Narcotic Painkiller Use Associated with Depression


Opioid-like non-addictive drug beats depression in clinical trials

Video taken from the channel: News Direct


Study finds ‘strong’ link between depression, opioid use

Video taken from the channel: ANI News Official


Reversing opioids’ depressive effects on breathing

Video taken from the channel: Research Square


“The Comorbidity of Depression, Anxiety, and Opioid Use Disorders” Dean Krahn, MD, MS

Video taken from the channel: UW Department of Family Medicine and Community Health


Opioid Induced Respiratory Depression: New Tools for Risk Assessment

Video taken from the channel: PAINWeek


Opioid dependence & opioid use disorder

Video taken from the channel: Osmosis


Signs of Opioid Withdrawal

Video taken from the channel: Psych Hub Education

They also suggest that opioids are less effective if a person suffers from depression, which can lead to increased use to achieve the desired effect. 6 Researchers recommend that physicians or other medical professionals screen patients for symptoms of depression prior to giving them an opioid prescription. Signs of depression can include: 7. Lack of interest in activities; Depressed mood or. If you take prescription painkillers known as opioids, be careful about how long you use them.

More than 90 days of use may put you at risk of developing opioid depression, according to a new study that adds one more risk to a growing list of negative consequences surrounding opioid use. The study showed that those taking opioids for 90 to 180 days had a 25% increased risk of depression. FRIDAY, Feb. 20, 2015 (HealthDay News) High doses of powerful narcotic painkillers appear to be linked to a higher risk of depression in patients, new research finds.

The study focuses on a class of prescription narcotic painkillers called opioids, which include drugs such as Oxycontin and Vicodin. It is not clear why the long-term use of opioids is linked to a greater risk of depression, but it may have something to do with lowered levels of testosterone, Scherrer said. “We know that chronic. A new study has found that patients who are treated with opioid painkillers for longer than one month face an increased risk of depression. Although pain itself can increase a patient’s risk of depression, researchers found that the link between pain and opioid use was still present even when they accounted for the potential role of pain in causing depression symptoms. Extended abuse of prescription painkillers known as opioids could be responsible for significantly increasing one’s risk of developing opioid-induced depression. In fact, individuals who took these drugs for 90 to 180 days demonstrated an increased risk of depression of 25 percent while those who took the drugs for longer than 180 days exhibited an increased risk of 53 percent.

Opioid depression is something that commonly occurs in patients who take painkillers. When opiate drugs enter the system, they affect the levels of serotonin in the brain. Serotonin is a chemical that can make a person feel extremely happy. When the drug wears off, however, depression can set in, and the person can start to feel depressed.

Opioids may be used by patients with chronic pain and depression to compensate for a reduced endogenous opioid response to stressors. Depressed patients seem to continue opioid use at lower pain intensity levels and higher levels of physical function than do nondepressed patients. Evidence suggests that opioid use can contribute to mental health problems. A 2016 study in the Annals of Family Medicine found that about 10 percent of people prescribed opioids. Depression complicates the management of chronic pain.

10 – 12 Research has shown that patients with depression are more likely to receive COT. 3, 13 – 18 Some evidence suggests that a mental health diagnosis may be a risk factor for opioid misuse. 3, 13, 14, 19 – 22 The association between a mental health diagnosis and opioid misuse may.

List of related literature:

Long term opioid analgesic use is linked to increased risk of depression, study shows.

“The Oxford Handbook of Emotion Dysregulation” by Theodore P. Beauchaine, Sheila E. Crowell, Sheila Elizabeth Crowell
from The Oxford Handbook of Emotion Dysregulation
by Theodore P. Beauchaine, Sheila E. Crowell, Sheila Elizabeth Crowell
Oxford University Press, 2020

Similar effects have also been reported after electroconvulsive therapy (ECT) in depressed patients.

“Stress Consequences: Mental, Neuropsychological and Socioeconomic” by George Fink
from Stress Consequences: Mental, Neuropsychological and Socioeconomic
by George Fink
Elsevier Science, 2010

They may interact with opioid analgesics and cause excessive depression.

“Anesthesia E-Book” by Ronald D. Miller, Lars I. Eriksson, Lee A Fleisher, Jeanine P. Wiener-Kronish, William L. Young
from Anesthesia E-Book
by Ronald D. Miller, Lars I. Eriksson, et. al.
Elsevier Health Sciences, 2009

Since then, numerous studies have been undertaken to examine the role of SAMe in treating depression, osteoarthritis and liver pathology.

