How Effective Are Antidepressants in youngsters, Teens

 

Warnings about teens and antidepressants may have backfired

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Are Antidepressants Effective for Children?

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Kids on Antidepressants – The alarming side-effects parents aren’t told about.

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Antidepressants and Autism Adolescents

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Treating Depression in Children and Adolescents

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Are antidepressants ineffective for teens?

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Adolescent Depression

Video taken from the channel: National Institute of Mental Health (NIMH)


WEDNESDAY, June 8, 2016 (HealthDay News)—Treating children and teens suffering from depression with antidepressants may be both ineffective and potentially dangerous, a new analysis suggests. Of the 14 antidepressants studied, only fluoxetine (Prozac) was more effective in treating depression than an inactive placebo in children and teens, the review found. A new finding. Recent research from England reports that depressed children and teens taking antidepressants thought about or attempted suicide more often than those not taking these drugs.

In response to this report, the FDA reviewed the results of 24 research studies of children and teens. Of the 14 antidepressants studied, only fluoxetine (Prozac) was more effective in treating depression than an inactive placebo in children and teen. The only effective antidepressant for children and adolescents with major depression, the researchers said, is fluoxetine, sold under the brand names Prozac and Sarafem.

A Word From Verywell. In general, antidepressants are safe and effective to treat depression and anxiety in children and teenagers, especially when combined with psychotherapy. 6  Also, keep in mind that antidepressant use is often temporary and may just be needed for a short time. The most prescribed antidepressants are reuptake inhibitors. These medications for teenage depression prevent neurotransmitters from being absorbed back into the nerve cells in the brain.

The theory is that keeping levels of the neurotransmitters higher. Most antidepressants on the market are ineffective for children and teens with major depressive disorder, and some may be unsafe for young patients, according to. Atypical antidepressants: These antidepressants (including Wellbutrin, Cymbalta, and Effexor) have fewer side effects and are generally better tolerated by younger patients. Pros of medication.

For many teens, antidepressants combined with psychotherapy are an effective way to treat depression. Antidepressants can help teens in the following way. T he vast majority of antidepressants given to kids and teens are ineffective and potentially dangerous, according to a new study in The Lancet.

Antidepressants May Be Ineffective for Children and Teens A new study suggests that most commonly prescribed drugs may not be the answer for adolescents suffering with major depression. By Kaelyn Riley| June 29, 2016 Oxford University researchers have found that the majority of antidepressants are ineffective for children and teens.

List of related literature:

Use in children and teenagers: Antidepressants should be used cautiously in children and teenagers, because about 1 out of 50 children report suicidal ideation as a result of SSRI treatment.

“Pharmacology” by Michelle A. Clark, Richard A. Harvey, Richard Finkel, Jose A. Rey, Karen Whalen
from Pharmacology
by Michelle A. Clark, Richard A. Harvey, et. al.
Wolters Kluwer Health, 2011

Use in children and teenagers: Antidepressants should be used cautiously in children and teenagers, because about 1 out of 50 children becomes more suicidal as a result of SSRI treatment.

“Pharmacology” by Richard Finkel (PharmD.), Michelle Alexia Clark, Luigi X. Cubeddu
from Pharmacology
by Richard Finkel (PharmD.), Michelle Alexia Clark, Luigi X. Cubeddu
Lippincott Williams & Wilkins, 2009

Based on data from clinical trials, fluoxetine, at doses ranging from 20 to 40 mg, and escitalopram, at doses ranging from 20 to 40 mg, do appear to have efficacy in the treatment of pediatric depression, with the majority of controlled studies demonstrating positive results.

“Berman's Pediatric Decision Making E-Book” by Lalit Bajaj, Simon Hambidge, Ann-Christine Nyquist, Gwendolyn Kerby
from Berman’s Pediatric Decision Making E-Book
by Lalit Bajaj, Simon Hambidge, et. al.
Elsevier Health Sciences, 2011

The clinical consensus is that SSRIs are clearly beneficial for children with anxiety disorders, and probably beneficial for children with depression, but monitoring for suicidal ideation is important, especially during the first few weeks of treatment.

“The American Psychiatric Association Publishing Textbook of Psychiatry, Seventh Edition” by Laura Weiss Roberts, M.D., M.A.
from The American Psychiatric Association Publishing Textbook of Psychiatry, Seventh Edition
by Laura Weiss Roberts, M.D., M.A.
American Psychiatric Association Publishing, 2019

Because children have been shown to have high placebo response rates in depression studies, open studies with other antidepressants provide little information about the efficacy of these agents in youths.

