Liquid Biopsy Might Help Doctors Track Alterations in Tumors

 

Liquid biopsy: Mayo Clinic Radio

Video taken from the channel: Mayo Clinic


 

‘Liquid biopsy’ may help earlier detection of lung cancer treatment resistance

Video taken from the channel: ecancer


 

Liquid Biopsies Could Transform Cancer Care

Video taken from the channel: Associated Press


 

Liquid biopsy may help guide treatment decisions for advanced solid tumours

Video taken from the channel: ecancer


 

Liquid Biopsy Promotes Precision Medicine By Tracking Patient’s Cancer

Video taken from the channel: Mayo Clinic


 

How a Liquid Biopsy Changes Cancer Treatment

Video taken from the channel: Fox5NY


 

Tracking cancer with a blood test

Video taken from the channel: Cancer Research UK


Liquid biopsies provide valuable information for doctors using targeted therapies to treat cancer, Mack said, because they detect when tumors are developing resistance to a particular therapy. Liquid biopsies provide valuable information for doctors using targeted therapies to treat cancer, Mack said, because they detect when tumors are developing resistance to a particular therapy. Tumors develop resistance “through the acquisition of new mutations that allow it to circumvent or otherwise ignore a therapeutic option,” Mack said. Liquid biopsy provides an easier way to keep track of treatment. “You can get a blood draw basically at any time, so you can really monitor the progression of a patient’s tumor.

Liquid biopsies provide valuable information for doctors using targeted therapies to treat cancer, Mack said, because they detect when tumors are developing resistance to a particular therapy. Tumors develop resistance “through the acquisition of new mutations that allow it to circumvent or otherwise ignore a therapeutic option,” Mack said. Liquid Biopsy May Help Doctors Track Changes in Tumors.

SATURDAY, June 4, 2016 (HealthDay News) Biopsies can be arduous and painful for cancer patients, but necessary to accurately diagnose the disease and determine the best course of treatment. Now, researchers report that a new blood-based “liquid biopsy” could be a groundbreaking alternative. A liquid biopsy may help determine treatment options as cancer evolves. A team of researchers from the Mayo Clinic Cancer Center and the Translational Genomics Research Institute (TGen) has reported that analyzing circulating tumor DNA (ctDNA) can track how a patient’s cancer.

Liquid biopsies may also help doctors understand what kind of molecular changes are taking place in a tumor, helping them to adequately respond and changed therapies if required. Real-time detection With the onset of novel, targeted and personalized treatment options, it is important that physicians can rapidly detecting responses to these therapies. Liquid biopsies may not detect all of the mutations present in any given cancer. As noted above, tumor biopsy can facilitate mutation discovery making possible a higher sensitivity due to less multiple hypothesis testing.

3. Provide a more complete picture of a cancer’s genetics. First, a tissue biopsy could be used to identify unique biomarkers for an individual’s tumor, he explained, and then liquid biopsy tests could be used to track those biomarkers. Another limitation is that ctDNA in the blood may not be truly representative of DNA in the actual tumor, and, therefore, may not be the best source of information for guiding clinical decisions.

Starting September 2014, Jefferson will offer patients this new diagnostic blood test, often called a “liquid biopsy” or circulating-tumor-cell (CTC) count, to detect cancer cells that have been shed or are actively moving from one site to another into the bloodstream.

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The principle supporting liquid biopsy is based on repeated findings that tumors shed molecules and cells into bodily fluids (particularly blood).

“Mosby's Diagnostic and Laboratory Test Reference E-Book” by Kathleen Deska Pagana, Timothy J. Pagana, Theresa N Pagana
from Mosby’s Diagnostic and Laboratory Test Reference E-Book
by Kathleen Deska Pagana, Timothy J. Pagana, Theresa N Pagana
Elsevier Health Sciences, 2018

A liquid biopsy is from cancer-derived components that circulate in the bloodstream and consists of the detection and isolation of circulating tumor cells, circulating tumor DNA, and exosomes.

“Understanding Pathophysiology E-Book” by Sue E. Huether, Kathryn L. McCance
from Understanding Pathophysiology E-Book
by Sue E. Huether, Kathryn L. McCance
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It is hoped that liquid biopsies may eventually be able to detect cancer before other symptoms appear.

“Molecular Pathology: The Molecular Basis of Human Disease” by William B. Coleman, Gregory J. Tsongalis
from Molecular Pathology: The Molecular Basis of Human Disease
by William B. Coleman, Gregory J. Tsongalis
Elsevier Science, 2017

Liquid Biopsy It is the diagnostic test to detect the cancer biomarkers in the body fluids, especially the blood; the procedure is also called “fluid biopsy” or “fluid phase” biopsy.

“Essentials of Oral Pathology” by Swapan Kumar Purkait
from Essentials of Oral Pathology
by Swapan Kumar Purkait
Jaypee Brothers,Medical Publishers Pvt. Limited, 2019

Liquid biopsy is becoming a common alternative approach to perform molecular analysis, because it is less invasive that tumor biopsy and it is easily repeatable, cost-effective, and rapidly gives information to the physician who guides decision making for therapeutic strategy [34,35].

“Advances in Molecular Pathology, E-Book 2019” by Gregory J. Tsongalis
from Advances in Molecular Pathology, E-Book 2019
by Gregory J. Tsongalis
Elsevier Health Sciences, 2019

As liquid biopsies become better validated, they may replace some tumor biopsies.

“Principles and Applications of Molecular Diagnostics” by Nader Rifai, A. Rita Horvath, Carl T. Wittwer, Jason Park
from Principles and Applications of Molecular Diagnostics
by Nader Rifai, A. Rita Horvath, et. al.
Elsevier Science, 2018

A liquid biopsy offers what tissue biopsies cannot—a continuous monitoring of tumor-specific changes during the entire course of the disease.

“Advances in Clinical Chemistry” by Gregory S. Makowski
from Advances in Clinical Chemistry
by Gregory S. Makowski
Elsevier Science, 2017

However, only recently have technologies been available to detect and retrieve these rare cells from the circulation, thereby offering a “liquid biopsy” of the tumor.

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from Yamada’s Textbook of Gastroenterology
by Daniel K. Podolsky, Michael Camilleri, et. al.
Wiley, 2015

If the lump is filled with liquid (which is usually a sign of a harmless cyst), the fluid may be sent to a laboratory, where a pathologist uses a microscope to look for any abnormal cells.

“The Harvard Medical School Family Health Guide” by Anthony L. Komaroff, Harvard Medical School
from The Harvard Medical School Family Health Guide
by Anthony L. Komaroff, Harvard Medical School
Simon & Schuster, 1999

While this was formerly discouraged, in many series biopsies of solid tumors are now felt to be safe and useful for guiding treatment decisions.

“Fischer's Mastery of Surgery” by Josef Fischer
from Fischer’s Mastery of Surgery
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Wolters Kluwer Health, 2018

Oktay Kutluk

Kutluk Oktay, MD, FACOG is one of the world's foremost experts in fertility preservation as well as ovarian stimulation and in vitro fertilization for infertility treatments. He developed and performed the world's first ovarian transplantation procedures as well as pioneered new ovarian stimulation protocols for embryo and oocyte freezing for breast and endometrial cancer patients.

Mail: [email protected]
Telephone: +1 (877) 492-3666

Biography: https://medicine.yale.edu/profile/kutluk_oktay/
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  • Ian here in rutland Vermont with one urologist I told him I didn’t want a tissue biopsy yet where. In VT can I get one liquid biopsy done