Brain Depends on 2 Internal Timekeepers to manage Sleep


Nobel Lecture: Michael Rosbash, Nobel Prize in Physiology or Medicine, 2017

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(PL-PS04) The importance of circadian rhythm for athletic performance and skeletal muscle health

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Neurobiology of Sleep Circadian Rhythms, Sleep-Wake Cycle and Insomnia

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The Neurobiology of Sleep and Circadian Rhythm

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Circadian Rhythm and Your Brain’s Clock

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How Your Brain’s Internal Clock Works

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The DEEPEST Healing Sleep | 3.2Hz Delta Brain Waves | REM Sleep Music Binaural Beats

Video taken from the channel: SleepTube Hypnotic Relaxation

But the brain scans revealed a complicated interaction between two basic biological processes: the body’s central “circadian rhythm,” which pushes people. But the brain scans revealed a complicated interaction between two basic biological processes: the body’s central “circadian rhythm,” which pushes people to be awake and active during daylight, and wind down when it gets dark; and “homeostatic sleep drive,” which pressures people to go to bed when they’ve been awake too long. By Amy Norton HealthDay Reporter. FRIDAY, Aug. 12, 2016 (HealthDay News) Both an internal “clock” and an internal “hourglass” affect how different parts of your brain respond to sleep deprivation, a new study shows..

The Belgian researchers said these findings could eventually aid in the understanding of sleep disorders, and help folks who work night shifts or those with jet lag. Circuits in the brain act as an internal clock to tell us it is time to sleep and to control how long we then stay asleep. A new study in flies suggests a part of that clock constantly monitors.

At two peak times in the 24-hour day, just before waking and sleeping, neurons in cognition-related brain areas packed a timekeeping cell’s. Hundreds of biological timekeepers live your cells, governing your sleep, appetite, behavior, and more. Here’s how to manage your circadian rhythm so it works best for you. Your internal clock, or circadian rhythm, is always running in the back of your brain no matter what else is going on.

This is controlled by the hypothalamus and is another part of how your body knows when it’s time to be awake or time to sleep. Your internal clock works best when you have built good, regular habits of sleeping. Two internal biological mechanisms –circadian rhythm and homeostasis–work together to regulate when you are awake and sleep. Circadian rhythms direct a wide variety of functions from daily fluctuations in wakefulness to body temperature, metabolism, and the release of hormones.

Both CAT scans and MRIs are neuroimaging techniques that allow us to understand brain structures. While the CAT scan relies on _, the MRI uses _ to produce images of the brain. A) radiofrequency waves; radioactive dye and x-rays B) radioactive dye; x-rays and positrons.

Sleep Troubles, Heart Troubles? Why Some Women Find Good Sleep Tough to Get ; Brain Relies on Two Timekeepers for Sleep ; Drowsy Driving Causes 1 in 5 Fatal Crashes: Report ; Study Links Sleep Problems to Stroke Risk, Recovery.

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Sleeping and wakefulness, although dependent on the activities of the thalamus, the limbic system, and the reticular activating system, are also controlled by the hypothalamus.

“Clinical Neuroanatomy” by Richard S. Snell
from Clinical Neuroanatomy
by Richard S. Snell
Wolters Kluwer Health/Lippincott Williams & Wilkins, 2010

Regulation of wakefulness and sleep The regulation of wakefulness and sleep depends on complex neuronal and biochemical interactions involving the cortex (basal forebrain), diencephalon (thalamus and hypothalamus) and brainstem.

“Neurology: A Queen Square Textbook” by Charles Clarke, Robin Howard, Martin Rossor, Simon Shorvon
from Neurology: A Queen Square Textbook
by Charles Clarke, Robin Howard, et. al.
Wiley, 2016

Taking into account both suppressed neurogenesis and failure to develop to functional maturity, the authors estimate that sleep deprivation reduced the new neurons in this region by 60%, supporting the role of sleep in enabling the development of the structural substrates of brain plasticity.

“Sleep Deprivation and Disease: Effects on the Body, Brain and Behavior” by Matt T. Bianchi
from Sleep Deprivation and Disease: Effects on the Body, Brain and Behavior
by Matt T. Bianchi
Springer New York, 2013

NO also appears to play a special role in neurons with rhythmic firingsuch as the brain stem and thalamic neurons that regulate sleep—wakefulness, and the hypothalamic neurons that control bodily functions with daily variations (circadian rhythms).

