Can Poor Sleep Boost Odds for Alzheimer’s

 

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Video taken from the channel: FMF Clips


 

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Video taken from the channel: FORA.tv


 

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Video taken from the channel: Healthcare Triage


Can Poor Sleep Boost Odds for Alzheimer’s? TUESDAY, July 18, 2017 Breathing problems during sleep may signal an increased risk for Alzheimer’s disease, a trio of studies suggests. And, the researchers added, treating conditions like sleep apnea and hypopnea (shallow breathing) might lower the risk of dementia, or at. TUESDAY, July 18, 2017 (HealthDay News)— Breathing problems during sleep may signal an increased risk for Alzheimer’s disease, a trio of studies suggests. And, the researchers added, treating conditions like sleep apnea and hypopnea (shallow breathing) might lower the risk of dementia, or at least slow its.

TUESDAY, July 18, 2017 (HealthDay News) Breathing problems during sleep may signal an increased risk for Alzheimer’s disease, a trio of studies suggests. And, the researchers added, treating conditions like sleep apnea and hypopnea (shallow breathing) might lower the risk of dementia, or at least slow its. (HealthDay)— Breathing problems during sleep may signal an increased risk for Alzheimer’s disease, a trio of studies suggests. And, the researchers added, treating conditions like sleep apnea and. The following navigation utilizes arrow, enter, escape, and space bar key commands.

Left and right arrows move through main tier links and expand / close menus in sub tiers. “At this point, we can’t say whether improving sleep will reduce your risk of developing Alzheimer’s. All we can really say is that bad sleep increases levels of some proteins that are associated with Alzheimer’s disease.

But a good night’s sleep is something you want to be striving for anyway,” Ju said. WEDNESDAY, Jan. 8, 2020 (HealthDay News) Poor sleep has been linked to the development of dementia and Alzheimer’s disease, and now a new study suggests a possible reason why. Just one night’s bad sleep could increase your risk of Alzheimer’s disease, experts have warned Credit: Canopy Getty Previous research has hinted at a link between poor slumber and loss of brain.

Impaired sleep has been associated with Alzheimer’s disease. Studies suggest that sleep plays a role in clearing beta-amyloid out of the brain. Moreover, lack of sleep has been shown to elevate brain beta-amyloid levels in mice.

Less is known about the impact of sleep deprivation on beta-amyloid levels in people. A comfortable bedroom temperature can help the person with dementia sleep well. Manage medications. Some antidepressant medications, such as bupropion and venlafaxine, can lead to insomnia.

Cholinesterase inhibitors, such as donepezil, can improve cognitive and behavioral symptoms in people with Alzheimer’s but also can.

List of related literature:

In the same study, longer sleep was associated with increased levels of C-reactive protein after adjusting for age, BMI, different lifestyle factors, family history of diabetes, glycemic control, and use of medications.

“Sleep Disorders Medicine: Basic Science, Technical Considerations and Clinical Aspects” by Sudhansu Chokroverty
from Sleep Disorders Medicine: Basic Science, Technical Considerations and Clinical Aspects
by Sudhansu Chokroverty
Springer New York, 2017

It is now known that sleep disturbances and sleep apnea, a growing issue in younger and younger populations, are a contributing factor to chronic diseases such as Alzheimer’s, cancer, heart disease, diabetes, ADHD, mood disorders such as depression, and cognitive learning disorders.

“Boundless: Upgrade Your Brain, Optimize Your Body & Defy Aging” by Ben Greenfield
from Boundless: Upgrade Your Brain, Optimize Your Body & Defy Aging
by Ben Greenfield
Victory Belt Publishing, 2020

• Recent research points to life stressors and sleep disturbances playing a possible role as risk factors for Alzheimer disease; a single life stressor can increase someone’s chance of developing Alzheimer disease by 4%, especially in minority populations (Honig & Sano, 2017).

“Basic Geriatric Nursing E-Book” by Patricia A. Williams
from Basic Geriatric Nursing E-Book
by Patricia A. Williams
Elsevier Health Sciences, 2019

Considering that there are marked age-related changes in sleep quality, particularly reductions in slow-wave sleep, it is possible that the sleep disturbances of normal aging may also play a role in the increased diabetes risk in older populations.

