Narcotic Painkiller Use Associated with Depression


Opioid-like non-addictive drug beats depression in clinical trials

Video taken from the channel: News Direct


Study finds ‘strong’ link between depression, opioid use

Video taken from the channel: ANI News Official


Reversing opioids’ depressive effects on breathing

Video taken from the channel: Research Square


“The Comorbidity of Depression, Anxiety, and Opioid Use Disorders” Dean Krahn, MD, MS

Video taken from the channel: UW Department of Family Medicine and Community Health


Opioid Induced Respiratory Depression: New Tools for Risk Assessment

Video taken from the channel: PAINWeek


Opioid dependence & opioid use disorder

Video taken from the channel: Osmosis


Signs of Opioid Withdrawal

Video taken from the channel: Psych Hub Education

They also suggest that opioids are less effective if a person suffers from depression, which can lead to increased use to achieve the desired effect. 6 Researchers recommend that physicians or other medical professionals screen patients for symptoms of depression prior to giving them an opioid prescription. Signs of depression can include: 7. Lack of interest in activities; Depressed mood or. If you take prescription painkillers known as opioids, be careful about how long you use them.

More than 90 days of use may put you at risk of developing opioid depression, according to a new study that adds one more risk to a growing list of negative consequences surrounding opioid use. The study showed that those taking opioids for 90 to 180 days had a 25% increased risk of depression. FRIDAY, Feb. 20, 2015 (HealthDay News) High doses of powerful narcotic painkillers appear to be linked to a higher risk of depression in patients, new research finds.

The study focuses on a class of prescription narcotic painkillers called opioids, which include drugs such as Oxycontin and Vicodin. It is not clear why the long-term use of opioids is linked to a greater risk of depression, but it may have something to do with lowered levels of testosterone, Scherrer said. “We know that chronic. A new study has found that patients who are treated with opioid painkillers for longer than one month face an increased risk of depression. Although pain itself can increase a patient’s risk of depression, researchers found that the link between pain and opioid use was still present even when they accounted for the potential role of pain in causing depression symptoms. Extended abuse of prescription painkillers known as opioids could be responsible for significantly increasing one’s risk of developing opioid-induced depression. In fact, individuals who took these drugs for 90 to 180 days demonstrated an increased risk of depression of 25 percent while those who took the drugs for longer than 180 days exhibited an increased risk of 53 percent.

Opioid depression is something that commonly occurs in patients who take painkillers. When opiate drugs enter the system, they affect the levels of serotonin in the brain. Serotonin is a chemical that can make a person feel extremely happy. When the drug wears off, however, depression can set in, and the person can start to feel depressed.

Opioids may be used by patients with chronic pain and depression to compensate for a reduced endogenous opioid response to stressors. Depressed patients seem to continue opioid use at lower pain intensity levels and higher levels of physical function than do nondepressed patients. Evidence suggests that opioid use can contribute to mental health problems. A 2016 study in the Annals of Family Medicine found that about 10 percent of people prescribed opioids. Depression complicates the management of chronic pain.

10 – 12 Research has shown that patients with depression are more likely to receive COT. 3, 13 – 18 Some evidence suggests that a mental health diagnosis may be a risk factor for opioid misuse. 3, 13, 14, 19 – 22 The association between a mental health diagnosis and opioid misuse may.

List of related literature:

Long term opioid analgesic use is linked to increased risk of depression, study shows.

“The Oxford Handbook of Emotion Dysregulation” by Theodore P. Beauchaine, Sheila E. Crowell, Sheila Elizabeth Crowell
from The Oxford Handbook of Emotion Dysregulation
by Theodore P. Beauchaine, Sheila E. Crowell, Sheila Elizabeth Crowell
Oxford University Press, 2020

Similar effects have also been reported after electroconvulsive therapy (ECT) in depressed patients.

“Stress Consequences: Mental, Neuropsychological and Socioeconomic” by George Fink
from Stress Consequences: Mental, Neuropsychological and Socioeconomic
by George Fink
Elsevier Science, 2010

They may interact with opioid analgesics and cause excessive depression.