“The Central Nervous System: Structure and Function” by Per Brodal, Ralph Erskine Conrad Memorial Fund
from The Central Nervous System: Structure and Function
by Per Brodal, Ralph Erskine Conrad Memorial Fund
Oxford University Press, USA, 2004

The brain contains two major cholinergic projection systems, both of which play a role in generating states of sleep and wakefulness.

“Encyclopedia of Behavioral Neuroscience” by Elsevier Science
from Encyclopedia of Behavioral Neuroscience
by Elsevier Science
Elsevier Science, 2010

Neurons of the aminergic arousal system (serotonergic, histaminergic, and noradrenergic), and other sleep state– dependent neuronal groups, are also positioned to provide a source of tonic (nonrespiratory) drive to respiratory neurons across sleep–wake states.

“Principles and Practice of Sleep Medicine: Expert Consult Premium Edition Enhanced Online Features” by Meir H. Kryger, Thomas Roth, William C. Dement
from Principles and Practice of Sleep Medicine: Expert Consult Premium Edition Enhanced Online Features
by Meir H. Kryger, Thomas Roth, William C. Dement
Elsevier Health Sciences, 2010

Furthermore, if consolidation involves the transfer of information from hippocampus to neocortex (an idea developed further in Chapters 12 and 13), one might expect there to be increased interaction between cells in these brain areas during and after sleep.

“The Hippocampus Book” by Per Andersen, Richard Morris, David Amaral, Tim Bliss, John O'Keefe
from The Hippocampus Book
by Per Andersen, Richard Morris, et. al.
Oxford University Press, 2006

These neuromodulators control the excitability of thalamus and forebrain, mediate the alternation between wakefulness and sleep, as well as the general level of both behavioral and brain arousal.

“Fundamental Neuroscience” by Larry Squire, Floyd E. Bloom, Nicholas C. Spitzer, Larry R. Squire, Darwin Berg, Sascha du Lac, Anirvan Ghosh
from Fundamental Neuroscience
by Larry Squire, Floyd E. Bloom, et. al.
Elsevier Science, 2008

Serotonergic neurons projecting to the suprachiasmatic nucleus of the hypothalamus help to regulate circadian rhythms (e.g., sleep–wake cycles, body temperature, and hypothalamic-pituitary-adrenocortical axis function).

“Kaplan & Sadock's Study Guide and Self-Examination Review in Psychiatry” by Benjamin J. Sadock, Virginia A. Sadock, Pedro Ruiz
from Kaplan & Sadock’s Study Guide and Self-Examination Review in Psychiatry
by Benjamin J. Sadock, Virginia A. Sadock, Pedro Ruiz
Wolters Kluwer Health/Lippincott Williams & Wilkins, 2011

Giuseppe Moruzzi argued that “sleep concerns primarily not the whole cerebrum, nor even the entire neocortex, but only those neurons or synapses, and possibly glial cells, which during wakefulness are responsible for the brain functions concerned with conscious behavior.”

“The Neuroscience of Sleep” by Robert Stickgold, Matthew P. Walker
from The Neuroscience of Sleep
by Robert Stickgold, Matthew P. Walker
Elsevier Science, 2010

Oktay Kutluk

Kutluk Oktay, MD, FACOG is one of the world's foremost experts in fertility preservation as well as ovarian stimulation and in vitro fertilization for infertility treatments. He developed and performed the world's first ovarian transplantation procedures as well as pioneered new ovarian stimulation protocols for embryo and oocyte freezing for breast and endometrial cancer patients.

Mail: [email protected]
Telephone: +1 (877) 492-3666

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  • Great videos Zac, very relaxing ��! Also love the absolutely beautiful scenery in your vids. Question: Does this work on pets too?? My hyper dog is fast asleep after 10 minutes…thank you ����!!

