Antidepressants Can lead to Putting On Weight


How I Manage Weight Gain on Antipsychotic Medication

Video taken from the channel: Living Well with Schizophrenia


Antipsychotics, Antidepressants and Weight Gain

Video taken from the channel: HealthyPlace Mental Health


HealthWatch: Antidepressants May Cause Weight Gain; Eating Fish May Improve A Couple’s Fertility

Video taken from the channel: CBS Boston


Can Sertraline Cause Weight Gain? Will SSRIs Make me Fat?

Video taken from the channel: A Happy Change Adventures in Mental Health


How psychiatric drugs can cause weight gain

Video taken from the channel: CBC News: The National


Antidepressant use may be linked to increased risk of weight gain

Video taken from the channel: The BMJ


Why do you gain weight with antidepressants and mood stabilizers?

Video taken from the channel: Dr. Tracey Marks

During the second and third years of taking antidepressants, a patient’s risk of a 5 percent weight gain was about 46 percent higher than that of nonusers, researchers found. The study looked at 12 common antidepressants: Remeron, Cymbalta, Zoloft, Effexor, Celexa, Prozac, Lexapro, Desyrel, Elavil, Paxil, Pamelor and Prothiaden. During the second and third years of taking antidepressants, a patient’s risk of a 5 percent weight gain was about 46 percent higher than that of nonusers, researchers found. These include: Certain tricyclic antidepressants, such as amitriptyline, imipramine (Tofranil) and doxepin. Certain monoamine oxidase inhibitors (MAOIs), such as phenelzine (Nardil) Paroxetine (Paxil, Pexeva), a selective serotonin reuptake inhibitor (SSRI) Mirtazapine (Remeron), which is.

Long-term use of the following SSRIs may cause weight gain: paroxetine (Paxil, Pexeva, Brisdelle) sertraline (Zoloft) fluoxetine (Prozac) citalopram (Celexa). During the second and third years of taking antidepressants, a patient’s risk of a 5 percent weight gain was about 46 percent higher than that of nonusers, researchers found. The study looked at 12 common antidepressants: Remeron, Cymbalta, Zoloft, Effexor, Celexa, Prozac, Lexapro, Desyrel, Elavil, Paxil, Pamelor and Prothiaden. The older types of antidepressants (tricyclics) and the medication mirtazapine appear more likely to cause weight gain for this reason.

Other types of antidepressants may have different effects on appetite and metabolism. And there are probably genetic factors determining your. During the second and third years of taking antidepressants, a patient’s risk of a 5 percent weight gain was about 46 percent higher than that of nonusers, researchers found.

The study looked at 12 common antidepressants: Remeron, Cymbalta, Zoloft, Effexor, Celexa, Prozac, Lexapro, Desyrel, Elavil, Paxil, Pamelor and Prothiaden. Types that may cause weight gain Tricyclic antidepressants (TCAs) Monoamine oxidase inhibitors (MAOIs) Selective serotonin reuptake inhibitors (SSRIs) Atypical antidepressants. Some antidepressants appear to encourage more weight gain than others. For example, Paxil (paroxetine) is believed to be the SSRI most likely to cause weight gain. 3  We are all wired differently.

An antidepressant that works well for one person may not be as effective for another. Up to 25% people on antidepressants tend to pack extra pounds. However, there are a few that cause weight loss, while others do not affect weight.

Taking Paxil (class of antidepressants belonging to the SSRI group) carries the highest risk of gaining weight, while taking Zoloft (another SSRI) has the lowest risk of gaining weight.

List of related literature:

Although antidepressant medication can have side effects that include weight gain, most research to date has found no differences in studies of participants with depression who undergo pharmacological treatment compared to those who do not (Luppino et al., 2010).

“Handbook of Obesity Treatment, Second Edition” by Thomas A. Wadden, George A. Bray
from Handbook of Obesity Treatment, Second Edition
by Thomas A. Wadden, George A. Bray
Guilford Publications, 2019

Antidepressants, mainly tricyclic antidepressants and MAOIs, are more likely to cause weight gain than selective serotonin reuptake inhibitors (SSRIs).

“Manual of Dietetic Practice” by Briony Thomas, Jacki Bishop
from Manual of Dietetic Practice
by Briony Thomas, Jacki Bishop
Wiley, 2013

Most antidepressants and mood stabilizers cause weight gain, although bupropion often induces weight loss.