“Anesthesia E-Book” by Ronald D. Miller, Lars I. Eriksson, Lee A Fleisher, Jeanine P. Wiener-Kronish, William L. Young
from Anesthesia E-Book
by Ronald D. Miller, Lars I. Eriksson, et. al.
Elsevier Health Sciences, 2009

Since then, numerous studies have been undertaken to examine the role of SAMe in treating depression, osteoarthritis and liver pathology.

“Herbs and Natural Supplements, Volume 2: An Evidence-Based Guide” by Lesley Braun, Marc Cohen
from Herbs and Natural Supplements, Volume 2: An Evidence-Based Guide
by Lesley Braun, Marc Cohen
Elsevier Health Sciences, 2015

Studies have also shown that patients with moderate-to-severe chronic pain are more likely to be severely depressed and are more likely to be taking antidepressant medications and prescription opioids (Uebelacker et al., 2015).

“Palliative Care Nursing: Quality Care to the End of Life” by Marianne Matzo, PhD, APRN-CNP, FPCN, FAAN, Deborah Witt Sherman, PhD, APRN, ANP-BC, ACHPN, FAAN
from Palliative Care Nursing: Quality Care to the End of Life
by Marianne Matzo, PhD, APRN-CNP, FPCN, FAAN, Deborah Witt Sherman, PhD, APRN, ANP-BC, ACHPN, FAAN
Springer Publishing Company, 2018

In recent decades, researchers have experimented with mixed opioid agonist/antagonists such as buprenorphine for the treatment of depression and other psychiatric disorders, encouraged by the decreased liability toward abuse of and dependence on these compounds, compared with full opioid agonists.

“Health & Drugs: Disease, Prescription & Medication” by Nicolae Sfetcu
from Health & Drugs: Disease, Prescription & Medication
by Nicolae Sfetcu
Nicolae Sfetcu, 2014

However, an increasing body of evidence, including in part results from the “global” etanercept study, supports a central role for TNF in the mediation of depression in patients experiencing chronic inflammatory conditions [36–38].

“Biologic and Systemic Agents in Dermatology” by Paul S. Yamauchi
from Biologic and Systemic Agents in Dermatology
by Paul S. Yamauchi
Springer International Publishing, 2018

Of course, either drug could be used to treat the pain even if depression were not present.

“Wall & Melzack's Textbook of Pain E-Book” by Stephen B. McMahon, Martin Koltzenburg, Irene Tracey, Dennis Turk
from Wall & Melzack’s Textbook of Pain E-Book
by Stephen B. McMahon, Martin Koltzenburg, et. al.
Elsevier Health Sciences, 2013

Chronic pain almost always leads to depression, and the use of this drug will prevent depression from occurring.

“Study Guide for Lewis' Medical-Surgical Nursing E-Book: Assessment and Management of Clinical Problems” by Mariann M. Harding, Collin Bowman-Woodall, Jeffrey Kwong, Dottie Roberts, Debra Hagler, Courtney Reinisch
from Study Guide for Lewis’ Medical-Surgical Nursing E-Book: Assessment and Management of Clinical Problems
by Mariann M. Harding, Collin Bowman-Woodall, et. al.
Elsevier Health Sciences, 2019

There is some evidence in support of the use of this drug in pain–depression syndromes as an alternative to tricyclics.

“Handbook of Psychiatric Drug Therapy” by Lawrence A. Labbate, Jerrold F. Rosenbaum
from Handbook of Psychiatric Drug Therapy
by Lawrence A. Labbate, Jerrold F. Rosenbaum
Wolters Kluwer Health/Lippincott Williams & Wilkins, 2010

Oktay Kutluk

Kutluk Oktay, MD, FACOG is one of the world's foremost experts in fertility preservation as well as ovarian stimulation and in vitro fertilization for infertility treatments. He developed and performed the world's first ovarian transplantation procedures as well as pioneered new ovarian stimulation protocols for embryo and oocyte freezing for breast and endometrial cancer patients.

