How Metformin Can Be Used for Fertility

 

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How Metformin works for PCOS and fertility

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Fertility Treatment of PCOS Using Metformin | Infertility Healthcare

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Metformin is an insulin-sensitizing drug primarily used to treat diabetes, but it can also be used for fertility. Exactly how metformin improves fertility is unclear. 1  People who have polycystic ovarian syndrome (PCOS) might benefit from taking metformin alone, with. Metformin for Infertility Treatment Metformin reduces blood sugar levels and is approved by the FDA for treatment of type 2 diabetes. In women with infertility due to polycystic ovarian syndrome (PCOS), trials found Metformin plus Clomid to be more effective than Clomid alone in ovulation induction.

ANSWER. Metformin (Glucophage) may help you ovulate normally if you have insulin resistance or PCOS (polycystic ovarian syndrome). Fro. The role of Metformin is to establish properly balanced blood sugar and insulin levels [source: Fertility Authority ]. Proper blood sugar and insulin levels can help prevent or reduce cysts. When cysts are removed, menstrual cycles tend to become more regular.

When menstrual cycles are more predictable, the chances of becoming pregnant increase. Metformin appears to have a positive effect on fertility. Metformin is commonly used to treat PCOS, or polycystic ovary syndrome. According to research posted to.

I started clomid again 150mg for 9 months with no success this time. I did ovulate every month though. My obgyn referred me to a fertility specialist and after doing more lab work decided to put me on a dose of metformin 850mg 2 tabs per day of metformin. I took 1. Metformin may stimulate ovulation in a premenopausal woman and may increase the risk of unintended pregnancy.

Talk to your doctor about your risk. You should not breastfeed while using this medicine. Metformin should not be given to a child younger than 10 years old. Some forms of metformin are not approved for use by anyone younger than 18 years old.

Metformin Improves Ovulation and Pregnancy Rates in Patients With Polycystic Ovary Syndrome We evaluated the fertility promoting effect of metformin in infertile patients with polycystic ovary syndrome. Treat polycystic ovarian syndrome with Glucophage / Metformin Alone Metformin Dosing and Protocol We start metformin at 500 mg once daily, increase to 500 mg twice a day after one week, then to 500 mg 3 times daily If the 3 times daily dose cannot be tolerated due to side effects, we remain on. If metformin does not help restore regular ovulation, your fertility doctor may prescribe Clomid, as well. If your doctor prescribes metformin for your PCOS, metformin can work within 4 to 8 weeks.

Insulin stabilization may balance other hormones in a woman’s body and reduce other symptoms of PCOS. Some women use metformin as a tool for.

List of related literature:

Treatment for fertility  Metformin alone may improve ovulation and achieve conception.

“Kumar and Clark's Clinical Medicine E-Book” by Parveen Kumar, Michael L Clark
from Kumar and Clark’s Clinical Medicine E-Book
by Parveen Kumar, Michael L Clark
Elsevier Health Sciences, 2012

One example is metformin, which has been widely studied for improving blood sugar control in PCOS and diabetes.337 The theory of using metformin to improve fertility in PCOS is that by returning insulin levels to normal, we could also rebalance reproductive hormones and restore ovulation.

“It Starts with the Egg: How the Science of Egg Quality Can Help You Get Pregnant Naturally, Prevent Miscarriage, and Improve Your Odds in IVF (Second Edition)” by Rebecca Fett
from It Starts with the Egg: How the Science of Egg Quality Can Help You Get Pregnant Naturally, Prevent Miscarriage, and Improve Your Odds in IVF (Second Edition)
by Rebecca Fett
Franklin Fox Publishing LLC, 2019

It is the drug of choice for anovulatory infertility.

“Elsevier Comprehensive Guide To PGMEE With Companion Website Volume 2” by Exam
from Elsevier Comprehensive Guide To PGMEE With Companion Website Volume 2
by Exam
Elsevier India Pvt. Limited, 2009

Metformin and Other Insulin Sensitizers Metformin, a biguanide used to control blood sugar in diabetics, has a role in ovulation induction in women with PCOS and has been shown to be superior to placebo.

“Comprehensive Gynecology E-Book” by Rogerio A. Lobo, David M Gershenson, Gretchen M Lentz, Fidel A Valea
from Comprehensive Gynecology E-Book
by Rogerio A. Lobo, David M Gershenson, et. al.
Elsevier Health Sciences, 2016

Abstract Metformin has been used extensively in multiple reproductive settings to ameliorate hyperandrogenism and chronic anovulation, to treat infertility, to prevent miscarriage and to prevent later pregnancy complications as well.

“Reproductive Endocrinology and Infertility: Integrating Modern Clinical and Laboratory Practice” by Douglas T. Carrell, C. Matthew Peterson
from Reproductive Endocrinology and Infertility: Integrating Modern Clinical and Laboratory Practice
by Douglas T. Carrell, C. Matthew Peterson
Springer New York, 2010

Metformin is frequently used in patients with polycystic ovary syndrome and type 2 diabetes mellitus to improve insulin resistance and fertility (Legro et al, 2007).

