Antidepressants Might Have Unwanted Effects on Bone Health

 

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FRIDAY, June 26, 2015 (HealthDay News) Women prescribed a common class of antidepressants to ease menopausal symptoms may face a long-term rise in their risk for bone fracture, a new study suggests. Antidepressant Use Linked to Bone Loss Older men and women who take the most widely used type of antidepressant medication may be at increased risk for bone loss, according to the results of 2 large studies. SSRIs work by blocking the protein associated with the movement of serotonin, the brain chemical linked to depression.

The protein has also recently been discovered in bone, and laboratory studies. Even with the use of the new-user design, confounding by indication remains an important potential source of bias in observational studies examining the association between antidepressant use and bone outcomes because antidepressants are often prescribed for depressive symptoms and depressive symptoms have been linked to lower BMD, higher rates of bone loss, and higher risk of fracture. A common medication for depression is a selective serotonin receptor uptake inhibitor or SSRI. This particular antidepressant medication increases fracture risk and bone loss in older women and is associated with lower bone density in children and men. To lessen the harm to the bones from antidepressant.

Some medications prescribed for common health problems, such as heartburn or depression, could affect your bone health. “That doesn’t necessarily mean. Since the late 1980s, America and the world have been enjoying the benefits of the selective serotonin reuptake inhibitors (SSRIs). These antidepressants — fluoxetine (Prozac), sertraline (Zoloft), paroxetine (Paxil), fluvoxamine (Luvox), citalopram (Celexa), and escitalopram (Lexapro) — are among the world’s most widely prescribed medications. Despite the widespread use of these prescription drugs (globally, this is a $14 billion business), antidepressants can have potentially negative effects on your health. While they are life-saving for some, for others these medications can trigger side effects and symptoms that can disrupt normal routines, or they may be ineffective at alleviating depression.

Antidepressant side effects can range from mild discomfort to severe impacts on your daily life. We’ll go over and compare the common side effects associated with different types of antidepressants. At least one in seven community-dwelling older adults is prescribed an antidepressant.

1 Concerns have been raised about the safety of serotonin-reuptake inhibitor (SRI) antidepressants in older adults, 2 particularly whether these medications may increase risk for osteoporosis, falls and fractures. 3-6 In this review, we examine the putative bone loss risk.

List of related literature:

This section will focus on the emerging evidence that second D on generation antipsychotics and selective serotonin reuphuman body weight has been suggested by the observatake inhibitor (SSRI) can adversely affect bone and fat.

“Osteoporosis” by Robert Marcus, David W. Dempster, Jane A. Cauley, David Feldman
from Osteoporosis
by Robert Marcus, David W. Dempster, et. al.
Elsevier Science, 2013

Although the data on effects by serotonin on the skeleton are not conclusive, the available information clearly demonstrates that serotonin can influence bone cell activities in vitro and bone metabolism in vivo.

“Principles of Bone Biology” by John P. Bilezikian, Lawrence G. Raisz, T. John Martin
from Principles of Bone Biology
by John P. Bilezikian, Lawrence G. Raisz, T. John Martin
Elsevier Science, 2008

Although antidepressant medication can have side effects that include weight gain, most research to date has found no differences in studies of participants with depression who undergo pharmacological treatment compared to those who do not (Luppino et al., 2010).

“Handbook of Obesity Treatment, Second Edition” by Thomas A. Wadden, George A. Bray
from Handbook of Obesity Treatment, Second Edition
by Thomas A. Wadden, George A. Bray
Guilford Publications, 2019

Furthermore, there have been no negative effects reported from the use of exercise for depression which cannot be said for most of the antidepressant medications, the literature accompanying which usually clearly states the risk of negative side effects.

“Psychology of Physical Activity: Determinants, Well-Being and Interventions” by Stuart J. H. Biddle, Nanette Mutrie
from Psychology of Physical Activity: Determinants, Well-Being and Interventions
by Stuart J. H. Biddle, Nanette Mutrie
Taylor & Francis, 2007

Antidepressants, mainly tricyclic antidepressants and MAOIs, are more likely to cause weight gain than selective serotonin reuptake inhibitors (SSRIs).

