Natural Killer Cells and Infertility Options to consider

 

Natural Killer Cells and reproduction

Video taken from the channel: Instituto Bernabeu


 

Natural Killer Cells in Miscarriage

Video taken from the channel: IVF Australia


 

I Have MTHFR + Natural Killer Cells (INFERTILITY)

Video taken from the channel: KatekaGood


 

INFERTILITY NATURAL KILLER CELLS?

Video taken from the channel: Phil and Alex


 

Natural Killer Cells: What are they and How do they Affect Fertility Treatment?

Video taken from the channel: Center for Human Reproduction


 

The Truth About NK Cells and Fertility Treatment | Ask Doctor Tomáš

Video taken from the channel: Your IVF Journey


 

Miscarriage and natural killer (NK) cells Everything you know is wrong

Video taken from the channel: Infertility TV


Natural killer cells are a healthy part of the immune system normally used by the body to destroy anything perceived to be “foreign” and/or harmful. They are a sub-type of white blood cell (cytotoxic lymphocyte) that provides a rapid response to. Natural Killer Cells in Miscarriage and Infertility.

There has been much interest in the possible role of the immune system in determining the outcome of fertility treatment and pregnancy. Unfortunately, there has been much misinformation about the role of natural killer cells in miscarriage and infertility. Natural killer cells, also known as NK cells or CD56 cells, have.

Link between NK cells and implantation of embryos may be overblown. Natural killer (NK) cells are an important subgroup of lymphocytes (a subgroup of white blood cells) which have a large variety of functions, from killing cancer cells to, potentially, also killing the “invading” (i.e., implanting) embryo if the immune system sees the embryo as “foreign.”. According to Beers, there are four main types of immune problems in women with recurrent pregnancy loss: antithyroid antibodies, antiphospholipid antibodies (thrombophilias), antinuclear antibodies and “Natural Killer Cells.” These conditions cause the body to mistakenly attack normal cells as if they were invaders.

Current papers recently published in the two leading infertility journals, Fertility and Sterility in the United States and Human Reproduction in Europe, state that elevated natural killer cell activity has not been found to be a risk factor for miscarriage or decreased implantation potential and should, at the present time, only be collected. Uterine natural killer (uNK) cells form the major leucocyte population in the endometrium at the time of implantation1and have received considerable attention in relation to their role in normal implantation and early placental development. As we’ve said before in this blog, natural killer cell therapy is an easy sell to anxious couples battling infertility. Just look at the prices being charged at UK clinics for the suppression, or down regulation, of uterine NK cells. We found one clinic charging £450 for a single intralipid infusion to ‘stabilise your immune system’.

Natural killer cells, also known as NK cells or large granular lymphocytes (LGL), are a type of cytotoxic lymphocyte critical to the innate immune system.The role of NK cells is analogous to that of cytotoxic T cells in the vertebrate adaptive immune response.NK cells provide rapid responses to virus-infected cells, acting at around 3 days after infection, and respond to tumor. Reproductive Immunology. Failure to implant and miscarriage after IVF are very common. This of course is also true of natural pregnancies, but where a couple has paid thousands of pounds for treatment, the desire to explain such events may be overpowering. Some clinicians have offered an answer to this question in the form of Natural Killer cells.

These naturally occurring. NK or natural killer cells play an important (and controversial) role in IVF. Despite their name, not all NK cells are killers and the NK cells of the uterus seem to play a supportive role for embryo implantation!

For more background info, check out my post on Embryo Implantation (opens in new tab).

List of related literature:

Moffett A, Regan L, Braude P. Natural killer cells, miscarriage, and infertility.

“Knobil and Neill's Physiology of Reproduction” by Tony M. Plant, Anthony J. Zeleznik
from Knobil and Neill’s Physiology of Reproduction
by Tony M. Plant, Anthony J. Zeleznik
Elsevier Science, 2014

Moffett A, Regan L, Braude P 2004 Natural killer cells, miscarriage, and infertility.

