Gene-Linked Iron Disorder More Prevalent Than Thought

 

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Sign Up for MedicineNet Newsletters! WEDNESDAY, Jan. 16, 2019 (HealthDay News) The most common genetic disorder among northern Europeans called hemochromatosis occurs more often than previously thought, according to a new study. The researchers also found that people with the condition often develop serious health problems. WEDNESDAY, Jan.

16, 2019 (HealthDay News) The most common genetic disorder among northern Europeans called hemochromatosis occurs more often than previously thought, according to a new study. READ: 9 Low Iron Symptoms. The researchers also found that people with the condition often develop serious health problems. More ; Gene-Linked Iron Disorder More Common Than Thought: Study.

WEDNESDAY, Jan. 16, 2019 The most common genetic disorder among northern Europeans called hemochromatosisoccurs more often than previously thought, according to a new study. WEDNESDAY, Jan.

16, 2019 (HealthDay News) — The most common genetic disorder among northern Europeans — called hemochromatosis — occurs more often than previously thought, according to a new study. READ: 9 Low Iron Symptoms. The researchers also found that people with the condition often develop serious health problems. Gene-Linked Iron Disorder More Common Than Thought By Weekly Sauce | January 17, 2019 The most common genetic disorder among northern Europeans — called hemochromatosis — occurs more often than previously thought, according to a new study.

The most common genetic disorder among northern Europeans called hemochromatosis occurs more often than previously thought, according to a new study. Gene-Linked Iron Disorder More Common Than Thought. Gene-Linked Iron Disorder More Common Than Thought.

The most common genetic disorder among northern Europeans called hemochromatosis occurs more often than previously thought, according to a new study. The researchers also found that people with the condition often develop serious health problems. Scientists have revealed that the western world’s most common genetic disorder is much more dangerous than previously thought. Haemochromatosis, a medical condition caused by an overload of iron in the body, may cause high levels of serious disease and disability, according to research. According to the World Health Organization (WHO), iron deficiency is the most common and widespread nutrient disorder in the world.

In fact, more than 30% of the world’s population is anemic, many due to low iron. Vitamins You’re Probably Missing Iron deficiency anemia, as the name implies, happens because of insufficient iron. For more information about genetic disorders that are more common in certain groups: The Norton & Elaine Sarnoff Center for Jewish Genetics provides information on disorders that occur more frequently in people with Jewish ancestry, including genetic traits that tend to be more common in Ashkenazi Jews and Sephardic Jews.

List of related literature:

However, Gordeuk et al., have demonstrated that there is a genetic component associated with African iron overload.78 This putative gene is not linked to the HLA locus.

“Manson's Tropical Diseases” by Gordon Charles Cook, Alimuddin Zumla
from Manson’s Tropical Diseases
by Gordon Charles Cook, Alimuddin Zumla
Saunders, 2009

One possible explanation for this shortcoming is that it has often been difficult to unequivocally ascertain the primary disease-risk HLA genes due to the remarkably strong linkage disequilibrium (LD) across the major histocompatibility region (MHC) (Miretti et al., 2005).

“Genomic and Personalized Medicine: V1-2” by Geoffrey S. Ginsburg, Huntington F Willard
from Genomic and Personalized Medicine: V1-2
by Geoffrey S. Ginsburg, Huntington F Willard
Elsevier Science, 2012

Thorough studies in both Britain and the USA have now confirmed that as few as 1 per cent of homozygotes for the predisposing mutation may develop clinically significant iron overload, although the figure could well be higher for close relatives on account of other shared genes.

“Practical Genetic Counselling” by Peter Harper
from Practical Genetic Counselling
by Peter Harper
CRC Press, 2010

Other HFE gene mutations associated with iron accumulation have been described, mostly in individual families.