“Herbs and Natural Supplements, Volume 2: An Evidence-Based Guide” by Lesley Braun, Marc Cohen
from Herbs and Natural Supplements, Volume 2: An Evidence-Based Guide
by Lesley Braun, Marc Cohen
Elsevier Health Sciences, 2015

Studies have also shown that patients with moderate-to-severe chronic pain are more likely to be severely depressed and are more likely to be taking antidepressant medications and prescription opioids (Uebelacker et al., 2015).

“Palliative Care Nursing: Quality Care to the End of Life” by Marianne Matzo, PhD, APRN-CNP, FPCN, FAAN, Deborah Witt Sherman, PhD, APRN, ANP-BC, ACHPN, FAAN
from Palliative Care Nursing: Quality Care to the End of Life
by Marianne Matzo, PhD, APRN-CNP, FPCN, FAAN, Deborah Witt Sherman, PhD, APRN, ANP-BC, ACHPN, FAAN
Springer Publishing Company, 2018

In recent decades, researchers have experimented with mixed opioid agonist/antagonists such as buprenorphine for the treatment of depression and other psychiatric disorders, encouraged by the decreased liability toward abuse of and dependence on these compounds, compared with full opioid agonists.

“Health & Drugs: Disease, Prescription & Medication” by Nicolae Sfetcu
from Health & Drugs: Disease, Prescription & Medication
by Nicolae Sfetcu
Nicolae Sfetcu, 2014

However, an increasing body of evidence, including in part results from the “global” etanercept study, supports a central role for TNF in the mediation of depression in patients experiencing chronic inflammatory conditions [36–38].

“Biologic and Systemic Agents in Dermatology” by Paul S. Yamauchi
from Biologic and Systemic Agents in Dermatology
by Paul S. Yamauchi
Springer International Publishing, 2018

Of course, either drug could be used to treat the pain even if depression were not present.

“Wall & Melzack's Textbook of Pain E-Book” by Stephen B. McMahon, Martin Koltzenburg, Irene Tracey, Dennis Turk
from Wall & Melzack’s Textbook of Pain E-Book
by Stephen B. McMahon, Martin Koltzenburg, et. al.
Elsevier Health Sciences, 2013

Chronic pain almost always leads to depression, and the use of this drug will prevent depression from occurring.

“Study Guide for Lewis' Medical-Surgical Nursing E-Book: Assessment and Management of Clinical Problems” by Mariann M. Harding, Collin Bowman-Woodall, Jeffrey Kwong, Dottie Roberts, Debra Hagler, Courtney Reinisch
from Study Guide for Lewis’ Medical-Surgical Nursing E-Book: Assessment and Management of Clinical Problems
by Mariann M. Harding, Collin Bowman-Woodall, et. al.
Elsevier Health Sciences, 2019

There is some evidence in support of the use of this drug in pain–depression syndromes as an alternative to tricyclics.

“Handbook of Psychiatric Drug Therapy” by Lawrence A. Labbate, Jerrold F. Rosenbaum
from Handbook of Psychiatric Drug Therapy
by Lawrence A. Labbate, Jerrold F. Rosenbaum
Wolters Kluwer Health/Lippincott Williams & Wilkins, 2010

Oktay Kutluk

Kutluk Oktay, MD, FACOG is one of the world's foremost experts in fertility preservation as well as ovarian stimulation and in vitro fertilization for infertility treatments. He developed and performed the world's first ovarian transplantation procedures as well as pioneered new ovarian stimulation protocols for embryo and oocyte freezing for breast and endometrial cancer patients.

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  • I don’t understand opioid withdrawal for everyone. I was on oxycodone for over 3 years. I had barely any withdrawal symptoms. I just had wrestled leg syndrome for 3 days and found it harder to sleep but once asleep the kicking would wake me up but on day 3 I was perfectly fine and felt much much better more clear headed and my pain was much better. The pills got to the point where they were hurting instead of helping. So I told my doctor and I just quit. I even have over 300 pills left over. I see these videos and feel so lucky.