“Manual of Dietetic Practice” by Briony Thomas, Jacki Bishop
from Manual of Dietetic Practice
by Briony Thomas, Jacki Bishop
Wiley, 2013

As there is increasing evidence that chronic low-grade inflammation frequently occurs in depression and schizophrenia, celecoxib has been investigated for its possible beneficial effects in patients who are responding poorly to antidepressants or antipsychotics.

“Seminars in Clinical Psychopharmacology” by Peter M. Haddad, David J. Nutt
from Seminars in Clinical Psychopharmacology
by Peter M. Haddad, David J. Nutt
Cambridge University Press, 2020

Although the often-repeated statement that antidepressants work by correcting the biochemical deficiency that is the cause of depression may be an effective promotional tack, it cannot be justified by the evidence.

“Blaming the Brain: The Truth About Drugs and Mental Health” by Elliot Valenstein
from Blaming the Brain: The Truth About Drugs and Mental Health
by Elliot Valenstein
Free Press, 2002

These nondepression effects of antidepressants are very important in determining patient well-being but are not fully assessed by evaluating symptom dimensions of antidepressant effects.

“Manual of Clinical Psychopharmacology” by Alan F. Schatzberg M.D., Charles DeBattista D.M.H. M.D.
from Manual of Clinical Psychopharmacology
by Alan F. Schatzberg M.D., Charles DeBattista D.M.H. M.D.
American Psychiatric Association Publishing, 2015

Some early evidence suggests that selective serotonin reuptake inhibitors may cause bone loss.

“Gynaecology E-Book: Expert Consult: Online and Print” by Robert W. Shaw, David Luesley, Ash K. Monga
from Gynaecology E-Book: Expert Consult: Online and Print
by Robert W. Shaw, David Luesley, Ash K. Monga
Elsevier Health Sciences, 2010

Studies show that SSRI medications may increase the risk for falls, fractures, and bone loss in older adults (Diem et al., 2007; Haney et al., 2007).

“Fasting: an Exceptional Human Experience” by Randi Fredricks
from Fasting: an Exceptional Human Experience
by Randi Fredricks
AuthorHouse, 2012

Oktay Kutluk

Kutluk Oktay, MD, FACOG is one of the world's foremost experts in fertility preservation as well as ovarian stimulation and in vitro fertilization for infertility treatments. He developed and performed the world's first ovarian transplantation procedures as well as pioneered new ovarian stimulation protocols for embryo and oocyte freezing for breast and endometrial cancer patients.

Mail: [email protected]
Telephone: +1 (877) 492-3666

Biography: https://medicine.yale.edu/profile/kutluk_oktay/
Bibliography: oktay_bibliography

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32 comments

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  • Why do they give depression especially Parkinsons’? Is it because they lower Serotonin or because they r AntiCholenergic? I’m surprised that L dopamine can cause depression!..or maybe I misunderstood it? Thanks Doctor for always amazing videos❤��

  • Thank you for the video.
    I have a question regarding the bit where you said testosterone level is the highest at 8am.

    What if someone has a night shift job and works till 7 am and then sleeps 8 am to 3pm.

    Will they still have highest testosterone at 8am or does those level change according to your working/resting cycle?

  • Antidepressants were meant for people who are truly struggling with episodes of major depression. The proposal of the video is discussing the tendency m.d’s have to push antidepressants on people who are experiencing symptoms that could be treated with other therapies. And that’s all. No need for judgements here. I suffered from anxiety disorders wich were treated with lower doisis of antidepressants… I assure you that was one of the worst decisions I took in my entire life. After some time, they simply stop working and all the shit you had been through rises again. And when you try quitting the drugs, you feel even worse than before. It’s a struggle but it’s better to fight and get rid of this shit than carry-on keep on feeling like a zombie.

  • The number of SSRI-defending lunatics shows us that the anti-depressant lobby has truly brainwashed the masses. How depressing indeed, ironically.

  • Bodies are so complicated! It’s over whelming the number of chemical reactions going on inside of each of us every minute of every day. Truly shows how every one of us is different and we all require different protocols. Do you have an opinion on BIO Identical hormone replacement? The kind administered via an MD where blood levels are monitored and hormones adjusted.

  • Everyone is quick to blame the drugs and to tell everyone to suck it up and be happy without medication. The greater issue, I believe, is that so many people find western civilization unnatural enough where they NEED to seek out medications and other resources to cope. Our model wasn’t built for sensitive and compassionate people, it was built for those with excessive greed. We live in a society curated for sociopaths to thrive off of the expense of the common man. I seriously wish this video dug deeper into a larger issue instead of placing guilt and shame on those who need help.