  • im feeling worthless and not good enough rn. i came to this video and looked at some comments. these comments mean so much and its crazy how strangers can make u feel better than people u know ��

  • I have IBS and lack of sleep gives me tummy ache and diarrhea, literally since I was a child,crazy and gross,I make sure to sleep as much as I can at night,for all my IBS people,make sure to SLEEP,it makes everything better with our sensitive tummies:)

  • They call it a “disorder” but it’s completely natural to the people (like me) who have it. The rest of the world, however, tends to think we’re lazy and doesn’t care that we don’t get enough sleep because work schedules are set up for “morning people.” I very much believe that the sleep deprivation caused by this has affected my health and makes me ill in other ways.

  • People in the comments: *inspirational and poetic
    Me trying to fall asleep at 3am on a school night: today I ate a slice of cheese, and it tastes like cheddar for some reason lol

  • We set the alarm at 4 AM every day for the first 10 days of
    Ramadan month.
    Initially, it was difficult to get up at such an early hour.
    Now we got used to it.
    With effortless ease, we get up.
    It is because of commitment!
    Because of sincerity!!
    Because we internalized the timing!!!
    It has become a habit or daily routine.
    The Inner Clock is set at 4 AM.
    It is ingrained in our psyche.
    Subconsciously, we get up.
    When Inner Clock is ticking, you don’t require alarm clock. you will get up automatically.
    When Inner Clock sleeps, no amount of external call can wake you up. You will press the button down.
    Once again you will go back to sleep.
    Keep your Inner Clock Ticking!!!
    All the time.
    Morning time is the best part of the day.

  • everythings is going wrong with me, everything is so dark from within, nothing is right, im stuck in the shade of overwhelming darkness…i am a fan of evil, but i do not like to dwell with it, and in this evil i am lost, in this darkness i walk, i hurt my closest ones, i lose everyone, and i cant fight it, it grew strong in me, it is stronger than me, i would like to end it, but i dont want to, i want to keep fighting, but i feel like i cant, im lost and i need guidance, i need a light in the end of the tunnel, so i can sprint to it, and than use the dark to dwell for good and not ruin, i seek for help, i seek for redemption, i seek…i seek for myself…..

  • My internal clock is all scrambled. I work the night shift now, which is about normal for me. However, when I worked at GoMart they had me on 2 night shifts and 3 evening shifts. This was done in such a way that I had to switch what pat of the day I slept twice a week.

  • My internal clock is to go to bed when the sun goes up.. it’s really weird. If I have absolutely nothing to get me up in the morning (like when I’m on vacation) My sleeping habits always goes back to the same thing.. Get tired around 4-5 in the morning, sleep until 1-2 in the afternoon.

  • Thanks for watching my latest upload with deeply relaxing binaural beats, hope you enjoy it ������ From where in the world are you listening? Let us know below!

  • If you happen to stumble upon this, I’d like to say I am so proud of how far you’ve come. Life isn’t easy but it’s definitely worth it. Let go of your anxiety, fear, doubt, worries, hate. Let love in. Let light in. Let this year be a time for transformation. Put your heart into the things that feel like sunshine. ☀️✨

    There are still good people in this world. ����
    Sending love and positive energy ��⚡

  • Whoa, I wonder if I have DSPD? 2-3:00 AM is when I get tired! And if you ask pretty much anyone I know, trying to wake my up is like trying to get a brick to tap dance. It’s impossible without persistence and imagination. XD I’ve been waking myself up at about 8:00 AM every day for a couple weeks, but even though I get sleepy and go to bed at midnight, it’s impossible to actually fall asleep until 2:00. Usually 2:00 exactly!

  • Every day i sleep about 48 minutes later

    Which cycles forward
    About 29 to 40 days like this
    I sleep my 8 hours every day no problem

    Day 1 i sleep at 00.00
    Day 2 00:50
    Day 3 01:36
    Day 4 02.24

    And so on……..

    I cant control irt
    It is not option
    Or choice

    What is this term is called?

  • This is like the nice comment section, since when were people that nice in comments or outside, all these comments are restoring faith in humanity:)

  • Circadian rhythm. Been able to change mine, all you need is coffee and a really free schedule so you can sleep during the day. The coffee is for night time.

  • Never thought I found my inner peace here.. Rejoice all living things! Let’s continue healing ourselves by this kind of sanctuary. All is well ��

  • When you wake up from this sleep tell yourself OUT LOUD “Today is the first day to the BEST part of my life.”
    It will be.
    Sleep well. Beautiful things are being set in motion for you.

