Lupron Negative Effects and Risks When Employed for In vitro fertilization treatments

 

IVF Day 6 Injections // Lupron Injection

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Video taken from the channel: Sher Fertility Institute


 

Side Effects of Lupron Depot Crazy Lady Symptoms

Video taken from the channel: Liv 4 Today


 

Lupron Side EffectsYour IVF Nurse

Video taken from the channel: Your IVF Nurse


 

IVF Prep and Update: Depot Lupron (Side Effects)

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Starting IVF Injections || Lupron Side Effects

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More women come forward with complaints about Lupron side effects

Video taken from the channel: KTNV Channel 13 Las Vegas


Lupron, a GnRH agonist, is one of the best known and most hated of IVF treatment injectable fertility drugs. This is primarily because of the unpleasant side effects: mood swings, headaches, and hot flashes. GnRH agonists like Lupron are primarily used for the treatment of endometriosis and fibroids. Any drug that alters the body’s hormones carries a risk of side effects. When used alone, Lupron may cause: bone thinning; decreased libido; depression; dizziness; headaches and migraine.

Lupron drastically lowers the body’s estrogen levels and suppresses the bodies production of luteinizing hormone, which is the hormone that stimulates ovulation. Among a few common Lupron side effects IVF are gastrointestinal issues such as constipation and nausea, headaches, and trouble sleeping are a few on them. Progesterone Side Effects IVF. Lupron is an injectable fertility drug that is in the category of GnRH agonists used in an IVF protocol.

GnRH agonists shut off your body’s normal process of hormone and egg development. As part of the Down Regulation protocol, it’s used to prevent premature ovulation during. Lupron, commonly known as “leuprolide acetate” or “long lupron,” is a fertility medication used to treat infertility, prostate cancer in men, heavy bleeding (menorrhagia) or for advanced endometriosis..

For many fertility practitioners, Lupron is the selected fertility drug and is the choice for in vitro fertilization (IVF). signs of a stroke -sudden numbness or weakness (especially on one side of the body), sudden severe headache, slurred speech. Common side effects may include: hot flashes, sweating, acne, rash, itching, scaly ski. IVF #4.2 April 2015 Lupron Stop Protocol with ICSI = PGD testing of embryo indicated it was abnormal IVF #5 June 2015 EPP with Antagonist Ever yo ne welcome!

I think the long term Lupron for treating Endo is different than the short term Lupron used for suppression in IVF. Usually you take it for two weeks only for ivf. I never really had any side effects from any of the IVF meds. At 39, I suggest you do not delay your egg freezing. Risks associated with taking Lupron, short periods of time in IVF, are in my experience rare and side effects are mild.

Long term use (especially when depot-Lupron is administered) is another matter altogether. In fact people who take Lupron for long periods are more prone to certain health risks. Gueriguian alleges that that TAP intentionally suppressed knowledge about the risks associated with Lupron, including bone density loss (leading to permanent disability in some cases), generalized pain, headaches, fluid retention, depression and immune and nervous system problems, including spinal fracture, convulsions and paralysis.”.

List of related literature:

In addition, pioglitazone can cause liver damage, bladder cancer, and fractures, and can cause ovulation in anovulatory premenopausal women, thereby posing a risk of unintended pregnancy.

“Lehne's Pharmacology for Nursing Care E-Book” by Jacqueline Burchum, Laura Rosenthal
from Lehne’s Pharmacology for Nursing Care E-Book
by Jacqueline Burchum, Laura Rosenthal
Elsevier Health Sciences, 2014

However, a consequence of these changes in hemostasis and fibrinolysis is an increased risk of VTE that is five times more frequent during pregnancy and occurs in 0.2% of cases (Nelson 2007, Dizon-Townson 2002).

“Drugs During Pregnancy and Lactation: Treatment Options and Risk Assessment” by Christof Schaefer, Paul W.J. Peters, Richard K Miller
from Drugs During Pregnancy and Lactation: Treatment Options and Risk Assessment
by Christof Schaefer, Paul W.J. Peters, Richard K Miller
Elsevier Science, 2014

A prevailing concern over the increased incidence of spontaneous abortions in women with PCOS and the potential reduction afforded by insulin sensitizers suggests that insulin sensitizers may be beneficial in combination with gonadotropin therapy for ovulation induction or in vitro fertilization (160).