  • My poor wife. She’s got depression and she’s also on a whole bunch of medication for health issues. I’m sure they make her depression worse…:(

  • Ive been on Prozac and smoking weed. I’ve quit nicotine and I’m quitting weed. Prozac I’m still unsure. I haven’t been taking it recently but I was on 40mg. I don’t know whether I want to continue it or not. I felt benefits but maybe my lack of empathy plus smoking weed just made me more antisocial. So I think I have to see how I feel without weed for a period of time before deciding on the ssri

  • The thing is sometimes you should say “Yeah whatever, so what” but there’re lots of situations that you have to think very well and carefully. You have to be sensitive, you have to do emphaty. But when you’re under drugs you can’t do that. Anxiety and stress are defense mechanism to fight what you’re going through. Somethings are wrong with you. You gotta make it right or you gotta be patient if you can’t and after that you’ll be stronger. This’s life. It’s not easy and pink always. Sometimes black, sometimes dark gray. It’s not always bright. Everytime there can be worse, but when you have it you gotta be ready. You gotta learn how to walk in darkness. It’s not gonna be easy, especially at first. You’ll fall more until your eyes get used to darkness. You are gonna keep falling until end of the road but you’re gonna rise again every time. As Less fearless, more experienced and strong, and capable to fight back.

  • I take antidepressants and I can function normally….
    So I don’t give a fuck if I die 10 years early also….
    Im happy because I don’t have to deal with depression and anxiety anymore….
    Anyone who is depressed must take antidepressants.
    Peace

  • I’m 38 and my Level is 278 and my Kaiser Doctor says it’s normal. Is it normal? Everything you mentioned feels spot on with my problems:(

  • Hello,

    I’ve been diagnosed with PTSD after domestic violences (psychological and sexual). I would say that I also went through cPTSD during my childhood due to high level harassment at school and coercive behaviors at home, with as cherry on top my mother committing suicide and my stepfather throwing me out of the house. Fun background one might say, well…

    But the story doesn’t just end there. The police ended up sending me to see a psychiatrist due to the domestic violences. He made some additional tests. It ends up that I’m also identified as gifted.

    Now this psychiatrist has also got me tested for testosterone as my sex drive dropped like hell.

    I still going through further analyses but considering what my psychiatrist told me. Low testosterone can also be explained by PTSD, cPTSD and is also noticed with people a little too brainy. So if he’s not mistaken, you can add those 3 explanations to your list.

    If not, I’d really appreciate your point of view on the matter.

  • antidepressants ruined my life, this is a painfully honest comment. the problem in my case is the DISHONESTY!!! psychiatrists lie all the time

  • Doc, low T could be the sign of too much sexual activity or too much masturbation, things which western promote through fashion, pornography and mentality.

  • All psy drugs can induce anhedonia (not only ssri, even if they are more likely to cause it), which is an intolerable condition. Anhedonia induced by psy drugs means: the total inhability to feel pleasure. It’s not just that mild depression where you have less interests or feeling very anxious, it’s just that you can’t “feel” anything. You can’t have sex because you don’t enjoy it physically. You don’t eat, and you are not hungry, because you don’t have any pleasure in eating even the most delicious meal. You can’t feel love, even for your partner. You don’t feel love for your children, or your parents, your pet, or anything like that. You don’t have any interests left. You can’t feel any pleasurable sensation. You don’t react to external stimulus. Someone can menace you or your loved ones, you don’t feel anything. You will only react because you know that if your emotions weren’t numb you would react, the rationality is the only thing left, but you are suffering so much you end losing all rationality. You are in this zombie-state, chemically induced, sometimes with only 5 or 6 pills, you never know how you will react and after how many pills since it’s due to your metabolism of the cytochrome P450 (mainly CYP2D6 for psy drugs). You never know when it will end. When you tell to your psychiatrist, he tell you it’s your disease. You was consulting for chronic tiredness and lack of confidence? Too bad, it’s your disease if you feel nothing!