“Gynaecology E-Book: Expert Consult: Online and Print” by Robert W. Shaw, David Luesley, Ash K. Monga
from Gynaecology E-Book: Expert Consult: Online and Print
by Robert W. Shaw, David Luesley, Ash K. Monga
Elsevier Health Sciences, 2010

To maximize your chances of a healthy pregnancy, you should seek treatment for preexisting anemia, begin prophylactic vaccinations against infections, eat healthfully even during painful episodes, and start a multivitamin containing ſolic acid at least three months before conception.

“Before Your Pregnancy: A 90-Day Guide for Couples on How to Prepare for a Healthy Conception” by Amy Ogle, Lisa Mazzullo, Mary D'Alton
from Before Your Pregnancy: A 90-Day Guide for Couples on How to Prepare for a Healthy Conception
by Amy Ogle, Lisa Mazzullo, Mary D’Alton
Random House Publishing Group, 2011

Diet and lifestyle in the prevention of ovulatory disorder infertility.

“Clinical Naturopathic Medicine E-Book” by Leah Hechtman
from Clinical Naturopathic Medicine E-Book
by Leah Hechtman
Elsevier Health Sciences, 2012

Tang AW, Alfirevic Z, Quenby S. Natural killer cells and pregnancy outcomes in women with recurrent miscarriage and infertility: a systematic review.

“Stiehm's Immune Deficiencies” by Kathleen E. Sullivan, E. Richard Stiehm
from Stiehm’s Immune Deficiencies
by Kathleen E. Sullivan, E. Richard Stiehm
Elsevier Science, 2014

Bohring C, Krause W, Immune infertility: towards a better understanding of sperm (auto)-immunity.

“Speroff's Clinical Gynecologic Endocrinology and Infertility” by Hugh S. Taylor, Lubna Pal, Emre Sell
from Speroff’s Clinical Gynecologic Endocrinology and Infertility
by Hugh S. Taylor, Lubna Pal, Emre Sell
Wolters Kluwer Health, 2019

Laven JS, Imani B, Eijkemans MJ, et al: New approach to polycystic ovary syndrome and other forms of anovulatory infertility.

“Yen & Jaffe's Reproductive Endocrinology E-Book: Physiology, Pathophysiology, and Clinical Management” by Antonio R. Gargiulo, Jerome F. Strauss, Robert L. Barbieri
from Yen & Jaffe’s Reproductive Endocrinology E-Book: Physiology, Pathophysiology, and Clinical Management
by Antonio R. Gargiulo, Jerome F. Strauss, Robert L. Barbieri
Elsevier Health Sciences, 2017

Intrauterine insemination with minimal hormonal stimulation due to the risk of thrombosis could be recommended as the safest treatment option of infertility in women with essential thrombocythemia [135].

“In Vitro Fertilization: A Textbook of Current and Emerging Methods and Devices” by Zsolt Peter Nagy, Alex C. Varghese, Ashok Agarwal
from In Vitro Fertilization: A Textbook of Current and Emerging Methods and Devices
by Zsolt Peter Nagy, Alex C. Varghese, Ashok Agarwal
Springer International Publishing, 2019

Laven JS, Imani B, Eijkemans MJ, et al: New approach to polycystic ovary syndrome and other forms of anovulatory infertility, Obstet Gynecol Surv 57(11):755–767, 2002.

“Endocrinology E-Book: Adult and Pediatric” by J. Larry Jameson, Leslie J. De Groot
from Endocrinology E-Book: Adult and Pediatric
by J. Larry Jameson, Leslie J. De Groot
Elsevier Health Sciences, 2010

Fertil Steril (Epub ahead of print) Gerris J, De Neubourg D, Mangelschots K, Van Royen E, Van de Meerssche M, Valenburg M (1999) Prevention of twin pregnancy after in-vitro fertilization or intracytoplasmic sperm injection based on strict embryo criteria: a prospective randomized clinical trial.