“Postgraduate Haematology” by A. Victor Hoffbrand, Douglas R. Higgs, David M. Keeling, Atul B. Mehta
from Postgraduate Haematology
by A. Victor Hoffbrand, Douglas R. Higgs, et. al.
Wiley, 2016

Small duplications also can result in single-gene phenotypes, such as Charcot–Marie–Tooth neuropathy [Chance et al., 1994], although this is recognized less often than with deletions.

“Swaiman's Pediatric Neurology E-Book: Principles and Practice” by Kenneth F. Swaiman, Stephen Ashwal, Donna M Ferriero, Nina F Schor
from Swaiman’s Pediatric Neurology E-Book: Principles and Practice
by Kenneth F. Swaiman, Stephen Ashwal, et. al.
Elsevier Health Sciences, 2011

Between 5 and 20% of the population inherit the gene from only a single parent; these individuals don’t have these serious symptoms but do absorb iron better than people who do not have the gene at all.

“Nutrition: Science and Applications” by Lori A. Smolin, Mary B. Grosvenor
from Nutrition: Science and Applications
by Lori A. Smolin, Mary B. Grosvenor
Wiley, 2019

There are also examples of diseases that are caused by pairing of two different mutations in a given gene, known as “co-dominance,” and combinations of specific alleles of two or more genes, in which PGD becomes more difficult.

“Human Genome Editing: Science, Ethics, and Governance” by National Academies of Sciences, Engineering, and Medicine, National Academy of Medicine, National Academy of Sciences, Committee on Human Gene Editing: Scientific, Medical, and Ethical Considerations
from Human Genome Editing: Science, Ethics, and Governance
by National Academies of Sciences, Engineering, and Medicine, National Academy of Medicine, et. al.
National Academies Press, 2017

We may refer to single-gene disorders, for example, but in virtually no case is the disease phenotype entirely attributable to a single gene locus (see Figure 7.21 for the example of β-thalassemia).

“Genetics and Genomics in Medicine” by Tom Strachan, Judith Goodship, Patrick Chinnery
from Genetics and Genomics in Medicine
by Tom Strachan, Judith Goodship, Patrick Chinnery
CRC Press, 2014

Unlike haemochromatosis, this disorder is not HLA linked, is phenotypically distinguishable from Caucasian haemochromatosis and is caused by the interaction of genetic factors and dietary iron.

“Encyclopedia of Genetics” by Eric C. R. Reeve, Isobel Black
from Encyclopedia of Genetics
by Eric C. R. Reeve, Isobel Black
Fitzroy Dearborn, 2001

It should be noted, however, that even if no evidence of familial aggregation or heritability is obtained from family studies, this does not rule out the possibility that a small subset of disease cases (e.g., 1% to 5%) might be caused by a mutation in a gene that causes a major increase in disease risk.

“Encyclopedia of Epidemiology” by Sarah Boslaugh, Louise-Anne McNutt
from Encyclopedia of Epidemiology
by Sarah Boslaugh, Louise-Anne McNutt
SAGE Publications, 2008

Oktay Kutluk

Kutluk Oktay, MD, FACOG is one of the world's foremost experts in fertility preservation as well as ovarian stimulation and in vitro fertilization for infertility treatments. He developed and performed the world's first ovarian transplantation procedures as well as pioneered new ovarian stimulation protocols for embryo and oocyte freezing for breast and endometrial cancer patients.

Mail: [email protected]
Telephone: +1 (877) 492-3666

Biography: https://medicine.yale.edu/profile/kutluk_oktay/
Bibliography: oktay_bibliography

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45 comments

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  • So the insert at 47:45 about dietary restriction, says it can lower the immune system. So is ‘restriction’ a lower than maintenance level of calories per day? And if fasting, the normal way, you get all required calories but in a short window of time? Trying to identify the key differences between the two.

  • In Longevity Institute person knowing cancer best is sitting, in Cancer Institutes,people knowing how to medicament poison other people are sitting.

