Autism, Bipolar and Schizophrenia Share Genetic Similarities

 

Why delayed onset of mental illness? Genes impact suspect brain areas late

Video taken from the channel: National Institute of Mental Health (NIMH)


 

Imagination diametric phenotype of autism / psychotic-affective conditions | Bernard Crespi

Video taken from the channel: Evolutionary Medicine


 

Evolution and genetics of autism, psychosis, and the social brain | Bernard Crespi

Video taken from the channel: Evolutionary Medicine


 

9.4 Mental disorders: Autism and schizophrenia

Video taken from the channel: YaleCourses


 

Schizophrenia and Bipolar Disorder Similar Genetics (14 of 15)

Video taken from the channel: DNA Learning Center


 

Five mental disorders share some of the same genes

Video taken from the channel: National Institute of Mental Health (NIMH)


 

Autism Spectrum Disorder and Schizophrenia: Shared Traits and Treatment

Video taken from the channel: MassGeneralHospital


HealthDay Reporter THURSDAY, Feb. 8, 2018 (HealthDay News) By examining brain tissue, researchers say they’ve found similarities in certain mental illnesses, including autism and schizophrenia. THURSDAY, Feb. 8, 2018 (HealthDay News) By examining brain tissue, researchers say they’ve found similarities in certain mental illnesses, including autism and schizophrenia. Specifically, some similar patterns of gene expression were found in people with autism, schizophrenia and bipolar disorder, the researchers say. THURSDAY, Feb.

8, 2018 By examining brain tissue, researchers say they’ve found similarities in certain mental illnesses, including autism and schizophrenia. Specifically, some similar patterns of gene expression were found in people with autism, schizophrenia and bipolar disorder, the researchers say. By examining brain tissue, researchers say they’ve found similarities in certain mental illnesses, including autism and schizophrenia. Specifically, some similar patterns of gene expression were found in people with autism, schizophrenia and bipolar disorder, the researchers say.

Gene expression refers to cells’ conversion of genetic instructions into proteins. Specifically, some similar patterns of gene expression were found in people with autism, schizophrenia and bipolar disorder, the researchers say. Gene expression. THURSDAY, Feb.

8, 2018 (HealthDay News)—By examining brain tissue, researchers say they’ve found similarities in certain mental illnesses, including autism and schizophrenia.. Specifically, some similar patterns of gene expression were found in people with autism, schizophrenia and bipolar disorder, the researchers say. At least three neuropsychiatric disorders — autism, schizophrenia and bipolar disorder — appear to share similar patterns of gene activity, a new study suggests. THURSDAY, Feb. 8, 2018 (HealthDay News) — By examining brain tissue, researchers say they’ve found similarities in certain mental illnesses, including autism and schizophrenia.

Specifically, some similar patterns of gene expression were found in people with autism, schizophrenia and bipolar disorder, the researchers say. Gene expression refers to cells’ conversion of genetic instructions. Gene expression patterns in the brains of people with autism are similar to those of people who have schizophrenia or bipolar disorder, according to a large study of postmortem brain tissue. Making connections: Networks of genes derived from certain ‘modules’ (neuron, top right, and astrocyte, bottom left) are altered in autism, schizophrenia and bipolar disorder.

Gene expression patterns in the brains of people with autism are similar to those of people who have schizophrenia or bipolar disorder, according to a large study of postmortem brain tissue 1.

List of related literature:

Additionally, the same mutation (or different mutations in the same gene) may lead to different neuropsychiatric phenotypes in different individuals, including ASD, bipolar disorder, or intellectual disability.

“Dulcan's Textbook of Child and Adolescent Psychiatry” by Mina K. Dulcan
from Dulcan’s Textbook of Child and Adolescent Psychiatry
by Mina K. Dulcan
American Psychiatric Publishing, 2015

Autism and its broader phenotype breed true, and there is no evidence of any genetic association between schizophrenia and autism (see chapter 46).

“Rutter's Child and Adolescent Psychiatry” by Sir Michael J. Rutter, Sir Dorothy Bishop, Sir Daniel Pine, Sir Stephen Scott, Sir Jim S. Stevenson, Sir Eric A. Taylor, Sir Anita Thapar
from Rutter’s Child and Adolescent Psychiatry
by Sir Michael J. Rutter, Sir Dorothy Bishop, et. al.
Wiley, 2011

For instance, one study found that people diagnosed with schizophrenia, autism, and bipolar disorder tended to have numerous shared genetic factors (Gandal et al., 2018).

