5 Signs and Signs and symptoms of von Willebrand Disease

 

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VON WILLEBRAND DISEASE: Pathophysiology, Clinical Findings, Diagnosis, Treatment

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Other bleeding events in individuals with VWD include: blood in the stool from bleeding into the stomach or intestines. blood in the urine from bleeding into the kidneys or bladder. rarely, bleeding. Bleeding symptoms in von Willebrand disease tend to occur in mucous membranes or the skin. The most common symptoms in people diagnosed with von Willebrand disease include the following: Nose bleeding. Abnormal or easy bruising (also known as ecchymosis or hematoma). The signs and symptoms of von Willebrand disease (VWD) depend on which type of the disorder you have.

They also depend on how serious the disorder is. Many people have such mild symptoms that they don’t know they have VWD. If you have type 1 or type 2 VWD, you may have the following mild-to-moderate bleeding symptom. Von Willebrand disease (VWD) is a disorder that makes it hard for your blood to clot.

This happens because you don’t have enough of a clotting protein called von Willebrand factor (VWF). Symptoms include nosebleeds with no previous history of bleeding abnormalities. Treatment of acquired von Willebrand disease includes medicines that help your body have enough von Willebrand clotting factor in the blood. This von Willebrand factor helps your blood clot. Top of the page.

Signs and symptoms can include easy bruising, heavy menstrual periods, and frequent nosebleeds that happen often. Your doctor will review your symptoms, risk factors, medical history, and blood test results to diagnose a bleeding disorder. Your doctor may recommend medicines or clotting factor replacement therapy to treat the bleeding disorder.

The most common signs of von Willebrand disease (vWD) include nosebleeds and hematomas. Prolonged bleeding from trivial wounds, oral cavity bleeding, and excessive menstrual bleeding are common. The following 5 signs and symptoms are common in VWD and other bleeding disorders: 1 Easy bruising 2 Frequent or prolonged nosebleeds 3 Heavy or prolonged menstrual periods (menorrhagia). Von Willebrand disease is the most common inherited bleeding disorder among American women, with a prevalence of 0.6–1.3% 1.The overall prevalence is even greater among women with chronic heavy menstrual bleeding, and ranges from 5% to 24% 2 3.Among women with heavy menstrual bleeding, von Willebrand disease appears to be more prevalent among Caucasians (15.9%) than African Americans.

The signs and symptom information on this page attempts to provide a list of some possible signs and symptoms of Von Willebrand disease. This medical information about signs and symptoms for Von Willebrand disease has been gathered from various sources, may not be fully accurate, and may not be the full list of Von Willebrand disease signs or.

List of related literature:

The common congenital bleeding disorder—type 1 von Willebrand disease (vWD-1), which occurs to a mild extent in 1% to 2% of the population, is not a common cause of bleeding post-trauma, because the physiologic response to injury includes release of endothelial stores of vWF (29).

“Trauma: Critical Care” by William C. Wilson, Christopher M. Grande, David B. Hoyt
from Trauma: Critical Care
by William C. Wilson, Christopher M. Grande, David B. Hoyt
CRC Press, 2007

How Is von Willebrand’s Disease Diagnosed?

“Ferri's Clinical Advisor 2016 E-Book: 5 Books in 1” by Fred F. Ferri
from Ferri’s Clinical Advisor 2016 E-Book: 5 Books in 1
by Fred F. Ferri
Elsevier Health Sciences, 2015

Update on the pathophysiology and classification of von Willebrand disease: a report of the Subcommittee on von Willebrand Factor.

“Transfusion Medicine and Hemostasis: Clinical and Laboratory Aspects” by Beth H. Shaz, Christopher D. Hillyer, James C. Zimring, Thomas C. Abshire
from Transfusion Medicine and Hemostasis: Clinical and Laboratory Aspects
by Beth H. Shaz, Christopher D. Hillyer, et. al.
Elsevier Science, 2009

Infants with von Willebrand disease will present with similar symptoms as hemophilias with bleeding into the joints and intracranially.

“Comprehensive Neonatal Nursing Care: Fifth Edition” by Carole Kenner, PhD, NNP, FAAN, Judy Wright Lott, DSN, RN, BC-NNP, FAAN
from Comprehensive Neonatal Nursing Care: Fifth Edition
by Carole Kenner, PhD, NNP, FAAN, Judy Wright Lott, DSN, RN, BC-NNP, FAAN
Springer Publishing Company, 2013

There are three main types of von Willebrand’s disease.