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  • I don’t understand opioid withdrawal for everyone. I was on oxycodone for over 3 years. I had barely any withdrawal symptoms. I just had wrestled leg syndrome for 3 days and found it harder to sleep but once asleep the kicking would wake me up but on day 3 I was perfectly fine and felt much much better more clear headed and my pain was much better. The pills got to the point where they were hurting instead of helping. So I told my doctor and I just quit. I even have over 300 pills left over. I see these videos and feel so lucky.

  • Hi doc. I have been experiencing severe anxiety lately following a hectic hypnogogic jerk from sleep a few weeks ago. Woke up with my spine and muscles feeling constricted like I had no control. Can’t get any sleep and the anxiety has affected my daily life. My question is, are these known side effects of long term use of tramadol? Been on it for 5 years now

  • I always have problems focusing during self study so watching one of your videos on the topic before going through my notes really helps. Thank you so much

  • Day 2 getting clean on percs. Im going cold turkey…. Body aches are so bad i slept for 18 hours yesterday because i cant handle being awake to feel the pain and chills and headache. Pretty sure all the pills i did were laced with herion or fentanyl thats why im coming down so bad. Prayers to everybody going thru this we can do it your not alone

  • What alternative treatments do you recommend when the NSAIDS have started eating your GI tract and liver or kidneys. Exercise can cause more damage. Some alternative therapies are just too expensive for many. No one has really studied chronic pain treatment, so it is mainly speculation as to what works. Most of this was good, but the DSM guide gets changed for political reasons and to get insurance to pay for treatments, I find much of it suspect. Not all that long ago a woman could be involentarily put in a mental institution for menopause symptoms. There is big money to be made by labeling all chronic pain patients as addicts. The recovery business is booming and what better way to make more money and bilk insurance than to change the definition of substance use disorder.

  • It’s bullshit. Opiate withdrawal CAN BE DEADLY. My friend ended up in ER twice, the third day of withdrawal, dying. Her kidneys stopped because she lost too much liquid from throwing up every 3 hours.

  • I am having a brain fog, some pressure and a brain fog, I have been on oxy for 8 years last year only in am, now after dropping to 1.25 MGS in am having my head feel like I’m dizzy is it possible

  • Just got over the worst withdrawals of my life. All the stuff out there now is laced with Fentanyl which is 50+ times more potent than Heroin. I just kicked a 10 year long habit. I almost died. Dry heave so bad I was puking blood and bile. Fever, chills felt like my frail body was laying over slabs of ice. Felt like 1000 knives being stabbed through my entire body. Cravings so bad I was literally shaking with convulsions. Ambulance came just in time as I was choking on my own puke. Don’t ever ever ever EVERRRRRRRRRRRR get involved with smack.

  • I’m trying to quit I haven’t been it on year+ so I’m hopeful and thankful that it will be faster for me to heal my stomach is the one thing that is problematic right now I either have diarrhea or I start to throw up or I feel nauseous or if my stomach hurts that bad it triggers me throwing up and if you’re thinking about doing it DONT!!!! It’s not worth your health I promise you

  • I have a question. Kaplan pharmacology says opioid-induced respiratory depression is treated by naloxone and should not be treated with oxygen because the patient has little response to pCO2. Is that right? Thanks: )

  • Great videos, Osmosis! Can you do a video on ehlers danlos? And how the genetic condition causes opioids and anesthetics unable to work

  • This is really helpfulll and your all other videos too,the way you describe everything make every topic so easy to understand and intersting.Thanks:)

  • I have been prescribed by a Dr now I’m stop taking them its 4 o’clock in the morning I can’t sleep I have pain absolutely every where in my body I feel I have been hited by a car

  • When you live in chronic pain daily, and can’t move. Acetaminophen and NSAIDS may as well be tic-tacs. Acetaminophen is toxic for the liver and NSAIDS can cause inflammation of the stomach. I had to stop taking ibuprofen, because I had abdominal pain from inflamed bowels.