“Andrology: Male Reproductive Health and Dysfunction” by Eberhard Nieschlag, Hermann M. Behre, Susan Nieschlag
from Andrology: Male Reproductive Health and Dysfunction
by Eberhard Nieschlag, Hermann M. Behre, Susan Nieschlag
Springer Berlin Heidelberg, 2010

Oktay Kutluk

Kutluk Oktay, MD, FACOG is one of the world's foremost experts in fertility preservation as well as ovarian stimulation and in vitro fertilization for infertility treatments. He developed and performed the world's first ovarian transplantation procedures as well as pioneered new ovarian stimulation protocols for embryo and oocyte freezing for breast and endometrial cancer patients.

Mail: [email protected]
Telephone: +1 (877) 492-3666

Biography: https://medicine.yale.edu/profile/kutluk_oktay/
Bibliography: oktay_bibliography

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50 comments

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  • If you and your husband have it there’s a high chance your baby will have it. please research vaccines and mthfr, might save your babies life!

  • I am sure you don’t remember… but when you begin posted videos I told you that I voted for your video on E&J channel. I am not sure why I feel so close to you instead of the others… Even thou I also follow them!!! (Cant miss any of the pregnancies) 😉 

    Lots of love!!! xoxoxo

  • Can you please discuss about bicornuate uterus and fibroids, how it effects conceiving, miscarriages, ability to carry the embryo full term?

  • (Just so you know, you have homozygous and heterozygous mixed up. So YOU have two copies of the mutation and are homozygous but your husband, who only has one bad copy, is heterozygous.)
    My story is 10 years of infertility with 11 miscarriages and 4 rainbow babies. It took 7 years and so much testing before we found out I am a homozygous carrier of MTHFR. (Subsequent testing showed my husband is also homozygous MTHFR but he has a different mutation than I do.) For me, MTHFR causes recurrent pregnancy loss, bleeds in the first trimester even with my successful pregnancies, and exacerbates my existing anxiety and depression disorders. I usually notice increased body aches, fatigue, and apathy when I forget to take my folate supplement as well. My current pregnancy regimen is to take progesterone supplements and high dose methylfolate (my dr prescribes the one I take during pg but I take one called Brain Restore when I’m not pregnant) during the first trimester and 2 baby aspirin every day during pregnancy. I’m monitored by my OB and if we ever feel the aspirin isn’t enough, I’ll go on Lovenox injections but as yet, I’ve made it to term with just the baby aspirin.
    I’m really hoping this is it for you and you have a wonderfully amazing successful pregnancy. You deserve it after everything you’ve been through.

  • I just found your channel. I have MTHFR and I’m homozygous as well. We lost 3 pregnancies before finding this out. My OB put me on lovenox injections every 12 hours while pregnant and with the help of those shots and a progesterone supplement we finally have 2 amazing babies:) wishing you guys tons of baby dust ❤️❤️

  • ahhhhhhhhhhh you make me laugh, you make me cry, I love you guys so much, you’re such a beautiful soul!!!! I’m praying for you! xoxo

  • Hi, what a great video that has actually answered my question i had for my consultant. I recently went through ivf and the first transfer with two perfect embryos and unfortunately they didn’t take inthink it’s because not much was done done to help it and deactivate my conditionstage 4 endometriosis. i deeply believe i should ask for natural killer cells medication before my next transfer! the question is, will i need it just throughout the transfer and implantation stage or for longer i the transfer is successful? thank you! xxx

  • How ironic that the acronym is MTHFR LOOKS like a reeeeeeally bad word����. Appropriate!! But YAY for some answers!!! Finally!!!! You are getting there girl!! And its ok to cry..i think it really brings us into what you are going through also (someone else said that). I cried in my vlog last night too��kinda hard not to under any infertility journey. Love you guys! Cant wait for your next update!! ������������

  • My 6ivf cycles with donor eggs all transferred on 5th day failed. I was given intralipids for nk cells. Now doctors suggested donor embryo but with intralipids. What I must do should I again try donor eggs cycle??

  • If the embryo made upto 6 weeks 4 days than their heart stops could this be a natural killer cell attack? I live in Italy how can I get this checked. This baby that we lost was a natural conception, at first try, one single try in the ovulation day at age 46. I have no chronic disease or any other condition that I know of father of the baby as well 49 pretty much healthy. They suggested us to move IVF. I can conceive easily apparently what will be the advantage of IVF to me. If we come to NY how long I must stay, how long my husband must stay we both must work. Do you have a partner clinic in Europe, Italy?

