Ovidrel and Trigger Shots

 

Instructions for Injecting Ovidrel® | Encompass Fertility Treatment

Video taken from the channel: CVS Health


 

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Ovidrel and Trigger Shots

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Ovidrel® Trigger Shot Injection Instructions The Reproductive Medicine Group

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How To Inject Ovidrel® | Fertility Treatment | CVS Specialty®

Video taken from the channel: CVS Health


Ovidrel is a type of injectable medication that’s also known as a “trigger shot.” It may be used by itself or along with other fertility drugs. Ovidrel may be used in a cycle with timed sexual intercourse, intrauterine insemination (IUI), or in vitro fertilization (IVF) to improve the odds of pregnancy with each cycle. In general, the trigger shot is used in conjunction with other drugs to help with: anovulation (when your body doesn’t release eggs on its own) unexplained infertility (when the cause of infertility is unknown) in vitro fertilization (for a variety of infertility causes). Ovidrel is given as an injection under the skin or into a muscle.

If you use Ovidrel at home, your doctor, nurse, or pharmacist will give you specific instructions on how and where to inject this medicine. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles and syringes. Ovidrel shots are an injectable medication that may be used as a trigger shot during IUI, timed sexual intercourse of in vitro fertilization. Ovidrel is used by itself but also with other fertility drugs as belo.

Historically, the final shot, or the “trigger” shot, in an IVF cycle was almost always a fixed amount. While there was variability in what medication was given (hCG /novarel vs. ovidrel), the dosage was pretty standard. Both medications when administered correctly were pretty good at achieving egg maturation. Hey all!

I had my trigger shot last Wednesday after 5 days on Clomid. I had an IUI the next day. So Thursday June 18thMy doctor told me not to test for two weeks to make sure the Ovidrel is out of my system. Of course I tested. At the beginning.

Ovidrel ® PreFilled Syringe is intended for a single subcutaneous injection. Any unused material should be discarded. Ovidrel ® PreFilled Syringe may be self-administered by the patient. Follow the directions below for injecting Ovidrel ® PreFilled Syringe. Step 1: Wash your hands thoroughly with soap and water.

Step 2: Carefully clean the injection site. Step 1 – Preparing Your Injection. Step 2 – Preparing the Injection Site.

Step 3 – Injecting. Be sure to have all of the following items before you begin: One Ovidrel Prefilled Syringe. Alcohol swabs. Sterile gauze. and Safety container. Wash your hands with soap and water and dry thoroughly.

On CD16 I had one follie on the right side measuring 22.:) I used the Ovidrel trigger shot that night at 10pm and BD. We BD again on the morning of CD18 as Rx. Since the injection I have been enjoying waves of nausea and intermittent sharp pain on my right side. Has any one else experienced this pain after trigger?

Frequency not reported: injection site pain, injection site rash, localized hypersensitivity reaction. r-HCG: Very common (10% or more): Injection site pain (up to 19.5%), application site disorder (up to 14.6%) Common (1% to 10%): Injection site bruising, injection site inflammation, injection site reaction, vessel site hemorrhage. Nervous.

List of related literature:

You’ll probably start injecting Goserelin just before FSH and hMG shots are started if you’re doing an IVF cycle.

“What to Expect: Before You're Expecting” by Sharon Mazel, Heidi Murkoff
from What to Expect: Before You’re Expecting
by Sharon Mazel, Heidi Murkoff
Simon & Schuster UK, 2010

The progestin medroxyprogesterone acetate is injected into the muscle of the leg, arm or buttock once every 90 days and works by decreasing GnRH pulsatility, which inhibits the LH surge, thus preventing ovulation.

“Human Reproductive Biology” by Richard E. Jones, Kristin H Lopez
from Human Reproductive Biology
by Richard E. Jones, Kristin H Lopez
Elsevier Science, 2013

Because of the range in ovulation timing, mares treated with hCG should be palpated and evaluated with ultrasound every 6 to 8 hours after the injection.

“Current Therapy in Large Animal Theriogenology E-Book” by Robert S. Youngquist, Walter R. Threlfall
from Current Therapy in Large Animal Theriogenology E-Book
by Robert S. Youngquist, Walter R. Threlfall
Elsevier Health Sciences, 2006

Both hormones may be administered daily via intramuscular injection for 10 days or more commonly and easily by using PRIDs containing progesterone plus 10 mg oestradiol (held within a gelatin capsule) inserted for 10 days (Rutten et al., 1986).