“Sleep Deprivation and Disease: Effects on the Body, Brain and Behavior” by Matt T. Bianchi
from Sleep Deprivation and Disease: Effects on the Body, Brain and Behavior
by Matt T. Bianchi
Springer New York, 2013

If so, insufficient sleep across an individual’s life would significantly raise their risk of developing Alzheimer’s disease.

“Why We Sleep: Unlocking the Power of Sleep and Dreams” by Matthew Walker
from Why We Sleep: Unlocking the Power of Sleep and Dreams
by Matthew Walker
Scribner, 2017

Caring for aging parents or an aging spouse, or caring for anyone with a disordered sleep schedule (e.g., a person with Alzheimer’s disease) will also disrupt your sleep.

“Sink Into Sleep: A Step-by-Step Workbook for Reversing Insomnia” by Judith R. Davidson, Ph.D, C.Psych
from Sink Into Sleep: A Step-by-Step Workbook for Reversing Insomnia
by Judith R. Davidson, Ph.D, C.Psych
Springer Publishing Company, 2012

Quite possibly, many Alzheimer’s patients may be suffering from a vitamin B« deficiency, which is also affecting their production of melatonin.

“The Melatonin Miracle: Nature's Age-Reversing, Disease-Fighting, Sex-Enhancing Hormone” by Walter Pierpaoli, William Regelson, Carol Colman
from The Melatonin Miracle: Nature’s Age-Reversing, Disease-Fighting, Sex-Enhancing Hormone
by Walter Pierpaoli, William Regelson, Carol Colman
Pocket Books, 1996

The effects of sleep deprivation are similar to those seen in normal aging; therefore, sleep debt may increase the severity of age-related chronic disorders such as weight gain, elevated cholesterol or triglyceride levels and, eventually, diabetes and/or heart disease.

“The Supercharged Hormone Diet: A 30-Day Accelerated Plan to Lose Weight, Restore Metabolism, and Feel Younger Longer” by Natasha Turner
from The Supercharged Hormone Diet: A 30-Day Accelerated Plan to Lose Weight, Restore Metabolism, and Feel Younger Longer
by Natasha Turner
Rodale Books, 2013

Interestingly, some studies suggest that older persons with dementia have less sleep disturbance than older depressed persons.

“Assisted Living Nursing: A Manual for Management and Practice” by Dr. Ethel Mitty, EdD, RN, Dr. Barbara Resnick, PhD, CRNP, FAAN, Sandra Flores, RN
from Assisted Living Nursing: A Manual for Management and Practice
by Dr. Ethel Mitty, EdD, RN, Dr. Barbara Resnick, PhD, CRNP, FAAN, Sandra Flores, RN
Springer Publishing Company, 2009

If this is the primary mechanism, then it is possible that the dementia risk can be mitigated or eliminated by maintaining B12 levels.

“Professional Voice, Fourth Edition: The Science and Art of Clinical Care, 3-Volume Set” by Robert Thayer Sataloff
from Professional Voice, Fourth Edition: The Science and Art of Clinical Care, 3-Volume Set
by Robert Thayer Sataloff
Plural Publishing, Incorporated, 2017

Oktay Kutluk

Kutluk Oktay, MD, FACOG is one of the world's foremost experts in fertility preservation as well as ovarian stimulation and in vitro fertilization for infertility treatments. He developed and performed the world's first ovarian transplantation procedures as well as pioneered new ovarian stimulation protocols for embryo and oocyte freezing for breast and endometrial cancer patients.

Mail: [email protected]
Telephone: +1 (877) 492-3666

Biography: https://medicine.yale.edu/profile/kutluk_oktay/
Bibliography: oktay_bibliography

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28 comments

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  • Hi Dr. Carroll I don’t think you’ve done an episode about millennial health outcomes overall before.

    A new report called The Economic Consequences of Millennial Health was published by Blue Cross Blue Shield recently and has been covered rather dramatically by Vice as indicating that millennials will actually “get sick and die faster” than older generations.

    If you think the report merits further analysis, could you talk about these findings? They seem to contradict the standard assumption that younger generations will always be healthier than older ones.

    On a larger note, are reports like this generally reliable? I would assume the huge financial interests and deep pockets of insurance companies might mean they produce fairly accurate analysis, but I don’t know enough to be sure.