“Abnormal Psychology: Contrasting Perspectives” by Jonathan D. Raskin
from Abnormal Psychology: Contrasting Perspectives
by Jonathan D. Raskin
Macmillan International Higher Education, 2018

These findings confirm the genetic heterogeneity of schizophrenia and the idea that people with the same disorder (schizophrenia) may not necessarily have the same genetic factors contributing to the disorder.

“Abnormal Psychology: The Science and Treatment of Psychological Disorders” by Ann M. Kring, Sheri L. Johnson
from Abnormal Psychology: The Science and Treatment of Psychological Disorders
by Ann M. Kring, Sheri L. Johnson
Wiley, 2018

Therefore, they hypothesized that similar dysfunctions might exist in unaffected siblings of children with ASD.

“The Broad Autism Phenotype” by Anthony F. Rotatori, Julie A. Deisinger
from The Broad Autism Phenotype
by Anthony F. Rotatori, Julie A. Deisinger
Emerald Group Publishing Limited, 2015

Notably, several common regions have been implicated in linkage genome scans for bipolar illness and schizophrenia, which has led to the formulation of the hypothesis that the two disorders share some susceptibility genes.

“Psychiatry” by Allan Tasman, Jerald Kay, Jeffrey A. Lieberman, Michael B. First, Mario Maj
from Psychiatry
by Allan Tasman, Jerald Kay, et. al.
Wiley, 2011

That is, instead of distinct sets of genes for schizophrenia and bipolar depression, twin studies suggest that many of the same genes affect both.

“Blueprint: How DNA Makes Us Who We Are” by Robert Plomin
from Blueprint: How DNA Makes Us Who We Are
by Robert Plomin
MIT Press, 2019

Strikingly, many of the genes found in this study have also been implicated in sporadic autism and bipolar disorder.†

“The Gene: An Intimate History” by Siddhartha Mukherjee
from The Gene: An Intimate History
by Siddhartha Mukherjee
Scribner, 2016

It also is possible that genetic and obstetric risk factors for schizophrenia occur independently of each other but additively influence risk for disease expression (additive influence model).

“Clinical Handbook of Schizophrenia” by Kim T. Mueser, Dilip V. Jeste
from Clinical Handbook of Schizophrenia
by Kim T. Mueser, Dilip V. Jeste
Guilford Publications, 2008

Moreover, schizophrenia, bipolar disorder, and autism tend to occur together in the same families.

“Medical Genetics E-Book” by Lynn B. Jorde, John C. Carey, Michael J. Bamshad
from Medical Genetics E-Book
by Lynn B. Jorde, John C. Carey, Michael J. Bamshad
Elsevier Health Sciences, 2019

Oktay Kutluk

Kutluk Oktay, MD, FACOG is one of the world's foremost experts in fertility preservation as well as ovarian stimulation and in vitro fertilization for infertility treatments. He developed and performed the world's first ovarian transplantation procedures as well as pioneered new ovarian stimulation protocols for embryo and oocyte freezing for breast and endometrial cancer patients.

Mail: [email protected]
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Biography: https://medicine.yale.edu/profile/kutluk_oktay/
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  • I’m the granddaughters to people who served in the military and ministry of God christ and my two grandchild are in the military now enrich Lynn McKenzie army and William connor McKenzie marine I have prophet es in my jounel entry HELEN Marlene Evans DRIGGERS prophetess and Ellen Darlene Evans prophet es in my jounel entry I was diagnose with schizophrenia at one Point and time I’m very good now

  • So many people go from ASD to Schizophrenia this I’ve learnt through my own experiences. In these cases there has to be something going on to the brain over a period of time!! This needs to be studied

  • I’m having an episode right now and it’s very positive and good feeling voice, what do I do? It’s not going away, it’s like very persistent and it is very powerful. Am I dying? Is God actually or whatever actually talking to me? Is it because no one cares and I’m so lonely that this imaginary friend personality has taken over my mind or is it just the subconscious doing it’s job but I’m unfortunately too connected to it? Will it cause me to not move again for hours at a time again? Is it do to hypnosis as a child is that possible?