“Eating Disorders and Obesity: A Comprehensive Handbook” by Christopher G. Fairburn, Kelly D. Brownell
from Eating Disorders and Obesity: A Comprehensive Handbook
by Christopher G. Fairburn, Kelly D. Brownell
Guilford Publications, 2002

Among the atypical antidepressants, bupropion does not cause weight gain, but mirtazapine can cause significant weight gain, perhaps because of its potent antihistamine activity.

“Brody's Human Pharmacology E-Book” by Lynn Wecker, Lynn Crespo, George Dunaway, Carl Faingold, Stephanie Watts
from Brody’s Human Pharmacology E-Book
by Lynn Wecker, Lynn Crespo, et. al.
Elsevier Health Sciences, 2009

Antidepressants can also cause a significant weight gain.

“Handbook of Drug-Nutrient Interactions” by Joseph I. Boullata, Vincent T. Armenti
from Handbook of Drug-Nutrient Interactions
by Joseph I. Boullata, Vincent T. Armenti
Humana Press, 2010

The following drugs may depress appetite4: • Selective serotonin reuptake inhibitors (SSRIs): This class of antidepressants may cause anorexia and weight loss; an example is fluoxetine (Prozac).

“Williams' Essentials of Nutrition and Diet Therapy E-Book” by Eleanor Schlenker, Joyce Ann Gilbert
from Williams’ Essentials of Nutrition and Diet Therapy E-Book
by Eleanor Schlenker, Joyce Ann Gilbert
Elsevier Health Sciences, 2018

SSRIs do not typically cause weight gain but may cause loss of appetite and weight loss.

“Lippincott Q&A Review for NCLEX-RN” by Diane Billings, Desiree Hensel
from Lippincott Q&A Review for NCLEX-RN
by Diane Billings, Desiree Hensel
Wolters Kluwer Health, 2016

However, about 10 percent of patients on longer-term antidepressant treatment do report weight gain (this may not become readily apparent until after a number of months of treatment).

“Handbook of Clinical Psychopharmacology for Therapists” by John Preston, John H. O'Neal, Mary C. Talaga
from Handbook of Clinical Psychopharmacology for Therapists
by John Preston, John H. O’Neal, Mary C. Talaga
New Harbinger Publications, 2010

Although antidepressants may either increase or decrease appetite in any individual patient, there is some evidence that mirtazapine can induce weight gain.

“Brocklehurst's Textbook of Geriatric Medicine and Gerontology E-Book” by Howard M. Fillit, Kenneth Rockwood, Kenneth Woodhouse
from Brocklehurst’s Textbook of Geriatric Medicine and Gerontology E-Book
by Howard M. Fillit, Kenneth Rockwood, Kenneth Woodhouse
Elsevier Health Sciences, 2010

Some antidepressants can cause weight gain.

“Medical Problems in Dentistry E-Book” by Crispian Scully
from Medical Problems in Dentistry E-Book
by Crispian Scully
Elsevier Health Sciences, 2010

Oktay Kutluk

Kutluk Oktay, MD, FACOG is one of the world's foremost experts in fertility preservation as well as ovarian stimulation and in vitro fertilization for infertility treatments. He developed and performed the world's first ovarian transplantation procedures as well as pioneered new ovarian stimulation protocols for embryo and oocyte freezing for breast and endometrial cancer patients.

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  • I put on 40lbs after taking paroexetine for Anxiety. I’d say about 30 lbs is from the medication itself and the other 10 lbs is because the stress from the anxiety kept my weight down.

  • you are lucky the weight barely shows i gained 100+ pounds on olanzapine seroquel and risperidone finally tapering off the seroquel now and am hoping the weight will sluff off but dont worry you look great! my knees hurt lol i cant even skateboard now! so i am hoping once i stop the seroquel the weight will go away wish you nothing but the best but seriously dont let it get you down you look fantastic!

  • Hi Dr Tracy, great video, I apologize if this is a stupid qestion, but does this mean that all anti-histamines such as phenergan (promethazine hydrochloride) also cause weight gain? Thanks.

  • Looks like I’ll have to train like an athlete for as long as I’m on this damn medication. I like that I feel happy, but I don’t want to be fat when I’m already trying to lose weight.