  • ♡♡♡ Your submission video…made me fall in love with you guys! I voted for you, prayed for you, cried for you. Those videos of giving back were my favorites!!! You two were just being yourselves and trying to vlog it and it was ADORABLE!!! I remember that emotional video!!! I balled! Love you guys even more and I can’t wait to see all the amazing videos to come!!!! Prayers for retrieval this coming week…may there be MANY EGG-CELENT eggs!!! ♡♡♡

  • How is it that your in America you have to pay thousands for simple treatments and supposed to have top leading doctors yet they let you go through many treatments without these simple tests? And they don’t have a clue like it took a ordinary person to figure it out

  • Dang MTHFR. I have it too. I also take folate for it. You guys are so genuine. I am so happy you won a grant. I am praying for you guys!

  • Dearest Kateka and Stu: I remember the beginning of your vlogging and I am so happy that your IVF is now. ������❤️. I will remain in prayer and hopeful that all goes smoothly (including your house renovations). Much love to you both!❤️

  • You are taking it way much better than I did. I took an IVF only last year, got pregnant but had a miscarriage. My Husband and I then decided that we needed to take a break from this for some time to put ourselves together in case such thing happens again because he was over the moon when I did get pregnant successfully after the IVF but the later events blasted him off the rails. We were in in deep distress then, though no one can actually know unless they have been through this too. However, seeing you makes me strong and confident for it. There is only one thing that keeps bothering me; is the excessive use of IVF leads to any side effects..?

  • I never got tested by blood or biopsy. Four of my losses were early, and six later 9-15 weeks fetal measurement. Doctors had me try steroids once (20mg prednisalone) but that ended as an early loss. Only one later 9 week loss had a known trisomy. I have always wondered about intralipid infusions, but must admit, I do tend to agree with your assessment. Nobody seems interested in old cases for research purposes….older patients hold more secrets than stab in the dark random preventative treatments on random patients with less proven histories…..many of whom must just have normal egg quality DNA chromosomal anomolies going on…. “normal losses”.

  • You are so super inspiring! I literally wait every week for your videos to pop up. You deserve only blessings! You will be in my prayers for everything to work out!

  • Appreciate the video but perhaps talking about what SHOULD be done might be more useful?? Ive read many women having success after IV therapy.

  • Hi Kate, I watch you guys all the time, sending lots of love your way x like you I have stage 4 advanced endometriosis, we have been trying for 8yrs we were told that nothing was wrong and I only had PCOS, so for years We were one are own as doctors were not listening to me. I new something was wrong because from the age of 11yrs I had very prolonged and painful cycles, 2 years ago things took a turn for the worst, I ended up in the hospital in server pain and I lost the feeling in my pelvis and part way down my legs, I spent to months in the hospital were they preformed lots of tests on me, I was then discharged with no answers to rehab unit, were I spent a further month before going home, it was only diagnosed a year ago by my private doctor, they think the Clomid we took a few years ago pushed it to this advanced state now, we have just had two failed IUI cycles and now are only option is IVF which we can have yet because I have to have major surgery in May and they have told me I may loose part of my bowl, so I will have a bag for 3 months until they can operate again to reverse it, not going to lie this scares the shit out of me because they have told me I am going to be in more pain after the op than I am now, I am already on all kinds of meds and morphine and they make me feel like a zombie, which I hate, I know surgery is my only option if we want to try for IVF but I am scared if they are right about the pain being worse, my main worry is after the surgery and if the IVF works, how the hell do I look after a baby on all these drugs and being stuck in this bloody wheelchair, I totally get what you are going through and it’s the hardest thing in the world, I am sending lots of hugs your way and you will be in my thought. I am here if you ever just want to chat xx

  • Anyone who tells you that ONE THING causes a huge list of very different ailments has been looking at woo-pseudoscience, or trying to sell you some made-up therapy. MTHFR does not work the way she says. 23andMe is literally in the business of selling genetic tests, yet, because they are not pseudoscientists, have published this blog post that talks all about what MTHFR actually is, and what it does.

    https://blog.23andme.com/health-traits/our-take-on-the-mthfr-gene/

  • Hi Kate, I’m so excited to be following your journey, and I’m praying you get your baby soon, I also want to tell you that one of the affects of MTHFR is poor methylation, so people who have MTHFR have a really hard time detoxing their bodies, this might be something you want to look into, as this can lead to childhood illnesses, vaccine injuries etc!

