Natural Killer Cells and reproduction
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Natural killer cells are a healthy part of the immune system normally used by the body to destroy anything perceived to be “foreign” and/or harmful. They are a sub-type of white blood cell (cytotoxic lymphocyte) that provides a rapid response to. Natural Killer Cells in Miscarriage and Infertility.
There has been much interest in the possible role of the immune system in determining the outcome of fertility treatment and pregnancy. Unfortunately, there has been much misinformation about the role of natural killer cells in miscarriage and infertility. Natural killer cells, also known as NK cells or CD56 cells, have.
Link between NK cells and implantation of embryos may be overblown. Natural killer (NK) cells are an important subgroup of lymphocytes (a subgroup of white blood cells) which have a large variety of functions, from killing cancer cells to, potentially, also killing the “invading” (i.e., implanting) embryo if the immune system sees the embryo as “foreign.”. According to Beers, there are four main types of immune problems in women with recurrent pregnancy loss: antithyroid antibodies, antiphospholipid antibodies (thrombophilias), antinuclear antibodies and “Natural Killer Cells.” These conditions cause the body to mistakenly attack normal cells as if they were invaders.
Current papers recently published in the two leading infertility journals, Fertility and Sterility in the United States and Human Reproduction in Europe, state that elevated natural killer cell activity has not been found to be a risk factor for miscarriage or decreased implantation potential and should, at the present time, only be collected. Uterine natural killer (uNK) cells form the major leucocyte population in the endometrium at the time of implantation1and have received considerable attention in relation to their role in normal implantation and early placental development. As we’ve said before in this blog, natural killer cell therapy is an easy sell to anxious couples battling infertility. Just look at the prices being charged at UK clinics for the suppression, or down regulation, of uterine NK cells. We found one clinic charging £450 for a single intralipid infusion to ‘stabilise your immune system’.
Natural killer cells, also known as NK cells or large granular lymphocytes (LGL), are a type of cytotoxic lymphocyte critical to the innate immune system.The role of NK cells is analogous to that of cytotoxic T cells in the vertebrate adaptive immune response.NK cells provide rapid responses to virus-infected cells, acting at around 3 days after infection, and respond to tumor. Reproductive Immunology. Failure to implant and miscarriage after IVF are very common. This of course is also true of natural pregnancies, but where a couple has paid thousands of pounds for treatment, the desire to explain such events may be overpowering. Some clinicians have offered an answer to this question in the form of Natural Killer cells.
These naturally occurring. NK or natural killer cells play an important (and controversial) role in IVF. Despite their name, not all NK cells are killers and the NK cells of the uterus seem to play a supportive role for embryo implantation!
For more background info, check out my post on Embryo Implantation (opens in new tab).
List of related literature:
|from Knobil and Neill’s Physiology of Reproduction|
|from Gynaecology E-Book: Expert Consult: Online and Print|
|from Before Your Pregnancy: A 90-Day Guide for Couples on How to Prepare for a Healthy Conception|
|from Clinical Naturopathic Medicine E-Book|
|from Stiehm’s Immune Deficiencies|
|from Speroff’s Clinical Gynecologic Endocrinology and Infertility|
|from Yen & Jaffe’s Reproductive Endocrinology E-Book: Physiology, Pathophysiology, and Clinical Management|
|from In Vitro Fertilization: A Textbook of Current and Emerging Methods and Devices|
|from Endocrinology E-Book: Adult and Pediatric|
|from Andrology: Male Reproductive Health and Dysfunction|