  • I gained a lot of weight from taking antidepressants and it sent me into a spiral of severe body dysmorphia. Because I am autistic I have the tendency to hyperfocus on one thing at a time and that’s really scary if you’re trying to lose weight. It almost always ends up in me getting obsessed with calories, comparing myself to others and starving myself.
    What I realized though, is that every single body I look at and want, is often the body of a person with an eating disorder.

  • I love your videos and understanding people with schizofrenia. I take meds for ocd and lost weight so I’m a little confused especially because I also started to eat sweets way more often ��

  • I wish I could sue for the antidepressants they gave me as a kid. The stuff messed me up so bad. I was fucking sad because my dad died and my moms boyfriends were abusive. I didnt have a fuckin chemical imbalance.

  • “Greasy stools, you might want to have your own bathroom so you don’t offend anyone.”

    Now I know what that racing stripe in my toilet the fuck is LOL

  • Thank you for your videos. I’ve searched for years about this. I gained 40 pounds in less than a year on Paxil. A Psychiatric nurse weaned me to fast office Paxil and I ended up in the hospital because of it. I hate looking at myself in the mirror. I have no control over my eating and it just makes me feel worse about myself. I feel hopeless about the continual weight gain. I am currently on Zoloft and Lamictal.

  • I took Zoloft for three years and gained 66 pounds. When is stopped taking them I lost all of it. Now I’m taking Luvox but I’m starting to gain weight again and I don’t eat more than before. I have exercised now for one month and I’m eating less but I haven’t lost a pound. EXERCISE AND EATING LESS DOES NOT WORK. I told my psychiatrist two months ago about my problem with weight gain and he Is not listening. Why do Psychiatrists ignore this problem?

  • I’ve been taking bupropion (Wellbutrin) for about 4 months. I’ve gained nearly 30 pounds. But I doesn’t look like I have. Should I be worried

  • I started taking Lexapro Jan 27 and I’ve switched to Zoloft 3 days ago. I switch because I gained 31 pounds on Lexapro while I was still dieting and exercising. I also tracked my calories and carbs intake with MyFitnessPal. My depression got so much worse on Lexapro and I used to get migraines and headaches. Hopefully Zoloft is different and I can finally lose this unwanted weight. So far I have no symptoms, just gassy and a bit more energetic ��

  • I took seroquel for 5 months and went from 59-70kg very quickly. I’m an athlete and kept working out the entire time, 2+ hour lifting sessions 5x/week in the gym. Now Im off it and I can’t lose any weight at all. It’s incredibly disheartening and frustrating. I also did a dexa before and after I took it and I went up 10% in body fat, gained no muscle, and lost a small percentage of bone density.

  • Antipsychotics and antidepressants destroy your cortical matter and make you.more susceptible to psychosis, depression, dementia, and many other disorders. If you have a psychotic episode and go on antipsychotics, you could have psychosis for life that could have been avoided by simply not taking antipsychotics… You feel not heard, abused, and stigmatized by the mental health system? Because its tearing you and everyone trapped in it apart, people who were already vulnerable to begin with. No matter how well you try to live, you will always be a prisoner not of schizophrenia, but of the people and things that are supposed to help you

  • I’m not on anti-psychotics but I do take meds for my epilepsi that a lot of people do take for conditions such as schizophrenia and bipolar 1 and and 2. So I’ve experienced the extreme weight gain and crazy hunger. I just had to see other people talk about this.

  • I was about 60 pounds heavier than I am now when I was on medication. Plus the meds caused severe hyperhidrosis and I would sweat like a pig from the smallest amount of activity. I was so miserable.

  • i have never been able to lose the weight i gained with my meds. does anyone know of a mechanism that couldve been turned off in my body? i never ate more i just got bigger and that was it. its been a nightmare since. its been 5 years and i havent lost the weight.

  • It cause me to have diabetes. Everytime i try to fight the hunger i get painfull headache i tell my family and doctors this they just ignore me like it aint nothing because it doesnt bother them. Im around a lot of selfish people A lot. Or maybe they dont give a shit about what im going through because they dont care for me. Of course my parents who neglected me as a child why would i think they would care.

  • I went on meds a few months ago that caused me to gain 50+ pounds in like 4 months. I just posted a video talking about the emotional toll it took. You video was very helpful <3 I'm glad we have a platform to talk about this stuff.

