone therapy. About hormone therapy. Hormone therapy is a form of systemic therapy—a way of administering drugs so they travel throughout the body, rather than being delivered directly to the cancer—that works to add, block or remove hormones from the body to slow or stop the growth of cancer cells.
After surgery, women diagnosed with hormone-receptor-positive breast cancer usually take hormonal therapy medicine to reduce the risk of the cancer coming back (recurrence). Hormonal therapy medicines work in two ways: by lowering the amount of estrogen in the body by blocking the action of estrogen on breast cancer cells. Breast cancer remains one of the most common types of cancer, affecting more than 300,000 new patients each year. While chemotherapy has been used effectively in the past, new studies suggest there may be better ways to combat the disease, avoiding potentially severe or permanent side effects caused by some chemotherapy drugs like Taxotere. Financial Assistance Program.
Helps with treatment-related costs, such as transportation, home care and child care. View available assistance and eligibility guidelines. Learn more Co-Payment Assistance Foundation.
Helps people with cancer overcome financial access and treatment barriers by assisting them with co-payments for their prescribed.
List of related literature:
Hormone replacement therapy and risk of breast cancer with a favorable histology: results of the Iowa Women’s Health Study.
Overall Community Health Advisor (CHA) Project Goals: to impact breast and cervical cancer in AfricanAmerican women in Shelby and Fayette County Tennessee through screening, treatment, and care to reduce breast and cervical cancer incidences and mortality rates.
from AACR 2016: Abstracts 1-2696 by American Association for Cancer Research (AACR) CTI Meeting Technology, 2016
The Women’s Health Initiative (WHI) demonstrated a higher rate of heart disease and breast cancer in women who had estrogen plus progestin therapy (Rossouw et al., 2002).
This program, funded by the Susan G. Komen Foundation and others, uses the mammography van from a local hospital to go to the women who need the service.
Hormone replacement therapy and risk of breast cancer with a favorable histology: results of the Iowa Women’s Health Study.j.A.M.A.
from Journal of the National Cancer Institute: JNCI. by National Cancer Institute (U.S.), National Institutes of Health (U.S.) U.S. Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, 2010
Breast cancer and hormone-replacement therapy in the Million Women Study.
Adjuvant endocrine therapy for women with hormone receptor-positive breast cancer: American Society of Clinical Oncology clinical practice guideline focused update.
Kutluk Oktay, MD, FACOG is one of the world's foremost experts in fertility preservation as well as ovarian stimulation and in vitro fertilization for infertility treatments. He developed and performed the world's first ovarian transplantation procedures as well as pioneered new ovarian stimulation protocols for embryo and oocyte freezing for breast and endometrial cancer patients.
I appreciate the video. I have to say, I’m not sold on it at all. Reducing recurrence by half with all the establishes side effects, paired with the unknown both short and long term. I think there are better gambles out there.
I been diagnosed w HER2 triple positive breast cancer. I have 2 rounds of chemo left out of 6, many months of immunotherapy drugs to do, and I’ll b on hormone therapy for years. I’m also BRCA 1 & 2 negative (thank God), and I’m still trying to do a full hysterectomy and double mastectomy (not at the same time) I’m also switching my eating habits a lot and switched to purified drinking water only. I’m going to do everything I can to not have a reoccurrence of cancer. ❤️
Thank you for these videos. My OC is good but it helps hearing this and knowing it is going correctly. IBC, IDC, cancer with 2lymph nodes involved. I will keep taking that sticking pill for my 10 yrs as I do not want this back
I’m very sorry but after chimo and hormonal therapy my cancer is back right after 1,5 year… my doctor told me…”well it didn’t work for you and we should stop hormonal therapy”… chimo didn’t as well but why they still want me to do chimo again since none of therapies didn’t work for me? First place my cancer was because of my hormones….
This guy has NFI. “Some joint aching” 36%, wow he knows how to minimise what women actually report and experience, ie awful, life altering severe joint pain, bone density loss, arthritis and osteoporosis, fractures, and thinks anybody cares about vaginal dryness in the same category, when AI will give severe chronic pain to a person where before they had none.
I see many people keep on talking about Clegenatur Methods (just search it on google). But I’m not sure if it is good. Have you ever tried using this popular breast enhancement methods?
I’m post menopause and 53 and want to try HCG. HCG levels are 2.6 and estrogen is 0,5 testosterone is also very low. With enough HCG all hormones will be there in the right amount including E2. I only need a doctor who wants to try this on me. Please respond if you are able to do this. Thanks.
IDC 2cm in size. ER+ PR+ HER2.Can mastectomy or any kind of surgery be avoided and just do light chemo or hormone therapy? Thank you so much for your helpful videos
Thank you so much for your excellent videos. I’ve just been diagnosed with invasive ductal carcinoma. You are a Godsend. I’m better prepared for my cancer journey. God bless you.
Dr. You may experience some joint and muscle aching. Female patients, it feels like someone is tearing my muscles off with their fingers and burning me with fire. Funny how the description of this isn’t exactly equal.
I switched to Tamoxifen after 6 weeks on Femara. Femara is an aromatase inhibitor and it nearly did me in with severe and painful side effects. It was much harder on me than chemo. Was on Tamoxifen for 5 years with no adverse effects other than the occasional hot flash.
Does Clegenatur Methods really help to increase breast size naturally by using healthy ways? I have learn a lot of good things about this popular natural breast enhancement.
Thank you so much Doctor. You are very knowledgeable and patient, I enjoy watching your videos and learning a lot, I’m starting my radiation next week, also oral endocrine. You are such an angel, God bless you.
Seems to me we need more women talking about this issue and their voices heard so that more work is done to lessen the side effect of these drugs. They are not mild they can be so bad that we know there is a drop out rate of at least 30% where women are choosing cancer risk instead of taking this “wonder drug”. You’d think there was a strong message in that.