  • Hi doc. I have been experiencing severe anxiety lately following a hectic hypnogogic jerk from sleep a few weeks ago. Woke up with my spine and muscles feeling constricted like I had no control. Can’t get any sleep and the anxiety has affected my daily life. My question is, are these known side effects of long term use of tramadol? Been on it for 5 years now

  • I always have problems focusing during self study so watching one of your videos on the topic before going through my notes really helps. Thank you so much

  • Day 2 getting clean on percs. Im going cold turkey…. Body aches are so bad i slept for 18 hours yesterday because i cant handle being awake to feel the pain and chills and headache. Pretty sure all the pills i did were laced with herion or fentanyl thats why im coming down so bad. Prayers to everybody going thru this we can do it your not alone

  • What alternative treatments do you recommend when the NSAIDS have started eating your GI tract and liver or kidneys. Exercise can cause more damage. Some alternative therapies are just too expensive for many. No one has really studied chronic pain treatment, so it is mainly speculation as to what works. Most of this was good, but the DSM guide gets changed for political reasons and to get insurance to pay for treatments, I find much of it suspect. Not all that long ago a woman could be involentarily put in a mental institution for menopause symptoms. There is big money to be made by labeling all chronic pain patients as addicts. The recovery business is booming and what better way to make more money and bilk insurance than to change the definition of substance use disorder.

  • It’s bullshit. Opiate withdrawal CAN BE DEADLY. My friend ended up in ER twice, the third day of withdrawal, dying. Her kidneys stopped because she lost too much liquid from throwing up every 3 hours.

  • I am having a brain fog, some pressure and a brain fog, I have been on oxy for 8 years last year only in am, now after dropping to 1.25 MGS in am having my head feel like I’m dizzy is it possible

  • Just got over the worst withdrawals of my life. All the stuff out there now is laced with Fentanyl which is 50+ times more potent than Heroin. I just kicked a 10 year long habit. I almost died. Dry heave so bad I was puking blood and bile. Fever, chills felt like my frail body was laying over slabs of ice. Felt like 1000 knives being stabbed through my entire body. Cravings so bad I was literally shaking with convulsions. Ambulance came just in time as I was choking on my own puke. Don’t ever ever ever EVERRRRRRRRRRRR get involved with smack.

  • I’m trying to quit I haven’t been it on year+ so I’m hopeful and thankful that it will be faster for me to heal my stomach is the one thing that is problematic right now I either have diarrhea or I start to throw up or I feel nauseous or if my stomach hurts that bad it triggers me throwing up and if you’re thinking about doing it DONT!!!! It’s not worth your health I promise you

  • I have a question. Kaplan pharmacology says opioid-induced respiratory depression is treated by naloxone and should not be treated with oxygen because the patient has little response to pCO2. Is that right? Thanks: )

  • Great videos, Osmosis! Can you do a video on ehlers danlos? And how the genetic condition causes opioids and anesthetics unable to work

  • This is really helpfulll and your all other videos too,the way you describe everything make every topic so easy to understand and intersting.Thanks:)

  • I have been prescribed by a Dr now I’m stop taking them its 4 o’clock in the morning I can’t sleep I have pain absolutely every where in my body I feel I have been hited by a car

  • When you live in chronic pain daily, and can’t move. Acetaminophen and NSAIDS may as well be tic-tacs. Acetaminophen is toxic for the liver and NSAIDS can cause inflammation of the stomach. I had to stop taking ibuprofen, because I had abdominal pain from inflamed bowels.

    Tapering off of opioids just means you’re condemning the patient to a life of pain, with no relief.

    Chronic pain patients don’t look for a high. They just want to function.

  • There are also the physical effects of taking drugs such as infections from dirty needles, breathing difficulties from smoking, and choking caused by vomiting.

  • Med students: I declined spinal anesthesia while in active labor, they gave me morphine, it was not helpful at all & it just left me constipated…ask your teacher’s why codeine isn’t used

  • theres an error in the video, inhalation is a faster way to stimulate the brains chemical reactions through drug use, injection is 2nd because it takes longer for the drug to circulate to the brain whereas when you inhale it the chemicals have a more direct route to the brain.

  • I don’t drink or smoke. I don’t use any drug. But I’m going to speak for everyone how was called Crack-Head and for the 1,000,000 people put in prison during  the War-on-Drugs…………Bah ahahhahahahhhahahh!!!!!!

  • Opiates cause oxygen deprivation, that causes organ damage. The withdrawal fever coocks your brain, and dehydrates you. �� After quitting, exercise helps oxygenation. But u never the same again

  • Tolerance is a “Nice” way of saying addiction! I was prescribed 450mg a day for many failed back surgeries, NONE of your information is going to help myself nor other chronic pain SUFFERS!