  • I’d like to see a video on how people living at extreme latitudes like Alaska adapt to the extremes of light and dark present here. People seem to get by alright up here, so theres gotta be some science to explain that

  • Mama mia! Glad to learn “ 18:30 Highest blood pressure”. My routine physical checks are typically scheduled to 19:00; that helped the nurses to report on the high side. LOL.

  • I was the same as a baby except that I would happily stay in my crib and the play with a toy or talk to myself babbling. A spring warm sunny day when the sun is on my bed is when I crave to go to sleep and I usually have a nap because it’s too beautiful not to have a nap.

  • My body used to be an early bird back in 2016.
    My body has been a night owl since 2017 till this day.
    I fall asleep at 5 AM and wake up at 11 AM

  • Their was this odd tapping sound in the background of the music and it was super annoying and I couldn’t continue listening idk I guess I’m just weird or something but it really got in my nerves lmao ��

  • Yesterday night I slept with the lights on (square led fittings) and today my whole day was confusing during my classes!!! Can someone suggest a solution

    P. S. Let me tell you I had a complete undisturbed sleep of 7 hours, but still I felt unsatisfied!!!������

  • I don’t know when I slept listening to this. When I woke earphones was on me and phone was dead. After I charged and switch on the phone I found 2:43:45.. Such a deep sleep.

  • I’m from Texas and I moved to Georgia about 3 months ago. I have been staying up from 9-11 and waking up around 2 and I would end up having about 1 hour naps 3 separate times a day. Well this help me?

  • What i wanna know is….if i know i have to be up at 5am for work and i set my alarm….why i always wake up automatically at 4:58am…..but when i know i dont have work….i just sleep….thats what i wanna learn about….how that works like that….how do i always wake up minutes before my alarm

  • I am Close to 7000 km away from Home, in the Gambia. I Chose to come here, to try to build Up Life once more. Build it Up from Scratch after my Ex wife left me, the 2 years further i am now showed me Life goes on. When we got seperated i lost every materialistic thing you can Imagine. I felt personally into a deep hole, i thought there was no way Out of that. But Life showed me there is Hope and there is Light at the End of the Tunnel. Cause that what was left was Love, the Love to Not give in/Up, the Love to get Up and stand proud. To Show the beautifull daughter we created she has a Father. A guideline, a rolemodel someone to Look Up to. To Show her what strength is, to have the Courage to go to a Continent far away from Home. To do the unexpected when everybody thinks your Not going to make it, you prove them wrong. You Take responsabillity for your Life and that of your own Child. Cause who is going to Show your child how Things are done?!? Exactly, it is you and in this Case it is me. And you know what?!? I am fucking proud of myself, that I just did it and had the balls to take Action in Life. And trust me this was Not easy, but we are Not allone and when you want to succeed, and to move Forward then also you will move Forward. The strength any of you out there have lays deep within in any of you. And you can do it, but you personally need to want to do it. And believe in yourself, you are remarkable and Not known of your capabillity and the real strength in you.

    I forgot to Love myself after i was Not Loved anymore. But Trust me you can Love yourself at any time. Cause you are damn worth it my Brothers and Sisters!!!

  • My internal clock is all screwed up, I use to have a hard time getting to sleep but now it’s staying asleep, I only get about 5 hours of sleep now, I think it’s because of my gf Cuz she kept waking me up n now my body wakes up on it’s own, I think she fucked me up, if anyone knows how to fix this plz hmu, thanks…

  • i suffer ptsd and ive been listening to this kind of music to try to sleep better and it really helps with diminishing flashbacks. sometimes they get bad to the point where i flail and hit the wall and they’re especially bad at night when i close my eyes. this music has helped me greatly thank you