  • A huge weight gain was something I did not tolerate. This is not a minor side effect. The doctors have to come up with a good weight control plan or they can keep their meds.

  • Stay away from sugar like my mom said,” only way to lose weight is eating too much and sugar, if you stay away from it, you’ll lose weight and you won’t have any bad symptoms anymore, but if you go back to eating and drinking sugar, you’ll end up gaining all that weight back on and you’ll regret it, don’t make that same eating and drinking sugar mistakes again and if you will listen to your body you won’t have no worries����

  • Its not true at all, i loose all my hunger on pills. I dont have much though without them either but nonetheless, not all gain weight.

  • I have bipolar 2, unfortunately I spend 9 months mostly depressed. I only have hypomania so I am really never energetic enough for anything! I suffer from severe insomnia and take seroquel 200 mg at night otherwise I am up every 3 hours. I do like lifting weights, that is the only thing that has helped me with my depression. I used to run half marathons but I started getting heel pain (plantar fasciitis) can’t run anymore.:-(

  • I gained weight on the medication I’m taking about 10 pounds and I feel embarrassed or conscious about it. I think I’m going to stick to working out everyday at least 30 minutes to an hour. But some days I don’t have the motivation to work out or do anything active it’s really strange.

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  • if society didn’t treat fat people so badly it probably wouldn’t need to be such a major stressor for people trying to improve their health with these meds

  • Where have you been all my life? This information is highly appreciated! Thank God for this. It has been a year since Dr. Tracey Marks started. I wish she started earlier. ����

  • I took myself off Sertraline about two months ago and it has been a nightmare. I can’t believe how stressed and anxious I have felt and these feelings don’t seem to be abating. I can no longer see the point in continuing with life. I feel I have nothing. I’m in my late forties with no family and live on my own and feel a complete failure. I really believe it’s just a matter of time before I end it all. There’s very little keeping me going. I just don’t know what to do

  • Why are physicians still telling us BMI has anything to do with body fat percentage. It’s how much weight you carry for your height and not it’s composition.

  • I treat PTSD with sertraline, there is no way for me to get out of the meds as it helped me have my life back, I feel lucky that the meds are working on me, but geez I gained 30 kg in one year, thank God I was underweight when I started them, otherwise my life would have turned into hell with all the extra weight. I started taking this issue seriously before losing control of my body, and I lost 2 kg so far ( meh ), I feel that no nutritionist is tackling this problem, there must be something different that would work for those who are under antidepressants. Anyone know someone who did some solid tests, please share anything you know ����

  • My best “medicine” against weighr gain was my friends. The medicine made me inactive but my friends pushed me every day to do some kind of work out. I also changed my plates to smaller ones so I couldn’t overfill them. I was feeling a bit hungry after finishing the meal but it was a bit different. A bit like regular and diet soda. Both are sweet but you taste the difference. I did get munchies so I never purchased junk or if I didn’t resist, I’d had to walk to the furthest store and back to buy it. Didn’t always work of course but I didn’t gain much at all untillmy doc told me I didn’t need the meds. Best day of my life and best choise I did was starting the treatment. It wasn’t easy but the end result was totally worth it.

  • I have fibromyalgia which is causing a lot of chronic pain especially in my lower back, hips and feet. I am currently taking paxil cr 37.5 mg and glucophage xr 1000mg and I’ve gained over 50 lbs over 2 yrs. I’m unable to do any type of strenuous exercise because of the pain and I am an emotional eater. The most I can do is mild, gentle short workouts. What can I do to lose weight?

  • Can you do a video on how to deal with negative symptoms like lack of interest, reduced feelings (also not being able to feel happy) and thus limited expressions that stay when on meds? I am currently struggling with that and feel kinda sad about it..

  • I have schizoaffective. I have tried 1200kcal and exercising 5 times a week. I only lost 20 pounds in a year. I couldn’t sustain that lifestyle so I switched to just diet of 1200kcal a day. I kept gaining weight everyday, 5 pounds a month. Yes, I weighed everything I eat and recording everything I ate. I still gained weight. I feel so hopeless since I can’t stay on the 1200kcal diet, I’m so hopeless. I exercised 3 times a day and exercised with a trainer and the nutrition plan. I only lost 1 pound a month. I have asked my doctors and they just tell me to diet, which I already did, and exercise, which I already did. The lifestyle starved me too much so I don’t know what to do.