  • Been sleep tracking for about 5 years, or whenever SleepAsAndroid started collecting data. (Funny, I don’t remember when that was.) During the school year getting up way before my body does in the summer, which in turn triggers first terminal, then internal, then initial, and then rather complete insomnia. All.school.year. It’s like this every year. (And no, I can’t home school. I am forced into the public school system. I’m single… likely because I’m half-out-of-my-gourd looking like a Gary Oldman body-double… pick any villain role.)

    I’m going to anecdotally posit that we’d help resolve a huge portion of US mental health issues if we could put permanent socks in the mouths of people who think getting up earlier means you’re more invested in life.

    THANK YOU CA for giving substance to the importance of later school start times!!!! Politics matter folks PleasePleasepleasepleaseplease vote (and double-check your registration about 2 months ahead of time)!

  • shrug I have no idea where else to put this where one of y’all might see it. This study is right on the edge of your wheelhouse, and as far as I know the first of its kind. https://onlinelibrary.wiley.com/doi/pdf/10.1111/1475-6773.13203

  • Sleep issues means extra stress on their body. Increased stress shifts your body from repair to protective mode.

    Being in protective mode means you don’t repair. As you age you’re less able to repair. These combined leads to slow degeneration, starting in your 30’s & 40’s, reaching obvious symptoms by 60-70’s

    If you remove enough stressors from your body, them you’ll shift back to repair mode. Lack of sleep is simply 1 stressor, in a multifactorial problem.

    I recommend looking up the ReCODE protocol. There’s a great overview of it on
    http://mybiohack.com/blog/dale-bredesen-protocol-recode-alzheimers-mend

  • Sir! Your Videos having an awesome Animation. I’m a teacher and i want to dubbed your Videos in hindi for Hindi(indian) students. And all I want only your permission. Please give me permission, with your conditions.

  • You are SOOO helpful! And I thank you sooo much for that. Also I have NEVER been a good or easy sleeper not even in childhood sigh. Plus I love sugar sigh again.

  • If a lack of deep sleep does indeed contribute to the development of Alzheimer’s disease, would people who work a lot of night shifts be at a greater risk? This has me curious now.

  • Im 38 and average 4-5 hours a night sleep, and have been in this pattern since my early teens.

    I might be in trouble with this one.

  • Other studies looking at the glymphatic system have shown that dementia patients, and those likely to suffer from it later in life, were more likely to suffer chronic insomnia (sleep onset and/or early awakening), need more sleep when they do sleep, and often don’t get good enough quality of sleep. So the focus should be on how to allow those people to get the time and quality of sleep they need.

    The way we think about sleep, especially in older generations, is unhealthy. People call you lazy if you sleep more than 7 hours, and people brag about how little sleep they need. It’s absurd. You need the amount of sleep you need. If you’re waking up with an alarm every day, you’re doing it wrong.

    But, especially for women, it’s difficult to get a doctor to help you with sleep issues beyond handing you a sleep hygiene checklist (which is made up entirely of common sense things). Even with sleep studies and a familial history of chronic insomnia, parasomnias, and neurodegenerative disease. It needs to stop. Everyone needs to take it more seriously. And not just because of the neurodegenerative disease angle. Sleep is one of the most important things we can do to stay healthy.

  • If you want to know more about this you can look up the podcast of Peter Attia talking with Matthew Walker on Sleep. There are three long ones. Although I am impressed by the podcast, I have not checked sources.

  • Sleep sweeping…a new favorite.

    11 subjects, pffft.

    Has there been any study on whether deep practitioners of meditation, the ones that “make a living” of it, can slip into these states; I mean if we can train a brain to do this consciously similarly to muscular exercise, well…the sky’s the limit, eh?

  • Let’s hope this information brings us a step closer to understanding the disease enough to come up with a cure. In the meantime, Alzheimer’s caregivers can find helpful resources here: http://gracehomecare.com/category/alzheimers-disease/

  • A number of my colleagues work in Alzheimers, it’s astonishing how many still think that there’s a single event that goes wrong at old age, they’re positively obsessed with the protein aggregation. That’s like trying to understand diabetes by staring at a gangrenous foot in an advanced case of diabetes, you’ve completely missed what’s causing the disease and are rather focused on the secondary effects of the disease. I don’t pretend to know the ’cause’ of AD, but most diseases of old age, diabetes, cancer, etc, only become clinical after decades of subclinical problems (insulin resistance, and so on). It makes sense that decades of poor sleep (or other stressors) from our 20s through middle age may be just as damaging to the brain as eating too much sugar every day would be to your pancreas. Alzheimers is clearly a complex disease that likely manifests after years, if not decades, of stressors on our biology. This is a huge step forward in understanding the actual etiology rather than the end stage of the disease.