“Avery's Diseases of the Newborn E-Book” by Christine A. Gleason, Sherin Devaskar
from Avery’s Diseases of the Newborn E-Book
by Christine A. Gleason, Sherin Devaskar
Elsevier Health Sciences, 2011

Its use with folic acid appears to lower triglycerides and/or testosterone and improve ovarian function, including ovulation rates in overweight women with PCOS, working as well as metformin (Jellin and Gregory, 2018).

“Krause and Mahan’s Food and the Nutrition Care Process E-Book” by Janice L Raymond, Kelly Morrow
from Krause and Mahan’s Food and the Nutrition Care Process E-Book
by Janice L Raymond, Kelly Morrow
Elsevier Health Sciences, 2020

Lifestyle measures and drugs that reduce KEY POINT insulin levels, such as metformin, have reversed the anovulation and improved fertility in patients with this disorder.

“Textbook of Family Medicine E-Book” by Robert E. Rakel
from Textbook of Family Medicine E-Book
by Robert E. Rakel
Elsevier Health Sciences, 2007

The use of metformin for women with PCOS undergoing IVF treatment.

“Textbook of Assisted Reproductive Techniques Fourth Edition: Volume 2: Clinical Perspectives” by David K. Gardner, Ariel Weissman, Colin M Howles, Zeev Shoham
from Textbook of Assisted Reproductive Techniques Fourth Edition: Volume 2: Clinical Perspectives
by David K. Gardner, Ariel Weissman, et. al.
Taylor & Francis, 2012

Use of Antidiabetic Drugs to Treat Anovulation and Androgen Excess A logical approach to the management of PCOS includes using medications that improve insulin sensitivity in target tissues, achieving reductions in insulin secretion, and stabilizing glucose tolerance.

“Williams Textbook of Endocrinology E-Book” by Shlomo Melmed, Ronald Koenig, Clifford Rosen, Richard Auchus, Allison Goldfine
from Williams Textbook of Endocrinology E-Book
by Shlomo Melmed, Ronald Koenig, et. al.
Elsevier Health Sciences, 2019

Oktay Kutluk

Kutluk Oktay, MD, FACOG is one of the world's foremost experts in fertility preservation as well as ovarian stimulation and in vitro fertilization for infertility treatments. He developed and performed the world's first ovarian transplantation procedures as well as pioneered new ovarian stimulation protocols for embryo and oocyte freezing for breast and endometrial cancer patients.

Mail: [email protected]
Telephone: +1 (877) 492-3666

Biography: https://medicine.yale.edu/profile/kutluk_oktay/
Bibliography: oktay_bibliography

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27 comments

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  • I have been married for 7years without any child. My Fallopian tubes were blocked. I tried everything possible to get pregnant and nothing was working. I visited so many hospital’s my problem never seems to end. I lost hope and felt depressed. One faithful day I started checking online on how to get pregnant in the comment section. People were testify about how they get results with Dr Oku I was surprise  about the testimony and decided to talk with him about my own issue… After explaining to him he said I have to purchase some medication from him after getting this medication for 3weeks i became pregnant and I decided to give a testimony for the great healer If you want to talk to DR Oku contact him on whatsapp +2348163425519
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  • 40 years ago the cholesterol number was under 250. 20 years ago it was under 200. Then 5 years ago under 150. After 4 stents and an aortic valve replacement my 2 cardiologists said THE LOWER THE BETTER. It is now 104. So I take 80 mgs of atorvastatin once daily and all my blood work is good and I feel great!

  • so I’m on the Marina now then getting a glucose test tomorrow then after getting on either Clomid or metformin if I want a baby in the next year should I get off the birth control they had me on it to level out hormones I guess my estrogen levels are high and they think my insulin is all messed up what should I ask about to get pregnant in the next year

  • Did you change your diet while on metformin? Did you eat healthier or drink lots of water? This week will be my 3rd week of metformin I started the beginning of May. & I’ve been eating better since March, but no period. so hoping this works.

  • I’ve been gaining weight despite eating low carb and sugars only from fresh fruits. I’m not eating processed food, no cake or breads. I am now considering metformin to help. Its really comblicated. Perhaps the combination would have a better effect:(

  • This is a serious subject. My friend with type 1 uses alphalopoic acid to keep down his neropathy and exersize it off. He is 54. He does quite well with diet, insulin shots, and other things. 100 years ago these people just died. What about alpha lopoic acid? As a doc, what do you think?

  • Helo mam i want to know ki agr mujh pcod hai or mera baby ivf ke through horha hai to meri body.kitna weight gain kr skti hai or after delivery may kab tak apna weight loss kr skti hu

  • Thanks for watching! My end screen got a little screwed up…whoops! Sorry! ��‍♀️

    What other things do you want me to do videos about?

