Negative Effects and Perils of Fertility Drugs


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The most common side effects include: mood changes, including mood swings, anxiety, and depression temporary physical side effects, including nausea, vomiting, headaches, cramps, and breast tenderness ovarian hyperstimulation syndrome multiple births increased risk of pregnancy loss. Side effects of commonly used fertility medications Headache Dizziness Nausea Weight gain Breast tenderness/pain Fatigue Abnormal menstrual bleeding/spotting Mood swings Acne Hot flashes Body pain Vaginal dryness Blurred vision Trouble sleeping. Higher levels of estrogen used to induce ovulation can lead to a slightly increased risk of blood clots immediately after fertility therapy, says Natalie Dayan, an assistant professor of medicine at McGill University and director of obstetric medicine at the McGill University Health Centre in Montreal.

The side-effects that occur most often during the treatment with Clomid, include weight gain, severe hot flashes, nausea, bloating and breast tenderness. In rare cases, side-effects include alopecia, uterine bleeding or vision-problems. When severe, OHSS can result in nausea, vomiting, rapid weight gain, dehydration, blood clots, kidney dysfunction, twisting of an ovary (torsion), fluid collections in the chest and abdomen, and, rarely, even death.

In severe cases, hospitalization is often required for monitoring. The condition is temporary, usually lasting only a week or two. Commonly noted adverse effects encountered with the use of pharmacological agents to treat infertility include the following.

Clomifene has been associated with hot flushes, multiple gestation, visual disturbances, cervical mucus abnormalities and luteal phase deficiency. Side effects: They’re generally mild. They include hot flashes, blurred vision, nausea, bloating, and headache.

Clomid can also cause changes in. Dosage may be increased if ovulation still does not occur, although the chances of side effects increase as the dosage increases. The American Society for Reproductive Medicine (ASRM) recommends that clomiphene is prescribed for only 3-6 cycles. Potential side effects include: Increased incidence of. Fertility Drugs May Increase or Decrease Your Cancer Risk In 2005, a widely publicized study reported that Clomid use might increase the risk of uterine cancer.

However, since that time, more studies have been done, and most have found no significant increase in cancer risk after Clomid use. Mild reactions to fertility drugs can involve physical symptoms such as hot flashes, headaches, abdominal pain or bloating, and emotional symptoms such as restlessness, mood swings, or just generally feeling down or irritable. While these side.

List of related literature:

Risks to women from these fertility drugs include ovarian hyperstimulation syndrome, ovarian cysts, menstrual irregularities, premature menopause, and ovarian cancer.

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from The Reader’s Companion to U.S. Women’s History
by Wilma Pearl Mankiller, Gwendolyn Mink, et. al.
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These include younger women, women with PCOS (taking metformin as well as fertility drugs reduces the risk of OHSS), and women with highestrogen levels and a large number of follicles or eggs.

“Making Babies: A Proven 3-Month Program for Maximum Fertility” by Jill Blakeway, Sami S. David
from Making Babies: A Proven 3-Month Program for Maximum Fertility
by Jill Blakeway, Sami S. David
Little, Brown, 2009

No reports have described diminished fertility in women taking SSZ; however, men can have oligospermia, impaired sperm motility, and abnormal sperm morphology223 that returns to normal 2 to 3 months after cessation of the drug.

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As recently stressed by a group of experts, androgens and drugs that increase ovarian androgens, such as letrozole, may become important adjuncts for patients with low prognosis IVF (174).

“Textbook of Assisted Reproductive Techniques Fourth Edition: Volume 2: Clinical Perspectives” by David K. Gardner, Ariel Weissman, Colin M Howles, Zeev Shoham
from Textbook of Assisted Reproductive Techniques Fourth Edition: Volume 2: Clinical Perspectives
by David K. Gardner, Ariel Weissman, et. al.
Taylor & Francis, 2012

Drugs used to treat infertility, such as clomiphene citrate, human menopausal gonadotropin, and Gonadotropin Releasing Hormone (GnRH) analogues have been associated with depressive side effects (Daniluk & Fluker, 1995).