  • لا أدري لماذا تتجاهل طلب المتابعين بأن تكون فيديوهاتك مترجمة أو بالعربية ليستفيد الآخرين ممن لايتقنون الانجليزية
    أم لأنك تعتقد أن الذين لايتكلمون الانجليزية غير مثقفين ولا يحبون المعرفة

  • sleep apnea leads to alzheimers I went to doctor they wanted to do a colonoscopy I think they had dementia I bought a used bi pap /cpap now I sleep like a baby doctors are still drooling wanting me to get a colonoscopy

  • Hi doctor, I do a lot of early morning shifts due to which I have developed very poor sleep patterns.. I am not able to recall things that I have done the previous day because my brain feels tired and strained.. will this increase my risk for alzheimers? Please tell me. Am very worried and wish to do anything to reduce the risk.

  • Really interesting to see this old video now that the research that Matt Walker alluded to has been published, and does indeed show that sleep patterns can predict the accumulation of Alzheimer’s proteins later in life. His conclusion:” the message is very clear,.”If you are starting to struggle with sleep, then you should go and see your doctor and find ways, such as CBT-I, that can help you improve your sleep. The goal here is to decrease your chances of Alzheimer’s disease.”. Time that we told Professor Walker about the work we have been doing.

  • I really appreciate that you don’t sensationalize news, as a chronic insomniac I try to stay up to date with sleep research and do whatever I can to minimize damage and a big part of that is just trying to dodge the NEW STUDY SAYS POOR SLEEP WILL KILL YOU SUPER DEAD IN LIKE A WEEK TOPS sorta thing.

  • One important thing you all can do is to keep away from all the prescriptions drugs. The chemicas in them accumulate in your brain and block its operation. Go for a long walk come tired, lie down and sleep. Dont try it DO IT.

  • When it comes to a field as new and undeveloped as neurology, any correlation seems significant, thus making a great many “false positives”.

  • He seems to be turning events that are positively correlated into a one-way causal relationship.

    Couldn’t it just as easily be that as whatever damages the brain, eventually resulting in Alzheimer’s has an earlier result of disrupting a person’s sleep?

    Correlation often is a result of causation, but not always directly, nor always in the direction initially assumed.

  • Watch the full episode:
    https://youtu.be/bEbtf7uS6P8

    FoundMyFitness episode page:
    https://www.foundmyfitness.com/episodes/matthew-walker

    More clips from this guest:
    https://www.youtube.com/playlist?list=PLrGxo-5Uw8gLqsHAowyhrKT-7U8aWy4Ng

  • So prioritize sleep over staying up late (read a book in the evenings), exercise in a way the elevates your heart rate, eat a Mediterranean diet, and deal with your stress in a healthy manner. Bonus, this will help prevent more than just Alzheimers!

  • @Hishamalghaili bro, it’s good you are providing scientific researched information mashallah, may Allah reward you for this. But the sad thing is you got a platform to do dawah on Islam through your knowledge, I pray to Allah that you upload informative scientific videos and prove it the existence of Allah and why we were created, purpose of life etc.
    Jazakumullahukhair

  • Hm. Well, whatever we find out in the future, this is certainly more motivation for me to work on having a better relationship with sleep!

  • Im doing night duty and i use to sleep 2 hours on duty and 3-4 hours in room. By this does it apply sleep disorder on me? By aggregate i take 6-7 hours of sleep. though i want to sleep more more at room but my eyes open itself.
    don’t tell to my supervisor

  • Prophet Muhammad (peace and blessings of Allah be upon him).
    Prohabited 1440 years before, staying awake after Ish prayer.
    I
    it was narrated in al-Saheehayn from Abi Barzah that the Messenger of Allaah (peace and blessings of Allaah be upon him) used to dislike sleeping before ‘Isha’ and speaking afterwards. Narrated by al-Bukhaari, 568; Muslim, 647.

  • It seems once a tau protein moves out of neuron axon..it stimulates the release of tau from others neurons too how is this fixed back then??!