  • Excelente. PEro Para Hempel la ley puede explicar y no solo describe algo. Lo llama modelo de cobertura. Además, una hipotesis confirmada se convierte en ley y varias leyes hacen o conforman teorias. Al final este video acaba aceptan a Lakatos y su cinturon de hipotesis protector. Saludos cordiales

  • My gf has Lupus. She has been suffering for years and I has had an effect on me. I hope this message gets to someone with some advice. Do you think long term fasting would help her?

  • Hey, then what is the extent of recombination of the blue and green genes? Is it more likelier than the recombination of purple and green?(cuz of greater distance?)

  • I’m loving this dialogue on mental hygiene. Would like to see it included as standard fare for all social media like several others below have mentioned. Anyone else have good recommendations on this subject?

  • I have the Adult onset have not been tested for GSD 13 have asked my Doctor still waiting if someone will do something no blood or biopsy done. If you want my blood or biopsy I am willing to send it anywhere. Since Birth always had food issues

    fruits, oils, sugars hate them all I am Negative on Gluten Celiac but there is a Family History Celiac. I have seen HFI & also Baker Winegard Fructose 1,6 in these illness populations. Some have copies of the tryptase Gene HATS Hereditary Alpha

    Tryptasemia Syndrome tested here in Houston, Texas *key in tryptase the test opens up here http://www.genebygene.com

  • Dr. Camille Birch, I was searching on types of GSD in EDS 3 with CFS diagnosis I noticed a Family with 2 types combined GSD VIII & GSD IX combined I think VIII is now a type of IX but they all had EDS3 with CFS I saw this on the Coriell Medical Research Group USA site of Family Histories they have there so thought I would mention this as well most of them were symptomatic but not all of them who tested Positive to both GSD’s combined it was in children & Adults

  • When you say Diabetes do you mean Type One Diabetes or Type Two Diabetes? It would be helpful if you could be clear about the difference

  • I always have a hard time trusting researchers who have a personal financial interest in the thing they are researching. I think researchers should be rewarded for discovery but when money becomes the driver then bias is almost inevitable. I get really suspect when the representative product doesn’t go through FDA approval because efficacy doesn’t need to be proven. Even “independent” studies are problematic because someone has to fund those and if you look at disclosures you can usually find something that is suspect.

  • Please NOTE: hypothesis is not something you PROVE; hypothesis is something you test and reject or fail to reject. Science can never tell you something is true, but the surmountable evidence of hypothesis testing will support the null hypothesis (no change) or it will reject null hypothesis and it will offer an alternative explanation/hypothesis, but it will not prove it to be the explanation!

  • Habba Syndrome? Dr. Habba Gastroenterologist New Jersey USA Gal Bladder not properly functioning with bile they use same medicne in Gal Bladder removals one with no sucrose the Light one in powder form 4 mg pouch. He does gal bladder Scan

  • FMD was an answer for offering fasting to people who refused to do a water fast.
    Is FMD better than water fasting. Or just a substitute?

  • With the help of a relative, whose life has been separate from my “social unit” for quite a number of years, I have made a new observation for myself:
    The most strenuous mental exercise one can practice is finding someone with a “totem” against your viewpoint and find the information and perceptions that are missing from your viewpoint, while separating it from its totem… Then, in exchange, finding what information and perceptions you could present, while dissecting it from your own totem.

    When done with another person, in person, it is possible, and it is beneficial. It is even more beneficial when all people, even spectators to the debate, come into this exercise with the collaborative goal to not let the exercise become “personal.”

    However, it is mentally exhausting to the point of spontaneous emotional lapse to do the same exercise with a video, personal narrative or one-on-one in tone, designed to build the totem up and make it more intricate.

    I live in a family with airline pilots. No one can stand listening to the modern TV 24/7 news channels. We lament the absence of channels that provide weather updates and news snippets in 30-minute loops.
    I hope I’m not alone in being willing and able to learn this lesson when it is presented to me.