  • what about bad parenting? wanting it diagnosed so they can get benefits..what a joke the system is….some idiot social psychologist now retired listening to mom blah blah blah….now retired..so where do we stand here? studied this..and taking away from the kids whom are really needing this..down to money and bad diagnosis…

  • Dear Channel Manager,

    Hi! Do you have the slides for this talk? If you do, would you kindly share them? Either put them in the description or in a pinned comment. Thank you in advance!

  • A few questions: What is a variation copy? What is 1q21.1 and wherein the brain is it located.?
    Deletions of What? Can medical procedures stop the deletions or the copies?
    What is Angelman, Prader-Willi, Silver=Russell, and Beckwith-Wiedemann have to do with Autism/Schizophreia?

  • Most people with autism can speak. You talked about more low functioning autistic I thought you were going to talk about all kinds I’m high functioning.

  • Try this: https://youtu.be/ytLM_zgwqsM
    (How Shizophrenia and autoimmune thing related to each other)
    It maybe helps to find a new way of thinking in this field

  • erotomania has nothing categorically to do with fame at all. The last few cases I witnessed were of patients developing obsessions after fleeting social contact, such as via a church group or in a bar. Aspien patients frequently develop elaborate fantasy worlds (including romantic delusions looking like…erotomania) via “maladaptive daydreaming”. These can involve real or imaginary characters, so is this a version of imagination categorically different to the “imagination” of the imagined (pun intended) binary here, or is there an implied but not indicated split between autism and Aspergers? That is partly a rhetorical question as we know from EEG studies that compared to controls the two conditions look similar but taking an autism (eg not HFA) cohort and comparing it to a HFA Aspergers cohort shows clear differences. Basically all the symptomatology on the right red column (at 24 minutes) has been indicated for Aspien patients (eg, averting gaze is because they do share the BPD trait of over-reading negative expressions). I would also like to ask, if you remove any sort of median-typical patient for brain weight, what is the highest weight schizophrenic brain, and what is lowest for autism? Clearly what I am implying is are we actually looking at a spectrum of brain weight rather than a binary if we remove averages. I’m not being ridiculously pedantic, my point is that a low end Aspien might mirror a high end schizo-affective in weight because they mirror each other in genetics, epigenetics (for instance in uterine stressors due to social environment of mother & grandmother), and life experience (imagine the difference for a highly sensitive Aspien patient who alternatively is raised by alcoholic manic-depressive/BPD/NPD parents versus that patient raised by two very calm, frontal cortex dominant (hence emotion-mastering) middle-class general practitioners of medicine (I say medicine as that has been indicated as a statistically common Aspien career path).

  • Has it ever been theorized that those with ranges in the autistic spectrum need to be taught to operate within a 3-dimensional perspective instead of 2-d?

  • The brain is a very complex machine and this means there are a lot of mechanisms to understand such mental conditions. If we talk about mechanisms there could be symptoms which are quite similar to other mental problems but they could have completely different origin. For this reason it could be quite difficult to considere any comorbidity between such mental issues. Schizophrenia usually have similar symptoms to autism but in the case of autism it is known to be caused by extra-synapses which cause extra connection in local scale but low connection in general scale of the brain. I haven’t read any investigation about extra-synapses and schizophrenia but the opposite!! So in my opinion it may be very almost impossible to have autism and schizophrenia at same time

  • This is really interesting. There are however a few common errors of splitting off frequently co-morbid conditions that, based on man-made definitions, shouldn’t exist together, but often do. Aspergers for instance, has been known to manifest incredible intuitive understanding of human behaviour, resulting in “empath” being a frequent category attributed to a subset of patients. Further, placing BPD in opposition to the Aspien population in terms of a symptomatology binary is close to impossible as the most common observation is that the two have a striking number of identical traits and the general debate is on whether or not the cause is really developmental or epigenetic. This does not even begin to address the statistical incidence of misdiagnosis or the expert calls for schizophrenia to be collapsed back into autism, for example. The much cited STEM v Humanities study of student’s family histories includes conditions in one column (eg humanities & manic depression) that have now been implicated in autism via specific genes.