“Clinical Reproductive Medicine and Surgery” by Tommaso Falcone, William W. Hurd
from Clinical Reproductive Medicine and Surgery
by Tommaso Falcone, William W. Hurd
Mosby/Elsevier, 2007

von Willebrand disease: Defects in hemostasis and thrombosis.

“Hematology E-Book: Basic Principles and Practice, Expert Consult Premium Edition Enhanced Online Features” by Leslie E. Silberstein, John Anastasi, Ronald Hoffman, Edward J. Benz, Helen Heslop, Jeffrey Weitz
from Hematology E-Book: Basic Principles and Practice, Expert Consult Premium Edition Enhanced Online Features
by Leslie E. Silberstein, John Anastasi, et. al.
Elsevier Health Sciences, 2012

Affecting approximately 1% of the population, von Willebrand disease (vWD) is the most common inherited disorder of coagulation (see Chapter 139).

“Hematology: Basic Principles and Practice E-Book” by Leslie E. Silberstein, John Anastasi, Ronald Hoffman, Edward J. Benz, Helen Heslop, Jeffrey Weitz
from Hematology: Basic Principles and Practice E-Book
by Leslie E. Silberstein, John Anastasi, et. al.
Elsevier Health Sciences, 2017

The diagnosis of von Willebrand disease requires a careful personal and family history and appropriate laboratory testing.

“Clinical Maternal-Fetal Medicine” by Hung N. Winn, John C. Hobbins
from Clinical Maternal-Fetal Medicine
by Hung N. Winn, John C. Hobbins
Taylor & Francis, 2000

Von Willebrand’s disease is a congenital disorder of hemostasis characterized by defective or deficient von Willebrand factor (vWF).

“Ferri's Clinical Advisor 2012: 5 Books in 1, Expert Consult Online and Print” by Fred F. Ferri
from Ferri’s Clinical Advisor 2012: 5 Books in 1, Expert Consult Online and Print
by Fred F. Ferri
Elsevier Health Sciences Division, 2011

Because von Willebrand disease (VWD) is the most common bleeding diathesis and presents with bleeding symptoms similar to (rarer) platelet defects as well, it can be eliminated or diagnosed by performing the three previously listed VWF tests.

“Platelets” by Alan D. Michelson
from Platelets
by Alan D. Michelson
Elsevier Science, 2011

Oktay Kutluk

Kutluk Oktay, MD, FACOG is one of the world's foremost experts in fertility preservation as well as ovarian stimulation and in vitro fertilization for infertility treatments. He developed and performed the world's first ovarian transplantation procedures as well as pioneered new ovarian stimulation protocols for embryo and oocyte freezing for breast and endometrial cancer patients.

Mail: [email protected]
Telephone: +1 (877) 492-3666

Biography: https://medicine.yale.edu/profile/kutluk_oktay/
Bibliography: oktay_bibliography

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6 comments

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  • Beleive me guys,if u make videos of all MBBS related subjects and MCQ for NEET PG, I will be the first to buy it.Your way of teaching is amazing ��. Osmosis is the best!

  • Very interesting…I inherited VWD Type 2b from my dad who inherited it from his dad, who inherited it from his dad! We bleed a lot, but it is manageable. I have doubts about getting pregnant and having children, it seems pretty risky for someone with my disorder. I always thought it was that I couldn’t clot because I had no VWF. But Type 2b just means my VWF binds to my platelets and then gets eliminated by the body. This makes sense for the multiple internal bleeding episodes I’ve had in my life and I had to get platelet transfusions.

  • Clear, simple, easy, perfect, thank You very much sir. By the way, can You share Your experience and tell me which programs or applications do You use in creating Your videos. Thank You very much.

  • I have hemophilia, and I have to get a shot every 3 days, it sucks. But the worst part of it, is that the factor is extracted from a hamster, and I love animals.

  • Hii osmosis…..very helping videoss…. Pls keep to upload more and more videos…..there is a question…. Why u are deleting old videos????…..plss upload them too… And again wonderful job… Keep it up

  • Thanks doctor but I have question which type i studied the bleeding time increase with type 2b but type 1A normal
    Can you explain more!