Bone Health insurance and Oestrogen

 

Hormones and Osteoporosis

Video taken from the channel: Teriblast English


 

Hormones and Healthy Bones

Video taken from the channel: Penn Medicine


 

Introduction to Bioidentical Hormones for Bone Health

Video taken from the channel: Margaret Martin, Physical Therapist


 

Treating Osteoporosis or Low Bone Density

Video taken from the channel: American College of Physicians


 

Estrogen | Reproductive system physiology | NCLEX-RN | Khan Academy

Video taken from the channel: khanacademymedicine


 

Osteoporosis in Postmenopausal Women Mode of Action Animation

Video taken from the channel: CAST PHARMA


 

Postmenopausal Osteoporosis

Video taken from the channel: Amgen


When you have sufficient levels of estrogen, that estrogen helps kill off the breakdown cells (the osteoclasts) so you have less cells breaking down bone in your body. That estrogen also helps protect the cells that build your bone (osteoblasts) so they don’t die off. The major physiological effect of estrogen is to inhibit bone resorption. Bone cells have two kinds of intracellular steroid receptors for estrogen.

When estrogen binds to the receptors, various genes become active. Estrogen also has effects that do not depend on activating the DNA. Estrogen and bone health in men and women. Estrogen is the key regulator of bone metabolism in both men and women. Menopause and the accompanying loss of ovarian estrogens are associated with declines in bone mineral density (BMD): 10-year cumulative loss was 9.1% at the femoral neck and 10.6%, lumbar spine.

Estradiol concentrations also pre. Estrogen plays an important role in the growth and maturation of bone as well as in the regulation of bone turnover in adult bone. During bone growth estrogen is needed for proper closure of epiphyseal growth plates both in females and in males. Also in young skeleton estrogen deficiency leads to increased osteoclast formation and enhanced bone resorption. Estrogen is a sex hormone that is essential to female bone health because it promotes the activity of osteoblasts, which are cells that produce bone.

When estrogen levels drop during menopause, the osteoblasts aren’t able to effectively produce bone. Estrogen replacement therapy used to be the only FDA-approved treatment to prevent osteoporosis. Hormones and Bones Hormones are really important to bone strength.

Hormones are chemicals made by glands that travel throughout the body and have many effects on growth, maturation, energy, weight, and bone strength. Sex hormones (estrogen made in the ovary of females and testosterone made by the testes in males) control ability to reproduce. The 2008 guideline based its recommendation on studies showing estrogen decreased fracture risk—but, as the 2017 guideline points out, “many of these studies focused on postmenopausal women with low bone density, or on postmenopausal women in general rather than those with established osteoporosis.”. Systemic estrogen helps protect against the bone-thinning disease called osteoporosis.

However, doctors usually recommend medications called bisphosphonates to treat osteoporosis. But estrogen therapy may help if you either can’t tolerate or aren’t benefiting from other treatments. Experience early menopause or have estrogen deficiency.

Estrogen is the key regulator of bone metabolism in both men and women. Menopause and the accompanying loss of ovarian estrogens are associated with declines in bone mineral density (BMD): 10-year cumulative loss was 9.1% at the femoral neck and 10.6%, lumbar spine. Estradiol concentrations also predict fractures.

Estrogen is the key regulator of bone metabolism in both men and women. and the accompanying loss of ovarian estrogens are associated with declines in bone mineral density (BMD): 10-year cumulative loss was 9.1% at the femoral neck Estradiol concentrations also predict fractures.

List of related literature:

Although systemic estrone helps to maintain skeletal health, it is the local production within the skeleton itself that becomes the primary source of estrogen for bone preservation.

“The Whole-Body Approach to Osteoporosis: How to Improve Bone Strength and Reduce Your Fracture Risk” by R. McCormick
from The Whole-Body Approach to Osteoporosis: How to Improve Bone Strength and Reduce Your Fracture Risk
by R. McCormick
New Harbinger Publications, 2009

Estrogen is essential to the preservation of normal calcium levels and bone density, and low levels of this hormone are associated with osteoporosis, a disease that is characterized by low bone mass and the premature weakening of bones.

“Applying Sport Psychology: Four Perspectives” by Jim Taylor, Gregory Scott Wilson
from Applying Sport Psychology: Four Perspectives
by Jim Taylor, Gregory Scott Wilson
Human Kinetics, 2005

Estrogen plays an important role in the maintenance of bone mass in women, and prolonged strenuous activity may result in low estrogen levels, causing bone loss.

“Encyclopedia of Human Nutrition” by Benjamin Caballero, Lindsay Allen, Andrew Prentice
from Encyclopedia of Human Nutrition
by Benjamin Caballero, Lindsay Allen, Andrew Prentice
Elsevier Science, 2005

It is true that estrogen is more effective than calcium in preventing postmenopausal bone loss, but the same is true in the rather analogous case of iron-deficiency anemia and blood loss; it is always more effective to correct this anemia by stopping the blood loss than by administering iron.