    Tapering off of opioids just means you’re condemning the patient to a life of pain, with no relief.

    Chronic pain patients don’t look for a high. They just want to function.

  • There are also the physical effects of taking drugs such as infections from dirty needles, breathing difficulties from smoking, and choking caused by vomiting.

  • Med students: I declined spinal anesthesia while in active labor, they gave me morphine, it was not helpful at all & it just left me constipated…ask your teacher’s why codeine isn’t used

  • theres an error in the video, inhalation is a faster way to stimulate the brains chemical reactions through drug use, injection is 2nd because it takes longer for the drug to circulate to the brain whereas when you inhale it the chemicals have a more direct route to the brain.

  • I don’t drink or smoke. I don’t use any drug. But I’m going to speak for everyone how was called Crack-Head and for the 1,000,000 people put in prison during  the War-on-Drugs…………Bah ahahhahahahhhahahh!!!!!!

  • Opiates cause oxygen deprivation, that causes organ damage. The withdrawal fever coocks your brain, and dehydrates you. �� After quitting, exercise helps oxygenation. But u never the same again

  • Tolerance is a “Nice” way of saying addiction! I was prescribed 450mg a day for many failed back surgeries, NONE of your information is going to help myself nor other chronic pain SUFFERS!

  • wait….but then… why didnt patient gain dependence to methadone and buprenorphine eventhough it act just like opioid? this is so complicated

  • I’ve lived with pain constantly  since  1994. started with a popped disc, c6 c7 fused. I’ve had to add both knees and lower and mid back. my left elbow was relocated to my left shoulder, now my left hand is hyper sensitive, warn is hot, cool is freezing.I have a hard time finding my meds, I do not expect a high, just slight relief. I hope every politician including  trump ends up in agony with no relief, just like me. the assholes deserve it.

  • To my own demise I tried meth the day after i ran out of opiates. withdraw got thrown in hyperdrive. It was like having the flu along with the worst panic attack that didnt stop. I finally slept and ate for the first time 3 days later. I would rather catch the plague than to ever have to go through that again.

  • Opioids work very well for many types of chronic pain.You should consider doing more research.Seriously what do you think dr.s were doing prescribing opioids for atrotious diseases?Try redoing that part of your video.IT IS A GOOD VIDEO

  • Currently on to day 6 of what has to be my 6th or 7th attempt at getting clean, My situation speaks to how strong withdrawal can be because for the past 3 months i have been quitting for around the first 5 or 6 days before using again, and today is one of the hardest days i have experienced. I kept a diary (and i would suggest doing the same) and in it is all my thoughts and feelings both prior to using again and also about the guilt i felt afterwards, the disappointment etc. To help me stay strong, i read these entries all the while trying to avoid going to the shop to get more.
    This is the hardest thing some people will experience in a long time, but you can get through it with support from friends and family, but honestly try keeping a journal about your journey and use it to empower your decisions. Good luck


  • I’m using sleeping pills from long time now I quite it and I’m feeling like shivering and sleepless nights and sometimes felt bloating too… Feeling like nervous…. But I want to quite it anyhow with taking help of other drug

  • Would you rather spend the after life in Heaven with all the puffy clouds and harps and Angels but be in full opiate withdrawal or be in that other place down below with the caves and kettles and devils but be completely normal physically and mentally and comfortable enough to deal with all the heat and stuff? Im really not sure what I would choose that is how bad withdrawal is for me:( if there is such a place as ” hell on earth ” its opiate withdrawal!! Ive been on suboxone for 8 years and im terrified of the withdrawal!

  • Wait, Let’s get back to the reason I ask my Doctor for something stronger than Tylenol. PAIN! If I did not have Pain from Osteoartheritus in my joints and Lower Back, I wouldn’t be taking Hydrocodon-Acetaminoph or any other Opioid.

  • According to all the information I gathered, inhalation is a faster route of administration than IV when it comes to psychoactive substances. One source I can quote from the top of my head is prof. David Presti from Berkley.