  • Hi can you list all the Vitamins you are taking i have gone thru 4 early miscarriage this year and Doctors dont have answers as to why. Also here in Miami FL everything is a business and to do any test is too much money i cannot afford.

  • I highly recommend checking into the autoimmune protocol diet. It is amazing how much foods impact out immune system and how our body attacks itself.

  • Very informative. My wife had the transfer at early blastocyst D5. Unfortunately we had failed implantation 3 days before the end of 2 week wait. We have a follow up appointment with the dr so will ask could be could be done. Thankyou. Any advice would be appreciated.

  • I’m a hormonal 54 year old & ‘THAT moment’ made me cry all over again too. I’ve had a really good feeling about you both ever since I voted for you & am so excited for the future xxxx

  • You are so brave. And this is by far the best video I have seen. My husband and I have been trying for a couple of years. I had block tubes that’s why can’t conceive by myself. So we’ve been referred for ivf and are waiting for the appointment date for our first ivf appointment. We choose rather distant but very professional fertility center in Ukraine. We choose it because of the prices and reviews. I know that many people can complain about lot of thing based on personal attitude. But we were looking not for a pleasant smiles and dialogues; we need results and this clinic can guarantee it for us. I’m really scared too, the injections terrify me and the thought that you can go through all that and still not be successful. You have answered a lot of questions that I had in mind. Hearing it from someone who has experienced it is a lot better than being told by a doctor. Plus we should be mindful of others. Honestly, you deserve the best in life for helping us out with this.

  • I know it’s out there but have you tried to go gluten-free. Gluten can cause an inflammatory response in your body and make your immune system work harder. I have hashimotos and going gluten free has been very helpful.

  • What an incredible person you are Kateka. It takes a lot of strength to travel the road you have and a lot more to share it. I can see by the comments in this video and others that you are inspiring to so many! Now I am going to go watch some of your vlogs I have missed!

  • I’m 18. I know that i have the MTHFR mutation. Not gonna lie, this scares the shit out of me. I’ll keep you in my prayers and heart.

  • I also have the mthfr Gene and my midwife suggested that I take the smarty pants vitamins and I have had 2 successful pregnancies and one on the way:) I am so hopeful that you get your baby you so deserve.

  • I started IVF in germany 2015, i did 2 times insemination and monday 11.12.2017 is gonna be my 2nd embrio transfer. I pray for you guys who’s waiting for have a baby. We keep encourage each other. We keep going to try it until the last hope. I pray that i get pregnant on christmas 2017. Bless me ��☺

  • I’m so glad that you guys get this opportunity. I hope someday I can make an impact on the world like Elle + Jared have. I keep you in my prayers for this miracle to work and I hope this coming week is everything for you. I also have the MTHFR gene and was told it was the reason behind my HG (hyperemesis gravidarum). So many health struggles but it looks like so many people are struggling together. If you ever need anything, don’t hesitate to reach out. Your story reminds me a lot of my own. Hugs!

  • This is such a sweet vlog. We love you and Stu so much! You are such a huge support to us, and we are so grateful to know you, and beyond blessed to get to go through this with you guys. Such a sweet and amazing group we have been blessed to get to know and love and support! <3 I feel so hopeful for everyone! We send so much love and hope to all of you all the time! <3 We are praying so much for you this week and are excited to hear the outcome next week! Love you so much! <3 <3 <3

  • I love you girl! I’m praying for you! I love when you cry because it lets us in that this is painful and it makes me want to help carry your burden. I’m so hopeful for you. ❤️

  • Hi there. Nice to see you are excited about your IVF procedure. I hope it works out well for you. Do let me know your experience. I am trying to decide bwtween surrogacy and IVF. For now surrogacy seem to be the winner. Video like https://www.youtube.com/watch?v=-gcRwUrSwwc&t=131s sound really promising.