“Treating and Preventing Adolescent Mental Health Disorders: What We Know and What We Don't Know” by Dwight L. Evans M.D., Edna B. Foa Ph.D., Raquel E. Gur M.D., Ph.D., Herbert Hendin M.D., Charles P. O'Brien M.D., Ph.D., Martin E. P. Seligman Ph.D., B. Timothy Walsh M.D.
from Treating and Preventing Adolescent Mental Health Disorders: What We Know and What We Don’t Know
by Dwight L. Evans M.D., Edna B. Foa Ph.D., et. al.
Oxford University Press, 2005

The best studied antidepressants in children and adolescents are the SSRI class of antidepressants.

“Handbook of Australian School Psychology: Integrating International Research, Practice, and Policy” by Monica Thielking, Mark D. Terjesen
from Handbook of Australian School Psychology: Integrating International Research, Practice, and Policy
by Monica Thielking, Mark D. Terjesen
Springer International Publishing, 2017

A FDA review of studies for antidepressant drugs in children and adolescents found 20 placebo-controlled studies of 4100 paediatric patients for 8 SSRI drugs noted that there was an excess of suicidal ideation and suicide attempts when receiving certain SSRIs, although there were no suicides.

“Case Studies in Child and Adolescent Mental Health” by M. S. Thambirajah
from Case Studies in Child and Adolescent Mental Health
by M. S. Thambirajah
Radcliffe Pub., 2007

Antidepressants are widely used in children and adolescents for a variety of disorders, with significant increases over the past 20 years.

“Dulcan's Textbook of Child and Adolescent Psychiatry” by Mina K. Dulcan
from Dulcan’s Textbook of Child and Adolescent Psychiatry
by Mina K. Dulcan
American Psychiatric Publishing, 2015

Antidepressants would appear to be effective, low-risk options for children with ASDs; surprisingly very few studies have evaluated their use in this group.

“Handbook of Early Intervention for Autism Spectrum Disorders: Research, Policy, and Practice” by Jonathan Tarbox, Dennis R. Dixon, Peter Sturmey, Johnny L. Matson
from Handbook of Early Intervention for Autism Spectrum Disorders: Research, Policy, and Practice
by Jonathan Tarbox, Dennis R. Dixon, et. al.
Springer New York, 2014

Although it has been difficult to demonstrate that the TCAs or other antidepressants are more effective than placebo in the treatment of childhood depression, there is some evidence of at least fluoxetine’s superiority to placebo in children.

“Manual of Clinical Psychopharmacology” by Alan F. Schatzberg M.D., Charles DeBattista D.M.H. M.D.
from Manual of Clinical Psychopharmacology
by Alan F. Schatzberg M.D., Charles DeBattista D.M.H. M.D.
American Psychiatric Association Publishing, 2015

Oktay Kutluk

Kutluk Oktay, MD, FACOG is one of the world's foremost experts in fertility preservation as well as ovarian stimulation and in vitro fertilization for infertility treatments. He developed and performed the world's first ovarian transplantation procedures as well as pioneered new ovarian stimulation protocols for embryo and oocyte freezing for breast and endometrial cancer patients.

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8 comments

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  • the title is really misleading, that child should never have been put on anti-depressants. he was only 5 and a child should only be put on them after long deliberation and assessment. it puts fear into people who really need them and may do way more harm than good. he was clearly dealing with a relatively minor issue yet was thrown on antidepressants without appropriate after care. any doctor who knows anything about antidepressants knows the child is monitored monthly every other month to deal with suicidal thoughts. the doctor was wrong in this case NOT the antidepressants. and secondly antidepressants for under 18s are NOT banned in the uk at all, doctors don’t throw kids on them tho.

  • I take aropax… since I was 18 and now I’m 34.. many times have I tried to ween off it.. to no avail… children should not take this drug at all!

  • My son was so happy before school started and then he wouldn’t concentrate in prek and got aggressive on ritalin and adderall took him off that now he is on zolaft it worked for 6 years and now it’s like it’s doing hitting and defiant I am getting my son off of it tomorrow zolaft

  • Mom hang on in there!!! Send him to Dr Berg!!! Help him on natural supplements.. Do Something Mum!! U cld have made him a Camomile tea for his anxiety!! This is so wrong!! My heart stopped for a second hearin “I Wanna Die” how cld u dr.. how cld u

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  • The forensic psychiatrist was very incorrect. The only approved antidepressant for paediatric use for Major Depression is FLUOXETINE (Prozac) not PAROXETINE (Aropax).

  • Had 2 boys 16 and 12 that got admitted for 2 different reasons. They where there 24 hours and I got 3 calls trying to put them on Zoloft. Even after I explained that there is a anti depressant pill addiction and suicide attempts on my moms side and they continued to try to push it.

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