“Berek & Novak's Gynecology” by Jonathan S. Berek
from Berek & Novak’s Gynecology
by Jonathan S. Berek
Wolters Kluwer Health, 2019

Almost any complications that occur from the anovulatory drug can parallel those of early pregnancy, including facial pigmentation, nausea, depression, and fatigue.

“Family Medicine: Principles and Practice” by J. L. Buckingham, E. P. Donatelle, W. E. Jacott, M. G. Rosen, Robert B. Taylor
from Family Medicine: Principles and Practice
by J. L. Buckingham, E. P. Donatelle, et. al.
Springer New York, 2013

The study concluded that the use of a GnRHa trigger reduces, if not eliminates, the risk of OHSS in highrisk patients, without compromising pregnancy outcomes.

“Textbook of Assisted Reproductive Techniques: Two Volume Set” by David K. Gardner, Ariel Weissman, Colin M. Howles, Zeev Shoham
from Textbook of Assisted Reproductive Techniques: Two Volume Set
by David K. Gardner, Ariel Weissman, et. al.
CRC Press, 2017

These unwanted side-effects mean that only 50% of patients who do ovulate successfully with clomifene will become pregnant, even with its continued use.

“Treatment of Infertility with Chinese Medicine E-Book” by Jane Lyttleton
from Treatment of Infertility with Chinese Medicine E-Book
by Jane Lyttleton
Elsevier Health Sciences, 2013

As recently stressed by a group of experts, androgens and drugs that increase ovarian androgens, such as letrozole, may become important adjuncts for patients with low prognosis IVF (174).

“Textbook of Assisted Reproductive Techniques Fourth Edition: Volume 2: Clinical Perspectives” by David K. Gardner, Ariel Weissman, Colin M Howles, Zeev Shoham
from Textbook of Assisted Reproductive Techniques Fourth Edition: Volume 2: Clinical Perspectives
by David K. Gardner, Ariel Weissman, et. al.
Taylor & Francis, 2012

Women with these autoimmune antibodies are at increased risk of fetal loss in any trimester from placental thrombosis or growth restriction (Empson, Lassere, Craig, & Scott, 2002).

“Women's Health Care in Advanced Practice Nursing, Second Edition” by Ivy M. Alexander, PhD, APRN, ANP-BC, FAANP, FAAN, Versie Johnson-Mallard, PhD, ARNP, WHNP-BC, FAANP, Elizabeth Kostas-Polston, PhD, APRN, WHNP-BC, FAANP, Catherine Ingram Fogel, PhD, RNC, FAAN, Nancy Fugate Woods, PhD, RN, FAAN
from Women’s Health Care in Advanced Practice Nursing, Second Edition
by Ivy M. Alexander, PhD, APRN, ANP-BC, FAANP, FAAN, Versie Johnson-Mallard, PhD, ARNP, WHNP-BC, FAANP, et. al.
Springer Publishing Company, 2017

A prevailing concern over the increased incidence of spontaneous abortions in women with PCOS and the potential reduction afforded by insulin sensitizers suggest that insulin sensitizers may be beneficial in combination with gonadotropin therapy for ovulation induction or in vitro fertilization [202].

“Reproductive Endocrinology and Infertility: Integrating Modern Clinical and Laboratory Practice” by Douglas T. Carrell, C. Matthew Peterson
from Reproductive Endocrinology and Infertility: Integrating Modern Clinical and Laboratory Practice
by Douglas T. Carrell, C. Matthew Peterson
Springer New York, 2010

After three months on Lupron, the pain from the endometriosis was gone, but there were some terrific side effects.

“For Women Only!: Your Guide to Health Empowerment” by Gary Null, Barbara Seaman
from For Women Only!: Your Guide to Health Empowerment
by Gary Null, Barbara Seaman
Seven Stories Press, 2001

Oktay Kutluk

Kutluk Oktay, MD, FACOG is one of the world's foremost experts in fertility preservation as well as ovarian stimulation and in vitro fertilization for infertility treatments. He developed and performed the world's first ovarian transplantation procedures as well as pioneered new ovarian stimulation protocols for embryo and oocyte freezing for breast and endometrial cancer patients.

Mail: [email protected]
Telephone: +1 (877) 492-3666

Biography: https://medicine.yale.edu/profile/kutluk_oktay/
Bibliography: oktay_bibliography

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14 comments

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  • Endo pain can be reduced by changing diet. The grow of endo will also reduce.
    No sugars, no bad oils/ fat, processed food.