“Osteoporosis” by Robert Marcus, David W. Dempster, Jane A. Cauley, David Feldman
from Osteoporosis
by Robert Marcus, David W. Dempster, et. al.
Elsevier Science, 2013

While estrogen therapy for elderly women stops further bone loss and decreases the risk of fractures of thinned bones after menopause, alone it may not prevent osteoporosis.

“The Encyclopedia of Nutrition and Good Health” by Robert A. Ronzio
from The Encyclopedia of Nutrition and Good Health
by Robert A. Ronzio
Facts On File, 2003

There is no question that hormones are involved in bone-building and bone loss, but declining estrogen levels after menopause do not by themselves cause osteoporosis.

“Linda Page's Healthy Healing: A Guide to Self-healing for Everyone” by Linda G. Rector-Page
from Linda Page’s Healthy Healing: A Guide to Self-healing for Everyone
by Linda G. Rector-Page
Traditional Wisdom, 2000

• Estrogen is believed to play a significant role in bone metabolism: it is important for bone mineral deposition in females during puberty and peak bone mass accrual.

“Netter's Sports Medicine E-Book” by Christopher Madden, Margot Putukian, Eric McCarty, Craig Young
from Netter’s Sports Medicine E-Book
by Christopher Madden, Margot Putukian, et. al.
Elsevier Health Sciences, 2017

Oestrogen medication (hormone replacement therapy, HRT) is the most effective way of maintaining bone density and reducing the risk of fracture after the menopause; when treatment is stopped, bone loss proceeds at the usual rate.

“Apley's Concise System of Orthopaedics and Fractures” by Louis Solomon, David Warwick, Selvadurai Nayagam
from Apley’s Concise System of Orthopaedics and Fractures
by Louis Solomon, David Warwick, Selvadurai Nayagam
CRC Press, 2005

Although estrogen is of predominant importance for bone mass in both women and men, testosterone is important in stimulating periosteal apposition; as a result, cortical bone in men is larger and thicker.

“Comprehensive Gynecology E-Book” by Rogerio A. Lobo, David M Gershenson, Gretchen M Lentz, Fidel A Valea
from Comprehensive Gynecology E-Book
by Rogerio A. Lobo, David M Gershenson, et. al.
Elsevier Health Sciences, 2016

When estrogen levels are low, bone serves as a source of calcium to maintain normal levels of calcium in the blood and perform important physiological functions in the body.

“Sports Nutrition for Endurance Athletes, 3rd Ed.” by Monique Ryan, MS, RD, CSSD, LDN
from Sports Nutrition for Endurance Athletes, 3rd Ed.
by Monique Ryan, MS, RD, CSSD, LDN
VeloPress, 2012

Oktay Kutluk

Kutluk Oktay, MD, FACOG is one of the world's foremost experts in fertility preservation as well as ovarian stimulation and in vitro fertilization for infertility treatments. He developed and performed the world's first ovarian transplantation procedures as well as pioneered new ovarian stimulation protocols for embryo and oocyte freezing for breast and endometrial cancer patients.

Mail: [email protected]
Telephone: +1 (877) 492-3666

Biography: https://medicine.yale.edu/profile/kutluk_oktay/
Bibliography: oktay_bibliography

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5 comments

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  • Video is really important, and especially the ideas concerning reverse osteoporosis. Another resource I also found helpfull for anxiety postmenopausal osteoporosis treatment was Renkarter Expert Osteo Report it should be on Google if you need it

  • Do the ovaries straight up produce estrogen, or do they produce testosterone that is then aromatized into estrogen but at a higher rate?

  • Hello there. Thanks for the useful information and video! I was wondering, if cholesterol creates estrogen through aromatase, then why are so many women and also men with android fat distribution? With that being asked, I’ve also seen women and men with gynoid fat distribution. Can you let me know what determines the type of fat one person gets? What are the factors for both types of fat distribution patterns? I used to have android fat, then gynoid fat, sadly again, the dreaded, android fat. I would like to know what triggers the unlikeable android fat. I’ve read that it’s ‘free testosterone’ that hasn’t or can’t be turned to estrogen (because of higher levels of testosterone or cholesterol?). Can you weigh in on that? Is it too much cholesterol the root of android fat? Sometimes I get so confused. Do phytoestrogens have an effect on estrogen? Can the enzyme aromatase be increased? Is that even possible? I don’t even know if that’s the right term for it. I would very much appreciate it if you replied. Thanks for reading!

  • Why pcos condition is so complicated?? Please make a video on it. Is imbalanced hormones of one gland effects the other gland hormones. If yes then how??

  • https://www.youtube.com/watch?v=Gb3G2Kv7kU8. High dosages of boron reverses osteoporosis according to Dr. Jorge Flechas. He is a 60 year old who reversed osteopenia and his wife reversed osteoporosis with Boron. So hard to believe but it is that simple. He now has the skeleton of a 20 year old at age 60. The level of boron that people consume in Western China is 135mg of boron. I guess the pharmaceutcal industry does not want you to know. The company selling high dosage of boron is Hakala Research. God bless you!