  • so fact is an observation
    hypothesis is a whatever explanation of the observation
    theory is a experimentally proven hypothesis
    and a law is a prediction based on a theory

  • “we count chromosomes by the amount of centromeres present” finally somebody said it that clear; you could add to your def. that the equation counts for 1 centimorgen; btw i like your voice

  • Nicely done, and I will likely use it in my class in the future assuming the pandemic ever ends. My one issue is the repeated insistence that a theory is well supported and the implication they only become theories once they are accepted. “Eliminate the bad ones and we are left with a theory.” This feels like a defensive position to head off evolution skeptics. Theories are broader explanations that attempt to tie together facts, hypotheses, and observations they are at the heart of science because they can answer not just “what?” but “why?” Unfortunately, they often end up being disproven and discarded. Lamarckism was a theory. So was vitalism, spontaneous generation, phlogiston, and caloric theory. And these weren’t tweaked and improved over the years like Darwinian evolution, gravitation, or atomic theory. No, they were tossed out root and branch because they were flat wrong, but it doesn’t mean they were not theories.

  • Wrong, “the sun is out” wasn’t a fact until you went outside and observed it, which now qualifies it as true, and as fact. Any fact is true. You are simply wrong.

  • Hhhhhhhhhh
    Evolution is a fact we know that it happens no doubt But how does it happen?
    Who said that is no doubt?!
    Monkey to human?!
    As a fact..
    This cynicism from you does not match what you are calling?
    When said something is no doubt you have to give one fact for that.
    I’m not goog in English but if in my language I can be more interested and can to answer.

  • 30:30. So it cost $50m to go through FDA to get a feeding protocol approved. Wtf. This will never happen because there’s no money to be made on dietary formulas. Effn insane.

  • The title is a bit misleading. I came here trying to help my sister’s autoimmunity, and came away with basically nothing. Perhaps, I can ask here/now…”””how can an individual who suffers autoimmunity reset their autoimmunity?””. Thank you for your time. =D

  • Thanks to Dr Apala for curing me of HPV2, Indeed you are great, your herbal medicine its real and 100% satisfactory, am glad to have patronised you. Once again thanks to you for the good work you have done in my life. i will advised anyone out here living with herpes should please contact him to get the herbal cure for herpes its 100% guarantee and work, with no side effects. I recommend his service for you kindly contact him to get your cure as well,.on his email: [email protected] gmail.com Whatsapp: +2348114047176….

  • I came to see this video after so many years because it is more and more relevant. when are we going to stop? in another civil war?

  • I am trying to find out how I upload my DNA report from Ancestry DNA in order to obtain reports from FMF. Has anyone succeeded in doing this from Ancestry.ca? Thank you

  • Evolution shouldn’t even be called a theory according to the definition of theory given in this video. The definition says “repeatedly tested and confirmed through OBSERVATION and experimentation”. Macro evolution cannot be and has not been repeatedly confirmed through observation. Maybe it needs to be knocked back down to a hypothesis where it belongs.

  • I don’t understand why the products in the Longo FMD diet series have starch in them(rice) when he says in every intervju that the carbs in the diet must come from vegetables, not from starch…

  • Any time I talk to a creationist, they always say “Evaluation is only is a theory” This irks me to the to no end, so I point out that their creation hypothesis is based on faith. The irony is that they think faith is the best method to determine truth.

  • citizens of the internet don’t know the language of science, many unnecessary science vs religion arguments could be avoid if people could stop asking the most stupid question on the internet
    “how do you know the theory is true” this question is invalid!!

  • to paraphrase potholer 54, if the scientific consensus is in contradiction with my own belief, there are 3 possibilities: 1 scientist are lying, 2 scientists are deceived or 3 maybe scientists know 2-3 things more than what i know and i try to understand them. it’s always better to investigate the 3rd possibility.

  • I like how he starts evolution as a fact. Why did he get to jump right to a fact with evolution? That alone proves this video was designed to deceive you. He didn’t use his own formula with that one. Why you might ask. Because you have to cheat to prove evolution.