  • Dr.Bailey, can you please comment on Berberine which some people commented here? Especially this study https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410097/

  • hello doctor my gynic examined me by doing scan and said iam having pcos problem but am a allergitic patient so which. type of diet I prefer please man advice me

  • Congrats that’s awesome. Being a mum is the most amazing and challenging thing you will ever do. How exciting for you both, hope all goes well with your pregnancy ����

  • Good morning! I got my cycles ovulated with diet and lifestyle change. I use to take it but it never worked for me nor did it regulate my cycles. Now that my cycles are regular and I ovulate on my own but not getting pregnant do I need to seek starting back or is it just timing?

  • Mam mujhe 1 year se zaada ho gya metformine khatey but period irregular hi h medicine se hi aatey h and baby b nhi h 6 year hue shadi ko bhoot pareshan hu

  • mam ur sayng pcos patient should take milk nd its products but usually i read that one should avoid all pulses nd dairy products
    plz help mam by telling what’s true nd what is mith

  • TF HELPS WOMEN BECOME PREGNANT

    Dr Flor Perea, an OBGyne had 10 patients 23-35 yo who never had experience of childbirth. But because of 4life products they all became pregnant in 2months.

    According to Dr Perea they also took a medicine called Chlomid together with 4life products:
    Tf Pure 2 caps 3x a day, Cardio 2caps 3x a day and Glutamine Prime 2 caps 3x a day..
    The problem why they could not be pregnant before is due to a blighted ovum (bugok na itlog). The NK cells mistook the ovum as a foreign body so they attack the poor ovum which eventually dies. So she recommended tf to educate the NK cells to recognize them as an ovum which succesfully lead to pregnancy for the first time. So ten women became extremely happy mothers for the first time in their lives.
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  • milk products r not health doctor plz give correct advice. don’t talk nonsense here it’s a serious issue. egg is not healthy for pcos. Badam and Almonds r one n the same

  • Hi r u suffering with pcod and want to conceive… Ayurveda siddha medicine is the best solution.. lots of ladies as found helpful.. for more information please call me +91 9741169412 Jaya

  • Dr. Sam thank you for sharing your knowledge. This is very informative, though I am not a diabetic. I know many people who are. These videos are super helpful and your smile brightens our day! ☺️☀️��

  • Not looking to conceive, nor do I have any wish to in the future. But I am interested in using Metformin to help weight loss with PCOS. I’m also going back on Orlistat for the same reason is this something you’ve tried before?

    Thanks x

  • Hi Dr Sam Bailey. I’m a medical professional from uk can I please have your contact details as I tried to find your social media but couldn’t succeed. Please give me your contact details I need your help. I will be waiting. Thank you

  • I am a diagnosed diabetic T2 in Australia on Metformin( Extended Release) 500mg once per day plus exercise and high fibre healthy diet. The 850mg dosage you mentioned is not available in Australia.-only 500 and 1,000mg. Possibly your video should have stated the relevant country.eg New Zealand.

  • Hello, I want to ask you I am pregnant after four miscarriages and I have pcos. Is it normal to take metformin during pregnancy? All doctors ordered me to stop it, and I did not stop it. I am now 10 weeks and take a dose of 850 mg twice a day. Is it normal please answer me, all the best for you

  • OMG so it made me get testosterone instead of progesterone no wonder ever since I was young for some reason I just had hair way more than my sister and my mom I had hairy arms hairy legs hairy chin I even felt like I was so ugly I felt like I was less girly than a lot of the other girls I was so chunky I gain weight more than all of my family members did all of my brothers and sisters can eat a bunch of food and they won’t gain weight but if I eat a burger you can see it like I hate myself I wanted to be a boy for a couple years until I got about 16 almost 17 then I started to realize that I wanted to be a girl again but I’m 25 years old now and I just found out that I have PCOS and literally I am full-blown the signs of PCOS and I’m so mad that no doctor even was able to see that and I’ve been in and out the hospital pretty much since I’ve been born but luckily I am completely healthy it was just my insulin level and I think it was the exercising that I need to get together but I’ve been eating healthy I’ve been doing yoga breathing exercises I’m not big on exercising but I do dance taxes eyes and I can definitely tell that metformin has been working for me thank you for your video I also made a video but I don’t know how to make as good videos as you but thank you so much for explaining it and basically breaking it down for us you’re awesome

  • I’ve been on metformin for about 5 weeks now. We are doing IVF if I donf fall pregnant naturally this month. I take 2 x 500ml tablets at 6:30 every night.
    It can make you feel sick but if you eat something even if its something small before taking the tablets then you’ll be fine and not feel sick at all.

  • Hi doctor I suffering from pcod I consult doctor they prescribed drome X and Mac nac sachet for three months I taken MNS I get pergant old help me

  • Thank you so much Dr. Bailey for this information/education. I have been taking metformin for almost 5 years and I learned more about it today from you. You are amazing beautiful doctor. Greetings and big hugs from the state of Oklahoma. ��������

  • This is such good news. I’m trying to conceive and I will try to ask my OBGYN if I can start with metformin and other medications. I am going to buy prenatal & other healthy supplements for PCOS