Negative Effects and Perils of Fertility Drugs

 

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The most common side effects include: mood changes, including mood swings, anxiety, and depression temporary physical side effects, including nausea, vomiting, headaches, cramps, and breast tenderness ovarian hyperstimulation syndrome multiple births increased risk of pregnancy loss. Side effects of commonly used fertility medications Headache Dizziness Nausea Weight gain Breast tenderness/pain Fatigue Abnormal menstrual bleeding/spotting Mood swings Acne Hot flashes Body pain Vaginal dryness Blurred vision Trouble sleeping. Higher levels of estrogen used to induce ovulation can lead to a slightly increased risk of blood clots immediately after fertility therapy, says Natalie Dayan, an assistant professor of medicine at McGill University and director of obstetric medicine at the McGill University Health Centre in Montreal.

The side-effects that occur most often during the treatment with Clomid, include weight gain, severe hot flashes, nausea, bloating and breast tenderness. In rare cases, side-effects include alopecia, uterine bleeding or vision-problems. When severe, OHSS can result in nausea, vomiting, rapid weight gain, dehydration, blood clots, kidney dysfunction, twisting of an ovary (torsion), fluid collections in the chest and abdomen, and, rarely, even death.

In severe cases, hospitalization is often required for monitoring. The condition is temporary, usually lasting only a week or two. Commonly noted adverse effects encountered with the use of pharmacological agents to treat infertility include the following.

Clomifene has been associated with hot flushes, multiple gestation, visual disturbances, cervical mucus abnormalities and luteal phase deficiency. Side effects: They’re generally mild. They include hot flashes, blurred vision, nausea, bloating, and headache.

Clomid can also cause changes in. Dosage may be increased if ovulation still does not occur, although the chances of side effects increase as the dosage increases. The American Society for Reproductive Medicine (ASRM) recommends that clomiphene is prescribed for only 3-6 cycles. Potential side effects include: Increased incidence of. Fertility Drugs May Increase or Decrease Your Cancer Risk In 2005, a widely publicized study reported that Clomid use might increase the risk of uterine cancer.

However, since that time, more studies have been done, and most have found no significant increase in cancer risk after Clomid use. Mild reactions to fertility drugs can involve physical symptoms such as hot flashes, headaches, abdominal pain or bloating, and emotional symptoms such as restlessness, mood swings, or just generally feeling down or irritable. While these side.

List of related literature:

Risks to women from these fertility drugs include ovarian hyperstimulation syndrome, ovarian cysts, menstrual irregularities, premature menopause, and ovarian cancer.

“The Reader's Companion to U.S. Women's History” by Wilma Pearl Mankiller, Gwendolyn Mink, Marysa Navarro, Gloria Steinem, Barbara Smith
from The Reader’s Companion to U.S. Women’s History
by Wilma Pearl Mankiller, Gwendolyn Mink, et. al.
Houghton Mifflin Company, 1999

These include younger women, women with PCOS (taking metformin as well as fertility drugs reduces the risk of OHSS), and women with highestrogen levels and a large number of follicles or eggs.

“Making Babies: A Proven 3-Month Program for Maximum Fertility” by Jill Blakeway, Sami S. David
from Making Babies: A Proven 3-Month Program for Maximum Fertility
by Jill Blakeway, Sami S. David
Little, Brown, 2009

No reports have described diminished fertility in women taking SSZ; however, men can have oligospermia, impaired sperm motility, and abnormal sperm morphology223 that returns to normal 2 to 3 months after cessation of the drug.

“Firestein & Kelley’s Textbook of Rheumatology E-Book” by Gary S. Firestein, Ralph C. Budd, Sherine E Gabriel, Iain B. McInnes, James R O'Dell, Gary Koretzky
from Firestein & Kelley’s Textbook of Rheumatology E-Book
by Gary S. Firestein, Ralph C. Budd, et. al.
Elsevier Health Sciences, 2020

As recently stressed by a group of experts, androgens and drugs that increase ovarian androgens, such as letrozole, may become important adjuncts for patients with low prognosis IVF (174).

“Textbook of Assisted Reproductive Techniques Fourth Edition: Volume 2: Clinical Perspectives” by David K. Gardner, Ariel Weissman, Colin M Howles, Zeev Shoham
from Textbook of Assisted Reproductive Techniques Fourth Edition: Volume 2: Clinical Perspectives
by David K. Gardner, Ariel Weissman, et. al.
Taylor & Francis, 2012

Drugs used to treat infertility, such as clomiphene citrate, human menopausal gonadotropin, and Gonadotropin Releasing Hormone (GnRH) analogues have been associated with depressive side effects (Daniluk & Fluker, 1995).