  • Dr Jarvis said they can find a medicine that will work for you eventually. Well, how can they find the right one when they don’t even know why the drugs work on the few that they do? They used to think it was a serotonin deficiency, but we know now that isn’t the case. So this fraud doctor thinks we should just keep trying other ones until we find one that works? The data from their own studies show they work no better than a placebo for most people, while having terrible side effects. The healthcare industry is one big ripoff for the patient.

  • Thanks Dr. Tracey I gor 15 kgs for just one year, was drinking a lot, day by day and last year in August I got first panic attack and blood pressure at high levels. After a month I started medications such as anti-depressants and inhibitors, breasts was growing, but now I’m not getting attacks, also was fighting against agoraphobia, even now I am not fully healthy from agoraphobia, but things have been changed to right direction. Was it caused by alcohol? Also I was sleeping less than 6-7 hours for years. Thank you Dr. Tracey

  • Love you Dr.Berry, you’re amazing an always provide much needed information. Thank you for what you do! God Bless you and your family ������

  • That’s because I am the man in the family for over26 years I’ve pretty much supported my family. I like my job and fulfilled. So no choice Had to take it.

  • I know this isn’t related to the video but I wanted to ask you something. I am mostly depressed(and suicidal) for maybe a week or two and then I get happy and think the world is great for a couple of days. I don’t do anything drastic, I’m just happy for a couple of days and not sad at all. Do I have bipolar disorder or depression? I’ve been to a couple of psychiatrists and some say I have bipolar and some say depression.

  • I used to take ibuprophen a lot. I had headaches. And I lived. Survived with depression. Until recently that I began yo take vit c in Big quantities. I am happy thanks to vit c and the sun. No more headaches no more sinus infections no more extrange noise from My lungs. No more doctors. No more medicin.

  • You can tell that this dude wants us all on PROZAC. Not a low dose, either. He wants up popping 80mg every morning! He also only approves of fluoxetine by Eli Lilly. Yes sir!

  • Been on 40mg of Prozac for little over a year, I’ve just become very incredibly emotionally numb, I can’t cry I barely laugh, I barely feel anything anymore…

  • I’m already doing keto and I’ve just found out that I have a ventricular fibrillation problem and only just been put on beta blockers. I’m a little worried now that all of my efforts will be thwarted

  • I’ve been trying to beat anger depression and anger for 20 years and finally had enough. Started buproprion 3 months ago, now adding lexapro to help with the anxiety aspects

  • What are some ways to achieve total control over your erectile dysfunction? I read loads of great reviews on the net about how exactly Erectodom Secrets can assist you solve your erectile dysfunction problem. Has any one tried this popular erectile dysfunction natural treatment?

  • Nice Video! Sorry for the intrusion, I would appreciate your thoughts. Have you considered Teyulian Extraordinary Takeover (probably on Google)? It is a smashing one off product for lasting longer in bed to keep your partner happy without the hard work. Ive heard some awesome things about it and my buddy finally got cool results with it.

  • ECT is in fact dangerous. Sorry but there’s clear proof of it and live feedback of those who have experienced it. Side effects exceed the benefits and the fact that is still in use is beyond questionable.

  • For anyone people suffering with a debilitating mental illness, I implore you try a MAOI inhibitor.
     
    MAOI INHIBITORS, such as PHENELZINE, are the most powerful antidepressants in EXISTENCE.
     
    Psychiatrists don’t prescribe them often because of outdated and incorrect dietary restrictions, and because they are not profitable to corrupt pharmaceutical companies.
    For more information look at highly respected psycho-pharmacologist Dr Ken Gillman’s website https://psychotropical.com/

  • Im very glad I found this video. I am FTM transgender who has taken testosterone supplementation (injections) for 4 years now and it baffles me that this connection between low mood and low testosterone has never been drawn… due to a severe depression I often found myself administering my shot 1-3 days late. I was never able to get it on track because my mood only got worse each week. it was only once i began taking the medication on time that my depression lifted.

  • I just recently got off of gabapentin, which I took for over 10 years. Hoping that I can move past the stress and anxiety that I have suffered from the past 5 years. Also added in the Keto lifestyle the last 5 months. Between the two I am looking forward to 2019-

  • I got panic disorder from an illness. Couldn’t sleep. Sky high blood pressure. Was put into the hospital for hyperventilation by ambulance. Some people can’t live functioning lives without shutting parts of the brain down. Sad but true