  • 2 years ago I was in a car accident was t-boned but a 18 wheeler, was pronounced dead heart stopped and all but they shocked me back to life. I spent almost 3 months in the hospital finally went home never thought I’d get it but I had severe PTSD couldn’t sleep without having night terror then the woman I was suppose to marry was caught in my bed with another man the split of terrible, all that depression worsened my PTSD I had a mental breakdown was diagnosed with Bipolar stress disorder I’ve been having it hard then I found this community seeing how such kind saying nice things to each other I swear when I’m having a hard day I love coming to these videos and seeing all the nice and thoughtful things said amongst this community. I’ve also found love too she been a Saint she picks me up on days that I’m down try’s her best to put up with my Mental Illness she’s always asking “how’s my mental and if I’m okay” emotionally checking up on me because her and this channel I sleep all night now, I would get up every half hour when I was having night terrors. So lastly thank you all, people like you make the world on round and it’s nice to know that there’s still Sweet People in this world
    Love Peace Respect��

  • If you read this, I love you and see the light in every ounce of Star dust you are made of. The whole world is inside of you. Shhh, just breathe.

  • God I havent forgot how you took care of me when my momy died and I was a little girl. I just wanna thank you, for Always being right there beside me. My suffering these last few years have Not changed my gratefulness lord… you bring me Peace, I love you jesus ��

  • I’ve worked night shift for about 12 years. It took about 2 weeks to get used to sleeping during the day. The whole trick is blackout curtains and actually letting yourself sleep. Over the years, the biggest problem I have seen with night shift workers is refusal to sleep. They find excuses to stay up far too late into the day or get up much too early in the afternoon, and complain about the lack of sleep. If you have 16 hours from the end of one shift to the beginning of the next, you can find time for a solid 7 hours of sleep somewhere in there.

  • Wow, this is great stuff very beneficial for my state of mind allright…
    Like some huge accordion musicsloweddown a billion percent…
    Boy is that uplifting……
    Quick where’s the box of Rockabilly CD’s…….!!!!!!!

  • I loove your channel i listening from South Africa..i have bouts of insomnia n since discovering this channel i know what regular normal uninterupted sleep feels like

  • Are you happy with your life? If not, it need not have to be that way anymore. There’s just so much waiting for you out there. Stop clinging to what’s making you depressed. Wake up tomorrow and find your purpose. You can make life begin any moment ❤️

  • I would love to sleep at night time. But I am unable to fall asleep before sunrise. I don’t even sleep through the whole day. Only until noon, not more than 5 to 6 hours a day. I have big eye bags. But I still am unable to sleep in the night. It’s not because of social media. Sometimes I try to fall asleep but I only end up lying on my bed for like 3 hours without falling asleep. I theorize it might have to do with my anti-social personality. Mornings are the busiest time of the day. They are filled with people. This is why I end up staying awake during the night where there are almost no people and sleeping through the morning.

  • Biological Alarm Clock: Biological alarm clocks are biological mechanisms that tell us when to eat, when to sleep, and when to make babies. For women, oftentimes the biological clock goes awry, and begins to signal all sorts of jarring behaviors that seem at least to the man of the house to be most untimely. This biological alarm clock jolts a woman into action, or more likely, into prodding a man into actions at the wrong time. A woman’s biological alarm clock is often out of sync with her husband’s own biological clock, which naturally runs much slower. The man compensates by resetting his own clock to give himself more time. Unfortunately, women have no capability to reset their own clocks. This results in their ringing just in time to tell their husband to vacuum the floor as he settles back to relax from a hard day at the office, or to mow the law or bath the kid just as the big game comes on TV. All too often the wife gets all wound up just as the husband starts to unwind. Unfortunately, the only way to set back your wife’s clock is with a blunt object to the head. However, this is not recommended since it would set her back in time permanently, and force you to do time, as in jail.
    from Dr. Mezmer’s World of Bad Psychology, found on an internet near you!

  • I have and had many panic attacks. An d I hope this music will help me to sleep better and to feel more the hand of God in my life. Thank you so much for the nice comments and this beautiful music..

  • I play this to fall asleep and it has helped so much…just wish this particular delta wave sound mash up could be longer than 5 hours

  • Well, my internal clock is pretty fine when I was young. But now, it’s all haywire… screw it.

    Sleep from 22:00 to 23:00, can take as long as an hour for me to fall asleep, wakes up at 5 (everyday, no alarm). This always makes me sluggish in the morning.

    And if I slept sooner, say, like an hour earlier, I’ll get headaches for as long as I’m doing it.