  • Wow, they should start a publicity campaign with the NFL to aware players and people, who play the sport, of its consequences and injuries. I mean they obviously know them, but just as a reminder and certifier…

  • So… keto is a no-no, because some miniscule fraction of cancers can metabolize ketones (though vast majority can’t and die in glucose deprived environment), but chemo is a great way to go! Thanks dr Longo, but no thanks.

  • i was the thinnest when i would eat one fast food meal a day and diet soda the rest of the day and i felt pretty good, i guess i was fasting ��

  • The word “theory” has been smeared by the cliche-phrase “conspiracy theory”, which is used to counter arguments that are too difficult to destroy otherwise.

  • the observation none of these experts will admit publicly……….is that the human genome shows clear evidence of being an engineered product. Why cant they find the gene that makes people gravitate to violent,extremist ideologies so we can eradicate marxists and muslims?

  • i’m italian and i usually understand easily when someone talk in english but it’s very difficult for me to follow when Walter Longo talks in english.. (and since he’s talking an italian version of english it should be easier for me)..

  • I had a young earth creationist (in a public school) teach my biology class in high school that went over evolution. I’m so glad I was able to be deprogrammed from that. It took longer than I’ll admit.

  • ,,,, detoxification and eat clean dark greens
    No sugar no alcohol no smoking
    Don’t cook fruits and vegetables
    Now get away from these 2 trying to sell you their books and products
    OMG. She is gone

  • 1. Prolonged Fasting Dry / 2. Prolonged Fasting Water Only / 3. Prolonged Fasting Water, Black Tea, Black Coffee Only. Currently on a 5 day, water / black coffee only fast. 2 cups of coffee a day.

  • Very interesting presentation, with findings and concepts that offer new avenues of research challenge focusing on our disease. Many thanks!

  • I hate to be a pedant after such a brilliant film which clearly every school child should see….but

    You ended with a hypothesis, not a theory!

  • Here are a few things that this video gets wrong:

    Gluten is a cause of sickness for some people, and yet was discarded as a reason. Sure, the ultimate reason for their sickness is a result of their bodies’ intolerance due to imbalances in their digestive system, but gluten is still the cause of that sickness. If people who are gluten intolerant aren’t exposed to it, then they don’t suffer the associated illness. In the same way that people don’t get sick if they are not exposed to the germs or viruses that cause various illnesses.

    Supra species macro evolution (i.e., one type of creature evolving into another type of creature) is not an observable fact. This phenomena has not been observed or tested. Sure creatures can speciate, but no-one has ever observed, or has any tangible evidence, for one type of creature evolving into another through through incremental transitions. As such, evolution is not a theory at this level, it is still a hypothesis. Conversely, speciation and micro evolution occur so they provide the basis for a scientific theory at this level, but supra species macro evolution has never been empirically observed, tested, or reproduced, so it does qualify as part of the theory of evolution.

    Evolution presupposes abiogenesis (i.e., the spontaneous creation of the first forms of life from non living elements). This phenomena has not been observed, tested or reproduced. The problem of abiogenesis has even tried to be avoided by hypothesising pan-spermia, which just kicks the problem down the road. How did life on this planet, or any other planet spontaneously come into being? No scientific theory can explain it.

  • “A Summary of Scientific Method” by Peter Kosso is a brilliant 50-page summary read on this topic, published by Springer in 2011 (SpringerBriefs in Philosophy). He explains all these terms: fact, hypothesis, theory and law. There’s a brief mention of how Popperian Model of scientific method is incorrect, and why we don’t go about discarding theories even if they’re falsified. Overall, science is a knowledge enterprise whose engine is inductive reasoning. We develop hypothesis, test them, make predictions through them and try to confirm and disconfirm them, while always taking into consideration auxiliary theories and experimental conditions.

  • Ok, what should i eath after 5 days of fasting, while refiding? Should i eath just soups for 2-3 days, or how that whole thing goes from there? Does anyone know?

  • Great video! He says, “I predict that future is going to be very bright. I like that theory.” Well, it’s a prediction, not a theory. A prediction does not equate to a theory. For the records:)