    Would be great if you could verify this information and, if I’m right, correct this part.

    Apart from that a wonderful and well-made video!

  • Been taking them for years past 6 months 10 a day today I ran out of it before my next cycle and can’t go to dr won’t give me so now I have to live with it for 2 weeks but if I make it for 2 weeks I’m not planning to go back yesterday night I took some this morning didn’t have and I’m craving it now need to stop and if I make it for 2 weeks I’m done don’t wanna have this feeling again yes they make me happy feel good but it’s all temporary so now if I can quit for 2 weeks I won’t start again I really don’t wanna go through any withdraws again this morning as I’m typing I’m sweating I’m cold all feelings in the same time I feel confused I can feel it in my blood that I want it I started with 1 then 2 then3 then 4 I started taking 5 to 6 in the morning and 4 in the evening and keeps going up and up I hope I can make it for 2 weeks with no bad withdraw or emergency will see wish you all luck and wish me luck

  • very useful information thanks. can anybody tell me if someone is addicted to opioid and trying to stop how long will it take for withdrawing to ease off or disappear? thank you.

  • they ought to outlaw all opiates and arrest all chronic pain patients and doctors who prescribe these powerful addicting drugs! t is the same as heroin!! take naproxen or ibuprofen or try to use bio feedback, thinking positive thoughts physical therapy ect people can’t really be in that much pain sooner or later chronic pain gets better right? if you take these drugs you will die cause my brothers cousins nieces aunt died!! she was in the hospital for pneumonia and they gave her 15 mg,s of morphine’dope” and three weeks later she died! from opiate overdose said the coroner!! I am a law enforcement officer and i’ll bust everybody on pain killers! i will never take on of them hardcore prescription opioid drugs even for surgery! if you take this legal heroin you are an addict!! and if you take even one pill you will die! you can’t tell if the pharmacy pills have hydrocodone or heroin in them I have heardon T.V. news!

  • Im writing an essay and would like to use this as my reference, however, my uni does not give good marks for video references. May i know what research or study u used for your video? Thanks. Are there such thing as peer reviewed videos? Thanks

  • Thanks Osmosis! I recently weened off Tapentadol (palexia) which was really rough. I was on the drug for 10 months. I’m doing better now, however.

    COULD YOU PLEASE DO A VIDEO ON SEROTONIN SYNDROME! I suffered from this a year ago after perhaps ODing on a SSRI drug (even though i was on a small dosage). A video on this topic would be greatly appreciated.

  • Isn’t the decreased perception of pain mediated by inhibition of inhibitory neurons in regions of the brain like the periaqueductal gray and therefore increased serotonergic activity from the Raphe nuclei not by dopaminergic neurotransmission?

  • Amazing! Love the speed, clarity, and helpful visuals. Much more detail than KhanAcademy in less time. These videos are helping me so much for the MCATs and for my internship at the hospital.

  • Since the major projection of dopaminergic neurons in the reward system is the mesolimbic pathway, does that mean ΔFosB is also similarly induced thereby causing desensitization from repeated drug challenge?

  • I have been so impressed in the past with your product this one however is beyond absurd I would suggest not doing such a video if you cannot maintain your standard you do not have to make any “social scientific” statement just do not go near the subject to begin with. The science and chemistry “suddenly becomes ambiguous” is tragic in this video you actually sound like one of those silly drug commercials with happy smiling people while the narrator speaks of organ destruction and suicidal side effects……… unless the Sacklers pay you directly…. get back to being you please.

  • Osmosis, If you guys expect to have subscribers from Non-English Speaking Backgrounds such as China, India, France, Brazil, for god sake can you make these videos with little less talking speed? I think Khan Academy has understood this point now, but not you guys. Thanks.

  • Whoah the animations on this video are amazing, I just uploaded a video on Caffeine on my channel, check it out if you’re interested!

  • Oh sometimes its just not that complex. An opioid with a benzo is enough for respiratory depression or death. A benzo and a z-drug.