    If needed have endo surgical removed, not burned, but cut off.

  • My dear, dont lose hope and stay hopeful and positve. IVF will definitely work for you. Just be patient and be positve. Things are becomig very easy for the infertile couples nowadays. IVF is really a wonderful procedure. Wish you best of luck for it.

  • It is the worst thing I have done to my body. I loose a lot of weight, my hair fell, my skin looked aged. I started to have indescribable bone and muscle pain, mouth sores, night sweats, etc. I was supposed to take 12 shots, but by the 11 I was feeling so bad that I told my mom I was going to stop because I wasn’t sure if my body could handle it anymore and I stopped. Its been more than a year since I ended the treatment and I still feel like I haven’t completely overcome the side effects of Lupron.

  • YES!!! ��
    My doctor kept pushing me to go on Lupron for 2 years! I prayed & God told me not to go on it. I was shocked because I wanted to go on it… My doctor told me it would help me get pregnant. I hadn’t done any research on it. Then I contacted my friend that also has endo. She went on it & said it was the worst decision of her life!! She was on it for 6 months. Years later she still has horrible side effects from it. �� She actually begged me not to go on it! After having 2 children & a miscarriage, I eneded up get a partial hysterectomy. Best decision ever!!!!! Here’s a little video I made of a sweet moment I had with God, for those who are of faith. God bless!!
    https://youtu.be/_0z8CXFEr34

  • I have multiple fibroids that are ruining my life. My gyno told me she wont perform a Myonectomy until I take the Lupron shots. Excuse my french but F_CK that! I will be looking for other alternatives!

  • I tried orilissa it helped with my endometriosis. But I have a large fibroid so I’m still going to try Lupron and I’ve met people who Tried it and they were fine. I will try anything to get rid of this pain.

  • Kind of an important one. It’ll be alright with you. It’s going to be alright. We must take good care of ourselves. You must do it too. Always take great care. Take it very seriously. Everything will be alright.

  • Don’t tAke this BS. Took this for 2 years and stopped it at the age of 12. I am now 23 and feel like all my health issues were related to that stupid shot I would get once a month. I have thyroid issues, skin issues, mood swings and terrible insomnia, I eat extremely healthy everyday, no sugar lots of vegetables and fruit and organic proteins and still suffer from thyroid problems, I have a feeling it was the Lupron shots I got over a decade ago. I’m not sure if it is that but it’s a big possibility it was the Lupron injections.

  • I did depo for 6 months. You are right on with the symptoms, did you mention hot flashes and night sweats if so I missed that part. Your hair loss is just temporary. I still I ended up doing the laparoscopy surgery and it was much easier than I had anticipated.you might want to look into taking a thyroid med. not something that my fertility doctors looked much into. I went to a natural path it worked for me and if you do a little research on thyroid and miscarriage you might find it’s what you’re missing along with the endometriosis. Our stories sound very similar. Good luck!!!! ( this is my husband account)

  • I love watching your videos, you are so real and funny! And not like I have any authority on the matter but I don’t think vlogging in bed is weird at all ahahah. Thanks for bringing us along on this journey!

  • I feel for these women. Endometriosis is so misunderstand by so many that my husband just won’t ever fully understand my struggle with this condition and the side effects to this medication.

  • I just got my first shot, 11.25 this very morning!!!!!! Since the day my gyno told me about Lupron, I’ve been having a doubt on takin it or not! I wanted a 2nd oppinion before taking it, I asked my familly doctor 2 times to see the doctor who performed my c-seciton 5 years ago inorder to hear what she thinks and I was told not to worry so it was denied for me! I never got my 2nd oppinion! Along with Lupron, I am taking 2 additional daily hormones (to balance everything, supposably). I took Orilissa for 6 months last year and ended up like a monster and stoped the treatment myself! Now I wonder what on earth did my gyno got me into! I never had any bone or joint pain! I pray I’ll be ok cause they all convinced me I would!

  • I was never on Lupron but had similar side effects to you on the birth control for both of my IVF cycles. I am now dreading the Lupron they’re making me do for my FET cycle. Thanks for sharing and best wishes for stims!!!

  • I’ve also been trough this treatment. I stayed on it for 7 months! Hope you are well sweetie❤️ I’m also making videos about endometriosis, and just posted my story with temporary menopause. Maybe you would like to check it out?