“Psychiatric Care of the Medical Patient” by Barry S. Fogel, Donna B. Greenberg
from Psychiatric Care of the Medical Patient
by Barry S. Fogel, Donna B. Greenberg
Oxford University Press, 2015

Increasingly, aromatase inhibitors such as letrozole or anastrazole are being used both for ovulation induction in anovulatory patients and for superovulation in couples with unexplained infertility.

“Ferri's Clinical Advisor 2015 E-Book: 5 Books in 1” by Fred F. Ferri
from Ferri’s Clinical Advisor 2015 E-Book: 5 Books in 1
by Fred F. Ferri
Elsevier Health Sciences, 2014

Drugs may contribute to male infertility by affecting gonadotropin (steroids, opiates) or prolactin (psychotropic agents) secretion, affecting spermatogenesis (sulfasalazine, alkylating agents), or reducing sexual performance (psychotropic and antihypertensive drugs).

“Endocrinology: Adult and Pediatric E-Book” by J. Larry Jameson, Leslie J. De Groot
from Endocrinology: Adult and Pediatric E-Book
by J. Larry Jameson, Leslie J. De Groot
Elsevier Health Sciences, 2015

Fertility enhancing drugs, such as clomiphene citrate and gonadotropins used for ovulation induction have been thought to increase the risk of ovarian cancer, but the data have not been consistent and have not adequately distinguished the influence of infertility perse from the use of fertility stimulating agents.”

“Holland-Frei Cancer Medicine 8” by Waun Ki Hong, Robert C. Bast Jr, American Association for Cancer Research, William Hait, Donald W. Kufe, James F. Holland, Emil Frei Iii
from Holland-Frei Cancer Medicine 8
by Waun Ki Hong, Robert C. Bast Jr, et. al.
People’s Medical Publishing House, 2010

There is concern with the use of aromatase inhibitors such as anastrozole or letrozole in the treatment of premenopausal women because these drugs are known to stimulate ovulation and continuous administration can result in the development of functional ovarian cysts.

“Berek & Novak's Gynecology” by Jonathan S. Berek
from Berek & Novak’s Gynecology
by Jonathan S. Berek
Wolters Kluwer Health, 2019

Fertility medications for women may have physical side effects and risks, such as ovarian hyperstimulation syndrome (OHSS).

“Sexuality Counseling: Theory, Research, and Practice” by Christine Murray, Amber Pope, Ben Willis
from Sexuality Counseling: Theory, Research, and Practice
by Christine Murray, Amber Pope, Ben Willis
SAGE Publications, 2016

Oktay Kutluk

Kutluk Oktay, MD, FACOG is one of the world's foremost experts in fertility preservation as well as ovarian stimulation and in vitro fertilization for infertility treatments. He developed and performed the world's first ovarian transplantation procedures as well as pioneered new ovarian stimulation protocols for embryo and oocyte freezing for breast and endometrial cancer patients.

Mail: [email protected]
Telephone: +1 (877) 492-3666

Biography: https://medicine.yale.edu/profile/kutluk_oktay/
Bibliography: oktay_bibliography

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40 comments

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  • Clomid put me in the hospital so now I’m try letrozole with the tigger shot. I’m praying this work cause this has been a long journey.

  • For three years, my pal and her hubby made several attempts to conceive but all useless. Their counselors have not been able to assist them as well. She acquired the “Sοkοpο Wοzz” (Google it) with sticking to the guidelines in the plan for 2 months, they to be expectant. To acquire additional information regarding this wonderful method, kindly go to Google.

  • There could be many risks in IVF. but only one benefit. But that’s okay. A baby for a benefit is enough for us haha. Thank you for sharing this amazing video with us. It was really informative. Looking forward to watching more videos from you people.

  • My husband and I had been trying to conceive for 6 months. I figured let me try “Get Pregnant Fertility Tea” by secrets of tea before we go back to the doctor and go the fertility medicine route like we had with our son. Well we tried it and I finally ovulated and we conceived on the first try.

  • I am 50 and my wife is 40 from Brazil. We are trying to have IVF for our first baby in January, 2018. I am very anxious about my wife. I love my wife lots!

  • Love your videos. I recently started vlogging our infertility journey with ivf and pcos. It’s a great way to vent without offending anyone. Any videos on tips and trick for stims?

  • I’m currently on my infertility/TTC journey and I just found your channel. So glad to have found you. I’ve been crying and binging your videos ��

  • If you wish to learn more about this amazing pregnant plan “Sοkοpο Wοzz”, search it on Google. At the age of forty-four, I was able to fix my big fertility issue utilizing it. My period delay made me truly happy. I`m making necessary arrangements since I`m glad about the delay of my monthly period. I`m now preparing myself to become a mother.