  • I was put on antipsychotics 5 years ago lost all my weight once then went back into psycosis got put back on them gained 50pounds I’m in the process of losing the weight again I’m 237 I was 262 only 27 pounds to go to get back were I was at 210 so it is possible just takes abit longer hope thos was helpful to some one and the weight loss happened in 4 months on and off 25lbs,I done it by intermittent fasting mainly plant based and exercise.

  • Dr. Marks. I take 100mg Quetiapine every day for Bipolar. It does indeed give me FEROCIOUS sugar cravings! Not like: I’d like to have a piece of pie… but more like: I want to eat this entire pie right now. The weight gain has been pronounced, but NOTHING like when I was on Depakote for the BPD. On Depakote, I went from 185lbs to 275lbs in about 14 months. That drug is nasty, and I’m so glad I’m off of it. Seroquel seems the next best thing. Depakote put me mentally in what I called “no-man’s land”: I was too drowsy to achieve anything or work…. but too stimulated to sleep. I just stayed in this medium haze in which I couldn’t do much of anything. Depakote also gave me NO satiety… I was always hungry for something, but I knew not what.

  • There are several medications that can be prescribed to address anti-psychotic weight gain, you should encourage people to talk to their doctor about these because sometimes diet and exercise do not work for this type of weight gain.

  • I’ve been on Zoloft, Lexapro and Moclobemide, and none caused any weight gain or make any difference at all. Most of the time I’m so anxious, I don’t have an appetite at all until about 10pm, and then it’s just for sweet, sugary things.

  • I was super under weight and struggled to gain anything.. teaches at school.. and friends mum’s always tried feeding me.. I’m assuming they thought I had an eating disorder.. but after a while on the meds I gained 15kg and i was just so happy about it.. since then I’ve gained more and i feel now that I’m happy with my body..

  • Wow, now I know why I gained 40kg in about 3 years �� I took paroxetine because of depression and… an eating disorder ������ I’m so mad now!!! I stopped taking paroxetine and could finally lose weight. I lost 25kg in about 1,5 years but there are still about 7kg to go… I would never take antidepressants again.

  • Does anyone have tips to get motivated while in depression? I’m bipolar and antipsychotics made me gain tons of weight, my mood is “stable” leaning more to depressed, I miss being hypo manic.

  • Dr Marks
    I found it this is the video! Vraylar what is the worst for gaining weight I’ve ever taken also Aripiprazole garbage ��. I am so happy to hear about these receptors I talk to my primary care about this problem and he goes I talk to the drug representatives and I said why do you put out these medications with this massive weight gain and he explained me that some of his patients are now diabetic from taking antipsychotics a friend of mine Laura from Mississippi has tardive dyskinesia really bad she takes three antipsychotics per day something needs to change the FDA is a freaking mess!
    Thank you very much for this informative video and help me get off some of these lousy medications. I hope somebody could read this and try Lamotrigine aka lamictal. The only part I don’t like about Lamotrigine is the headaches and the insomnia. Other than that no weight gain. I’ve lost 6 pounds since getting off of this cocktail of medications. Including vraylar Latuda Wellbutrin and trintellix. No thank you.
    General repair

  • My dr and I recently decided to add an adjunct medication to help manage the weight gain. I was eating mindfully and getting as much exercise as my body can handle (I have arthritis) and kept gaining. My weight is at the stage where it is impairing my mobility and worsening my bone health. The trio of psychiatric medication I use have kept me stable so we don’t want to mess with it.

  • Thank you Lauren for talking about this, I had been on olanzapine and felt depressed about my weight. I find it encouraging that someone understands.

  • I gained 8 kilograms in a year of being on paroxetine which was devastating. I’m finally coming off it and managing my anxiety through alternative methods and trying to slowly shift the weight.

  • SeroquHELL..good luck with it, people, i got none…i got ptsd since the army, with seroquhell i got TD, no sleep, falls, cataracts, headaches, boobs, loss of speech, loss of memory, can’t work, ur face will turn into a zombie one, people will run from you, even your family. Shrinks are chemical butchers.Good luck.

  • I am diagonised with bi-polar
    I am proscribed with olazapine and divalproex
    How much will I gain weight in 2 months
    I am a female
    Age -23
    Height -5 3