I just start 3 months ago zoladex and anastrazole hate side effects:hit flashes,fatigue, change moods, sleep problems but need to learn to live with that keep cancer away.
Can’t still believe that i got cured from Genital Herpes through herbal treatment from Dr david who I met through the internet, I actually couldn’t believe it at first because it sounded impossible to me knowing how far I have gone just to get rid of it. Dr david send me his medicine which I took as instructed and here I am living a happy life once again, a big thanks to Dr david, I am sure there are many herbal doctors out there but Dr david did it for me, contact him [email protected] com or also whats app him +2347042992115
I’m starting Femara this evening. Picking up the packet this afternoon. I need to get my weight down too. I have 15kgs to lose. HER2+, node negative, 21mm. Mastectomy, three cycles FEC100, nine cycles Taxol, 23 sessions radiotherapy, 18 ongoing cycles Herceptin, and now Femara for five years. I’ve elected for a DIEP reconstruction in June 2019.
I appreciate the video. I have to say, I’m not sold on it at all. Reducing recurrence by half with all the establishes side effects, paired with the unknown both short and long term. I think there are better gambles out there.
I been diagnosed w HER2 triple positive breast cancer. I have 2 rounds of chemo left out of 6, many months of immunotherapy drugs to do, and I’ll b on hormone therapy for years. I’m also BRCA 1 & 2 negative (thank God), and I’m still trying to do a full hysterectomy and double mastectomy (not at the same time) I’m also switching my eating habits a lot and switched to purified drinking water only. I’m going to do everything I can to not have a reoccurrence of cancer. ❤️
Thank you for these videos. My OC is good but it helps hearing this and knowing it is going correctly. IBC, IDC, cancer with 2lymph nodes involved. I will keep taking that sticking pill for my 10 yrs as I do not want this back
I’m very sorry but after chimo and hormonal therapy my cancer is back right after 1,5 year… my doctor told me…”well it didn’t work for you and we should stop hormonal therapy”… chimo didn’t as well but why they still want me to do chimo again since none of therapies didn’t work for me? First place my cancer was because of my hormones….
This guy has NFI. “Some joint aching” 36%, wow he knows how to minimise what women actually report and experience, ie awful, life altering severe joint pain, bone density loss, arthritis and osteoporosis, fractures, and thinks anybody cares about vaginal dryness in the same category, when AI will give severe chronic pain to a person where before they had none.
I see many people keep on talking about Clegenatur Methods (just search it on google). But I’m not sure if it is good. Have you ever tried using this popular breast enhancement methods?
I’m post menopause and 53 and want to try HCG. HCG levels are 2.6 and estrogen is 0,5 testosterone is also very low. With enough HCG all hormones will be there in the right amount including E2. I only need a doctor who wants to try this on me. Please respond if you are able to do this. Thanks.
IDC 2cm in size. ER+ PR+ HER2.Can mastectomy or any kind of surgery be avoided and just do light chemo or hormone therapy? Thank you so much for your helpful videos
I’d rather die than have no estrogen in my body. Personally. It’s every women’s choice. I take a hefty dose of HRT and I will never come off it.
Thank you so much for your excellent videos. I’ve just been diagnosed with invasive ductal carcinoma. You are a Godsend. I’m better prepared for my cancer journey. God bless you.
Dr. You may experience some joint and muscle aching.
Female patients, it feels like someone is tearing my muscles off with their fingers and burning me with fire.
Funny how the description of this isn’t exactly equal.
I would just like to thank you for providing this information to newly diagnosed cancer patients.
It is very complex, and the treatment options can be overwhelming. Your expertise is crucial to patients in making their own decisions. Thank you.
We already know about the joint pain, insomnia and weight gain but could you please address the cognitive impairment caused but these drugs.
I switched to Tamoxifen after 6 weeks on Femara. Femara is an aromatase inhibitor and it nearly did me in with severe and painful side effects. It was much harder on me than chemo. Was on Tamoxifen for 5 years with no adverse effects other than the occasional hot flash.
Does Clegenatur Methods really help to increase breast size naturally by using healthy ways? I have learn a lot of good things about this popular natural breast enhancement.
So do people who have high or low estrogen and progesterone tend to get the progesterone and estrogen receptor positive breast cancer?
Thank you so much Doctor. You are very knowledgeable and patient, I enjoy watching your videos and learning a lot, I’m starting my radiation next week, also oral endocrine. You are such an angel, God bless you.
Seems to me we need more women talking about this issue and their voices heard so that more work is done to lessen the side effect of these drugs. They are not mild they can be so bad that we know there is a drop out rate of at least 30% where women are choosing cancer risk instead of taking this “wonder drug”. You’d think there was a strong message in that.
I just start 3 months ago zoladex and anastrazole hate side effects:hit flashes,fatigue, change moods, sleep problems but need to learn to live with that keep cancer away.
Can’t still believe that i got cured from Genital Herpes through herbal treatment from Dr david who I met through the internet, I actually couldn’t believe it at first because it sounded impossible to me knowing how far I have gone just to get rid of it. Dr david send me his medicine which I took as instructed and here I am living a happy life once again, a big thanks to Dr david, I am sure there are many herbal doctors out there but Dr david did it for me, contact him [email protected] com or also whats app him +2347042992115
I’m starting Femara this evening. Picking up the packet this afternoon. I need to get my weight down too. I have 15kgs to lose. HER2+, node negative, 21mm. Mastectomy, three cycles FEC100, nine cycles Taxol, 23 sessions radiotherapy, 18 ongoing cycles Herceptin, and now Femara for five years. I’ve elected for a DIEP reconstruction in June 2019.