  • In case you have an infertility problem as a couple, then it is recommended to try the “Sοkοpο Wοzz” (Google it). I extremely got distressed with the results that I was getting from the West prescriptions. I was able to get pregnant after having a healthy diet and having planned acupuncture treatment options for several months. Seeing my year old daughter walking around around the home is highly enchanting. Check out Google to learn more about this excellent plan.

  • Hello, guys. Thank you so much for this video. It’s really informative. I’m glad you posted it. I got to learn so much. Keep up the lovely job. It’s great to see these kinds of videos.

  • Hello. Thanks for uploading this video. I enjoyed watching it. It was really informative on the other hand too. A lot of people including me didn’t know about these risks and benefits. A friend just got her IVF treatment. I wish I had found this video earlier for her.

  • At 34 years, I wouldn’t believe that my providence of bearing children had run out. As such, I settled on spending over $21,000 to overcome my infertility with infertility cures. I did not realize any promising results. Fortunately, “wucu shocking plan”(Google it) helped me conceive kids. You can learn more about the formula by simply Google searching it.

  • Risks:
    -5-10% cancelation rate
    -Ovarian hyper stimulation syndrome
    -Allergic reaction to medication
    -Needle could cause damage to the uterine wall
    -1 in 1000 chance for infection during embryo transfer
    -high chance for multiple gestation which l/t preterm labor and delivery, hemorrhaging
    -birth defects: heart septal defect, esophageal narrowing anal narrowing
    -higher chance for bleeding
    -gestational hypertension
    -gestational diabetes
    -high chance for small for gestational age

    Benefits:
    -ability to freeze embryos

  • Mam nan two times ivf panninaga second time success atchu.but 52 daysla baby heart beats illa sollithaga so imsscarge atchu.ippo restla irruken.aguest monthla treatment start pana poren. First time 14 egg kidaitatu ippo second time egg kidaikama please reply

  • I had IVF done, 3 days embryo transfer and got possitive result on first cycle. Right now I am almost 5 weeks pregnant and started bleeding for past 3 days. Dr are taking blood test to chekc on HCG level, hoping we can keep this baby. I hope this is jsut bleeding disorder like Dr said in this video, not a miscarriage. We pray everday

  • Well, balanced video! I’m still going for it this month at a center in Kiev. So, yes! Anyway! Now, we are going abroad already for our process later this month. So, yes! things are well explained here. But, many and many couples go for it every year I believe.

  • I had a successful experience at LIV Mexico I saved about 50% for IVF & gender selection at ivfin Mexico….I highly recommend
    call to get more details USA +1-855-534-5340MEXICO +52-322-29-72077

  • Im now experiencing all of what you mentioned.its so horrible feeling.thank you for ur information!!!GOD bless you and ur family!!!<3

  • I was an ivf baby and a twin my bro had a hole in his heart and did sadly pass away was looking this up to find out more thank you

  • We are wanting to do the IVF and we require a sperm giver for that. I have such huge numbers of inquiries, and my primary inquiries and concerns are: Does IVF have any socio-enthusiastic results for the youngsters in the future?Why would kids conceived from IVF have any scatters, if the sperm contributor was tried on hereditary defects? Much obliged to you for the considerable video.

  • I loved watching this video and how you explained it all. Some people still frown upon the modern fertility treatments and the procedures but we need to spread awareness about IVF and surrogacy. It brings more good than harm and we need to accept it worldwide.

  • Infertile partners must try the “wucu shocking plan” (Google it) I highly got distressed with the outcomes which I was got from the West medications. I became conceived after few months of adopting to a healthy diet and having planned acupuncture treatment.it’s a blissful to see my one year old child run through the home. Learn much as regards to this great plan from Google.

  • hello there, this is an extraordinary video. It will be useful for some individuals. My sister is fruitless. Presently she is considering picking this procedure for treatment. My all the best for each one of those reasoning of picking the treatment. Keep my sister in your supplications. What’s more, continue sharing such astounding stuff.

  • For 3 years, my mate and her husband made several attempts to conceive but all useless. Their counsellors informed them on most occasions where their problem was “unknown.” She bought the “Sοkοpο Wοzz” (Google it) with sticking to the guidelines in the plan for two months, they to be expectant. To acquire extra particulars regarding this excellent method, kindly visit Google.

  • dr is doing a great job very helpful video it helps to remove misunderstanding on IVF.and amazing thing is that Biotexcom is doing a great job in this. Then help you lot. They provided me with all the necessary information before starting my procedure.

