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FRIDAY, June 26, 2015 (HealthDay News) Women prescribed a common class of antidepressants to ease menopausal symptoms may face a long-term rise in their risk for bone fracture, a new study suggests. Antidepressant Use Linked to Bone Loss Older men and women who take the most widely used type of antidepressant medication may be at increased risk for bone loss, according to the results of 2 large studies. SSRIs work by blocking the protein associated with the movement of serotonin, the brain chemical linked to depression.
The protein has also recently been discovered in bone, and laboratory studies. Even with the use of the new-user design, confounding by indication remains an important potential source of bias in observational studies examining the association between antidepressant use and bone outcomes because antidepressants are often prescribed for depressive symptoms and depressive symptoms have been linked to lower BMD, higher rates of bone loss, and higher risk of fracture. A common medication for depression is a selective serotonin receptor uptake inhibitor or SSRI. This particular antidepressant medication increases fracture risk and bone loss in older women and is associated with lower bone density in children and men. To lessen the harm to the bones from antidepressant.
Some medications prescribed for common health problems, such as heartburn or depression, could affect your bone health. “That doesn’t necessarily mean. Since the late 1980s, America and the world have been enjoying the benefits of the selective serotonin reuptake inhibitors (SSRIs). These antidepressants — fluoxetine (Prozac), sertraline (Zoloft), paroxetine (Paxil), fluvoxamine (Luvox), citalopram (Celexa), and escitalopram (Lexapro) — are among the world’s most widely prescribed medications. Despite the widespread use of these prescription drugs (globally, this is a $14 billion business), antidepressants can have potentially negative effects on your health. While they are life-saving for some, for others these medications can trigger side effects and symptoms that can disrupt normal routines, or they may be ineffective at alleviating depression.
Antidepressant side effects can range from mild discomfort to severe impacts on your daily life. We’ll go over and compare the common side effects associated with different types of antidepressants. At least one in seven community-dwelling older adults is prescribed an antidepressant.
1 Concerns have been raised about the safety of serotonin-reuptake inhibitor (SRI) antidepressants in older adults, 2 particularly whether these medications may increase risk for osteoporosis, falls and fractures. 3-6 In this review, we examine the putative bone loss risk.
List of related literature:
|from Principles of Bone Biology|
|from Handbook of Obesity Treatment, Second Edition|
|from Psychology of Physical Activity: Determinants, Well-Being and Interventions|
|from Manual of Dietetic Practice|
|from Seminars in Clinical Psychopharmacology|
|from Blaming the Brain: The Truth About Drugs and Mental Health|
|from Manual of Clinical Psychopharmacology|
|from Gynaecology E-Book: Expert Consult: Online and Print|
|from Fasting: an Exceptional Human Experience|