“Equine Reproductive Physiology, Breeding and Stud Management, 4th Edition” by Mina C G Davies Morel
from Equine Reproductive Physiology, Breeding and Stud Management, 4th Edition
by Mina C G Davies Morel
CABI, 2015

Ovulation may be triggered by the administration of hCG (5000 to 10,000 U), but the injection must be timed to coincide with maximum follicular development as assessed by ultrasonography and/or estradiol levels.

“Endocrinology E-Book: Adult and Pediatric” by J. Larry Jameson, Leslie J. De Groot
from Endocrinology E-Book: Adult and Pediatric
by J. Larry Jameson, Leslie J. De Groot
Elsevier Health Sciences, 2010

The recommended approach to treatment based on the evidence reviewed above is to offer IUI in a natural cycle as the first line treatment, unless the woman is anovulatory, where clomiphene or injectable gonadotropins should be used to induce ovulation.

“Textbook of Assisted Reproductive Techniques Fourth Edition: Volume 2: Clinical Perspectives” by David K. Gardner, Ariel Weissman, Colin M Howles, Zeev Shoham
from Textbook of Assisted Reproductive Techniques Fourth Edition: Volume 2: Clinical Perspectives
by David K. Gardner, Ariel Weissman, et. al.
Taylor & Francis, 2012

To induce ovulation with hormones, the doe can be given an injection of human chorionic gonadotropin (hCG) at 20 micrograms intramuscularly, or a gonadotropin releasing hormone (GnRH) analog such as Buserelin at 0.8 microgram, subcutaneously (Morrell, 1995).

“The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents” by Mark A. Suckow, Karla A. Stevens, Ronald P. Wilson
from The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents
by Mark A. Suckow, Karla A. Stevens, Ronald P. Wilson
Elsevier Science, 2011

For women who do not ovulate in response to clomiphene citrate or letrozole, FSH injections are started on day 3 of spontaneous or progestin-induced uterine bleeding.

“Williams Textbook of Endocrinology E-Book” by Shlomo Melmed, Ronald Koenig, Clifford Rosen, Richard Auchus, Allison Goldfine
from Williams Textbook of Endocrinology E-Book
by Shlomo Melmed, Ronald Koenig, et. al.
Elsevier Health Sciences, 2019

• Medroxyprogesterone is available in vials and prefilled syringes for 150-mg IM injection, as well as in prefilled syringes for 104-mg subQ injection.

“Pharmacology for the Primary Care Provider E-Book” by Marilyn Winterton Edmunds, Maren Stewart Mayhew
from Pharmacology for the Primary Care Provider E-Book
by Marilyn Winterton Edmunds, Maren Stewart Mayhew
Elsevier Health Sciences, 2008

The LH surge, or trigger injection for patients undergoing IVF, starts the clock which dictates the timing of events as the oocyte progresses through the completion of meiosis [29]; however, many of the assessments performed in clinical labs are based on the timing of insemination or ICSI.

“In Vitro Fertilization: A Textbook of Current and Emerging Methods and Devices” by Zsolt Peter Nagy, Alex C. Varghese, Ashok Agarwal
from In Vitro Fertilization: A Textbook of Current and Emerging Methods and Devices
by Zsolt Peter Nagy, Alex C. Varghese, Ashok Agarwal
Springer International Publishing, 2019

Oktay Kutluk

Kutluk Oktay, MD, FACOG is one of the world's foremost experts in fertility preservation as well as ovarian stimulation and in vitro fertilization for infertility treatments. He developed and performed the world's first ovarian transplantation procedures as well as pioneered new ovarian stimulation protocols for embryo and oocyte freezing for breast and endometrial cancer patients.

Mail: [email protected]
Telephone: +1 (877) 492-3666

Biography: https://medicine.yale.edu/profile/kutluk_oktay/
Bibliography: oktay_bibliography

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4 comments

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  • Thank you for your video and sharing something so personal! I’m going through this process and watching your video made me feel less alone in the process

  • I had a 5000iu trigger shot on the 7th at night and today is the 14th. I did 2 HPTs( a FRER and another that is not a very sensitive brand)…i got a very obvious line on a FRER (i know it picks up as low as 6 iu) and took another brand that i guess picks up 25iu and got a faint line… i know i tested early but the line is obvious..isnt the line by now(8 dpt) should not actually show up? Why are the lines so obvious?

  • I got 10000 Iu on 11 the day of my period today 11 dpo today I have stomach pain and white discharge it’s period symptom or pregnancy my period cycle 30-32 days after 10000 iu when period comes plz rly

  • Hi!! Did you have any PMS before you tested positive? I’m going crazy noticing all these little symptoms and I dont know what to think. I did the trigger shot and I got my last faint line yesterday. Today is a clear negative so your video is giving me hope.