  • Well, this is really a helpful video. Explains pretty much of it. So, yeah! I’m also undergoing surrogacy abroad at a center in Kiev. So, yes! Can relate things. That’s so right! But, still benefits are more, I believe. That is why people go!

  • This is an amazing video with great information. The person should know all these things before choosing an IVF treatment. I had my son via an IVF procedure. The doctor at Biotexcom clinic guided me through very nicely. He helped me at every step. And because of which my treatment was successful and I became pregnant. I believe that the benefits outweigh the risks!

  • That’s an informative video for us all. Thanks for posting. You are right we should know all the do’s and don’ts of any procedure before stepping into it. I am glad I had my IVF done by BioTex. They take all the responsibility to guide their customer through their respective methods. They provided me with all the necessary information before starting my procedure.

  • I adopted the “Sοkοpο Wοzz” (Google it) when my partner and I made the decision it was time for a baby. Numerous lives have become better because of this plan and if you would like to find out why, just go to Google. After enhancing my dietary and following the formula for three months, I discovered that I was about to become a parent. Even though the likelihood of conceiving is lower at my old age, this program were still able to help me make it possible and make my life a whole lot better.

  • I wish my doctors and nurses had told me that the progesterone would give similar pregnancy symptoms, because I had such hope going into my beta blood test. I was convinced I was pregnant because of all the symptoms I was getting. When I got the negative results I got the shock of my life. Nonetheless, we are dealing with the loss and trying to stay positive. Thank you for this video. Wish I viewed it 2 weeks ago. All the best.

  • Hello Dr. Meenu Sharma this side, my age is 51. I lost my son last year October 2016. now m trying ivf with Donner egg, Dr. Made embryo with my husband spurm. My problem is my utres lining not appropriate, what I do to improve my utres lining? Please help me.

  • I am looking for a real great Ivf and I am 38. Me and my Husband would like to have a children.I had an an eopic pregnancy.And having an Ivf would be the only way of having a baby.I wanted to know if this would lead me in to way of having a baby!!!Can you help me I live in Kearny,N.J.

  • hello Dr. Randall, a lot of studies say that fresh embryo implantation rates are higher compared to frozen. So what do we look for implantation success or issues with child… very confused please advise

  • I am looking for a really good IVF doctor. I am 36 and married and me and my husband would like to have a child together. Ivf is the only way I can possibly have a baby. My tubes are damaged to badly for a reversal. Can you please do my IVF? Or can you lead me to a really great doctor. I live in Tennessee and can travel anytime.

  • We are planning to do the IVF and we need a sperm donor for that. I have so many questions, and my main questions and concerns are: Does IVF have any socio-emotional outcomes for the children  in the future?Why would children born from IVF have any disorders, if the sperm donor was tested on genetic imperfections? Thank you for the great video.

  • My wife and I tried the “-3 fetching tavu tamvano” (Google it) when we made a decision to get one more child. If you want to learn why this formula is life-changing, you can check out Google. Right after altering my dietary and following the plan for 3 months, I learnt that I would become a mom. This method has changed my life style, despite the fact where I`m in the aged.

  • Hi dr enaku IVF confirm akiduchu….15 days la sacn soli irunthanga coming 17 sacn but today lite ah velai pattuthu athu yethum prblm varum ah

  • Mam nan 2017 November la ivf egg retivel paninen, ivf second time embryo click atchu but imsscarriga atchu.IUI second time try pannen not success.ippo embryo illa so aguestla treatment start panna poren.second time pick up panna poren.first time 14 egg kidaitatu ippo egg kidaikama.nan maduraila treatment ethuckuren.ellam testum nalla iruku.regular period aguren.HCG both side tube no black.Hormon test no problem.

  • I had 1 fresh trensfer no luck��….then i had 1 FET it didnt work��… and then 3rd FET i was pregnant for 6 weeks then misscarrage���� im going to do 4th FET maybe on February or March 2020….. and this will be my last chance going to be 41��….little but about my background i had pre-cancer on my Uterus im under oral tretment… then i have biconiate heart shape uterus ����.i dont know what should i do anymore…i dont have any kids����

  • Hello mam plz send me ur no.mam mene ivf karaya tha or Muje Ohss Ho gaya or sath me ectopic pregnancy bi. Kya mam m Dobara karao or karao to m un doctors se kya Bolo. Ye unki galati h na. Muje pcod bi thi mam.fir bi unhone egg nikale k Ek week bad ET Kar diya or Muje Ye problems ho gayi. Plz help me or reply me