  • Thank you so much for sharing your story! You will both be in my prayers over the next couple of weeks! I have never hoped so much for someone I’ve never even met.

  • Kateka!!! I swear we have the same life! Watching Jared tell Ellie they would change someone’s life I felt peace and I knew somehow i would be effected in this process! I had no idea we would get to travel this road with all of you! I cannot be more thankful for this last year! Love you!!

  • Love your channel! I had a failed IVF about a month ago and found you guys. I had an hsg of 13 but dropped down and stopped developing.I have a question did you had your embryos tested in your second IVF? I have one embryo frozen with normal chromosomes and hopefully I do transfer by summer.

  • You make me cry all the plans are coming true this is so exciting!! I’m so happy that you share this Vlogs with us! so we can pray and send good energy for you guys!! You have more than 4 thousand subscribers on your side praying for good outcomes in your plans! That’s a lot of energy! Thanks for this vlog!

  • I love you two! I can’t thank you enough for sharing your story. I absolutely agree that you have to advocate for yourself. After 4 years, 3 miscarriages, I finally went in to see a Reproductive Endocrinologist even after my OBGYN regularly told me everything is “ok.” Watching your videos has helped me tremendously in my journey. Please continue to share and I can’t wait to watch videos of your miracle baby as I am praying with all my heart your IVF cycle will lead to not only a successful pregnancy but also to a healthy baby or babies you will bring home!

  • I still cycle like clockwork, every 28 days, with + opks and EWCM, at a great age…when does it start to go random before stopping?

  • hi!! wondering how the grant works? is it only for a certain amount of tries and then you have to pay for them yourself or does the grant cover however many times you want/need to try?

  • You know I couldn’t agree more about being your own advocate regarding any and all health issues. No one knows your body better than you. I am so hopeful for you, praying with everything I have that this works for you xxxx

  • You got me crying with you. Wish you all the best in your coming ivf cycle. This journey is so hard and the struggles is real. After my miscarriage to quadruplets (pregnancy through ivf) and my 2nd & 3rd ivf cycles failed i was so done and giving up on trying another treatment. But after seeing all the ivf grant winners journey gives me a lil bit of hope that maybe we should try another cycle? Maybe? But I’m just not sure. Good luck to you and I’ll keep you in my prayers.

  • I really feel like you should be on an Autoimmune diet called The AIP and taking Youngevity 90 for Life’s, Healthy Body Start Pak 2.0 twice a month. Give it 6 months and try again.

  • oh Kateka, I absolutely lost it. I absolutely agree about being your own advocate when it comes to your health. I trust all my doctors to an extent, (in general they know more than me medically, but they are human too) if i hadn’t pushed for testing on a list of medical issues. I would still be severely depressed, probably lying in my room in the dark. Even when in labor with my son. I was the one who had to say ” Something is wrong, i want a C-Section” which all the nurses scoffed out thinking i was just being dramatic. Eventually, i got that C-Section and my doctor personally apologized to us, saying I should of had one all along. So i strongly believe in knowing your body and fighting for it.

  • My sister was told that she has thick or sticky blood and had to go on asprin, she lost 8 babies all before 12 weeks and that her immune system was killing her babies. She has 3 wonderful children now. Im wishing you all the best and will be with you every step of the way x

  • Kateka, I want you to know how much of an impact you have had through sharing your journey. You are an outstanding source of knowledge, and a great resource to others who need your message. Thank you for being a great example to me. You are so refreshing. You are the “real deal”. I’m hopeful for you ♡

  • I have a fet in a couple weeks, I haven’t been tested for mthfr or natural killer cells. My doctor isn’t very concerned with me as our infertility is male factor. Should I ask for these tests?

  • Cried with you as you told your IVF Grant story. Don’t appologize for your tears. I love how you support all the other IVF Grant winners. In every video or post there’s a comment or at least a like from you. ❤ You’re such a good soul.