“Psychiatric Care of the Medical Patient” by Barry S. Fogel, Donna B. Greenberg
from Psychiatric Care of the Medical Patient
by Barry S. Fogel, Donna B. Greenberg
Oxford University Press, 2015

Increasingly, aromatase inhibitors such as letrozole or anastrazole are being used both for ovulation induction in anovulatory patients and for superovulation in couples with unexplained infertility.

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Drugs may contribute to male infertility by affecting gonadotropin (steroids, opiates) or prolactin (psychotropic agents) secretion, affecting spermatogenesis (sulfasalazine, alkylating agents), or reducing sexual performance (psychotropic and antihypertensive drugs).

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Fertility enhancing drugs, such as clomiphene citrate and gonadotropins used for ovulation induction have been thought to increase the risk of ovarian cancer, but the data have not been consistent and have not adequately distinguished the influence of infertility perse from the use of fertility stimulating agents.”

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People’s Medical Publishing House, 2010

There is concern with the use of aromatase inhibitors such as anastrozole or letrozole in the treatment of premenopausal women because these drugs are known to stimulate ovulation and continuous administration can result in the development of functional ovarian cysts.

“Berek & Novak's Gynecology” by Jonathan S. Berek
from Berek & Novak’s Gynecology
by Jonathan S. Berek
Wolters Kluwer Health, 2019

Fertility medications for women may have physical side effects and risks, such as ovarian hyperstimulation syndrome (OHSS).

“Sexuality Counseling: Theory, Research, and Practice” by Christine Murray, Amber Pope, Ben Willis
from Sexuality Counseling: Theory, Research, and Practice
by Christine Murray, Amber Pope, Ben Willis
SAGE Publications, 2016

Oktay Kutluk

Kutluk Oktay, MD, FACOG is one of the world's foremost experts in fertility preservation as well as ovarian stimulation and in vitro fertilization for infertility treatments. He developed and performed the world's first ovarian transplantation procedures as well as pioneered new ovarian stimulation protocols for embryo and oocyte freezing for breast and endometrial cancer patients.

Mail: [email protected]
Telephone: +1 (877) 492-3666

Bibliography: oktay_bibliography

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  • Clomid put me in the hospital so now I’m try letrozole with the tigger shot. I’m praying this work cause this has been a long journey.

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  • My husband and I had been trying to conceive for 6 months. I figured let me try “Get Pregnant Fertility Tea” by secrets of tea before we go back to the doctor and go the fertility medicine route like we had with our son. Well we tried it and I finally ovulated and we conceived on the first try.

  • I am 50 and my wife is 40 from Brazil. We are trying to have IVF for our first baby in January, 2018. I am very anxious about my wife. I love my wife lots!

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  • Risks:
    -5-10% cancelation rate
    -Ovarian hyper stimulation syndrome
    -Allergic reaction to medication
    -Needle could cause damage to the uterine wall
    -1 in 1000 chance for infection during embryo transfer
    -high chance for multiple gestation which l/t preterm labor and delivery, hemorrhaging
    -birth defects: heart septal defect, esophageal narrowing anal narrowing
    -higher chance for bleeding
    -gestational hypertension
    -gestational diabetes
    -high chance for small for gestational age

    -ability to freeze embryos

  • Mam nan two times ivf panninaga second time success atchu.but 52 daysla baby heart beats illa sollithaga so imsscarge atchu.ippo restla irruken.aguest monthla treatment start pana poren. First time 14 egg kidaitatu ippo second time egg kidaikama please reply

  • I had IVF done, 3 days embryo transfer and got possitive result on first cycle. Right now I am almost 5 weeks pregnant and started bleeding for past 3 days. Dr are taking blood test to chekc on HCG level, hoping we can keep this baby. I hope this is jsut bleeding disorder like Dr said in this video, not a miscarriage. We pray everday